Download or read book Ectopeptidases written by Jürgen Langner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.
Download or read book Biological Barriers to Protein Delivery written by Kenneth L. Andus and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2009-07-03 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology—both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.* Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists
Download or read book Cellular Peptidases in Immune Functions and Diseases 2 written by Jürgen Langner and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Download or read book Sustainable Chemistry Research written by Ponnadurai Ramasami and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-10-23 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book of proceedings is a collection of nineteen selected and peer-reviewed contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022). VCCA-2022 was held online from 8th to 12th August 2022. The theme of the conference was "Resilience and Sustainable Research through Basic Sciences". 500 participants from 55 countries participated in VCCA-2022. This volume 1 reflects the chapters covering chemical and biochemical aspects.
Download or read book Neurochemistry written by Albert Teelken and published by Springer. This book was released on 2013-11-11 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 11th European Society for Neurochemistry Meeting held in Groningen, The Netherlandes, June 15-20, 1996
Download or read book Cellular Biology of Ectoenzymes written by Georg W. Kreutzberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells do not normally live as single entities but are grouped together in specific functional and structural configurations in various tissues. Intra cellular mechanisms maintain cellular viability and provide the means necessary for their specific cellular functions. The interaction between cells is maintained by mechanisms involving extracellular signalling. Such extracellular mechanisms may include special properties of the cell surface which involve immediate cell contact, but may also represent mechanisms which act at a distance and are mediated via special secretions and/or re ceptors. Recent studies on cell-cell contact have tended to stress cell sur face components directly mediating cellular interactions; the extracellular medium as a metabolically active compartment has been rather neglected. However, it represents a vital medium through which cells communicate, being important in, for example, chemotaxis in primitive organisms, and in devel~ment and in the coordination of multiple functions in multi cellular 0 ganisms. It is not surprising, therefore, that a number of mole cular me anisms have developed together with increasing biological complexi during evolution. Two aspects of the extracellular space have received increasing attention in the last few years. First, several macro molecules such as collagen, laminin and fibronectin have been identified as components of an extracellular matrix giving a structural dimension to the extracellular compartment.
Download or read book Trends in Protein Research written by John W. Robinson and published by Nova Publishers. This book was released on 2005 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.
Download or read book Neuroimmunology of the Skin written by Richard D. Granstein and published by Springer Science & Business Media. This book was released on 2009-02-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much anecdotal information has suggested an influence of psychology and the nervous system on immunity within the skin and the expression of inflammatory skin disorders. Recent years have seen an explosion of knowledge providing a scientific basis for important regulatory interactions between the nervous system, the endocrine system and the immune system within the skin. The results of recent investigations have important implications, not only for an understanding of cutaneous immunity, but also for the development of novel treatments for diseases involving abnormal inflammation or immune reactivity within the skin. This book provides a comprehensive and interdisciplinary review of the molecular biology, cell biology, biochemistry and clinical aspects of nervous system–immune system interactions within the skin. It includes contributions from leading world experts in these areas. The contents are relevant to both investigators and clinicians interested in the skin, its functions and its disorders.
Download or read book Aminopeptidases in Biology and Disease written by Nigel M. Hooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.
Download or read book Dipeptidyl Aminopeptidases in Health and Disease written by Martin Hildebrandt and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Download or read book Dipeptidyl Aminopeptidases written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2006-12-11 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Download or read book Frontiers in Neurodegenerative Disorders and Aging written by Tomris Özben and published by IOS Press. This book was released on 2004 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Brain Immune Axis and Substance Abuse written by Burt M. Sharp and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the proceedings of the 2nd annual symposium on the Brain Immune Axis and Substance Abuse held at the Breakers Hotel in Palm Beach, FL in June 1994. The history of productive studies concerning the relationship between the nervous and the immune systems is relatively recent. Studies on the effects of drugs of abuse on the immune system and on infections among individuals who abuse drugs are also of recent vintage. Only in the last decade have investigators begun to describe the role of drugs of abuse and their endogenous counterparts on the brain-immune axis. Thus, the involvement of the neuroendocrine system in the interactions of drugs of abuse and the immune system has only recently been appreciated. In addition, it has been recognized that direct neural inputs impact immune function. Given the complexity of these interactions, characterization of biologically significant phenomena and elucidation of their mechanisms of action often requires a multidisciplinary approach. This meeting, on which the chapters in this book are based, brought together scientists from an array of biomedical disciplines whose work is focused on the effects of drugs of abuse on the neuro-endocrine immune axis. The meeting was unique in focusing on the brain-immune axis from the viewpoint of drugs of abuse rather than either immunity itself or the brain itself. Presentations addressed the direct effects of drugs of abuse on various components of the immune system, as well as those mediated indirectly by the central nervous system and the neuroendocrine system.
Download or read book Advances in Drug Research written by Bernard Testa and published by Elsevier. This book was released on 2013-10-22 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
Download or read book Hydrolysis in Drug and Prodrug Metabolism written by Bernard Testa and published by John Wiley & Sons. This book was released on 2003-08 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 2006 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
