Download or read book Effect of Exercise on in Vivo Insulin Signaling and Action in Insulin Resistant Skeletal Muscle written by Christine Yvonne Christ-Roberts and published by . This book was released on 2003 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Skeletal Muscle Metabolism in Exercise and Diabetes written by Erik A. Richter and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Copenhagen Muscle Research Centre was founded in 1994 with the support of a grant from the Danish National Research Foundation. Among the goals for the Centre is the organization of research symposia, with the aim of bringing a limited number ofintemation ally renowned scientists together to discuss the latest developments and perspectives in their field. The first Copenhagen Muscle Research Centre Conference was held in 1995 and dealt with cardiovascular regulation. The Second Copenhagen Muscle Research Centre Confer ence was held from October 23-26, 1997. The topic of the Symposium was Muscle Metabo lism: Regulation, Exercise, and Diabetes. Seventy invited scientists from all over the world discussed their latest research related to skeletal muscle metabolism. The speakers were asked to expand on their presentations and to write short, but comprehensive, chapters about their given topics. The result is 28 peer-reviewed and edited chapters covering many if not all aspects of muscle energy metabolism related to exercise and diabetes. Emphasis is on regulation of glucose and fatty acid metabolism and the mechanisms regulating their use as fuels for the muscle during exercise. In addition, abnormalities in the regulation of glucose metabolism in the diabetic state are described. However, amino acid and protein metabolism are also thoroughly discussed. We believe that this volume brings an unparralleled, up to date, and comprehensive review of the frontiers in muscle metabolism. Erik A.

Download or read book Mitochondria in Obesity and Type 2 Diabetes written by Beatrice Morio and published by Academic Press. This book was released on 2019-04-26 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.

Download or read book Effects of Exercise Training on Skeletal Muscle Insulin Signaling and Inflammation in Two Rodent Models of Insulin Resistance written by Lindsea Burns and published by . This book was released on 2016 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aims of this investigation were 1) to determine if resistance exercise training, like aerobic exercise training, improves insulin signaling in the skeletal muscle of the high fat-fed Sprague Dawley rat via suppression of the IKK inflammatory pathway, and 2) to determine if aerobic and resistance training are equally effective at improving skeletal muscle insulin resistance in the obese Zucker rat, and if these improvements are due to suppression of the IKK inflammatory pathway. Sprague Dawley rats were placed on a chow (NC, n=8) or high-fat (n=24) diet, while the Zucker rats (n=32) were fed a normal chow diet, for 4wks. During the subsequent 8-wk experimental protocol, high fat-fed Sprague Dawley rats were allocated (n=8/group) to sedentary control (HFC), aerobic exercise training (HFAX), or resistance exercise training (HFRX). Lean Zucker rats (LN, n=8) served as genetic controls while obese Zucker rats (n=24) were allocated (n=8/group) to sedentary control (FT), aerobic exercise training (FTAX), or resistance exercise training (FTRX). Following the 8-wk experimental period, animals underwent hindlimb perfusions and the insulin-stimulated red gastrocnemius was collected for viii analysis. High-fat diet induced impairments in insulin-stimulated rates of 3-MG transport in the Sprague Dawley rat were reversed by both aerobic and resistance training due to normalized IRS-1 pY and IRS-1 pS. IKK pS was similar across the HFRX, HFAX and NC animals. Insulin-stimulated rates of 3-MG transport and IRS-1 pY in the skeletal muscle of the FTRX, FTAX and LN groups were similar. Both aerobic and resistance training suppressed IKK pS in the skeletal muscle of the obese Zucker rat. These findings indicate that exercise training, regardless of mode, improves insulin signaling via suppressing IKK inflammation regardless of etiology of insulin resistance.

Download or read book A Flexible System of Enzymatic Analysis written by Oliver Lowry and published by Elsevier. This book was released on 2012-12-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Flexible System of Enzymatic Analysis is a multipurpose manual of laboratory methods that offers a systematic scheme for the analysis of biological materials from the level of the wholeorgan down to the single cell and beyond. It intends to guide the development of methods, the refinement of old ones, and the adaptation in general of methods to almost any scale of sensitivity. This manual is organized into three parts: a general section, one on quantitative histochemistry, and an appendix containing information that may be useful to have at the bench. The general section is comprised of nine chapters that focus on properties of the pyridine nucleotides, kinetics, and glassware, as well as on improvement, modification, adaptation, trouble shooting, and development of methods. This part also describes the preparation of tissues for analysis, the enzymatic cycling methods, and a compendium of 36 metabolite assays. The quantitative histochemistry section is comprised of four chapters that include information on the preparation of frozen-dried material and dissection of samples for analysis; the fishpole balance for weighing samples; and the generalities of analysis with emphasis on the ""oil well technique."" This book will be useful to novices as well as experts who are familiar with other analytical styles.

Download or read book Sports Endocrinology written by F. Lanfranco and published by Karger Medical and Scientific Publishers. This book was released on 2016-06-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an up-to-date, extensive overview of the effects of physical activity and training on endocrine function. It gives insights into a complex relationship by describing effects with respect to exercise performance, growth, development, and ageing. It includes discussions of the endocrine response depending on exercise mode, intensity, and duration as well as on gender, age, and fitness level. Additionally the book deals with the impact of environmental and psychological factors on endocrine level. A substantial part of Sports Endocrinology is devoted to the 'hot topic' of hormonal doping in sports. The properties of androgens, growth hormone, erythropoietin, and dietary supplements are highlighted. The use and abuse among professional and recreational athletes is discussed and specific methods of detection are presented and explained. All contributors are well-known experts in sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection, so this book is a must-read for every professional involved in the field.

Download or read book Insulin Signaling written by George Grunberger and published by CRC Press. This book was released on 2003-09-02 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models.

Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

Download or read book Muscle Metabolism written by Juleen R Zierath and published by CRC Press. This book was released on 2002-02-28 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav

Download or read book Insulin Resistance written by Sudhesh Kumar and published by John Wiley & Sons. This book was released on 2005-07-15 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research

Download or read book Regulation of Skeletal Muscle Insulin Action by SIRT1 and STAT3 written by Amanda T. White and published by . This book was released on 2013 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle insulin resistance is a primary metabolic defect underlying the etiology of type 2 diabetes. Consumption of a high-fat/high-calorie diet (HFD) is associated with the development of insulin resistance and type 2 diabetes, while calorie restriction (CR) (60% of ad libitum [AL] food intake) robustly reverses muscle insulin resistance. Remarkably, the signaling mechanisms linking nutrient status to muscle insulin sensitivity are incompletely defined. Considering that the prevalence of diabetes continues to grow at an alarming rate, addressing this fundamental gap in knowledge has the potential to significantly impact human health. Thus, the objective of this dissertation was to define the mechanisms underlying muscle insulin action in the context of nutrient availability. Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase, has been proposed to link perturbations in nutrient availability to muscle insulin action. In line with this, SIRT1 activity in skeletal muscle is increased by CR and decreased by HFD. Furthermore, mice with transgenic overexpression of SIRT1 exhibit a metabolic profile resembling CR, and small molecule activators of SIRT1 enhance insulin sensitivity in rodent models of insulin resistance. Nevertheless, little is known regarding the regulatory role of SIRT1 in muscle insulin action, particularly in vivo. We recently identified the SIRT1 target, signal transducer and activator of transcription 3 (STAT3), as an important regulator of muscle insulin sensitivity in response to CR. Furthermore, STAT3 is activated in insulin resistant states and inhibition of STAT3 in liver restores hepatic insulin sensitivity. Thus, we hypothesized that SIRT1 and STAT3 regulate muscle insulin sensitivity in response to nutrient availability. To address this hypothesis, we investigated muscle insulin signaling and sensitivity in response to HFD and CR using novel mouse models in which we modulated SIRT1 and STAT3 activity in skeletal muscle. Our findings demonstrate that muscle-specific overexpression of SIRT1 does not enhance muscle insulin action under AL or CR conditions or prevent HFD-induced obesity or insulin resistance. Finally, we showed that knockout of STAT3 in skeletal muscle does not enhance muscle insulin sensitivity on a control diet or HFD. Taken together, the studies from this dissertation broaden our understanding of the roles of SIRT1 and STAT3 in muscle insulin action in response to nutrient availability.

Download or read book Textbook of Sports Medicine written by Michael Kjaer and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Sports Medicine provides comprehensive coverage of both basic science and clinical aspects of sports injury and physical activity. More than one hundred of the World's leading authorities within exercise physiology, clinical internal medicine, sports medicine and traumatology have contributed with evidence-based state-of-the-art chapters to produce the most complete integration ever of sports medicine science into one book. Great attention has been given to providing balanced coverage of all aspects of sports medicine, with respect to the relevance and clinical importance of each area. The book isolates solid principles and knowledge, and the documentation to support these, as well as identifying areas where further scientific investigation is needed. The topics dealt with and the degree of detail in the individual chapters, makes the book ideal for both educational programs at University level within exercise science and sports medicine, as well as for post-graduate courses within all aspects of sports medicine. In addition, the book will be excellent as a reference book in any place where professionals whether doctors, exercise scientists, physiotherapists or coaches are dealing with supervision or treatment of sports-active individuals. Finally, the book is well structured to act as an introduction to research in the field of sports medicine.

Download or read book Skeletal Muscle Glucose Transport Following Exercise in Rodents written by Charles L. Dumke and published by . This book was released on 2000 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exercise Physiology Integrating Theory and Application written by William Kraemer and published by Lippincott Williams & Wilkins. This book was released on 2020-08-24 with total page 1759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Build the foundation of scientific knowledge and practical decision-making skills needed to excel in an exercise training career Master the core concepts of exercise physiology and learn how to apply them to the real-world challenges of exercise training with Exercise Physiology: Integrating Theory and Application, Third Edition. Designed to connect theory to practice, this engaging, accessible text gives students a thorough understanding of how the body adapts to exercise and environmental stresses and how basic physiology informs practical decisions. This new edition expands the coverage of practical applications, extends on our growing scientific knowledge of exercise physiology, explores the topic of “Exercise is Medicine”, and offers more guidance on finding reliable research-based answers to real-life questions. New content, as well as updated coverage of the endocrine system, applying research, nutritional support, and environmental effects make this the perfect resource to support the diverse case scenarios seen by personal trainers, strength coaches, fitness instructors, athletic trainers, and other exercise professionals.

Download or read book GeNeDis 2016 written by Panayiotis Vlamos and published by Springer. This book was released on 2017-10-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd World Congress on Genetics, Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international focum for the latest scientific discoveries, medical practices, and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation, and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2016 takes place in Sparta, Greece, 20-23 October, 2016. This volume focuses on the sessions that address geriatrics.