Download or read book The Family That Couldn t Sleep written by D. T. Max and published by Random House. This book was released on 2006-09-05 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.
Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
Download or read book Autonomic Nervous System and Sleep written by Sudhansu Chokroverty and published by Springer Nature. This book was released on 2021-02-23 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book addresses all elements of the autonomic nervous system (ANS) and sleep interaction, as well as ANS alterations in sleep and how these impact primary and comorbid sleep dysfunction. It meets the market need for a comprehensive text that deals with ANS changes in sleep and how these impact various neurological, medical, and primary sleep disorders. Organized into three parts, the book begins with a review of the foundational bodily systems that participate in coordination of ANS activity with other homeostatic responses such as respiration, cardiovascular reflexes, and responses to stress. Part two then examines methods of laboratory evaluation and the “why, when, how” of interpreting heart rate variability in sleep. To conclude, the final section of the book broadly covers the many clinical aspects of ANS, including insomnia, restless leg syndrome, sleep apnea, sleep related epilepsy, and acute autonomic neuropathy. Autonomic Nervous System and Sleep enhances the reader's understanding of the pathophysiology of various disorders, and explains how to apply this profound understanding is important to new lines of therapy to improve morbidity.
Download or read book Fundamentals of Sleep Medicine written by Richard B. Berry and published by Elsevier Health Sciences. This book was released on 2011-07-18 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by Richard Berry, MD, author of the popular Sleep Medicine Pearls, Fundamentals of Sleep Medicine is a concise, clinically focused alternative to larger sleep medicine references. A recipient of the 2010 AASM Excellence in Education award, Dr. Berry is exceptionally well qualified to distill today's most essential sleep medicine know-how in a way that is fast and easy to access and apply in your practice. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get clear guidance on applying the AASM scoring criteria. Reinforce your knowledge with more than 350 review questions. Get the answers you need quickly thanks to Dr. Berry's direct and clear writing style. Access the complete contents online at Expert Consult, including videos demonstrating parasomnias, leg kicks, and more.
Download or read book Sleep Donation written by Karen Russell and published by Vintage. This book was released on 2020-09-29 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newly illustrated and available for the first time in years, a haunting novella from the uncannily imaginative author of the national bestsellers Swamplandia! and Orange World: the story of a deadly insomnia epidemic and the lengths one woman will go to to fight it. Trish Edgewater is the Slumber Corps' top recruiter. On the phone, at a specially organized Sleep Drive, even in a supermarket parking lot: Trish can get even the most reluctant healthy dreamer to donate sleep to an insomniac in crisis--one of hundreds of thousands of people who have totally lost the ability to sleep. Trish cries, she shakes, she shows potential donors a picture of her deceased sister, Dori: one of the first victims of the lethal insomnia plague that has swept the globe. Run by the wealthy and enigmatic Storch brothers, the Slumber Corps is at the forefront of the fight against this deadly new disease. But when Trish is confronted by "Baby A," the first universal sleep donor, and the mysterious "Donor Y," whose horrific infectious nightmares are threatening to sweep through the precious sleep supply, her faith in the organization and in her own motives begins to falter. Fully illustrated with dreamy evocations of Russell's singular imagination and featuring a brand-new "Nightmare Appendix," Sleep Donation will keep readers up long into the night and long after haunt their dreams.
Download or read book Tales from the Gas Station Volume Two written by Jack Townsend and published by Jack Townsend. This book was released on with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nightshift clerk and high-functioning insomniac Jack is back to work, trying his best to keep out of trouble. But when his chain-smoking coworker discovers a mysterious radio signal revealing the guarded secrets of their town, Jack will learn that an annoying new dayshift manager is far from the worst of his problems. In this second installment of the Gas Station saga, Jack finds himself entangled in his most harrowing adventure yet. With the newest crew of coworkers along for the ride and the resident psychopath out for his blood, our hero(?) must navigate the drama of small-town murder conspiracies, vigilante justice, and demonic summoning rituals...whether he wants to or not.
Download or read book Creutzfeldt Jakob Disease written by Mic J. Stones and published by Nova Publishers. This book was released on 2006 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Creutzfeldt-Jakob Disease is a very rare and incurable degenerative neurological disorder that is ultimately fatal. It is the most common of the transmissible spongiform encephalopathies. Transmissible spongiform encephalopathy diseases (also known as prion diseases) are caused by a unique type of infectious agent called prions, an abnormally structured form of a protein found in the brain. Other prion diseases include Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru in humans, as well as bovine spongiform encephalopathy (BSE) and scrapie in animals. This book presents the latest research in this field.
Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
Download or read book The Shapeless Unease written by Samantha Harvey and published by Grove Press. This book was released on 2020-05-12 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Sleeplessness gets the Susan Sontag illness-as-metaphor treatment in this pensive, compact, lyrical inquiry into the author’s nighttime demons.” —Kirkus Reviews In 2016, Samantha Harvey began to lose sleep. She tried everything to appease her wakefulness: from medication to therapy, changes in her diet to changes in her living arrangements. Nothing seemed to help. The Shapeless Unease is Harvey’s darkly funny and deeply intelligent anatomy of her insomnia, an immersive interior monologue of a year without one of the most basic human needs. Original and profound, and narrated with a lucid breathlessness, this is a startlingly insightful exploration of memory, writing and influence, death and the will to survive, from “this generation’s Virginia Woolf” (Telegraph). “Captures the essence of fractious emotions—anxiety, fear, grief, rage—in prose so elegant, so luminous, it practically shines from the page. Harvey is a hugely talented writer, and this is a book to relish.” —Sarah Waters, New York Times–bestselling author “Harvey writes with hypnotic power and poetic precision about—well, about everything: grief, pain, memory, family, the night sky, a lake at sunset, what it means to dream and what it means to suffer and survive . . . The big surprise is that this book about ‘shapeless unease’ is, in the end, a glittering, playful and, yes, joyful celebration of that glorious gift of glorious life.” —Daily Mail “What a spectacularly good book. It is so controlled and yet so wild . . . easily one of the truest and best books I’ve read about what it’s like to be alive now, in this country.” —Max Porter, award-winning author of Lanny
Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Download or read book Molecular Aspects of Neurodegeneration and Neuroprotection written by Akhlaq A. Farooqui and published by Bentham Science Publishers. This book was released on 2011-01-26 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"
Download or read book Rare Diseases Epidemiology Update and Overview written by Manuel Posada de la Paz and published by Springer. This book was released on 2017-12-06 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fields of rare diseases research and orphan products development continue to expand with more products in research and development status. In recent years, the role of the patient advocacy groups has evolved into a research partner with the academic research community and the bio-pharmaceutical industry. Unique approaches to research and development require epidemiological data not previously available to assist in protocol study design and patient recruitment for clinical trials required by regulatory agencies prior to approval for access by patents and practicing physicians.
Download or read book Oxford Textbook of Sleep Disorders written by Sudhansu Chokroverty and published by Oxford University Press. This book was released on 2017 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a rapid global increase in the number of individuals making sleep medicine their career, resulting in an explosive growth in the number of sleep centres and programmes, as well as an increasing number of sleep societies and journals. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Sleep Disorders covers the rapid advances in scientific, technical, clinical, and therapeutic aspects of sleep medicine which have captivated sleep scientists and clinicians. This text aims to introduce sleep disorders within the context of classical neurological diseases, giving an in-depth coverage of the topic in a logical and orderly way, while emphasizing the practical aspects in a succinct and lucid manner. Divided into 12 sections, this book begins by discussing the basic science (Section 1), before moving onto the laboratory evaluation (Section 2) and the clinical science (Section 3). The remainder of the book focuses on specific sleep disorders (Sections 4-12), from insomnias and parasomnias to sleep neurology and sleep and psychiatric disorders. Chapters are supplemented by tables, case reports, and illustrations intended to succinctly provide relevant information in a practical manner for diagnosis and treatment of sleep disorders, while always emphasizing clinical-behavioural-laboratory correlations.
Download or read book Sleep written by Teofilo L. Lee-Chiong and published by John Wiley & Sons. This book was released on 2005-12-13 with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique resource on sleep medicine Written by contemporary experts from around the world, Sleep: A Comprehensive Handbook covers the entire field of sleep medicine. Taking a novel approach, the text features both syndrome- and patient-oriented coverage, making it ideally suited for both clinical use and academic study. Sleep: A Comprehensive Handbook begins with a brief introduction to the basic science of sleep, from neurobiology to physiologic processes. This leads into sections offering comprehensive coverage of insomnia, sleep apnea, narcolepsy, parasomnias, movement disorders, and much more. Sleep and related disorders are also discussed, followed by chapters on considerations for special patient groups. Special materials for practitioners include a sample interview and questionnaire as well as a chapter on operating and managing a sleep center. The text concludes with discussions of sleep assessment methods such as polysomnography, actigraphy, and video EEG monitoring. With full coverage of over 100 key topics in sleep medicine, Sleep: A Comprehensive Handbook offers the most practical, thorough, yet handy resource available on adult and pediatric sleep medicine. Praise from the reviews: "...no other publication in the field can begin to compare with the breadth or depth of the 'Handbook'...I cannot imagine a functioning sleep disorders clinic without at least one copy on standby as a ready reference." PscyCRITIQUES "Sleep: A Comprehensive Handbook is a first-rate textbook with concise, up-to-date information covering a wide range of subjects pertinent to the practice of sleep medicine." DOODY'S HEALTH SERVICES
Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Download or read book Prions Prions Prions written by Stanley B. Prusiner and published by Springer. This book was released on 2011-09-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.
Download or read book Emerging foodborne pathogens written by Yasmine Motarjemi and published by CRC Press. This book was released on 2006-06-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments such as the increasing globalization of the food industry, constant innovations in technologies and products, and changes in the susceptibility of populations to disease have all highlighted the problem of emerging pathogens, either newly discovered through more sensitive analytical methods, linked for the first time to disease in humans, or newly associated with a particular food. Designed for microbiologists and quality assurance professionals and for government and academic food safety scientists, this timely reference discusses ways of identifying emerging pathogens and includes chapters on individual pathogens, their epidemiology, methods of detection, and means of control.
