Download or read book Evaluation of Bone Healing Using RhBMP 2 Soaked Hydroxyapatite in Ridge Augmentation Prospective Case Observational Study written by Kim Sang Yun and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background NOVOSISu00ae-Dent (CG Bio, Seongnam, Korea) is a hydroxyapatite-based alloplastic bony substitute containing recombinant human bone morphogenetic protein-2 (RhBMP-2). RhBMP-2 is used as a multi-pore ceramic supporter to promote bone regeneration when used in combination with synthetic grafting materialsAim/Hypothesis We performed a prospective, cohort study to evaluate the effectiveness of alveolar ridge augmentation using rhBMP-2 soaked hydroxyapatite and to describe complications associated with this procedure.Materials and Methods We enrolled ten dental implant candidates in our study: four men and six women with an average age of 58.5+8.6 years. They were divided into experimental and control groups. In preparation for the implants, alveolar ridge augmentation was performed in several edentulous areas, including the posterior maxilla as well as the anterior and posterior mandible. Bio-Ossu00ae (Geistlich Biomaterials, Swiss) bone graft material was used in the control group (n=5) and NOVOSISu00ae-Dent was used in the experimental group (n=5). Cone beam computed tomography was taken immediately after the procedure and again four months later to evaluate relative changes in bone volume and resorption rate of the graft material. Eight patients received dental implants in Seoul National University Bundang Hospital, while the others received implants in local clinics. Bone specimens for further histologic examinations were obtained from the patients at Seoul National University using trephine burs during the implant procedure.Results No postoperative complications were found. When comparing CBCT radiographs obtained immediately after the procedure with those obtained 4 months later, alveolar bone widths (experimental: 1.75 u00b1 0.85 mm, control: 2.52 u00b1 0.18 mm) and alveolar bone heights (experimental: 1.57 u00b1 0.28 mm, control: 1.68 u00b1 0.17 mm) were increased in both groups. Resorption rates of augmented bone graft material in the alveolar bone widths were 31.49+7.42% (experimental) and 29.73+8.79% (control). Resorption rates of alveolar bone heights were 52.58 u00b1 6.46% (experimental) and 39.17 u00b1 21.80% (control). On histologic examination, there was an increase in new bone formation surrounding the graft material. The relative new bone formation ratios were 35.18 u00b1 19.68% (experimental) and 28.89 u00b1 10.25% (control).Conclusions and Clinical implications We found that ridge augmentation with NOVOSISu00ae-Dent is beneficial prior to dental implantation and does not seem to be associated with any serious postoperative complications.
Download or read book Evaluation of the Efficacy and Safety of Two Types of RhBMP 2 soaked Bone Graft Materials in Extraction Socket Preservation written by Kim Sang Yun and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BackgroundRecombinant human bone morphogenetic protein-2 (rhBMP-2), which is a potent osteoinductor, has long been considered a promising avenue for bone regeneration, and has been commercially available for the treatment of oral and maxillofacial hard-tissue defects. RhBMP-2-soaked bone graft materials have generally been used in sinus floor augmentation and extraction socket preservation.Aim/Hypothesis The aim of this study was to evaluate the safety and effect of two types of rhBMP-2-soaked bone graft materials on extraction socket preservation.Materials and Methods Between October 2015 and September 2016, bone graft was performed in 64 patients scheduled to receive implantation after single tooth extraction. O-BMP (Osstem Implant Co., Busan, Korea; scaffold: collagen sponge) and Cowell BMP (Cowellimedi, Busan, Korea; scaffold: u00df-TCP) were used. The experimental group (n=32) received O-BMP grafts, and the control group (n=32) received Cowell BMP grafts. After covering the resorbable collagen membrane, the flap was closed. Before and 12 weeks after the operation, cone-beam computed tomography (CBCT) was used to assess the changes in bone height, and the widths at 25%, 50%, and 75% of the extraction socket levels. To match the axis of the measurement sites on CBCT images for the same patient, the patients underwent scans while wearing customized stents with a radiopaque indicator. Patients who agreed to undergo biopsy were evaluated for histological healing by obtaining tissue specimens with a trephine bur at the time of implant placement.Results (The experimental and control groups showed good healing without specific complications, such as infection. CBCT evaluation of the width and height change of the extraction socket revealed that the amount of bone resorption in the experimental and control groups was not large and that the shape of the extraction socket was well maintained. The mean changes in bone height and bone width at 25%, 50%, and 75% of the extraction socket levels were -0.08 u00b1 0.90 mm, 1.15 u00b1 5.01 mm, 1.19 u00b1 4.75 mm, and 0.20 u00b1 1.42 mm, respectively, in the O-BMP group, and -0.68 u00b1 1.42 mm, 0.57 u00b14.41 mm, 0.68 u00b1 3.47 mm, and -0.26 u00b1 2.58 mm, respectively, in theCowell BMP group. The bone height change of O-BMP group showed lower than that of the Cowell BMP group(p
Download or read book Emerging Materials and Technologies for Bone Repair and Regeneration written by Ashok Kumar and published by CRC Press. This book was released on 2024-08-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers advancements in the field of bone repair and regeneration. It introduces bone development, repair, and regeneration and details different biomaterials and technologies involved in the fabrication and characterization of bone-related scaffolds and implants. The book explores nanotechnological intervention and folklore phytomedicines and their prospects in regenerating bone including major bone related disease conditions, infection, and their tackling via tissue engineering strategies. FEATURES: Covers polymer materials and technologies for bone repair and regeneration based on tissue engineering Defines the interdisciplinary mechanism of bone tissue repair ranging from the fields of material science, nanotechnology, and phytomedicine includes basic sciences, scaffolds, and bone infection Examines fabrication and characterization methods for the bone repair materials Reviews fundamentals of interlinked mechanisms of bone development, repair, and regeneration. This book is aimed at graduate students and researchers in biomedical and tissue engineering and biomaterial sciences.
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Download or read book Human Amniotic Membrane Basic Science And Clinical Application written by Nazly Hilmy and published by World Scientific. This book was released on 2017-08-23 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application.The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties.It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation.The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration.
Download or read book Analysis of Aggregates and Particles in Protein Pharmaceuticals written by Hanns-Christian Mahler and published by John Wiley & Sons. This book was released on 2011-12-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Download or read book Implant Site Development written by Michael Sonick and published by John Wiley & Sons. This book was released on 2011-12-14 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the desire for dental implant therapy ever escalating, clinicians are faced with the challenge of augmenting deficient natural physiology to provide effective sites for implantation. Implant Site Development helps the clinician decide if, when, and how to create a ridge site amenable to implantation. This practical book offers solutions to many implant site preservation scenarios, discussing different treatment options, timing, a variety of materials and techniques, and their application to the clinical practice. With a unique integrated clinical approach, Implant Site Development covers a range of site development techniques. Highly illustrated, Implant Site Development presents diagrams and clinical photographs to aid with clinical judgment and will prove useful for any dental professional involved in implant therapy, from general practitioners to prosthodontists, but especially surgeons. This literature-based, yet user-friendly, reference will be indispensable to the novice or veteran clinician.
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Bone graft substitutes written by Cato T. Laurencin and published by ASTM International. This book was released on 2003 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Postgraduate Orthopaedics written by Paul A. Banaszkiewicz and published by Cambridge University Press. This book was released on 2012-08-16 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).
Download or read book The Glossary of Prosthodontic Terms written by and published by . This book was released on 1994 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Tissue Engineering written by Farshid Guilak and published by Springer Science & Business Media. This book was released on 2003-07-09 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: -Softcover reprint of a successful hardcover reference (370 copies sold) -Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering -Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology
Download or read book Novel Biomaterials for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.
Download or read book Biomaterials and Regenerative Medicine written by Peter X. Ma and published by Cambridge University Press. This book was released on 2014-07-24 with total page 1283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; and medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine.
Download or read book Tissue Engineering in Oral and Maxillofacial Surgery written by Riitta Seppänen-Kaijansinkko and published by Springer Nature. This book was released on 2019-12-02 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough, up-to-date description of the scientific basis and concepts of tissue engineering in the oral and maxillofacial region. The opening chapters present an introduction to tissue engineering, describe the roles of biomaterials and stem cells, discuss the use of growth factors, and examine potential adverse reactions. The challenges of soft and hard tissue engineering for oral and maxillofacial reconstruction are then considered in detail. It is explained what has been achieved to date, and potential future perspectives are explored. The importance and the verification of adequate vascularization are discussed, and a further focus is the use of 3D printing, both in the planning and production of scaffolds and in the bioprinting of cells and biomaterials. Information is also included on safety, efficacy, and regulatory aspects. Tissue Engineering in Oral and Maxillofacial Surgery will be of interest to all researchers and practitioners who wish to learn more about the potential of tissue engineering to revolutionize practice in oral and maxillofacial surgery.
Download or read book Bone Research Protocols written by Miep H. Helfrich and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade has seen a tremendous advance in our understanding of bone biology. The genes responsible for the majority of rare inherited bone disorders have been identified and much progress has been made in the identification of genes in polygenic disorders such as Paget’s disease and complex multigene diseases such as osteoporosis. Transgenic technology has identified further genes, sometimes unexpectedly, with profound effects on bone. This wealth of new genetic information will undoubtedly lead to extensive cell biological studies to understand the mechanisms by which these gene products affect bone mass and bone strength. In Bone Research Protocols a catalogue of protocols has been assembled to perform such mechanistic studies. In the tradition of the Methods in Molecular Medicine series, the chapters are practical laboratory protocols that should enable the reader to carry out the techniques from scratch. To our knowledge this is the first time such a truly practical manual on well-established bone methods has been assembled, and this volume aims to be complementary to and follow on from the more theoretical Methods in Bone Biology, edited by Arnett and Henderson (1).
Download or read book Soft and Hard Tissue Regeneration written by Carlos E. Nemcovsky and published by . This book was released on 2020 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue entitled “Soft and hard tissue regeneration” will cover both periodontal and implant therapies. Regenerative periodontal treatment goal is to restore functional periodontal support offering a valuable treatment alternative even for teeth with large periodontal destruction, which may be successfully treated and maintained in health for long periods. In most cases where teeth are extracted for periodontal reasons, implant therapy will demand large bone augmentation procedures. Lack of sufficient bone volume may prevent placement of dental implants. In extreme cases, large bone reconstruction is indispensable before implant placement can be performed. Although, most bone grafts are only able to fill and maintain a space, where bone regeneration can occur (“osseoconductive”), the ideal bone graft will also promote osseous regeneration (“osseoinductive”). Several bone augmentation procedures have been described, each, presenting advantages and shortcomings. Success of bone augmentation procedures depends on the presence of bone forming cells, primary wound closure over the augmented area, space creation and maintenance where bone can grow and proper angiogenesis of the grafted area. Factors that influence the choice of the surgical technique are the estimated duration of surgical procedure, its complexity, cost, total estimated length of procedure until the final rehabilitations may be installed and the surgeons' experience. This special issue will have a definite clinical orientation, and be entirely dedicated to soft and hard tissue regenerative treatment alternatives, both in periodontal and implant therapy, discussing their rationale, indications and clinical procedures. Internationally renowned leading researchers and clinicians will contribute with articles in their field of expertize.
