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Book Forkhead Transcription Factors

Download or read book Forkhead Transcription Factors written by Kenneth Maiese and published by Springer Science & Business Media. This book was released on 2010-07-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.

Book Forkhead FOXO Transcription Factors in Development and Disease

Download or read book Forkhead FOXO Transcription Factors in Development and Disease written by and published by Academic Press. This book was released on 2018-02-07 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics. This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism. Provides the authority and expertise of leading contributors Includes sections on the regulation of FOXO factors and stem cells Presents a unique view of this highly evolutionary family of transcription factors

Book Forkhead Transcription Factors in Mammalian Development

Download or read book Forkhead Transcription Factors in Mammalian Development written by Margit Mahlapuu and published by . This book was released on 2001 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The DNA binding Specificity of Forkhead Transcription Factors

Download or read book The DNA binding Specificity of Forkhead Transcription Factors written by Chen, Xi and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Transcription Factors Advances in Research and Application 2011 Edition

Download or read book Transcription Factors Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription Factors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Transcription Factors in a concise format. The editors have built Transcription Factors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transcription Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Transcription Factors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Book Encyclopedia of Signaling Molecules

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Book The Forkhead Transcription Factors FoxC2 and FoxO1 Regulate Adipocyte Differentiation

Download or read book The Forkhead Transcription Factors FoxC2 and FoxO1 Regulate Adipocyte Differentiation written by Kathryn Ellen Davis and published by . This book was released on 2006 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Forkhead Transcription Factor FOXO3a MRNA Levels in the Bovine Preovulatory Follicle

Download or read book Forkhead Transcription Factor FOXO3a MRNA Levels in the Bovine Preovulatory Follicle written by Peter Sepp and published by . This book was released on 2004 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Chemical Modulation of the Forkhead Box M1 Transcription Factor

Download or read book Chemical Modulation of the Forkhead Box M1 Transcription Factor written by Seyed Amirhossein Tabatabaei Dakhili and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thousands of transcription factors control the process of gene expression and protein synthesis in the human body. These nuclear proteins are fundamental for healthy organ development, cellular function, immunity and body response to diseases and stress. Mutated, overexpressed, or dysregulated transcription factors are linked to cancer, neurological disorders, metabolic, and autoimmunity diseases. Forkhead Box M1 (FOXM1) is a transcription factor required for the normal progression of the cell cycle as well as tissue regeneration, homeostasis, and DNA repair. However, in many types of cancer, its expression is dysregulated. As the "master regulator of the cell cycle", its overexpression leads to tumorigenesis, angiogenesis, metastasis and poor patient prognosis. Accumulating evidence suggests that inhibition of FOXM1 as the Achilles heel of cancer could be the master key for the cancer-treatment lock. However, direct targeting of the FOXM1 transcription factor is a challenging task due to the lack of binding pocket and ligand-binding site. In the past decade, several small molecules have been introduced with the ability to decrease the FOXM1 expression with a different and distinct mechanism. Most-recently it is found that compounds thiostrepton (previously found to inhibit FOXM1 indirectly through proteasome inhibition) and Forkhead Domain Inhibitor-6 (FDI-6) can directly bind to the FOXM1 DNA binding domain (DBD) and suppress its activity. However, the exact mechanism of binding of these agents to the FOXM1-DBD is not reported. Since the fundamental of designing inhibitors for any target is an extensive structural analysis of the target, we used a series of molecular dynamics (MD) simulations to understand the mechanism of FOXM1-DBD/DNA recognition. Next, using different approaches, we identified a binding pocket on the DNA recognition helix of FOXM1-DBD. Furthermore, using molecular modeling and docking techniques, we found a mutual binding mode for known FOXM1 inhibitors, thiostrepton, FDI-6, and troglitazone. We found that these compounds form a complex with the FOXM1-DBD mainly through a strong pi-sulfur interaction with His287 of FOXM1-DBD. Additionally, we reported that FDI-6 forms an additional strong halogen bonding with Arg297 by its 4-fluorophenyl ring. To provide evidence regarding the existence of halogen bonding, we chemically modified the structure of FDI-6. Then, using protein immunoblot and EMSA of recombinant human FOXM1-DBD, we proved that only those derivatives carrying halogen atoms at positions 3 and 4 are active. To validate the hypothesis of pi-sulfur interaction, we used two different pathways, chemical and biological. First, we exchanged the sulfur atom in the structure of FDI-6 and confirmed that the sulfur atom is essential for its FOXM1 inhibitory activity. Next, using site-directed mutagenesis, we mutated the His287 of recombinant FOXM1-DBD to a simple and non-aromatic amino acid (alanine) and also to an aromatic amino acid (phenylalanine). Using EMSA, we confirmed that FDI-6 was unable to bind to the alanine mutated FOXM1-DBD, while its binding was unaffected by phenylalanine mutation. These results point to the probability that the theoretical binding site we identified using molecular modeling of the FOXM1-DBD is valid. Based on the gained knowledge of binding sites as well as the structural requirements necessary for a small molecule to inhibit this oncogenic transcription factor, we designed a series of compounds based on the structure of thiazolidinediones (troglitazone) capable of suppressing the FOXM1 transcriptional program. Among them, compound TFI-10 was able to target and decrease the cellular level of FOXM1 without affecting FOXM1's closely related family members and key tumor suppressors, FOXO1, and FOXO3a. We also showed that the currently known selective FOXO1 inhibitor, AS1842856, could also target FOXM1 and decrease its protein level as well as its target genes by a mechanism other than direct binding to the DBD. We demonstrated that FOXM1b could promote the expression of FOXO1 while the other FOXM1 isoform, FOXM1c, negatively regulates the level of FOXO1. We also presented using colony formation assay and gene silencing techniques that dual inhibition of FOXM1 and FOXO1 can dramatically decrease the ability of breast cancer cells to proliferate and form colonies.

Book Gonadotropins From Bench Side to Bedside

Download or read book Gonadotropins From Bench Side to Bedside written by Rajendra T. Kumar and published by Academic Press. This book was released on 2016-09-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology Informs and updates on all the latest developments available regarding the research of gonadotropins