Download or read book Expression of Differentiated Functions in Cancer Cells written by Roberto P. Revoltella and published by . This book was released on 1982 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Mechanisms of Differentiation written by Paul B. Fisher and published by CRC Press. This book was released on 1990-08-27 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.
Download or read book Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy written by G V Sherbet and published by Elsevier. This book was released on 2011-07-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. - Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes - Aids the development of therapeutic treatments for cancer - Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
Download or read book New Cell Differentiation Research Topics written by Hitoshi Saitama and published by Nova Publishers. This book was released on 2007 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book presents research developments from around the globe in the field of cellular differentiation which is a concept from developmental biology describing the process by which cells acquire a 'type'. The morphology of a cell may change dramatically during differentiation, but the genetic material remains the same, with few exceptions. A cell that is able to differentiate into many cell types is known as pluripotent. These cells are called stem cells in animals and meristematic cells in higher plants. A cell that is able to differentiate into all cell types is known as totipotent. In mammals, only the zygote and early embryonic cells are totipotent, while in plants, many differentiated cells can become totipotent with simple laboratory techniques.
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Download or read book Altered Expression of Proteins in Cancer Function and Potential Therapeutic Targets written by Varda Shoshan-Barmatz and published by Frontiers Media SA. This book was released on 2022-08-03 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment written by Yongsheng Li and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multifunctional Role of Pancreatic Differentiation 2 PD2 in Pancreatic Cancer written by Arokia Priyanka Vaz and published by . This book was released on 2015 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a devastating disease that claims the lives of countless people due to its uncontrolled growth pattern. Among various cancers, pancreatic cancer is one of the most lethal cancers due to its aggressive nature, lack of early symptoms and resistance to chemotherapy. The molecular profile of this deadly malignancy is not completely understood. Malignancy arises due to loss or gain of function in genes involved in cell cycle progression leading to disruption of tightly regulated transitions. In addition the evolving concept of cancer throws light on a small population of cells within the tumor known as the cancer stem cells (CSCs) or tumor-initiating cells that are resistant to all drugs treatment and contributes towards tumor initiation and recurrence. Several studies have been carried out to identify specific markers for the cancer stem cell population including that of pancreatic cancer. Pancreatic Differentiation 2 (PD2) or human Polymerase Associated Factor 1 (hPaf1) is an important component of the multifunctional PAF1 complex initially identified to play a crucial role in transcriptional elongation of genes. During the last decade, several papers on PD2 showed that it is a multifaceted molecule playing roles in cell cycle regulation, stem cell maintenance, histone methylation, chromatin remodeling and acinar-to-ductal metaplasia. In this dissertation, the first goal was to investigate the role of PD2 in pancreatic cancer stem cells. Initially, we analyzed the expression and function of PD2 in pancreatic cancer stem cells isolated from pancreatic cancer cell lines, Kras (G12D); Pdx1 (Cre)(KC), Kras (G12D); Trp53 (R172H/+.); Pdx1(Cre) (KPC) mouse models and human pancreatic tumors. Furthermore, the expression of PD2 was significantly higher in CSCs isolated from pancreatic cancer cells along with CSC markers. These cells were shown to exhibit a cobblestone appearance, increased tumorsphere formation and significant tumor growth, characteristic of the CSC phenotype. interestingly, PD2 was found to be specifically overexpressed in a subpopulation of cells within mouse KC, KPC and human pancreatic tumors, which co-express CSC markers. The drug resistance property was impaired upon knockdown of PD2 with simultaneous alteration in the CSC phenotype and reduction in CD133 and MDR2 gene expression. Overall, my study identified that PD2 has a role in self-renewal and drug resistance of pancreatic CSCs. The second part of my dissertation was primarily focused at exploring the functional role of PD2 in pancreatic cancer cells. The ectopic overexpression of PD2 resulted in increased growth rate of tumor cells both in vitro and in vivo. Overexpression of PD2 led to increased growth, colony formation and migration. Interestingly, elevated expression of PD2 also increased the percentage of CSCs. Furthermore, in vivo studies revealed that PD2 overexpression leads to increased tumor volume and metastasis to distant secondary sites. These results were corroborated at the protein level where elevated expression of PD2 led to the up-regulation of c-Myc which is an important player in tumorigenesis and metastasis. In addition, the expression of PD2 in pancreatic cancer tissues and in vitro pancreatic progression model was elucidated. We demonstrated that the expression of PD2 was increased in the ducts present in the pancreatic cancer tissues when compared to the normal tissues. Likewise, the expression of PD2 was elevated in the transformed Human Pancreatic Nestin expressing (HPNE) cells when compared to the untransformed HPNE cells. Understanding the role of PD2 through cell lines led to my next aim to generate PD2 conditional knockout mice in order to substantiate our earlier work in cancer stem cells and acinar to ductal metaplasia during PC initiation. The animal model would be an important resource for understanding the role of PD2 in detail. Taken together, our findings demonstrate that PD2 is an essential member of the oncogene family that plays a significant role in facilitating drug resistance and cancer stem cell maintenance thereby acting as a positive regulator of cancer.
Download or read book Systems Biology and Single cell Analysis of Cancer Metabolism and its Role in Cancer Emergent Properties written by Dongya Jia and published by Frontiers Media SA. This book was released on 2023-06-21 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.
Download or read book Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer written by Tammy A. Morrish and published by Frontiers Media SA. This book was released on 2018-01-16 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
Download or read book Role of Transcription Factors in Gastrointestinal Malignancies written by Ganji Purnachandra Nagaraju and published by Springer. This book was released on 2018-03-27 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.
Download or read book The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease written by Francesco Fazi and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book T Cell Differentiation and Function in Tissue Inflammation written by Amit Awasthi and published by Frontiers Media SA. This book was released on 2020-03-11 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
