Download or read book Eccentric Contraction induced Skeletal Muscle Injury and Its Consequences for the Sarcolemma and the Associated Cytoskeleton written by Richard Michael Lovering and published by . This book was released on 2003 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ECCENTRIC CONTRACTION INDUCED written by Wai Ella Yeung and published by Open Dissertation Press. This book was released on 2017-01-27 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Eccentric Contraction-induced Injury in Mammalian Skeletal Muscle" by Wai, Ella, Yeung, 楊慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Eccentric contraction-induced injury in mammalian skeletal muscle " submitted by Ella Wai YEUNG for the degree of Doctor of Philosophy at the University of Hong Kong in February, 2003 Eccentric contractions, in which muscles are lengthened during contraction, may injure skeletal muscle but the mechanism(s) for this remain uncertain. The hypothesis tested is that alterations in intracellular concentrations + + of ions such as Na or H may underlie some of the functional impairment. The initial phase of eccentric contraction-induced injury was investigated: the influence of eccentric contraction on developed force, intracellular pH, Na homeostasis and T-tubule morphology was examined; the roles of these changes in the development of muscle damage are discussed. Single fibres from the flexor brevis muscle of mice or small bundles of fibres from the soleus or extensor digitorum longus muscle of rats were dissected. Muscles underwent either 10 isometric tetani (controls) or 10 eccentric tetani, during which a 30 or 40 % stretch of the optimal length (L ) was applied. Eccentrically-contracted muscles showed 3 characteristic features of stretch- induced damage: (i) reduced maximal force, (ii) greater reduction of force at low stimulation frequencies, (iii) shift in L to a longer muscle length. Ten isometric o tetani or stretches of resting fibres reproduced none of these features. Intracellular pH ( pH ) was determined in rat soleus muscle with the fluorescent indicator BCECF. The resting pH was more acidic after eccentric contractions (6.80 0.06) than after isometric contractions (6.97 0.04). The rate of pH recovery following an acid load was reduced from 0.022 + 0.003 units i -1 -1 min following isometric contractions to 0.013 + 0.002 units min following eccentric contractions. The results suggested that the ability of the muscle to regulate pH was impaired after eccentric contractions, which may partially explain the reduction in force. T-tubule morphology and function were studied in single mouse muscle fibres with confocal microscopy. Following eccentric contractions, vacuoles connected to the T-tubules appeared, and the diffusion of an extracellular marker (sulforhodamine B) from the T-tubules was slowed to a half time 6.3 2.4 min, compared to 18 1 s in isometric controls. [Na ] measurements were performed with the fluorescent indicator SBFI or sodium green. Isometric tetani had no detectable effect on [Na ] (7.2 0.5 mM), whereas eccentric contraction increased [Na ] to 16.3 1.6 mM. Confocal i images showed a uniform increase in [Na ] after eccentric tetani with no localized elevations of [Na ]. Gadolinium, a blocker of stretch-sensitive channels prevented the rise of [Na ] and reduced the force deficit after eccentric damage. The slow extrusion of intracellular protons following eccentric contractions may be explained by the rise in [Na ] which would be expected to + + reduce the inward Na gradient and hence slow proton efflux. The Na may enter by very small and widely distributed membrane tears, or alternatively through stretch-sensitive channels which remain open for many minutes after eccentric contractions. The vacuoles may result from osmotic stresses involved in pumping out the excess Na . Th
Download or read book Eccentric Contraction induced Injury in Skeletal Muscle written by Tina Jitendra Patel and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Eccentric Contraction induced Injury in Mammalian Skeletal Muscle written by Wai Yeung (Ella) and published by . This book was released on 2003 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Whole body Electromyostimulation A Training Technology to Improve Health and Performance in Humans written by Wolfgang Kemmler and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Muscle Cell and Tissue written by Kunihiro Sakuma and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.
Download or read book Protein Degradation and Synthesis in Skeletal Muscle Following Eccentric Contraction induced Injury written by Dawn Annette Lowe and published by . This book was released on 1994 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stretch Intensity and the Inflammatory Response A Paradigm Shift written by Nikos C. Apostolopoulos and published by Springer. This book was released on 2018-12-27 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.
Download or read book Skeletal Muscle Damage and Repair written by Peter M. Tiidus and published by Human Kinetics. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.
Download or read book Skeletal Muscle Structure Function and Plasticity written by Richard L. Lieber and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its Second Edition, this text addresses basic and applied physiological properties of skeletal muscle in the context of the physiological effects from clinical treatment. Many concepts are expanded and recent studies on human muscle have been added. This new edition also includes more clinically relevant cases and stories. A two-page full color insert of muscle sections is provided to ensure integral understanding of the concepts presented in the text. Anyone interested in human movement analysis and the understanding of generation and control from the musculoskeletal and neuromuscular systems in implementing movement will find this a valuable resource.
Download or read book Muscle Homeostasis and Regeneration written by Antonio Musarò and published by MDPI. This book was released on 2020-11-20 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.
Download or read book The Muscular Dystrophies written by Alan E. H. Emery and published by . This book was released on 2001 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The muscular dystrophies are an important group of inherited disorders. They are characterized by muscle wasting and weakness, but vary considerably in their clinical manifestations and severity. This text reviews our understanding of the most important of these disorders. In many instances, the genes and protein products responsible for the dystrophies have been identified and it is now possible to establish a precise diagnosis, detect preclinical cases, identify carriers and offer prenatal dianostic testing. The book goes on to describe the opportunities for management of the symptoms through respiratory care, physiotherapy and surgical correction of contracture, and examines the potential, in the future, for effective treatment utilizing the new techniques of gene and cell therapy. Professor Emery has invited chapters from the leading international experts in the field providing a unique insight into the current situation and the hopes for the future.
Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuromuscular Disease Management and Rehabilitation Part I Diagnostic and Therapy Issues an Issue of Physical Medicine and Rehabilitation Clinics E Book written by Nanette C. Joyce and published by Elsevier Health Sciences. This book was released on 2012-08-28 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromuscular disease is a broad term that encompasses many diseases and ailments that either directly or indirectly impair the function of the body’s muscle system, via the nerves. This issue of PMR will provide an overview of current treatments and therapies for a variety of diseases. The GEs have gone through every issue published since 1998, and these 23 chapters will be meant to fill the numerous gaps in PMR’s coverage of the field over the past decade. The issue will include chapters on different treatment techniques, such as exercises, stretches, and nutrition. It will also provide chapters focusing on specific areas of the body, specific conditions, and an update on mobility technology for those with NMDs.
Download or read book The Lower Limb Tendinopathies written by Giannicola Bisciotti and published by Springer. This book was released on 2016-09-12 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the subject of lower limb tendinopathy and is divided into two main parts: the first covers the general aspects of tendinopathy, while the second focuses on the specific condition in the lower limb. Each chapter has a clear structure: etiopathogenesis, clinical presentation, imaging, conservative and surgical treatment, and therapeutic indications, making it easy to read. Furthermore, the section on conservative treatment includes important practical application tools.
Download or read book The Structure and Function of Muscle written by Geoffrey Howard Bourne and published by . This book was released on 1972 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Band 3.
