Download or read book Efficient Optimization Techniques for IMRT Treatment Planning written by Arinbjörn Ólafsson and published by . This book was released on 2006 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrating Delivery Issues in Intensity modulated Radiation Therapy Treatment Plan Optimization written by Ehsan Salari and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: My Ph. D. dissertation focuses on model and algorithm development to enhance several aspects of an IMRT treatment plan. In particular, it addresses two major clinical issues encountered in treatment delivery, which are efficiency and accuracy. The beam-on-time, as a measure of the delivery efficiency, is incorporated into the IMRT treatment planning problem using a Direct Aperture Optimization approach. This allows for taking the efficiency factor into consideration when designing a treatment plan. Moreover, we have proposed robust and efficient models and solution approaches to account for the dosimetric inaccuracies caused during the treatment delivery. More specifically, we have considered two sources of inaccuracy which may compromise the treatment outcome; (1) the tongue-and-groove effect and (2) the organ motion. To account for the tongue-and-groove effect, we have developed robust models and efficient solution methods to obtain clinically-attractive treatment plans regardless of the exact effect of this source of inaccuracy. Furthermore, to incorporate the uncertainty caused by the organ motion into the IMRT treatment planning problem, we have proposed an entirely new modeling framework as well as solution approaches to obtain high-quality treatment plans while taking the variation of the treatment outcome into account.
Download or read book Handbook of Optimization in Medicine written by Panos M. Pardalos and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Optimization in Medicine is devoted to examining the dramatic increase in the application of effective optimization techniques to the delivery of health care. The articles, written by experts, focus on models and algorithms that have led to more efficient and sophisticated treatments of patients. Topics covered include: optimization in medical imaging, classification and data mining with medical applications, treatment of epilepsy and other brain disorders, treatment of head-and-neck, prostate, and other cancers using conventional conformal and intensity-modulated radiation therapy as well as proton therapy, treatment selection for breast cancer based on new classification schemes, optimization for the genome project, optimal timing of organ transplants.
Download or read book Multiobjective Optimization in Imrt Treatment Planning written by Lizhen Shao and published by LAP Lambert Academic Publishing. This book was released on 2010-07 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of intensity modulated radiation therapy (IMRT) is to kill tumor cells while at the same time protecting the surrounding tissue and organs from the damaging effect of radiation. Given the number of beams and beam directions, beam intensity optimization needs to determine beam intensity profiles that yield the best dose distribution under consideration of clinical and physical constraints. In this book, we first review existing mathematical models and computation methods for the beam intensity optimization problem. Then we formulate the beam intensity optimization problem as a multiobjective linear programme (MOLP) with three objectives. The rest of the book is dedicated to developing methods to solve this large MOLP efficiently and to the application in the beam intensity optimization problem. The book provides the necessary mathmatical foundation of multiobjective optimization to solve multiobjective linear programming problems. It is well suitable to be used as a reference book on multiobjective optimization. Moreover it should also be useful to professionals who may be considering using multiobjective optimization.
Download or read book Optimization in Intensity Modulated Radiation Therapy written by Stewart Gaede and published by . This book was released on 2003 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Technologies in Radiation Oncology written by Wolfgang C. Schlegel and published by Springer Science & Business Media. This book was released on 2006-01-27 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Summarizes the state of the art in the most relevant areas of medical physics and engineering applied to radiation oncology - Covers all relevant areas of the subject in detail, including 3D imaging and image processing, 3D treatment planning, modern treatment techniques, patient positioning, and aspects of verification and quality assurance - Conveys information in a readily understandable way that will appeal to professionals and students with a medical background as well as to newcomers to radiation oncology from the field of physics
Download or read book Radiation Therapy Physics written by Alfred R. Smith and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide a uniquely comprehensive source of information on the entire field of radiation therapy physics. The very significant advances in imaging, computational, and accelerator technologies receive full consideration, as do such topics as the dosimetry of radiolabeled antibodies and dose calculation models. The scope of the book and the expertise of the authors make it essential reading for interested physicians and physicists and for radiation dosimetrists.
Download or read book Geometry based Constraint Generation for Large scale Radiation Therapy Treatment Planning written by Kourosh Khedriliraviasl and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Intensity-Modulated Radiation Therapy (IMRT) is a high precision radiotherapy with many beams that have different intensities to accurately irradiate a tumor/cancerous cells considering minimization of the dose to surrounding normal tissues. Different optimization methods are developed to achieve optimal beam intensities considering different criteria in objective function and number of constraints. IMRT optimization models are large-scale in nature because large number of constraints and/or variables associated with tumor/cancerous cells can be defined which is very hard to solve and takes a huge amount of computational time. A novel constraint generation solution method for IMRT treatment planning is presented in this research. A Fluence Map Optimization (FMO) framework is used to formulate the optimization problem for a breast cancer treatment planning case study. In addition, a data processing method is developed to form clusters of similar voxels with the highest dose associated from beamlets. Because in this optimization problem there are large number of constraints related to each voxel, these data clusters will help in deciding which voxels to pick as set of new constraints for the sub-problems. This is for the purpose of reducing the number of constraints. The optimal beam intensities do not cause a violation of any other constraints in the main model. The results show that the objective function value from constraint generation model is same as the objective function value that is resulted from the full-size model implementation considering all the constraints. Also, the optimal beam intensities from these two models are comparable and they create similar fluence map pattern. This shows that the new model is able to maintain the same quality as large-scale model. The advantages of this new method are, reducing the number of constraints that should be considered for the optimization significantly, and maintaining solution quality which can help create faster optimization algorithms.
Download or read book Khan s Treatment Planning in Radiation Oncology written by Faiz M. Khan and published by Lippincott Williams & Wilkins. This book was released on 2016-05-11 with total page 1475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, full-color reference offers a total team approach to radiation oncology treatment planning, incorporating the newest imaging techniques and offering a comprehensive discussion of clinical, physical, biological and technical aspects. A clear focus on the application of physical and clinical concepts to solve treatment planning problems helps you provide effective, state-of-the-art care for cancer patients. With authoritative coverage of the latest in sophisticated radiation oncology treatment modalities, the 4th Edition of Khan’s Treatment Planning in Radiation Oncology is an essential resource for the radiation oncologist, medical physicist, dosimetrist, and radiation therapist.
Download or read book Perturbed Projection Methods in Convex Optimization Applied to Radiotherapy Planning written by Esther Bonacker and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Practical Guide to Intensity modulated Radiation Therapy written by and published by Medical Physics Publishing Corporation. This book was released on 2003 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an account of the perspective, methodology, and experience in the physical and medical aspects of IMRT at Memorial Sloan-Kettering Cancer Center (MSKCC).
Download or read book A Direct Compensator Profile Optimization Approach for Intensity Modulated Radiation Treatment Planning written by Kevin J. Erhart and published by . This book was released on 2009 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation therapy accounts for treatment of over one million cancer patients each year in the United States alone, and its use will continue to grow rapidly in the coming years. Recently, many important advancements have been developed that greatly improve the outcomes and effectiveness of this treatment technique, the most notable being Intensity Modulated Radiation Therapy (IMRT). IMRT is a sophisticated treatment technique where the radiation dose is conformed to the tumor volume, thereby sparing nearby healthy tissue from excessive radiation dose. While IMRT is a valuable tool in the planning of radiation treatments, it is not without its difficulties. This research has created, developed, and tested an innovative approach to IMRT treatment planning, coined Direct Compensator Profile Optimization (DCPO), which is shown to eliminate many of the difficulties typically associated with IMRT planning and delivery using solid compensator based treatment. The major innovation of this technique is that it is a direct delivery parameter optimization approach which has adopted a parameterized surface representation using Non-Uniform Rational B-Splines (NURBs) to replace the conventional beamlet weight optimization approach. This new approach brings with it three key advantages: 1) a reduced number of parameters to optimize, reducing the difficulty of numerical optimization; 2) the ability to ensure complete equivalence of planned and actual manufactured compensators; and 3) direct inclusion of delivery device effects during planning with no performance penalties, eliminating the degrading fluence-to-delivery parameter conversion process. Detailed research into the affects of the DCPO approach on IMRT planning has been completed and a thorough analysis of the developments is provided herein. This research includes a complete description of the DCPO surface representation scheme, inverse planning process, as well as quantification of the manufacturing constraint control procedure. Results are presented which demonstrate the performance and innovation offered by this new approach and show that the resulting compensator shapes can be manufactured to nearly 100 percent of the designed shape.
Download or read book The Use of Computers in Radiation Therapy written by Wolfgang Schlegel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computers have had and will continue to have a tremendous impact on professional activity in almost all areas. This applies to radiological medicine and in particular to radiation therapy. This book compiles the most recent developments and results of the application of computers and computer science as presented at the XIIIth International Conference on the Use of Computers in Radiation Therapy in Heidelberg, Germany. The text of both oral presentations and posters is included. The book is intended for computer sientists, medical physicists, engineers and physicians in the field of radiation therapy and provides a comprehensive survey of the entire field.
Download or read book Optimization Models and Iterative Solution Methods for Intensity Modulated Radiation Therapy IMRT Planning written by Jaewon Choi and published by . This book was released on 2006 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: We consider optimization models and solution strategies for radiation treatment planning problems for cancer patients. The goal of radiation treatment planning is to control tumor volume by delivering radiation while sparing the surrounding normal and healthy tissues. Currently, Intensity Modulated Radiation Therapy (IMRT) is considered to be the most effective radiation therapy technique for cancer treatment. IMRT is delivered using a linear accelerator (LINAC) with a multileaf collimator (MLC or beam shaper) housed in the head of treatment unit. Obtaining optimal settings of beam orientations and beam intensity profiles, and MLC sequencing to generate beam intensity profiles can be an extremely tedious labor if it is done manually. Therefore, specialized computer-aided optimization methods are highly desired.
Download or read book A Computational Study on Different Penalty Approaches for Constrained Optimization in Radiation Therapy Treatment Planning with a Simulated Annealing Algorithm written by Mohammad Sadegh Mohammadi Khoroushadi and published by . This book was released on 2016 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intensity modulated radiation therapy (IMRT) is a cancer treatment method in which the intensities of the radiation beams are modulated; therefore these beams have non-uniform radiation intensities. The overall result is the delivery of the prescribed dose in the target volume. The dose distribution is conformal to the shape of the target and minimizes the dose to the nearby critical organs. An inverse planning algorithm is used to obtain those non-uniform beam intensities. In inverse treatment planning, the treatment plan is achieved by using an optimization process. The optimized plan results to a high-quality dose distribution in the planning target volume (PTV), which receives the prescribed dose while the dose that is received by the organs at risk (OARs) is reduced. Accordingly, an objective function has to be defined for the PTV, while some constraints have to be considered to handle the dose limitations for the OARs. In other words, the IMRT optimization problem is a constrained optimization problem. Depending on the type of the constraints that are used for the OARs, the degree of the complexity varies. In particular, introduction of dose-volume constraints (DVCs) changes the original convex optimization problem of the PTV into a non-convex problem with several local minima. In addition, the search space dimensionality of this optimization problem is high. For these reasons, the optimization methods and algorithms must be chosen to satisfy all conditions. In this research, the Simulated Annealing Algorithm (SAA) is used in three novel methods to optimize an IMRT plan with one PTV and two OARs. These methods were tested on data from five prostate patients, and they successfully achieved the IMRT goals.
Download or read book Incorporating Uncertainty and Motion in Intensity Modulated Radiation Therapy Treatment Planning written by Benjamin Charles Martin and published by . This book was released on 2008 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: In radiation therapy, one seeks to destroy a tumor while minimizing the damage to surrounding healthy tissue. Intensity Modulated Radiation Therapy (IMRT) uses overlapping beams of x-rays that add up to a high dose within the target and a lower dose in the surrounding healthy tissue. IMRT relies on optimization techniques to create high quality treatments. Unfortunately, the possible conformality is limited by the need to ensure coverage even if there is organ movement or deformation. Currently, margins are added around the tumor to ensure coverage based on an assumed motion range. This approach does not ensure high quality treatments. In the standard IMRT optimization problem, an objective function measures the deviation of the dose from the clinical goals. The optimization then finds the beamlet intensities that minimize the objective function. When modeling uncertainty, the dose delivered from a given set of beamlet intensities is a random variable. Thus the objective function is also a random variable. In our stochastic formulation we minimize the expected value of this objective function. We developed a problem formulation that is both flexible and fast enough for use on real clinical cases. While working on accelerating the stochastic optimization, we developed a technique of voxel sampling. Voxel sampling is a randomized algorithms approach to a steepest descent problem based on estimating the gradient by only calculating the dose to a fraction of the voxels within the patient. When combined with an automatic sampling rate adaptation technique, voxel sampling produced an order of magnitude speed up in IMRT optimization. We also develop extensions of our results to Intensity Modulated Proton Therapy (IMPT). Due to the physics of proton beams the stochastic formulation yields visibly different and better plans than normal optimization. The results of our research have been incorporated into a software package OPT4D, which is an IMRT and IMPT optimization tool that we developed.
Download or read book Intensity Modulated RadioTherapy IMRT written by Jan Seppälä and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of intensity-modulated radiotherapy (IMRT) has increased extensively in the modern radiotherapy treatments over the past two decades. Radiation dose distributions can be delivered with higher conformality with IMRT when compared to the conventional 3D-conformal radiotherapy (3D-CRT). This study evaluated the dosimetric limitations and possibilities of IMRT in small (treatments of head-and-neck, prostate and lung cancer) and large volumes (primitive neuroectodermal tumours). The dose coverage of target volumes and the sparing of critical organs were increased with IMRT when compared to 3D-CRT. The beam modulation in the IMRT treatments is realized by splitting a large radiation field to small apertures. A direct aperture based optimization technique was examined as a solution to decrease the IMRT treatment complexity. With direct optimization the effective field sizes were increased and the number of MUs was reduced with a factor of two. The optimality of a treatment plan and the therapeutic ratio can be further enhanced by using dose painting based on regional radiosensitivities imaged with functional imaging methods.
