Download or read book Endocrine Disruptors Brain Development and Behavior written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine Disruptors written by Carl-Elis Boström and published by . This book was released on 2002 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine Disruptors Brain and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017-04-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Download or read book Endocrine Disruptors and The Developing Brain written by Andrea C. Gore and published by Biota Publishing. This book was released on 2012-05-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of endocrine disruption has been the focus of increasing attention from scientists and the general public in the past 30 years, amidst concerns that exposure to environmental chemicals with the potential to alter endocrine system function, known as endocrine disrupting chemicals (EDCs), may be contributing to an overall decline in wildlife populations and the reproductive health of humans. These concerns are based on observations of adverse effects of EDCs on marine and land animals, an increased incidence of reproductive and endocrine disease in humans, epidemiological evidence for links between body burden and disease, and endocrine disruption in laboratory animals following exposure to EDCs. Owing to its role in regulation of endocrine function as well as its responsiveness to hormones, the developing brain is an especially vulnerable target for many classes of EDCs. This book will address the evidence for EDC action on the developing brain, organized into 7 chapters. Topics covered include background about EDCs, evidence for exposures, concerns about EDC effects in the developing organism, and particularly on the developing nervous system, how EDCs perturb the brain's neuroendocrine systems, transgenerational epigenetic effects of EDCs, EDC effects on non-reproductive behaviors, and future perspectives. This is the first book completely dedicated to understanding links between EDCs and the developing brain, an area of emerging importance for human health.

Download or read book Endocrine Disruptors written by and published by . This book was released on 2002 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemicals in the Environment and Brain Development Importance of Neuroendocrinological Approaches written by Fumihiko Maekawa and published by Frontiers Media SA. This book was released on 2017-05-11 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children’s brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children’s brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors.

Download or read book Losing Our Minds written by Barbara Demeneix and published by Oxford University Press, USA. This book was released on 2014 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exponential increases in neurodevelopmental disorders implicate both genetic causes and environmental factors. Flame-retardants, pesticides, plasticizers, and other every-day products contain chemicals shown to affect thyroid hormone signaling, which if disrupted can result in significant impairment to IQ. Across entire populations, such effects spell large-scale social and economic consequences. In this book Barbara Demeneix suggests what can and must be done to halt and reverse this disturbing trend.

Download or read book Endocrine Disruptors and Puberty written by Evanthia Diamanti-Kandarakis and published by Springer Science & Business Media. This book was released on 2011-12-01 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Download or read book Impact of Endocrine Distuptors on Brain Development and Behavior written by Rosemary Bauer and published by . This book was released on 2002 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Risk Assessment for PAHs in Air written by and published by . This book was released on 2002 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine Disruptors written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dioxins and Health written by A. Schecter and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in a series of cross-disciplinary conversations in the years 1984-1990 between the editor, who is a physician-researcher involved in clinical and laboratory research, and a dioxin toxicologist. During the years in which the conversations took place, an extraordinary amount of new scientific literature was published related to dioxins, defined for purposes of this text as the chlorinated dibenzo-p-dioxins, dibenzofurans, polychlorinated biphe nyls (PCB's) and other compounds that are structurally and toxicologically similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7 ,8-TCDD), the most extensively studied and most toxic of this group of chemicals. Dioxins also began to interest not only chemists and toxicologists, but also specialists from diverse disciplines such as wildlife and environmental science, immunology, neuroscience,public health, epidemiology, med icine, government, law, sociology, and journalism. Specialists from such varied disciplines, while familiar with their own literature, frequently did not have time to follow the dioxin literature outside their specialty area. In addition, each specialty had unique knowledge, methods, and perspectives. Cross disciplinary conversation was necessary, but all too frequently, specialists from the various disciplines did not speak the same language, resulting in misunderstanding.

Download or read book The Promise of Adolescence written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-07-26 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

Download or read book Neurobehavioral Teratology written by Joseph Yanai and published by Elsevier Publishing Company. This book was released on 1984 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine disrupting Chemicals Alter Embryonic Brain Development and Adult Neurobehavioral Phenotypes written by Morgan Elizabeth Hernandez and published by . This book was released on 2020 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine-disrupting chemicals are detectable in nearly every environment on the planet. Humans and wildlife are exposed to myriad of these pollutants throughout their life. Because these chemicals interfere with hormone systems in the body, exposure to them during early life development can have a severe impact on later neurobiological and reproductive health. In this dissertation, I investigated how prenatal exposure to two specific EDCs affected the organization of the embryonic brain and changed neuromolecular and behavioral phenotypes in adulthood. The weakly estrogenic mixture of polychlorinated biphenyls (PCBs), Aroclor 1221 (A1221), and the antiandrogenic fungicide vinclozolin (VIN) offer insight through their different mechanisms of interrupting normal endocrine function. I hypothesized that these chemicals would affect the brain and behavior of adult rats in a sex- and compound-specific manner. The first study in this dissertation demonstrates that prenatal exposure to these EDCs can disrupt an important sociosexual behavior in adult rats together with changes in the patterns of expression of associated genes. More specifically, in a test of sociosexual preference, adult rats failed to demonstrate the sex-typical preference for a mate after prenatal exposure to PCBs or VIN in males, and PCBs in females. The second study extends the previous findings by probing for deficits in the ability to distinguish between and/or prefer odorants that convey information about a mate’s fitness, i.e., hormonal status. I deduced that while changes to odor preference strongly resemble the mate preference phenotype, odor discrimination ability is not impaired. However, the activation of the ventrolateral portion of the ventromedial nucleus, a brain region known to regulate mate preference behavior, was altered by PCB exposure in females, suggesting that improper central processing of odor signals may explain some of the results. In the third study, I found that PCB exposure shifted the timing of the hormone-sensitive process of embryonic neurogenesis in the ventromedial nucleus but not the preoptic area. Taken together, these studies demonstrate a possible mechanism by which an EDC can change brain organization and functionally transfer the effects of a prenatal exposure into adulthood