Download or read book Dynamical Biostatistical Models written by Daniel Commenges and published by CRC Press. This book was released on 2015-10-02 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be ap

Download or read book Statistical Methods for Modeling Human Dynamics written by Sy-Miin Chow and published by Taylor & Francis. This book was released on 2011-02-25 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This interdisciplinary volume features contributions from researchers in the fields of psychology, neuroscience, statistics, computer science, and physics. State-of-the-art techniques and applications used to analyze data obtained from studies in cognition, emotion, and electrophysiology are reviewed along with techniques for modeling in real time and for examining lifespan cognitive changes, for conceptualizing change using item response, nonparametric and hierarchical models, and control theory-inspired techniques for deriving diagnoses in medical and psychotherapeutic settings. The syntax for running the analyses presented in the book is provided on the Psychology Press site. Most of the programs are written in R while others are for Matlab, SAS, Win-BUGS, and DyFA. Readers will appreciate a review of the latest methodological techniques developed in the last few years. Highlights include an examination of: Statistical and mathematical modeling techniques for the analysis of brain imaging such as EEGs, fMRIs, and other neuroscience data Dynamic modeling techniques for intensive repeated measurement data Panel modeling techniques for fewer time points data State-space modeling techniques for psychological data Techniques used to analyze reaction time data. Each chapter features an introductory overview of the techniques needed to understand the chapter, a summary, and numerous examples. Each self-contained chapter can be read on its own and in any order. Divided into three major sections, the book examines techniques for examining within-person derivations in change patterns, intra-individual change, and inter-individual differences in change and interpersonal dynamics. Intended for advanced students and researchers, this book will appeal to those interested in applying state-of-the-art dynamic modeling techniques to the the study of neurological, developmental, cognitive, and social/personality psychology, as well as neuroscience, computer science, and engineering.

Download or read book Dynamic Models in Biology written by Stephen P. Ellner and published by Princeton University Press. This book was released on 2011-09-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.

Download or read book Advances in Complex Data Modeling and Computational Methods in Statistics written by Anna Maria Paganoni and published by Springer. This book was released on 2014-11-04 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is addressed to statisticians working at the forefront of the statistical analysis of complex and high dimensional data and offers a wide variety of statistical models, computer intensive methods and applications: network inference from the analysis of high dimensional data; new developments for bootstrapping complex data; regression analysis for measuring the downsize reputational risk; statistical methods for research on the human genome dynamics; inference in non-euclidean settings and for shape data; Bayesian methods for reliability and the analysis of complex data; methodological issues in using administrative data for clinical and epidemiological research; regression models with differential regularization; geostatistical methods for mobility analysis through mobile phone data exploration. This volume is the result of a careful selection among the contributions presented at the conference "S.Co.2013: Complex data modeling and computationally intensive methods for estimation and prediction" held at the Politecnico di Milano, 2013. All the papers published here have been rigorously peer-reviewed.

Download or read book Handbook of Statistical Systems Biology written by Michael Stumpf and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

Download or read book Statistical Methods for Dynamic Treatment Regimes written by Bibhas Chakraborty and published by Springer Science & Business Media. This book was released on 2013-07-23 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.

Download or read book Modeling Biological Responses Using Gene Expression Profiling and Linear Dynamical Statistical Models written by Claudia Rangel Escareño and published by . This book was released on 2003 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Models of Science Dynamics written by Andrea Scharnhorst and published by Springer Science & Business Media. This book was released on 2012-01-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models of Science Dynamics aims to capture the structure and evolution of science, the emerging arena in which scholars, science and the communication of science become themselves the basic objects of research. In order to capture the essence of phenomena as diverse as the structure of co-authorship networks or the evolution of citation diffusion patterns, such models can be represented by conceptual models based on historical and ethnographic observations, mathematical descriptions of measurable phenomena, or computational algorithms. Despite its evident importance, the mathematical modeling of science still lacks a unifying framework and a comprehensive study of the topic. This volume fills this gap, reviewing and describing major threads in the mathematical modeling of science dynamics for a wider academic and professional audience. The model classes presented cover stochastic and statistical models, system-dynamics approaches, agent-based simulations, population-dynamics models, and complex-network models. The book comprises an introduction and a foundational chapter that defines and operationalizes terminology used in the study of science, as well as a review chapter that discusses the history of mathematical approaches to modeling science from an algorithmic-historiography perspective. It concludes with a survey of remaining challenges for future science models and their relevance for science and science policy.

Download or read book Dynamic Social Network Modeling and Analysis written by National Research Council and published by National Academies Press. This book was released on 2003-08-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 2002, the Office of Naval Research asked the Committee on Human Factors to hold a workshop on dynamic social network and analysis. The primary purpose of the workshop was to bring together scientists who represent a diversity of views and approaches to share their insights, commentary, and critiques on the developing body of social network analysis research and application. The secondary purpose was to provide sound models and applications for current problems of national importance, with a particular focus on national security. This workshop is one of several activities undertaken by the National Research Council that bears on the contributions of various scientific disciplines to understanding and defending against terrorism. The presentations were grouped in four sessions â€" Social Network Theory Perspectives, Dynamic Social Networks, Metrics and Models, and Networked Worlds â€" each of which concluded with a discussant-led roundtable discussion among the presenters and workshop attendees on the themes and issues raised in the session.

Download or read book Mathematical and Statistical Modeling for Emerging and Re emerging Infectious Diseases written by Gerardo Chowell and published by Springer. This book was released on 2016-07-27 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributions by epidemic modeling experts describe how mathematical models and statistical forecasting are created to capture the most important aspects of an emerging epidemic.Readers will discover a broad range of approaches to address questions, such as Can we control Ebola via ring vaccination strategies? How quickly should we detect Ebola cases to ensure epidemic control? What is the likelihood that an Ebola epidemic in West Africa leads to secondary outbreaks in other parts of the world? When does it matter to incorporate the role of disease-induced mortality on epidemic models? What is the role of behavior changes on Ebola dynamics? How can we better understand the control of cholera or Ebola using optimal control theory? How should a population be structured in order to mimic the transmission dynamics of diseases such as chlamydia, Ebola, or cholera? How can we objectively determine the end of an epidemic? How can we use metapopulation models to understand the role of movement restrictions and migration patterns on the spread of infectious diseases? How can we capture the impact of household transmission using compartmental epidemic models? How could behavior-dependent vaccination affect the dynamical outcomes of epidemic models? The derivation and analysis of the mathematical models addressing these questions provides a wide-ranging overview of the new approaches being created to better forecast and mitigate emerging epidemics. This book will be of interest to researchers in the field of mathematical epidemiology, as well as public health workers.

Download or read book Bayesian Forecasting and Dynamic Models written by Mike West and published by Springer. This book was released on 1999-03-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is concerned with Bayesian learning, inference and forecasting in dynamic environments. We describe the structure and theory of classes of dynamic models and their uses in forecasting and time series analysis. The principles, models and methods of Bayesian forecasting and time - ries analysis have been developed extensively during the last thirty years. Thisdevelopmenthasinvolvedthoroughinvestigationofmathematicaland statistical aspects of forecasting models and related techniques. With this has come experience with applications in a variety of areas in commercial, industrial, scienti?c, and socio-economic ?elds. Much of the technical - velopment has been driven by the needs of forecasting practitioners and applied researchers. As a result, there now exists a relatively complete statistical and mathematical framework, presented and illustrated here. In writing and revising this book, our primary goals have been to present a reasonably comprehensive view of Bayesian ideas and methods in m- elling and forecasting, particularly to provide a solid reference source for advanced university students and research workers.

Download or read book Dynamic Regression Models for Survival Data written by Torben Martinussen and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the aim of describing time-varying effects of explanatory variables. Use of the suggested models and methods is illustrated on real data examples, using the R-package timereg developed by the authors, which is applied throughout the book with worked examples for the data sets.

Download or read book Dynamic Data Analysis written by James Ramsay and published by Springer. This book was released on 2017-06-27 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text focuses on the use of smoothing methods for developing and estimating differential equations following recent developments in functional data analysis and building on techniques described in Ramsay and Silverman (2005) Functional Data Analysis. The central concept of a dynamical system as a buffer that translates sudden changes in input into smooth controlled output responses has led to applications of previously analyzed data, opening up entirely new opportunities for dynamical systems. The technical level has been kept low so that those with little or no exposure to differential equations as modeling objects can be brought into this data analysis landscape. There are already many texts on the mathematical properties of ordinary differential equations, or dynamic models, and there is a large literature distributed over many fields on models for real world processes consisting of differential equations. However, a researcher interested in fitting such a model to data, or a statistician interested in the properties of differential equations estimated from data will find rather less to work with. This book fills that gap.

Download or read book Dynamic Models for Intensive Longitudinal Data written by Jessica Trail and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional data analysis (FDA) of intensive longitudinal data is becoming increasingly popular in the behavioral sciences to study time-varying processes. This dissertation focuses on integrating two methods which are useful in FDA: dynamical systems models and time-varying coefficient models. Dynamic models provide a more detailed description of a time-varying process than some traditional longitudinal data methods, including effects that characterize the shape, magnitude, and speed of the outcome's response to a change in inputs, or predictors. Allowing these effects to vary as functions of time uses the intensive nature of the data to describe even more complex change. In the behavioral sciences, a better understanding of the dynamics of a process could be used to inform the design of behavioral interventions. For example, this dissertation was motivated by a study designed to examine the trajectories of change in students' smoking behavior during the freshman year of college. A better understanding of the trajectory of smoking onset will help inform the development of behavioral interventions to alter this trajectory and prevention smoking. This is important because smoking is the leading preventable cause of death in the US. The repeated measurements used to describe a dynamical system frequently contain measurement error, and so statistical methods are needed to estimate the parameters of the differential equation model. In this dissertation, we propose a two-step estimation method. The first step uses spline smoothers to smooth the noisy observed data and estimate the derivatives. The second step uses penalized splines to estimate the time-varying effects in the differential equation. We use simulated data to describe the performance of the proposed estimation method. To test hypotheses about the time-varying effects, for example, whether or not an effect is significantly time-varying or determining if a covariate is significant in the model, we propose a generalized likelihood ratio test statistic. We use bootstrap methods and a Monte Carlo simulation study to assess the finite sample properties of the proposed test statistic. The proposed methodology is applied to data from the UpTERN study (Tiffany, et al., 2004). In this empirical example, we examine and test hypotheses about the relations between covariates such as alcohol use and gender and the dynamics of cigarette smoking.

Download or read book Statistical Models written by David A. Freedman and published by Cambridge University Press. This book was released on 2009-04-27 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lively and engaging book explains the things you have to know in order to read empirical papers in the social and health sciences, as well as the techniques you need to build statistical models of your own. The discussion in the book is organized around published studies, as are many of the exercises. Relevant journal articles are reprinted at the back of the book. Freedman makes a thorough appraisal of the statistical methods in these papers and in a variety of other examples. He illustrates the principles of modelling, and the pitfalls. The discussion shows you how to think about the critical issues - including the connection (or lack of it) between the statistical models and the real phenomena. The book is written for advanced undergraduates and beginning graduate students in statistics, as well as students and professionals in the social and health sciences.

Download or read book Simulating Social Phenomena written by Rosaria Conte and published by . This book was released on 2014-01-15 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Randomization Masking and Allocation Concealment written by Vance Berger and published by CRC Press. This book was released on 2017-10-30 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomization, Masking, and Allocation Concealment is indispensable for any trial researcher who wants to use state of the art randomization methods, and also wants to be able to describe these methods correctly. Far too often the subtle nuances that distinguish proper randomization from flawed randomization are completely ignored in trial reports that state only that randomization was used, with no additional information. Experience has shown that in many cases, the type of randomization that was used was flawed. It is only a matter of time before medical journals and regulatory agencies come to realize that we can no longer rely on (or publish) flawed trials, and that flawed randomization in and of itself disqualifies a trial from being robust or high quality, even if that trial is of high quality otherwise. This book will help to clarify the role randomization plays in ensuring internal validity, and in drawing valid inferences from the data. The various chapters cover a variety of randomization methods, and are not limited to the most common (and most flawed) ones. Readers will come away with a profound understanding of what constitutes a valid randomization procedure, so that they can distinguish the valid from the flawed among not only existing methods but also methods yet to be developed.