Download or read book Emerging Safety Science written by Institute of Medicine and published by National Academies Press. This book was released on 2008-05-08 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the costs of new drug development have skyrocketed. The average cost of developing a new approved drug is now estimated to be $1.3 billion (DiMasi and Grabowski, 2007). At the same time, each year fewer new molecular entities (NMEs) are approved. DiMasi and Grabowski report that only 21.5 percent of the candidate drugs that enter phase I clinical testing actually make it to market. In 2007, just 17 novel drugs and 2 novel biologics were approved. In addition to the slowing rate of drug development and approval, recent years have seen a number of drugs withdrawn from the market for safety reasons. According to the Government Accountability Office (GAO), 10 drugs were withdrawn because of safety concerns between 2000 and March 2006 (GAO, 2006). Finding ways to select successful drug candidates earlier in development could save millions or even billions of dollars, reduce the costs of drugs on the market, and increase the number of new drugs with improved safety profiles that are available to patients. Emerging scientific knowledge and technologies hold the potential to enhance correct decision making for the advancement of candidate drugs. Identification of safety problems is a key reason that new drug development is stalled. Traditional methods for assessing a drug's safety prior to approval are limited in their ability to detect rare safety problems. Prior to receiving U.S. Food and Drug Administration (FDA) approval, a drug will have been tested in hundreds to thousands of patients. Generally, drugs cannot confidently be linked to safety problems until they have been tested in tens of thousands to hundreds of thousands of people. With current methods, it is unlikely that rare safety problems will be identified prior to approval. Emerging Safety Science: Workshop Summary summarizes the events and presentations of the workshop.

Download or read book Safety Science Research written by Jean-Christophe Le Coze and published by CRC Press. This book was released on 2019-08-13 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safety Science Research: Evolution, Challenges and New Directions provides a unique perspective into the latest developments of safety science by putting together, for the first time, a new generation of authors with some of the pioneers of the field. Forty years ago, research traditions were developed, including, among others, high-reliability organisations, cognitive system engineering or safety regulations. In a fast-changing world, the new generation introduces, in this book, new disciplinary insights, addresses contemporary empirical issues, develops new concepts and models while remaining critical of safety research practical ambitions. Their ideas are then reflected and discussed by some of the pioneers of safety science. Features Allows the reader to discover how contemporary safety issues are currently framed by a new generation of researchers, brought together for the first time Includes an introduction and guide to the development of safety science over the last four decades Features an extraordinary collection of expert contributors, including pioneers of safety research, reflecting the evolution of the discipline and offering insightful commentary on the current and future state of the field Serves as an invaluable reference and guide for safety professionals and students from any established disciplines such as sociology, engineering, psychology, political science or management as well as dedicated safety programmes Some figures in the eBook are in colour

Download or read book Food Safety written by Steven C Ricke and published by Academic Press. This book was released on 2015-07-08 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food Safety: Emerging Issues, Technologies and Systems offers a systems approach to learning how to understand and address some of the major complex issues that have emerged in the food industry. The book is broad in coverage and provides a foundation for a practical understanding in food safety initiatives and safety rules, how to deal with whole-chain traceability issues, handling complex computer systems and data, foodborne pathogen detection, production and processing compliance issues, safety education, and more. Recent scientific industry developments are written by experts in the field and explained in a manner to improve awareness, education and communication of these issues. Examines effective control measures and molecular techniques for understanding specific pathogens Presents GFSI implementation concepts and issues to aid in implementation Demonstrates how operation processes can achieve a specific level of microbial reduction in food Offers tools for validating microbial data collected during processing to reduce or eliminate microorganisms in foods

Download or read book Introduction to Safety Science written by Albert Kuhlmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years "safety technology" has constituted the essential instrument for the prevention of accidents as a direct result of handling new technology. Its awareness of the interactions prevalent in natural science causes safety technology to act on the basis of actual accidents, and it Ulilizes to their fullest extent any means provided by the engineering sciences. Man proceeds in a general direction towards preselVation and improvement, thus working towards the optimization of the technical design. However. a new set of basic problems presented itself the moment new large-scale technologies were introduced into the areas of processing, energy, and traffic, thereby creating a considerable amount of ad ditional danger potential. This also signified the end of an era when safety technology could be practiced chiefly on the basis of accident statistics. For ethical reasons it became necessary that a credible prognosis as to the type and effect of accidents took the place, or at least supplemented, the hitherto practiced purely reactive methods. The realization that the available means of safety technology were no longer sufficient in a highly technologized environment spurred the demand for entirely new concepts which would eventually lead to a higher degree of safety. A decisive step had to be taken away from a purely technical approach and fOwards and all-encompassing look at accident systems, because man had become aware of the fact that accidents will always be a part of the interaction between man, technology, and environment.

Download or read book Patient Safety and Management written by Eugene Williams and published by Nova Science Publishers. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The harm associated with health care is a questionable issue and several systemic global strategies to reduce it with a safer system are being developed. Despite these efforts, errors continue to happen and one of the most important challenges is to become aware of its real dimension and process-occurrence. This book provides new research on patient safety and management. It discusses different perspectives, principles and reviews emerging issues in the medical field.

Download or read book Advances in Patient Safety written by Kerm Henriksen and published by . This book was released on 2005 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.

Download or read book Rethinking Causality Complexity and Evidence for the Unique Patient written by Rani Lill Anjum and published by Springer Nature. This book was released on 2020-06-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is a unique resource for health professionals who are interested in understanding the philosophical foundations of their daily practice. It provides tools for untangling the motivations and rationality behind the way medicine and healthcare is studied, evaluated and practiced. In particular, it illustrates the impact that thinking about causation, complexity and evidence has on the clinical encounter. The book shows how medicine is grounded in philosophical assumptions that could at least be challenged. By engaging with ideas that have shaped the medical profession, clinicians are empowered to actively take part in setting the premises for their own practice and knowledge development. Written in an engaging and accessible style, with contributions from experienced clinicians, this book presents a new philosophical framework that takes causal complexity, individual variation and medical uniqueness as default expectations for health and illness.

Download or read book Introduction to Safety Science written by Albert Kuhlmann and published by Springer. This book was released on 2011-12-21 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years "safety technology" has constituted the essential instrument for the prevention of accidents as a direct result of handling new technology. Its awareness of the interactions prevalent in natural science causes safety technology to act on the basis of actual accidents, and it Ulilizes to their fullest extent any means provided by the engineering sciences. Man proceeds in a general direction towards preselVation and improvement, thus working towards the optimization of the technical design. However. a new set of basic problems presented itself the moment new large-scale technologies were introduced into the areas of processing, energy, and traffic, thereby creating a considerable amount of ad ditional danger potential. This also signified the end of an era when safety technology could be practiced chiefly on the basis of accident statistics. For ethical reasons it became necessary that a credible prognosis as to the type and effect of accidents took the place, or at least supplemented, the hitherto practiced purely reactive methods. The realization that the available means of safety technology were no longer sufficient in a highly technologized environment spurred the demand for entirely new concepts which would eventually lead to a higher degree of safety. A decisive step had to be taken away from a purely technical approach and fOwards and all-encompassing look at accident systems, because man had become aware of the fact that accidents will always be a part of the interaction between man, technology, and environment.

Download or read book Global Safety of Fresh Produce written by Jeffrey Hoorfar and published by Woodhead Publishing. This book was released on 2014-02-14 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing food poisoning outbreaks around the globe have put fresh produce safety at the forefront of food research. Global Safety of Fresh Produce provides a detailed and comprehensive overview of best practice for produce safety throughout the food chain, and unique coverage of commercial technologies for fresh produce safety. Part one covers the production and regulation of fresh produce on the agricultural level, including issues of niche farm fresh products, FDA regulation, and zoonotic transfer of pathogens from animals to farm products. Part two moves on to look at safety and environmental issues surrounding fresh produce processing, such as postharvest washing, alternative sanitizers, and using produce waste as animal feed. Part three focuses on current and emerging commercial solutions for fresh produce safety, like ionizing radiation and edible coatings, and part four covers methods of laboratory testing and related legislation. The final section of the book covers a series of case studies of fresh produce safety breaches, including European E. coli outbreaks in sprouts and leafy greens, and the illegal use of fluorescent whitening agents (FWAs) in China. This book is an essential text for R&D managers in the fresh produce industry, quality control professionals working with fresh produce throughout the food chain, postgraduate students, and academic researchers with an interest in fresh produce safety. Provides a comprehensive overview of best practice for produce safety Examines the production and regulation of fresh agricultural produce Looks at safety and environmental issues surrounding fresh produce processing

Download or read book EBOOK Patient Safety Research into Practice written by Kieran Walshe and published by McGraw-Hill Education (UK). This book was released on 2005-11-16 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Basis of Medicine Award in the BMA Book Medical Book Competition 2006! In many countries, during the last decade there has been a growing public realization that healthcare organisations are often dangerous places to be. Reports published in Australia, Canada, New Zealand, United Kingdom and the USA have served to focus public and policy attention on the safety of patients and to highlight the alarmingly high incidence of errors and adverse events that lead to some kind of harm or injury. This book presents a research-based perspective on patient safety, drawing together the most recent ideas and thinking from researchers on how to research and understand patient safety issues, and how research findings are used to shape policy and practice. The book examines key issues, including: Analysis and measurement of patient safety Approaches to improving patient safety Future policy and practice regarding patient safety The legal dimensions of patient safety Patient Safety is essential reading for researchers, policy makers and practitioners involved in, or interested in, patient safety. The book is also of interest to the growing number of postgraduate students on health policy and health management programmes that focus upon healthcare quality, risk management and patient safety. Contributors: Sally Adams, Tony Avery, Maureen Baker, Paul Beatty, Ruth Boaden, Tanya Claridge, Gary Cook, Caroline Davy, Susan Dovey, Aneez Esmail, Rachel Finn, Martin Fletcher, Sally Giles, John Hickner, Rachel Howard, Amanda Howe, Michael A. Jones, Sue Kirk, Rebecca Lawton, Martin Marshall, Caroline Morris, Dianne Parker, Shirley Pearce, Bob Phillips, Steve Rogers, Richard Thomson, Charles Vincent, Kieran Walshe, Justin Waring, Alison Watkin, Fiona Watts, Liz West, Maria Woloshynowych.

Download or read book Safety Reliability and Applications of Emerging Intelligent Control Technologies written by Tung-Sang Ng and published by Pergamon. This book was released on 1995 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paperback. Increasingly, over the last few years, intelligent controllers have been incorporated into control systems. Presently, the numbers and types of intelligent controllers that contain variations of fuzzy logic, neural network, genetic algorithms or some other forms of knowledge based reasoning technology are dramatically rising. However, considering the stability of the system, when such controllers are included it is difficult to analyse and predict system behaviour under unexpected conditions. Leading researchers and industrial practitioners were able to discuss and evaluate current development and future research directions at the first IFAC International Workshop on safety, reliability and applications on emerging intelligent control technology. This publication contains the papers, covering a wide range of topics, presented at the workshop.

Download or read book Safe Science written by National Research Council and published by National Academies Press. This book was released on 2014-10-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent serious and sometimes fatal accidents in chemical research laboratories at United States universities have driven government agencies, professional societies, industries, and universities themselves to examine the culture of safety in research laboratories. These incidents have triggered a broader discussion of how serious incidents can be prevented in the future and how best to train researchers and emergency personnel to respond appropriately when incidents do occur. As the priority placed on safety increases, many institutions have expressed a desire to go beyond simple compliance with regulations to work toward fostering a strong, positive safety culture: affirming a constant commitment to safety throughout their institutions, while integrating safety as an essential element in the daily work of laboratory researchers. Safe Science takes on this challenge. This report examines the culture of safety in research institutions and makes recommendations for university leadership, laboratory researchers, and environmental health and safety professionals to support safety as a core value of their institutions. The report discusses ways to fulfill that commitment through prioritizing funding for safety equipment and training, as well as making safety an ongoing operational priority. A strong, positive safety culture arises not because of a set of rules but because of a constant commitment to safety throughout an organization. Such a culture supports the free exchange of safety information, emphasizes learning and improvement, and assigns greater importance to solving problems than to placing blame. High importance is assigned to safety at all times, not just when it is convenient or does not threaten personal or institutional productivity goals. Safe Science will be a guide to make the changes needed at all levels to protect students, researchers, and staff.

Download or read book Food and Feed Safety Systems and Analysis written by Steven C Ricke and published by Academic Press. This book was released on 2017-10-27 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food and Feed Safety Systems and Analysis discusses the integration of food safety with recent research developments in food borne pathogens. The book covers food systems, food borne ecology, how to conduct research on food safety and food borne pathogens, and developing educational materials to train incoming professionals in the field. Topics include data analysis and cyber security for food safety systems, control of food borne pathogens and supply chain logistics. The book uniquely covers current food safety perspectives on integrating food systems concepts into pet food manufacturing, as well as data analyses aspects of food systems. Explores cutting edge research about emerging issues associated with food safety Includes new research on understanding foodborne Salmonella, Listeria and E. coli Presents foodborne pathogens and whole genome sequencing applications Provides concepts and issues related to pet and animal feed safety

Download or read book Science Medicine and Animals written by National Research Council and published by National Academies Press. This book was released on 2006-02-19 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Download or read book Indo U S Workshop on Challenges of Emerging Infections and Global Health Safety written by Indian National Science Academy and published by National Academies Press. This book was released on 2016-05-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States and India have pledged to deepen the linkages between their people, their businesses, and their governments for the mutual benefit of both countries and for the promotion of global peace, stability, economic growth and prosperity. Both nations are now inclined to improve relations and cooperation, but the nations need specific actions that will yield progress and build confidence and momentum for further cooperation. The Indo-U.S. Workshop on Challenges of Emerging Infections and Global Health Safety, held in November 2014, encouraged scientists from both countries to examine global issues related to emerging and existing infections and global health safety, to share experience and approaches, and to identify opportunities for cooperation to improve practice and research in these areas. This report summarizes the presentations and discussions from the workshop.

Download or read book From Safety to Safety Science written by Paul Swuste and published by Routledge. This book was released on 2021 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How do accidents and disasters occur? How has knowledge on accident processes evolved? A significant improvement in safety has occurred during the last century, with the number of accidents falling spectacularly within industry, aviation and road traffic. This progress has been gradual in the context of a changing society. The improvements are partly due to a better understanding of the accident processes that ultimately lead to damage. This book shows how contemporary crises instigated the development of safety knowledge and how the safety sciences pieced their theories together by research, by experience and by taking ideas from other domains. From Safety to Safety Science details 150 years of knowledge development in the safety sciences. The authors have rigorously extracted the essence of safety knowledge development from more than 2,500 articles to provide a unique overview and insight into the background and usability of safety theories, as well as modelling how they developed and how they are used today. Extensive appendices and references provide an additional dimension to support further scholarly work in this field. The book is divided into clear time periods to make it an accessible piece of science-history that will be invaluable to both new and experienced safety researchers, to safety courses and education, and to learned practitioners"--