Download or read book Early Clinical Drug Evaluation Units and Analysis Sample Output Package written by National Institute of Mental Health (U.S.) and published by . This book was released on 1973 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Early Clinical Drug Evaluation Units and Analysis Sample Output Package written by National Institute of Mental Health (U.S.) and published by . This book was released on 1973 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Download or read book The Documentation of Clinical Psychotropic Drug Trials Sample output package written by National Institute of Mental Health (U.S.). Psychopharmacology Research Branch and published by . This book was released on 1973 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Documentation of Clinical Psychotropic Drug Trials written by National Institute of Mental Health (U.S.). Psychopharmacology Research Branch and published by . This book was released on 1973 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Monthly Catalog United States Public Documents written by United States. Superintendent of Documents and published by . This book was released on 1973 with total page 1282 pages. Available in PDF, EPUB and Kindle. Book excerpt: February issue includes Appendix entitled Directory of United States Government periodicals and subscription publications; September issue includes List of depository libraries; June and December issues include semiannual index
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1966 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Documentation of Clinical Psychotropic Drug Trails written by Thomas H. McGlashan and published by . This book was released on 1973 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1998 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychopharmacology Service Center Bulletin written by and published by . This book was released on 1964 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Resource Materials for Community Mental Health Program Evaluation written by and published by . This book was released on 1974 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coordinating Clinical Trials in Psychopharmacology written by Jerome Levine and published by . This book was released on 1979 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Download or read book Psychopharmacology Abstracts written by and published by . This book was released on 1976 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Compendium of HHS Evaluations and Relevant Other Studies written by HHS Policy Information Center (U.S.) and published by . This book was released on 1985 with total page 956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
