Download or read book Human Electroencephalogram Based Biomarkers for Detection of Alzheimer s Disease written by Ali H. Husseen Al-Nuaimi and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electroencephalogram Based Biomarkers for Detection of Alzheimer s Disease written by Ali H Husseen Al-Nuaimi and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer,Äôs disease (AD) is an age-related progressive and neurodegenerative disorder, which is characterized by loss of memory and cognitive decline. It is the main cause of disability among older people. The rapid increase in the number of people living with AD and other forms of dementia due to the aging population represents a major challenge to health and social care systems worldwide. Degeneration of brain cells due to AD starts many years before the clinical manifestations become clear. Early diagnosis of AD will contribute to the development of effective treatments that could slow, stop, or prevent significant cognitive decline. Consequently, early diagnosis of AD may also be valuable in detecting patients with dementia who have not obtained a formal early diagnosis, and this may provide them with a chance to access suitable healthcare facilities. An early diagnosis biomarker capable of measuring brain cell degeneration due to AD would be valuable. Potentially, electroencephalogram (EEG) can play a valuable role in the early diagnosis of AD. EEG is noninvasive and low cost, and provides valuable information about brain dynamics in AD. Thus, EEG-based biomarkers may be used as a first-line decision-support tool in AD diagnosis and could complement other AD biomarkers.
Download or read book Biomarkers in Alzheimer s Disease written by Tapan Khan and published by Academic Press. This book was released on 2016-08-02 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Alzheimer’s Disease provides a comprehensive overview of all modalities of Alzheimer’s disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer’s disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer’s disease, and for differential diagnosis of Alzheimer’s disease with other non-Alzheimer’s dementia. Presents a comprehensive overview detailing all modalities of Alzheimer’s disease biomarkers Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer’s Disease Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer’s disease and the technological advancement of biomarkers techniques
Download or read book Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and published by BoD – Books on Demand. This book was released on 2021-01-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.
Download or read book EEG Based Diagnosis of Alzheimer Disease written by Nilesh Kulkarni and published by Academic Press. This book was released on 2018-04-13 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: EEG-Based Diagnosis of Alzheimer Disease: A Review and Novel Approaches for Feature Extraction and Classification Techniques provides a practical and easy-to-use guide for researchers in EEG signal processing techniques, Alzheimer’s disease, and dementia diagnostics. The book examines different features of EEG signals used to properly diagnose Alzheimer’s Disease early, presenting new and innovative results in the extraction and classification of Alzheimer’s Disease using EEG signals. This book brings together the use of different EEG features, such as linear and nonlinear features, which play a significant role in diagnosing Alzheimer’s Disease. Includes the mathematical models and rigorous analysis of various classifiers and machine learning algorithms from a perspective of clinical deployment Covers the history of EEG signals and their measurement and recording, along with their uses in clinical diagnostics Analyzes spectral, wavelet, complexity and other features of early and efficient Alzheimer’s Disease diagnostics Explores support vector machine-based classification to increase accuracy
Download or read book Novel Biomarkers in Alzheimer rsquo s Disease written by Chiara Villa and published by MDPI. This book was released on 2021-02-05 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.
Download or read book EEG Signal Processing written by Saeid Sanei and published by John Wiley & Sons. This book was released on 2013-05-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroencephalograms (EEGs) are becoming increasingly important measurements of brain activity and they have great potential for the diagnosis and treatment of mental and brain diseases and abnormalities. With appropriate interpretation methods they are emerging as a key methodology to satisfy the increasing global demand for more affordable and effective clinical and healthcare services. Developing and understanding advanced signal processing techniques for the analysis of EEG signals is crucial in the area of biomedical research. This book focuses on these techniques, providing expansive coverage of algorithms and tools from the field of digital signal processing. It discusses their applications to medical data, using graphs and topographic images to show simulation results that assess the efficacy of the methods. Additionally, expect to find: explanations of the significance of EEG signal analysis and processing (with examples) and a useful theoretical and mathematical background for the analysis and processing of EEG signals; an exploration of normal and abnormal EEGs, neurological symptoms and diagnostic information, and representations of the EEGs; reviews of theoretical approaches in EEG modelling, such as restoration, enhancement, segmentation, and the removal of different internal and external artefacts from the EEG and ERP (event-related potential) signals; coverage of major abnormalities such as seizure, and mental illnesses such as dementia, schizophrenia, and Alzheimer’s disease, together with their mathematical interpretations from the EEG and ERP signals and sleep phenomenon; descriptions of nonlinear and adaptive digital signal processing techniques for abnormality detection, source localization and brain-computer interfacing using multi-channel EEG data with emphasis on non-invasive techniques, together with future topics for research in the area of EEG signal processing. The information within EEG Signal Processing has the potential to enhance the clinically-related information within EEG signals, thereby aiding physicians and ultimately providing more cost effective, efficient diagnostic tools. It will be beneficial to psychiatrists, neurophysiologists, engineers, and students or researchers in neurosciences. Undergraduate and postgraduate biomedical engineering students and postgraduate epileptology students will also find it a helpful reference.
Download or read book Deciphering the biomarkers of Alzheimer s disease written by Yu Chen and published by Frontiers Media SA. This book was released on 2022-02-11 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applied Information Processing Systems written by Brijesh Iyer and published by Springer Nature. This book was released on 2021-07-20 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of selected high-quality research papers presented at the International Conference on Computing in Engineering and Technology (ICCET 2021), organized by Dr. Babasaheb Ambedkar Technological University, Lonere, India, during January 30–31, 2021. Focusing on frontier topics and next-generation technologies, it presents original and innovative research from academics, scientists, students and engineers alike. The theme of the conference is Applied Information Processing System.
Download or read book Guide to Voice and Video over IP written by Lingfen Sun and published by Springer Science & Business Media. This book was released on 2013-01-12 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a review of the latest advances in speech and video compression, computer networking protocols, the assessment and monitoring of VoIP quality, and next generation network architectures for multimedia services. The book also concludes with three case studies, each presenting easy-to-follow step-by-step instructions together with challenging hands-on exercises. Features: provides illustrative worked examples and end-of-chapter problems; examines speech and video compression techniques, together with speech and video compression standards; describes the media transport protocols RTP and RTCP, as well as the VoIP signalling protocols SIP and SDP; discusses the concepts of VoIP quality of service and quality of experience; reviews next-generation networks based on the IP multimedia subsystem and mobile VoIP; presents case studies on building a VoIP system based on Asterisk, setting up a mobile VoIP system based on Open IMS and Android mobile, and analysing VoIP protocols and quality.
Download or read book Biomarkers for Early Diagnosis of Alzheimer s Disease written by Daniela Galimberti and published by Nova Science Publishers. This book was released on 2008 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is characterized by the deposition into the brain of amyloid peptide, which originates a cascade of inflammatory events leading eventually to neuronal death. These pathological events likely occur several years before the clinical manifestation of the disease, implying that potential therapeutical interventions are currently started too late to give beneficial results. Recently, growing attention has been paid to the Mild Cognitive Impairment (MCI), considered the prodromal phase of AD, as 80% of subjects with MCI have been shown to develop AD within 5 years. Several studies aimed to identify biological markers to differentiate between normal aging and incipient AD have been carried out, including cerebrospinal fluid (CSF) analysis and neuroimaging. In particular, the evaluation of CSF Amyloid beta (1-42) levels, together with tau and phospotau, are of help for recognizing early AD. Besides, a number of additional molecules are altered in CSF. Other early modifications have been observed in peripheral cells, such as fibroblasts and leukocytes, as well as in serum from patients. Biomarkers for AD represent important tools supporting the clinical diagnosis and the choice of potential therapeutic options. Moreover, they would be of great help for the selection of cohorts of homogeneous patients for clinical trials with new disease-modifying compounds. This book is aimed to give an update about MCI as prodromal Alzheimer's disease (AD), to discuss the main known pathological mechanisms at the basis of AD and to describe the possible biomarkers to be used for an early diagnosis of the disease.
Download or read book EEG Biomarker for Alzheimer s Disease written by Demet √ñzbabalƒ±k Adapƒ±nar and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer,Äôs disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 50 million dementia cases estimated worldwide. There is no cure for AD. Currently, AD diagnosis is carried out using neuropsychological tests, neuroimaging scans, and laboratory tests. In the early stages of AD, brain computed tomography (CT) and magnetic resonance imaging (MRI) findings may be normal, but in late periods, diffuse cortical atrophy can be detected more prominently in the temporal and frontal regions. Electroencephalogram (EEG) is a test that records the electrical signals of the brain by using electrodes that directly reflects cortical neuronal functioning. In addition, EEG is noninvasive and widely available at low cost, has high resolution, and provides access to neuronal signals, unlike functional MR or PET which indirectly detects metabolic signals. Accurate, specific, and cost-effective biomarkers are needed to track the early diagnosis, progression, and treatment response of AD. The findings of EEG in AD are now identified as biomarkers. In this chapter, we reviewed studies that used EEG or event-related potential (ERP) indices as a biomarker of AD.
Download or read book Biomarkers in Psychiatry written by Judith Pratt and published by Springer. This book was released on 2019-01-05 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.
Download or read book Dementia with Lewy Bodies written by John O'Brien and published by CRC Press. This book was released on 2005-11-29 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder
Download or read book A Novel Electroencephalographic Method to Detect a Biomarker for Mild Cognitive Impairment Due to Alzheimer s Disease written by Jameson Douglas Beach and published by . This book was released on 2012 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: A novel electroencephalographic (EEG) method was developed in order to detect a biomarker in a group of individuals with mild cognitive impairment due to Alzheimer's disease (MCI-AD). Six MCI-AD patients and eight healthy controls participated in the study. A power law model was used to predict the amplitude of the flash visual evoked potential-P2 (FVEP-P2) electrophysiological responses at five different intensities of light which were delivered via a stroboscopic lamp. Though the MCI-AD group exhibited FVEP-P2 latencies that were longer than those of age-matched controls, results of the study indicate that the power law model did not adequately distinguish MCI-AD participants from controls.
Download or read book Proteomic based Signature of Brain related Proteins as Novel Candidate Biomarkers for Alzheimer s Disease Diagnosis written by Ilijana Begcevic and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is the most common type of dementia characterized by the progressive memory loss and cognitive decline, with typical age of onset after 65 years. The main disease hallmarks include extracellular amyloid beta deposits and intracellular neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, and be used in research and clinical trial settings for patients' enrichment and stratification or to monitor drug efficacy. The aim of the present dissertation is to evaluate diagnostic potential of brain-related proteins in CSF of AD patients. The study was focused on proteins with high specificity for brain tissue. Only proteins expressed predominantly in the brain and reliably identified in the human CSF proteome were selected for development of multiplex mass spectrometry-based assay. Candidate biomarkers were then evaluated in AD patients with different spectrum of disease severity and cognitively healthy individuals (in total 154 subjects). This exploratory study suggests APLP1 protein as a promising biomarker for early AD detection. Specifically, the protein was elevated in mild cognitive impairment compared to cognitively healthy individuals (p.
Download or read book Alzheimer s Disease written by Nigel M. Hooper and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.
