Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Download or read book Endothelial Function in Hypertension written by David Webb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium has become an increasing focus of research over the last 15 years. Nitric oxide and endothelin appear to have important and opposing actions on vascular tone, smooth muscle proliferation and platelet/monocyte activation, and endothelial dysfunction affecting the L-arginine/nitric oxide and endothelin systems both appear to be crucial to atherogenesis and to the pathophysiology of many forms of cardiovascular disease. Additionally, a number of new drugs of major clinical interest are now emerging that act favourably to modulate endothelial function and alter the outcome in these conditions. Here, a synthesis of the current understanding of endothelial dysfunction in hypertension and related disorders - and future therapeutic prospects - has been drawn together by a series of internationally recognised leaders in the field.
Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Download or read book Cardiovascular Biology written by J. F. Stoltz and published by IOS Press. This book was released on 2007 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. This volume focuses on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte.
Download or read book Endothelium and Cardiovascular Diseases written by Protasio L. Da Luz and published by Academic Press. This book was released on 2018-02-03 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Download or read book Manual of Neurosonology written by László Csiba and published by Cambridge University Press. This book was released on 2016-04-28 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurosonology is non-invasive, portable, and has excellent temporal resolution, making it a valuable and increasingly popular tool for the diagnosis and monitoring of neurological conditions when compared to other imaging techniques. This guide looks beyond the use of neurovascular ultrasound in stroke to encompass a wide range of other neurological diseases and emergencies. It offers a practical approach to the examination of patients, interpretation of ultrasound studies, and the application of neurosonology to the development of management and treatment strategies. Each chapter incorporates a thorough and clear procedural methodology alongside scanning tips for trainees; this step-by-step approach is further enhanced by example images and focused diagnostic questions. Authored and edited by international experts, this practical manual of neurosonology is an invaluable resource for neurologists, neurosurgeons, intensivists, radiologists, and ultrasonographers.
Download or read book PanVascular Medicine written by Peter Lanzer and published by Springer. This book was released on 2015-03-30 with total page 5004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Endothelial Dysfunction and Hypertension written by James Andrew Cockburn and published by . This book was released on 2011 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial dysfunction (ED) is thought to underpin the link between cardiovascular risk factors, atherosclerosis and cardiovascular events. However, in subjects with uncomplicated essential hypertension, clinical evidence for ED is inconsistent and has been examined only in conduit and resistance vessels of forearm vasculature. The finding that beta-2-adrenoreceptor ([beta]2-AR) stimulated vasodilatation is mediated in part through the endothelial L-arginine/NO pathway raises the possibility that [beta]2AR are functionally important in regulating vascular tone under conditions of sympathetic activation, such as during exercise with potential implications for the pathogensis of hypertension. It also provides a means for examining endothelial function within the systemic vasculature by using pulse wave analysis as a sensitive means for assessing change in endothelial-dependent vasomotor tone in response to a [beta]2-AR agonist. Endothelial function is thought to be maintained by "repair" from bone marrow derived circulating progenitor cells and these may also have a role in remodelling of arteries and resistance vessels in response to hemodynamic forces. Whether concentrations of circulating progenitor cells are abnormal in subjects with untreated hypertension is unknown. The aims of this thesis were to:- -- 1) Determine whether 0-AR play a role in regulating arterial vasomotor tone and hence blood pressure during exercise in healthy subjects. -- 2) Examine whether endothelial vasomotor function measured in the systemic vasculature, in forearm conduit arteries and resistance vessels, is impaired in subjects with uncomplicated essential hypertension compared with normotensive controls. -- 3) Determine whether concentrations of circulating progenitor cells are reduced in subjects with essential hypertension and whether these correlate with endothelial function.
Download or read book Endothelial Dysfunction written by Helena Lenasi and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.
Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Download or read book Endothelium Nitric Oxide and Atherosclerosis written by Julio Panza and published by Blackwell Publishing. This book was released on 1999-06-18 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opening chapter of this book, by scientist Dr. Robert Furchgott, details the discovery of endothelium’s role in the vasodilator effect of acetycholine in 1978. Its subsequent identification as nitric oxide has been critical to cardiovascular medicine in understanding the regulation of vascular homeostasis. This simple observation won Dr. Furchgott a Nobel Prize in 1998. Spanning from these initial observations to recent clinical investigations, this work offers an invaluable historical reference and clinical explanation about the intracellular mechanisms that regulate and stimulate endothelial nitric oxide synthase (eNOS). The basic mechanisms leading to endothelial dysfunction in cardiovascular disease complement information about the biological role and regulation of endothelial nitric oxide. Clinical studies of impaired endothelial function in patients with different cardiovascular conditions also reveal important and effective therapeutic strategies. Written for both established physicians and scientists investigating the basic mechanisms and treatment of cardiovascular disease, as well as medical students who want to initiate themselves in the study of endothelial regulation of vascular physiology, many will find this comprehensive review a stimulus for new research.
Download or read book The Endothelium written by Thomas F. Luscher and published by CRC Press. This book was released on 2020-04-15 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a comprehensive look at the role of the endothelium in cardiovascular control in health and disease. Experts offer detailed reviews on specific topics that address these roles of the endothelium: diffusion barrier, blood-brain barrier, regulator of capillary permeability, metabolic function (uptake and enzymatic destruction), conversion of vasoactive products, production of prostanoids, production and release of endothelium-derived relaxing factors, production of endothelium-derived contracting factors, production of coagulation factors, production of fibrinolytic factors, reticulo-endothelial function, role in atherosclerosis, and changes in function with aging and disease. This overview provides the reader with an update on the role of one of the most fascinating cells in cardiovascular biology. It focuses on the multiple functions of those cells and offers the first attempt to draw a parallel between these functions. Anyone studying the fields of physiology and pharmacology will benefit from this "must have" reference resource.
Download or read book The Endothelium in Cardiovascular Disease written by Thomas Luescher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the endothelium plays such an important role in the pathophysiology of the circulatory system, the readers attention is directed here towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.
Download or read book Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension written by Toshio Nakanishi and published by Springer Nature. This book was released on 2020-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
