Download or read book Egl 4 Mediates Sensory Regulation of Multiple Neuronal Signaling Pathways in C Elegans written by Susan A. Daniels and published by . This book was released on 2000 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Download or read book E coli in Motion written by Howard C. Berg and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Escherichia coli, commonly referred to as E. coli, has been the organism of choice for molecular genetics for decades. Its machinery and mobile behavior is one of the most fascinating topics for cell scientists. Scientists and engineers, not trained in microbiology, and who would like to learn more about living machines, can see it as a unique example. This cross-disciplinary monograph covers more than thirty years of research and is accessible to graduate students and scientists alike.
Download or read book Sensory Integration of Odor and Food Signaling in a Primary Sensory Neuron in C Elegans written by Jin Il Lee and published by . This book was released on 2008 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Mechanisms of Chemosensory Signaling in Caenorhabditis Elegans written by Michelle Christine Krzyzanowski and published by . This book was released on 2015 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: All animals rely on their ability to sense and respond to their environment to survive. While similar signal transduction pathways are implicated in both C. elegans and vertebrate chemosensation, there are still large gaps in our understanding of the mechanisms used to regulate signaling in these systems. In my thesis, I have identified a new role for the C. elegans cGMP-dependent protein kinase (PKG) EGL-4 in the negative regulation of nociceptive chemosensory signaling. Nociceptive sensory systems detect harmful stimuli and allow for the initiation of protective behavioral responses. The polymodal ASH sensory neurons are the primary nociceptors in C. elegans. The data suggest that EGL-4 negatively regulates signaling and behavior by activating known inhibitors of G protein-coupled signal transduction, RGS proteins. Using C. elegans behavioral response to aversive stimuli as the readout for neuronal activity, I provide the first evidence for PKG regulation of RGS function in sensory neurons in any system. Additionally, the suitability of a behavioral response is context-dependent, and must reflect both an animal's life history and its present internal state. Based on the integration of these variables, an animal's needs can be prioritized to optimize survival strategies. I show that cGMP movement through a gap junction neural network allows dynamic repurposing of several C. elegans head sensory neurons to regulate ASH sensitivity through EGL-4 function in response to an animal's feeding status. Such decentralized regulation of ASH signaling allows for rapid correlation between an animal's internal state and its behavioral output, and lends an unexpected modulatory flexibility to this hard-wired nociceptive neural circuit.
Download or read book Neuropeptide Systems as Targets for Parasite and Pest Control written by Timothy G. Geary and published by Springer Science & Business Media. This book was released on 2011-01-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.
Download or read book Genomic Regulatory Systems written by Eric H. Davidson and published by Elsevier. This book was released on 2001-01-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Download or read book Neuronal Regulation of Chemosensory Signaling in Caenorhabditis Elegans written by Meredith Jean Ezak and published by . This book was released on 2011 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: All animals rely on their ability to sense and respond to their constantly changing environments to survive. Caenorhabditis elegans depend heavily upon their ability to taste and smell chemical information in their soil habitat to find favorable conditions and avoid noxious environments. While similar signal transduction pathways are implicated in both C. elegans and vertebrate chemosensation, there are still large gaps in our understanding of the mechanisms used to regulate signaling in these systems. I have sought to define cellular pathways that modulate signaling activity, and ultimately responsiveness, of chemosensory neurons in C. elegans. I describe herein the identification of cell- and modality-specific pathways that regulate neuronal activity in response to aberrant signaling, as well as a novel mechanism by which neuronal cells may regulate expression of sensory genes to directly impact cellular activity.
Download or read book Nuclear Translocation of EGL 4 a CGMP Dependant i e Dependent Protein Kinase in Response to Odorant Adaptation in C Elegans written by Jeffrey Ryan Eastham-Anderson and published by . This book was released on 2004 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pre mRNA Processing written by Angus I. Lamond and published by Springer. This book was released on 2014-08-23 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.
Download or read book Caenorhabditis Elegans written by Henry F. Epstein and published by Academic Press. This book was released on 1995 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.
Download or read book C Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book The Oxford Handbook of Invertebrate Neurobiology written by John H. Byrne and published by Oxford University Press. This book was released on 2019-01-29 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.
Download or read book Behavioral Genetics of the Fly Drosophila Melanogaster written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Download or read book C Elegans Atlas written by David H. Hall and published by CSHL Press. This book was released on 2008 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Derived from the acclaimed online “WormAtlas,†C. elegansAtlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm†by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegansII monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
Download or read book Antibodies written by David Catty and published by Oxford University Press, USA. This book was released on 1988 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of a two-volume series covering the production of antibodies and their major applications. Volume I concentrates on how to raise monoclonal and polyclonal antibodies and how to use them in a set of universally applied tests. Now Volume II extends this repertoire of antibody applications with detailed accounts of important labelled antibody techniques using radioisotopes, fluorochromes and enzymes, along with descriptions of red cell and tissue typing. Specific techniques described here include assays with radiolabels, ELISA and related enzyme immunoassays, immunoperoxidase methods, immunofluorescence, fluorescence-activated cell sorting, tumor immunodetection, blood group serology, and HLA serology. The volume will be invaluable for any researcher interested in making greater use of antibodies as research tools, or in updating their present methodology. The detail given is sufficient to enable immediate use of the protocols.
Download or read book Regulation of the Stress Responsive DLK 1 Signaling in C Elegans Nervous System written by Yue Sun and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organisms endure environmental and internal perturbations throughout their lifetime. Environmental cues are integrated by the sensory neuron endings. Within the nervous system, the conserved MAPKKK DLKs play key roles in response to a variety of cellular stress, physical injury and pathological conditions. Previous studies have shown that regulation of DLK protein expression and activity in axonal compartments is pivotal in neuronal development, maintenance and stress response. However, it remains unclear whether DLKs may function in the sensory neuron endings. Moreover, experimental evidence that examines expression of DLKs is mostly based on overexpression approaches; how endogenously expressed DLKs are regulated remains elusive. The goal of my dissertation research focuses on identifying novel regulators of DLK-1 in C. elegans model, starting with a visual genetic screen for mutations altering the expression of endogenously GFP-tagged DLK-1. The first chapter of this dissertation summarizes the previously characterized cellular pathways that regulate DLKs level or activity in neurons. In the second chapter, I investigate the roles of a major group of mutations that affect the intraflagellar transport (IFT) and show that IFT actively controls DLK-1 levels in sensory cilia. Upon IFT disruption, DLK-1 triggers downstream signaling, which in turn represses dlk-1 transcription in sensory neurons. This IFT-dependent DLK-1 signaling protects cilia from degeneration, revealing a surveillance mechanism at the sensory endings of the organism. In the third chapter, I report the design of the genetic screen and phenotypes of additional mutants that specifically alter DLK-1 level in ciliated sensory neurons and are involved in multiple ciliary processes including anterograde IFT transport, BBSome, MAP kinase and olfactory signaling, and repress DLK-1 expression in a cell type-specific manner. Taken together, my dissertation establishes the methodology to uncover and also identifies new mechanisms regulating the stress responsive DLK signaling at sensory endings of the nervous system.
