Download or read book Radicals for Life written by Ernst van Faassen and published by Elsevier. This book was released on 2011-10-13 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases

Download or read book Polymeric Drugs and Drug Delivery Systems written by Raphael M. Ottenbrite and published by CRC Press. This book was released on 2019-04-30 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w

Download or read book Exploring Peace Formation written by Kwesi Aning and published by Routledge. This book was released on 2018-04-17 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines the dynamics of socio-political order in post-colonial states across the Pacific Islands region and West Africa in order to elaborate on the processes and practices of peace formation. Drawing on field research and engaging with post-liberal conceptualisations of peacebuilding, this book investigates the interaction of a variety of actors and institutions involved in the provision of peace, security and justice in post-colonial states. The chapters analyse how different types of actors and institutions involved in peace formation engage in and are interpenetrated by a host of relations in the local arena, making ‘the local’ contested ground on which different discourses and praxes of peace, security and justice coexist and overlap. In the course of interactions, new and different forms of socio-political order emerge which are far from being captured through the familiar notions of a liberal peace and a Weberian ideal-type state. Rather, this volume investigates how (dis)order emerges as a result of interdependence among agents, thus laying open the fundamentally relational character of peace formation. This innovative relational, liminal and integrative understanding of peace formation has far-reaching consequences for internationally supported peacebuilding. This book will be of much interest to students of statebuilding, peace studies, security studies, governance, development and IR.

Download or read book Biophysics of Electron Transfer and Molecular Bioelectronics written by C. Nicolini and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 1997 International Workshop on Biophysics of Electron Transfer: Fundamental Aspects and Applications, held in Bressanone, Italy, October 8-10, 1997

Download or read book Flavins and Flavoproteins written by R. C. Bray and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-04-01 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: To celebrate the 270th anniversary of the De Gruyter publishing house, the company is providing permanent open access to 270 selected treasures from the De Gruyter Book Archive. Titles will be made available to anyone, anywhere at any time that might be interested. The DGBA project seeks to digitize the entire backlist of titles published since 1749 to ensure that future generations have digital access to the high-quality primary sources that De Gruyter has published over the centuries.

Download or read book Water Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2018-03-12 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Download or read book Oncolytic Virotherapy written by Ahmed Majeed Al-Shammari and published by Frontiers Media SA. This book was released on 2023-11-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using viruses to treat cancer is an established concept, and many viruses have shown promising anti-tumor efficacies. Oncolytic viruses are safe and well-characterized pathogens with a stable genome. The outstanding clinical results for oncolytic virotherapy deserve serious attention and consideration to make it a treatment option alongside classical cancer therapeutics. Virotherapy uses replication-competent oncolytic viruses to replicate and destroy cancer cells selectively. The transformed nature of cancer cells offers a permissive environment for some viruses’ replication and to complement viral mutations. The in situ amplification and spread within the tumor mass is the key benefit of such replication-competent viruses. Oncolytic virotherapy is divided into two main groups, according to tumor specificity: naturally oncolytic viruses to replicate in human cancer cells; and gene-modified viruses engineered to accomplish selective oncolysis.

Download or read book Advances in Drug Delivery Systems 6 written by James M. Anderson and published by Elsevier. This book was released on 2013-10-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

Download or read book Frankia Symbiosis written by P. Normand and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 12th meeting on Frankia and Actinorhizal Plants that took place in Carry-le-Rouet, France in June 2001 was the opportunity for scientists to communicate about latest developments on this symbiosis that concerns a wide range of dicotyledonous plants, initiates ecological successions and is used in a number of countries to protect crops from winds or improve soil status. Selected papers on plant ecology, Frankia's genetics or physiology, and host plants' genetics or physiology are published in this special Plant & Soil issue.

Download or read book Advances in Polymeric Systems for Drug Delivery written by Raymond Bonnett and published by CRC Press. This book was released on 2002-03-07 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title examines new drug delivery strategies utilizing intelligent polymeric materials that perform sensing, processing and response functions. The authors demonstrate the design of polymers with integrated intelligent functions to achieve site specific and temporally controlled drug delivery, specifically for pharmaceutical applications. Using stimuli-responsive polymers as molecular devices for self-regulation and externally modulated drug delivery systems are reviewed from multi-disciplinary perspectives, employing materials science and bio-engineering as an important foundation.

Download or read book ADR and the Law 20th Edition written by American Arbitration Association and published by Juris Publishing, Inc.. This book was released on 2006 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: ADR & the Law is the flagship publication of the American Arbitration Association ® (AAA). It is a one-stop reference for attorneys, business executives, scholars and anyone who needs to track worldwide developments in alternative dispute resolution. Each consecutive volume presents a review of the year's most influential domestic and international ADR case law and legislation, along with expert commentary. The book includes significant court decisions, analysis of current trends, highlights of important domestic and foreign legislation and new ADR rules and procedures. Each volume is an essential addition to a professional library. Each Volume Contains: Significant Decisions by Federal and State Courts Articles on Such Topics as Employment Labor Mediation Judicial Review Domestic Alternative Dispute Resolution Legislation Significant Decisions by U.S. Courts Concerning International Alternative Dispute Resolution International Alternative Dispute Resolution Developments International Arbitration in Specific Countries

Download or read book Chemo Radiation Resistance in Cancer Therapy written by Zhe-Sheng Chen and published by Frontiers Media SA. This book was released on 2022-06-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Macromolecules 1992 written by Jaroslav Kahovec and published by VSP. This book was released on 1993-01-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of the invited special lectures which were delivered at the 34th International Symposium on Macromolecules (MACRO 92), held under the auspices of IUPAC, Prague, Czechoslovakia, 13--18 July 1992. The articles included in this volume range from classic topics in polymer science, such as polymerization chemistry, and structures and properties of macromolecules and polymers, to topics in the field of functional polymers such as pharmaceutical polymers, polymers with electrically and optically useful properties, polymeric sorbents, catalysts, and reagents. In addition articles on new polymeric materials, polymer blends and composites as well as the degradation and stabilization of polymeric materials are included in this volume.

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2010 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advanced Exercise Endocrinology written by Katarina T. Borer and published by Human Kinetics. This book was released on 2013-04-22 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Exercise Endocrinology presents a comprehensive examination of the relationship between physical activity and hormone function. As the newest addition to Human Kinetics’ Advanced Exercise Physiology Series, this resource offers the most up-to-date information on the quickly advancing field of exercise endocrinology. Written by leading exercise endocrinologist Katarina Borer, Advanced Exercise Endocrinology is an essential reference for exercise physiologists, physiotherapists, and other health professionals researching the connections between exercise, hormone function, and health. Advanced Exercise Endocrinology explains how the human body responds to exercise in order to support the increased energy demand. Readers will explore topics including body fluid balance during exercise and at rest, endocrine and autonomic control of cardiorespiratory function, hormonal control of energy expenditure, and the role of reproductive hormones in exercise. The text offers an integrative perspective and includes the following unique features: • An emphasis on the effects of hormones during exercise in the context of biological functions or physiological events to help readers appreciate the complexity of hormonal response from a functional, whole-body perspective • A discussion of hormone actions in exercise with an emphasis on the mechanisms of action, which is key to developing an advanced understanding of metabolism and somatic and physiological adaptations to training • A chapter that brings together research on nonhormonal signaling in exercise, a topic not often presented in a comprehensive manner • An introduction to the principles of hormone measurements, which will be especially helpful to students considering a future in research Combining foundational concepts and research, this text offers engaging and accessible coverage of this advanced field of study. Chapter summaries help readers focus on the most significant issues presented for each topic, and extensive illustrations, figures, and graphs provide visual reinforcement of key concepts and important research findings. Special sidebars highlight analyses of interesting research findings and practical applications. In examining current research, readers will be able to identify emerging topics and possible directions for future exploration. While the connection between exercise, hormones, and health is well acknowledged, the field had yet to be fully explored. Advanced Exercise Endocrinology will help students and professionals from many health fields better understand how interactions between physical activity and hormone action work to maintain health, improve exercise performance, and prevent metabolic disabilities. Human Kinetics’ Advanced Exercise Physiology Series offers books for advanced undergraduate and graduate students as well as professionals in exercise science and kinesiology. These books highlight the complex interaction of various systems both at rest and during exercise. Each text in this series offers a clear and concise explanation of the system and details how each is affected by acute exercise and chronic exercise training. Advanced Exercise Endocrinology is the fourth volume in the series.

Download or read book SEC Docket written by United States. Securities and Exchange Commission and published by . This book was released on 1992 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diamonds from the Arkhangelsk Province NW Russia written by Victor Garanin and published by Springer Nature. This book was released on 2021-07-19 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines and summarizes data on more than 40,000 diamonds from deposits in Russia’s diamondiferous Arkhangelsk province. The geological data of diamond deposits includes the geological setting, ore body morphology and mineral composition. Investigation techniques employed include: Color Cathode Luminescence, Fourier Transform Infrared Spectroscopy, Electron Paramagnetic Resonance, Raman Spectroscopy, and Carbon Isotopy. The book provides a full description of the diamond morphology. The problems of a potential (mantle) diamond grade for deposits are considered, depending on the physical and chemical conditions involved in the genesis and growth of diamond crystals. Further, there can be a significant impact on the productivity of bodies and the properties of diamonds during post-crystallization metasomatic processes. In this book, the authors propose a diamond crystallization model for changes in diamond crystals within mantle metasomatic transformations, and identify the factors affecting the growth and dissolution of diamonds in the mantle. In addition, they describe the complex evolution of kimberlite from the mantle up to the Earth’s surface. All of these factors affect the quality and quantity of diamonds in a particular diamond deposit, providing the basis for identifying optimal technological mining processes.