Download or read book Excitatory Amino Acids and the Cerebral Cortex written by Fiorenzo Conti and published by MIT Press. This book was released on 1996 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years.
Download or read book Excitatory Amino Acids written by Paul L. Herrling and published by Elsevier. This book was released on 1997-01-10 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists Reports of potential drugs in early and late clinical stages of development
Download or read book Excitatory Amino Acids written by Lechoslaw Turski and published by IOS Press. This book was released on 2001 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.
Download or read book Excitatory Amino Acids written by P.J. Roberts and published by Springer. This book was released on 1986-06-18 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacological Sciences Perspectives for Research and Therapy in the Late 1990s written by A. Claudio Cuello and published by Birkhäuser. This book was released on 2012-12-06 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we pursued was to produce a volume of reasonable size which would feature all of the plenary lectures and symposia from those authors who agreed to participate. To this end, we solicited mini reviews from plenary lecturers and asked symposia organizers to coordi nate a single short-review covering the individual topics within their event. Those who accepted this challenge are evident in this volume. We express our gratitude to these authors for doing so, and for exercising considerable ingenuity in completing their task within a reasonable time.
Download or read book Intracranial Pressure and Neuromonitoring in Brain Injury written by Anthony Marmarou and published by Springer Science & Business Media. This book was released on 1998-08-24 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the most recent works on intracranial pressure and neuromonitoring in brain injury selected from 300 abstracts submitted to the 10th International Symposium on Intracranial Pressure. It includes state of the art monitoring of the brain injured patient in intensive care as well as the current state of knowledge in neurochemical and oxygen monitoring of the injured brain. Recent advances in molecular mechanisms of injury and the pathophysiology of ischemia and trauma are also included. "... this publication presents a comprehensive survey of the present state of art in the field and thus gives directions for further research to those engaged in ICP measurement and neuromonitoring”. Intensive Care Med
Download or read book Excitatory Amino AcidsTheir Role in Neuroendocrine Function written by Darrell W. Brann and published by CRC Press. This book was released on 1995-10-24 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication focuses on the neuroendocrine functions of excitatory neurotransmitters in the brain known as the excitatory amino acid transmitters (EAAs). EEAs, such as glutamate and aspartate, regulate the release of pituitary hormones which in-turn effect most of the physiological systems in the body. This book gives detailed coverage of the role of EAAs in reproduction, growth, the stress axis, seasonal breeding, puberty, learning, and memory.
Download or read book Excitatory Amino Acids and Neuronal Plasticity written by Yehezkel Ben-Ari and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Neuroscience Association Satellite Symposium held in Fillerval, France, August 27-31, 1989
Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Download or read book Excitatory Amino Acid Receptors written by Povl Krogsgaard-Larsen and published by Taylor & Francis. This book was released on 1992 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to reflect the growing awareness of the chemical aspects of excitatory amino acids, this text uses computer-based methods and X-ray techniques to depict and analyze molecules and structure-activity relationships. The book incorporates stereochemical principles into all analyses.
Download or read book Excitatory Amino Acids and Second Messenger Systems written by Vivian I. Teichberg and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the mechanisms through which glutamate, the principal excitatory neurotransmitter in the mammalian central nervous system, modifies neuronal membrane functions and intraneuronal functions. Discussed are the hypothesis that the glutamate receptor signal may be processed by archidonic acid, nitric oxide, Ca 2+ and protein kinases. A key routefor glutamate receptors in synaptic plasticity and neuronal degeneration is beeing increasingly recognized. This is one of the most important new areas of endeavor by neurobiologists. The book, written by some of the most wellknown scientists in this field, provides a comprehensive reviewof conceptual approaches along with experiments showing a link between excitation mediated by glutamate and second messenger systems.
Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.
Download or read book Veterinary Psychopharmacology written by Sharon L. Crowell-Davis and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day veterinarians in practice are asked to treat petsexhibiting problem behaviors. In the last several yearspharmacologic treatments of behavior have made significant advancesand can serve as a critical part of therapy. Veterinary Pscyhopharmacology is a complete source of currentknowledge on the subject of pharmacologic behavior modificationthat veterinarians can turn to for the answers they need. Classification of disorders is eschewed in favor of in-depthexplanations of pharmacologic options in inducing behavior changes.Special emphasis is given to explaining the underlying mechanism ofpharmacologic agents used in therapy; thus, veterinarians will knownot only which drugs to prescribe but why they should be prescribedand how they work. Veterinary behaviorists, their students and residents, veterinarypractitioners of all levels, and veterinary students will find thisbook invaluable in providing information about their patients'behavior problems and the psychoactive medications that might helpthem.
Download or read book Excitatory Amino Acids Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitatory Amino Acids—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Excitatory Amino Acids. The editors have built Excitatory Amino Acids—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Excitatory Amino Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Excitatory Amino Acids—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Excitatory Amino Acids Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitatory Amino Acids: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Excitatory Amino Acids. The editors have built Excitatory Amino Acids: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Excitatory Amino Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Excitatory Amino Acids: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Excitatory Amino Acids written by Peter H. Seeburg and published by Springer. This book was released on 1998-03-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, emerging questions of current research on excitatory amino acids are addressed and new pathways which this research field may take in the future discussed. The book comments on the most recent discoveries in the field of neurodegeneration and neuroprotection.
Download or read book Neurobiology of the Locus Coeruleus written by and published by Elsevier. This book was released on 1991-11-21 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of the Locus Coeruleus
