Download or read book New Concepts in the Pathogenesis of NIDDM written by Claes-Goran Östenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book Genetic Variation and Dietary Response written by Artemis P. Simopoulos and published by Karger Medical and Scientific Publishers. This book was released on 1997-01-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume focuses on genetics and nutrition, and their interaction in the development of chronic diseases. Knowledge of genetic susceptibility to disease will not only help to identify those at higher risk for disease but also to ascertain their response to diet. The prospect of targeting specific dietary treatment at those predicted to gain the most therapeutic benefit clearly has important clinical and economic consequences, particularly in diseases of high prevalence. This book is unique in considering genetic variation in susceptibility to disease, and the importance of specific diets in influencing lipid levels in cardiovascular disease and bone density in osteoporosis. The contributions emphasize that dietary response is dependent on the genetic variant and that specific dietary recommendations rather than universal ones are needed for the prevention and management of chronic diseases. Bringing together vital information for the first time, this book is important reading for physicians, nutritionists, dietitians, geneticists, physiologists, molecular biologists, food technologists and policymakers.

Download or read book Diabetes Literature Index written by and published by . This book was released on 1974 with total page 1816 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diabetes Literature Index written by and published by . This book was released on 1976 with total page 1470 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Canadian Journal of Physiology and Pharmacology written by and published by . This book was released on 1988 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Atherosclerosis IV written by G. Schettler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.

Download or read book Lipids and Lipoproteins written by M. Fondu and published by S. Karger AG (Switzerland). This book was released on 1980 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Symposium proceedings of the Federation of Margarine Associations focused on lipids and lipoproteins. Structure and emergence of lipoproteins, and metabolic problems related to LDC and HDL are discussed. Alcohol's influence on lipoproteins and diabetes in clinical studies is reviewed along with biochemical studies, specifically corticosteriod biosynthesis and polyunsaturated fatty acids effects in heart muscle. Epidemiological papers, dietary studies, and fat processing technologies are examined. Extensive knowledge exists about lipoproteins and how apopolypeptides are attached to the phospholipids, cholesterol esters, triglycerides, and cholesterol as well as the amino acid sequence. Two areas for further research are suggested: a new apoprotein reported from studying the lymph, and the cellular functions and role of lipoproteins in triglyceride transport and specific organ activity. (kbc).

Download or read book Drugs Affecting Lipid Metabolism VIII written by David Kritchevsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings of the Eight International Symposium on Drugs Affecting Lipid Metabolism (8th D.A.L.M.) is the subject of this volume. Since the first symposium in 1960, each successive meeting has broken new ground in the field of pharmacological control of lipid levels - offering new and stimulating insights and exposing the audience to the state of the art. The field has progressed sufficiently to permit discussion of the cellular biology of athero sclerosis. The opening session was devoted to pathology, macrophages, lipoproteins and their receptors and choles terol ester metabolism. Because of the recent emergence of new apolipoprotein technology, a workshop devoted sole ly to apolipoprotein methodology was introduced followed by a plenary session devoted to their metabolism and structure. Another rapidly developing area of atherosclerosis research is non-invasive assessment of this condition. Accordingly, a session was devoted to new techniques for this research modality. The final plenary sessions were devoted to the roles of drugs and diet in athero~ scl~rosis - cause, treatment and mechanisms of action. The meeting was summarized by Dr. O.J. Pollak, one of the "founding fathers" of this field. There were nine sessions of proffered papers whose abstracts appear in this volume. In addition, special workshops (to be reported elsewhere) were devoted to several drugs including Oiyzanol, Probucol and Etofibrate.

Download or read book Principles and Treatment of Lipoprotein Disorders written by Gotthard Schettler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis still affects over 50 % of the population in the highly industrialized countries. This book is an update of the treatment of hyperlipidemia, necessary due to the identification in recent years of molecular mechanisms of atherogenesis. Emphasis is on the disease etiology of arteriosclerosis, the treatment of associated or causing diseases and treatment by dietary means or hypolipidemic drugs.

Download or read book Current Opinion in Lipidology written by and published by . This book was released on 1997 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hemostasis and Thrombosis written by and published by . This book was released on 1976 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cumulated from monthly issues.

Download or read book Metabolic Risk Factors in Ischemic Cardiovascular Disease written by Lars A. Carlson and published by Raven Press (ID). This book was released on 1982 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The American Journal of Clinical Nutrition written by and published by . This book was released on 1985 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Feeding Weight Obesity Abstracts written by and published by . This book was released on 1977 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diabetes Obesity and Hyperlipidemias written by Gaetano Crepaldi and published by . This book was released on 1978 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Atherosclerosis III written by G. Schettler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: