Download or read book Floating Drug Delivery System A Novel Technology written by Deepika Singh and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present work, floating microspheres of AZH were formulated to provide site specific delivery of drug with a view to providing an effective and safe therapy for eradication of H.pylori with a reduced dose and reduced duration of therapy. The developed floating microspheres of AZH have excellent buoyant ability, high encapsulation and good release pattern. The slow but complete drug release in the stomach is expected to increase bioavailability of the drug as well its complete utilization which may results to lower dose and GI side effects. It can be concluded that optimized multi-unit floating AZH microspheres floating more than 8 hrs in stomach. The floating microsphere is a potential system for delivery of AZH in the stomach. So it is expected to provide clinicians with a new choice of an economical, safe and low dose formulation in the management of eradication of H.pylori.
Download or read book Introduction of Novel Drug Delivery Systems written by Sonal Vyas and published by CBS Publishers & Distributors Pvt Limited, India. This book was released on 2020-01-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a useful textbook and resource for undergraduateand postgraduate students and anyone in the working concepts of a drug delivery system and its performance. A novel drug delivery system refers to strategy, technology, formulation-based approaches and customized system(s) developed for safe administration and within body transportation of drugs as needed for optimum therapeutic benefits while ensuring minimum to nil toxic effects. Multidisciplinary approaches and cutting edge technology have been used to develop the carrier modules to deliver the contained drug to the target tissues in a preprogrammed manner. The process desirably modifies the drug distribution and accumulation, thereby producing optimum therapeutic effects. Carrier-mediated drug delivery has emerged as a powerful technology for the treatment of various difficult pathologies. The therapeutic index of conventional and novel drug is enhanced owing to specificity due to targeting of drug to the particular tissue. This book includes an introduction to novel drug delivery, oral osmotic pumps, bioadhesive and mucoadhesive systems, multiple emulsions, colon-specific drug delivery systems, transdermal drug delivery systems, spherical crystallization, microemulsion, implants and inserts, micellar systems, liposomes, microspheres and microcapsules, nanoparticles, resealed erythrocytes, transfersomes and ethosomes, organogels, dendrimers, niosomes, solid lipid nanoparticles, drug conjugates, cyclodextrin complexes, multifunctional nanomedicines, and floating drug delivery system(s). Each chapter attempts to discuss introduction, concept, progress, status and future prospects of the concerned novel drug delivery system.
Download or read book Hot Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Download or read book Drug Delivery Systems written by and published by . This book was released on 1984 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Formulation and Evaluation of a Floating Drug Delivery System written by Dey Sanjoy Kumar and published by Independent Aurthor. This book was released on 2022-11-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high level of patient compliance in taking oral dosage forms is due to the ease of administration and handling of these forms [1]. Development of a successful oral controlled release formulation requires an understanding of three aspects: (a) gastrointestinal physiology (b) physiochemical properties of the drug and (c) dosage form characteristics [2]. In the development of oral controlled drug delivery system, one of the main challenges is to modify the GI transit time [1]. Using controlled release technology, oral delivery for 24 h(hours) is possible for many drugs; however, the substance must be well absorbed throughout the whole gastrointestinal tract. A significant obstacle may arise if there is a narrow window for drug absorption in the gastro intestinal tract (GIT), if a stability problem exists in gastrointestinal fluids, or the drug is poorly soluble in the intestine or acts locally in the stomach. Thus, the real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of the drugs for more than 12 h, but to prolong the presence of the dosage forms in the stomach or somewhere in the upper intestine until the entire drug is released over the desired period of time [3].
Download or read book Novel Drug Delivery Technologies written by Ambikanandan Misra and published by Springer Nature. This book was released on 2020-02-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.
Download or read book Controlled Drug Delivery Systems written by Emmanuel C. Opara and published by CRC Press. This book was released on 2020-02-28 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Download or read book Design of Controlled Release Drug Delivery Systems written by Xiaoling Li and published by McGraw Hill Professional. This book was released on 2005-11-24 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.
Download or read book Drug Delivery Systems written by Vasant V. Ranade and published by CRC Press. This book was released on 2003-08-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both
Download or read book Novel Drug Delivery Systems written by Technology Catalysts International Corporation and published by . This book was released on 1996 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modified Release Drug Delivery Technology written by Michael J. Rathbone and published by CRC Press. This book was released on 2002-11-07 with total page 1021 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.
Download or read book Novel Drug Delivery Systems written by and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NOVEL DRUG DELIVERY SYSTEM written by Dr. N.G. Raghavendra Rao and published by JEC PUBLICATION. This book was released on with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fascinating world of "Novel Drug Delivery Systems" is yours to explore. In this book, we set out on a thrilling voyage through the constantly changing field of drug distribution, where groundbreaking discoveries and fresh ideas are revolutionizing how we use and perceive medication. It is our honor to expose to the enormous world of innovative drug delivery systems and explore their principles, uses, and promise to transform healthcare as the author of this comprehensive resource. This book's rigorous planning ensures a thorough comprehension of the subject matter by covering a broad variety of subjects that line up with the drug delivery systems curriculum. We go into the fundamentals of controlled medication delivery systems in Unit-I. We discuss controlled release formulation language, meanings, and justifications. We investigate the design concepts of diffusion, dissolution, and ion exchange for creating controlled release formulations. We also look at drug formulation-relevant physicochemical and biological characteristics. Polymers and the creation of formulations and we categorize polymers according to their characteristics and talk about their benefits for controlled release medication delivery systems. Methods for microencapsulation are introduced in Unit II. We explore implantable drug delivery devices and acquire understanding of mucosal drug delivery systems, including bioadhesion and mucoadhesion concepts. Transdermal drug delivery methods are examined in Unit-III, with an emphasis on skin penetration and the variables that affect it. We look into transdermal medication delivery system components and permeability enhancers. We also explore techniques for delivering gastroretentive drugs, such as floating and high-density systems, inflatable systems, and gastro sticky systems. We address nasal and pulmonary routes, formulation strategies, and delivery devices as we examine the Nasopulmonary drug delivery system. Targeted drug delivery is the subject of Unit-IV, which examines theories, methods, and the potential of liposomes, niosomes, nanoparticles, and monoclonal antibodies.
Download or read book Handbook of Pharmaceutical Controlled Release Technology written by Donald L. Wise and published by CRC Press. This book was released on 2000-08-24 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!
Download or read book Novel Approaches for Drug Delivery written by Keservani, Raj K. and published by IGI Global. This book was released on 2016-07-15 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing optimal care to patients is a primary concern in the healthcare field. By utilizing the latest resources and research in biomedical applications, the needs and expectations of patients can be successfully exceeded. Novel Approaches for Drug Delivery is an authoritative reference source for the latest scholarly research on emerging developments within the pharmaceutical industry, examining the current state and future directions of drug delivery systems. Highlighting therapeutic applications, predictive toxicology, and risk assessment perspectives, this book is ideally designed for medical practitioners, pharmacists, graduate-level students, scientists, and researchers.
Download or read book Modified Release Drug Delivery Technology Second Edition written by Michael J. Rathbone and published by CRC Press. This book was released on 2008-05-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes, providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value. Topics include:
Download or read book Handbook of Non Invasive Drug Delivery Systems written by Vitthal S. Kulkarni and published by Elsevier. This book was released on 2009-12-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.
