Download or read book Principles of Mass Spectrometry Applied to Biomolecules written by Chava Lifshitz and published by John Wiley & Sons. This book was released on 2006-10-27 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.

Download or read book Interpretation of MS MS Mass Spectra of Drugs and Pesticides written by Wilfried M. A. Niessen and published by John Wiley & Sons. This book was released on 2017-01-30 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

Download or read book Ion Molecule Attachment Reactions Mass Spectrometry written by Toshihiro Fujii and published by Springer. This book was released on 2015-08-03 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the mechanism of alkali-metal ion/molecule association reaction, surveys the instrumental basis to study its kinetic, and describes the instrumentation to the measurement of alkali-metal ion affinities. The applications of the ion complexation mechanism in the condensed phase in reaction to direct analysis MS are also covered. Other topics include mechanism and reaction rate, experimental and theoretical ion affinities, applications of ion attachment reactions (IAR) to mass spectrometry such as alkali ion CIMS, ion attachment MS and cationization mass spectrometry of ESI, FAB, FD, LD, MALDI and SIMS and topics of IAR-based direct analysis mass spectrometry.

Download or read book Mass Spectrometry of Non Covalent Complexes written by Christoph A. Schalley and published by John Wiley & Sons. This book was released on 2009-09-08 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the many benefits of applying mass spectrometry to supramolecular chemistry Except as a method for the most basic measurements, mass spectrometry (MS) has long been considered incompatible with supramolecular chemistry. Yet, with today's methods, the disconnect between these two fields is not warranted. Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes provides a convincing look at how modern MS techniques offer supramolecular chemists a powerful investigatory toolset. Bringing the two fields together in an interdisciplinary manner, this reference details the many different topics associated with the study of non-covalent complexes in the gas phase. The text begins with brief introductions to supramolecular chemistry and such relevant mass spectrometric methods as ionization techniques, analyzers, and tandem MS experiments. The coverage continues with: How the analyte's transition into the gas phase changes covalent bonding How limitations and pitfalls in analytical methods may produce data misinterpretations Artificial supramolecular aggregates and their examination Biomolecules, their complexes, and their examination After the general remarks making up the first section of the book, the following sections describe specific experimental procedures and are illustrated with numerous examples and short tutorials. Detailed citations end each chapter. Mass spectrometrists, supramolecular chemists, students in these fields, and interested readers from other disciplines involving the study of non-covalent bonds will all value Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes as an innovative and practical resource.

Download or read book Monitoring Polymerization Reactions written by Wayne F. Reed and published by John Wiley & Sons. This book was released on 2014-01-21 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers new strategies to optimize polymer reactions With contributions from leading macromolecular scientists and engineers, this book provides a practical guide to polymerization monitoring. It enables laboratory researchers to optimize polymer reactions by providing them with a better understanding of the underlying reaction kinetics and mechanisms. Moreover, it opens the door to improved industrial-scale reactions, including enhanced product quality and reduced harmful emissions. Monitoring Polymerization Reactions begins with a review of the basic elements of polymer reactions and their kinetics, including an overview of stimuli-responsive polymers. Next, it explains why certain polymer and reaction characteristics need to be monitored. The book then explores a variety of practical topics, including: Principles and applications of important polymer characterization tools, such as light scattering, gel permeation chromatography, calorimetry, rheology, and spectroscopy Automatic continuous online monitoring of polymerization (ACOMP) reactions, a flexible platform that enables characterization tools to be employed simultaneously during reactions in order to obtain a complete record of multiple reaction features Modeling of polymerization reactions and numerical approaches Applications that optimize the manufacture of industrially important polymers Throughout the book, the authors provide step-by-step strategies for implementation. In addition, ample use of case studies helps readers understand the benefits of various monitoring strategies and approaches, enabling them to choose the best one to match their needs. As new stimuli-responsive and "intelligent" polymers continue to be developed, the ability to monitor reactions will become increasingly important. With this book as their guide, polymer scientists and engineers can take full advantage of the latest monitoring strategies to optimize reactions in both the lab and the manufacturing plant.

Download or read book Applications of Mass Spectrometry to Organic Stereochemistry written by Janet S. Splitter and published by Wiley-VCH Verlag GmbH. This book was released on 1994 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mass Spectrometry of Peptides written by Dominic M. Desiderio and published by CRC Press. This book was released on 1990-11-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to collect into one volume the research done on the mass spectrometry of peptides. It balances a range of topics including theory, instrumentation, analytical techniques, and biological applications. The scope of the work contains three major sections: ionization methods, instrumental developments, and analysis of peptides. It describes 252Cf plasma desorption and laser-induced multiphoton ionization methodology. This exciting resource covers many new areas, including continuous flow FAB, quantification of human neuropeptides, and peptide mapping. It also discusses Q-FTMS, cross-links, and metal ions.

Download or read book Modern Mass Spectrometry written by Peter B. Armentrout and published by Springer Science & Business Media. This book was released on 2003-06-23 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: I Reactivity: E. Uggerud: Physical Organic Chemistry of the Gas Phase. Reactivity Trends for Organic Cations.- S. Petrie, D.K. Bohme: Mass Spectrometric Approaches to Interstellar Chemistry.- F. Turecek: Transient Intermediates of Chemical Reactions by Neutralization-Reionization Mass Spectrometry.- II Metalorganic Chemistry: D. Schröder, H. Schwarz: Diastereoselective Effects in Gas-Phase Ion Chemistry.- D.A. Plattner: Metalorganic Chemistry in the Gas Phase: Insight into Catalysis.- III Mass Spectrometric Methodology: T. Wyttenbach, M.T. Bowers: Gas-Phase Conformations: The Ion Mobility/Ion Chromatography Method.- P.B. Armentrout: Threshold Collision-Induced Dissociations for the Determination of Accurate Gas-Phase Binding Energies and Reaction Barriers.- IV Medicinal Chemistry: S.A. Trauger, T. Junker, G. Siuzdak: Investigating Viral Proteins and Intact Viruses with Mass Spectrometry M. Brönstrup: High-Throughput Mass Spectrometry for Compound Characterization in Drug Discovery.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mass Spectrometry Bulletin written by and published by . This book was released on 1999 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Peptide Therapeutics written by Ved Srivastava and published by Royal Society of Chemistry. This book was released on 2019-08-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Download or read book Ionization Potentials written by L. H. Ahrens and published by Elsevier. This book was released on 2013-10-22 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionization Potentials: Some Variations, Implications and Applications covers several aspects of ionization potential that is a highly significant parameter in controlling the properties of electric discharge. Comprised of 17 chapters, the book covers topic relevant to ionization potentials, such as properties, concepts, and applications, in order to understand and fully comprehend all aspects of ionization potential. The opening chapter is a review of ionization potentials and a discussion of trends and features. The succeeding chapters then tackle complex topics such as the s and p electrons; d-transition elements; rare earth elements; screening (shielding); inert elements; cationic forces (polarizing power); and heats of hydration. This book will appeal to researchers from different fields.

Download or read book The Encyclopedia of Mass Spectrometry written by Michael L. Gross and published by . This book was released on 2003 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2009 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Mass Spectrometry written by and published by . This book was released on 2001 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissociative Recombination written by Bertrand R. Rowe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a NATO ARW held in Saint Jacut de la Mer, Brittany, France, May 3-8, 1992

Download or read book Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells written by Kenneth Kam-Wing Lo and published by Academic Press. This book was released on 2016-12-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. - Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas - Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells - Foscuses on the fundamentals and their potential therapeutic and diagnostic applications - Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents