Download or read book Dynamic Flowsheet Simulation of Solids Processes and Its Application to Fluidized Bed Spray Granulation written by Maksym Dosta and published by . This book was released on 2015-10 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dynamic Flowsheet Simulation of Solids Processes written by Stefan Heinrich and published by Springer Nature. This book was released on 2020-06-20 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest advances in flowsheet simulation of solids processes, focusing on the dynamic behaviour of systems with interconnected solids processing units, but also covering stationary simulation. The book includes the modelling of solids processing units, for example for comminution, sifting and particle formulation and also for reaction systems. Furthermore, it examines new approaches for the description of solids and their property distributions and for the mathematical treatment of flowsheets with multivariate population balances.
Download or read book Chemical Process Design Simulation and Optimization written by Jean-Pierre Corriou and published by MDPI. This book was released on 2021-02-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a series of articles devoted to modeling, simulation, and optimization of processes, mainly chemical. General methods for process modeling and numerical simulation are described with flowsheeting. Population balances are addressed in detail with application to crystal production; energy saving is frequently optimized, including exergy analysis. The coupling between process simulation and computational fluid dynamics is studied for air classification and bubble columns. Pressure swing adsorption, reactive distillation, and nanofiltration are explained in general and applied to particular processes. The synthesis of carbon dots is solved by the design of experiments method. A safety study addresses the consequences of gas explosion.
Download or read book Mesoscale Modeling in Chemical Engineering written by and published by Academic Press. This book was released on 2015-11-26 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing Mesoscales of Multiscale Problems in Chemical Engineering, a volume in the Advances in Chemical Engineering series provides readers with the personal views of recognized authorities who present assessments of the state-of-the-art in the field and help readers develop an understanding of its further evolution. Subjects covered in the book are not limited to the classical chemical engineering disciplines. Contributions connecting chemical engineering to related scientific fields, either providing a fundamental basis or introducing new concepts and tools, are encouraged. This volume aims to create a balance between well developed areas such as process industry, transformation of materials, energy, and environmental issues, and areas where applications of chemical engineering are more recent or emerging. Contains reviews by leading authorities in their respective areas Provides up-to-date reviews of the latest techniques in the modeling of catalytic processes Includes a broad mix of US and European authors, as well as academic/industrial/research institute perspectives Provides discussions on the connections between computation and experimental methods
Download or read book A Novel Method for Predicting Product Properties in Fluidized Bed Spray Granulation Band 19 written by Paul Kieckhefen and published by Cuvillier Verlag. This book was released on 2022-01-03 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidized bed spray granulation is a process that facilities particle size enlargement by injecting solids in the form of a suspension, solution or melt. The produced particles are often of high value due to their highly specific, functionalized nature. This work provides a method for utilizing particle-scale simulations method like the coupled Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) to predict the properties of particles produced in scaled-up apparatuses based on laboratory-scale experiments by correlating the conditions that particle experience to the properties they develop. Furthermore, a method for calibrating DEM models of weakly wetted particle systems by utilizing a novel, probabilistic liquid bridge state model is proposed.
Download or read book Dynamic Simulation of the Chemical Looping Combustion Process written by Johannes Haus and published by Cuvillier Verlag. This book was released on 2020-12-09 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Ph.D. thesis a system of coupled fluidized bed reactors is modelled and simulated dynamically. Chemical Looping Combustion was used as an exemplary process in both the numerical and the experimental part of this work. For the simulation purpose a novel flowsheeting software was used and models for the needed process units developed and integrated into this software. The needed unit models were three interconnected fluidized bed reactors in circulating and bubbling operation conditions, a cyclone for gas-solid separation and loop seals, which ensured solids transport and gas separation between the reactors. Additionally, lab scale experiments on the reactivity of the used solids, oxygen carrier and solid fuels, were conducted and kinetic parameters extracted. All unit models were connected to a process flowsheet and simulated dynamically. The simulation results were compared to experimental data from a 25 kWth pilot plant operated at the university by the author. It could be shown that a detailed and dynamic simulation of the whole process can be carried out over a time period of more than 45 minutes and the experimental results from start-up, steady state operation and shutdown of the plant were predicted accurately.
Download or read book Issues in Materials and Manufacturing Research 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 11119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Materials and Manufacturing Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Materials and Manufacturing Research. The editors have built Issues in Materials and Manufacturing Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Materials and Manufacturing Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Materials and Manufacturing Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Process Systems Engineering for Pharmaceutical Manufacturing written by Ravendra Singh and published by Elsevier. This book was released on 2018-03-16 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing
Download or read book Modeling and Flowsheet Simulation of Vibrated Fluidized Bed Dryers Band 18 written by Sören Ernst Lehmann and published by Cuvillier Verlag. This book was released on 2021-12-07 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidized bed dryers are the prime choice when it comes to drying of heat sensitive products, commonly processed in the pharmaceutical and food industry. As many products in these industries are fine and cohesive, mechanical vibration of the dryer is used to enable or improve fluidization. Thus, the goal of this thesis is the development of a fluidized bed drying model that accounts for the influence of mechanical vibration of the dryer, as well as its implementation in an open-source flowsheet simulation framework. Continuously operated fluidized bed dryers under steady-state conditions are the focus of this thesis. The aim during model development and implementation is the broadest possible application range of the model. A custom-built vibrated fluidized bed dryer is designed and constructed for comprehensive investigations of fluidized bed hydrodynamics and drying kinetics. Based on experimental investigations, a semi-empirical model for hydrodynamics of fine and cohesive powders is developed. The new model is combined with established models to allow for the flowsheet simulation of fluidized bed dryers for particles of all Geldart groups. Additionally, the influence of vibration is accounted for. Comprehensive validation experiments are performed for particles of different Geldart groups, different dryer geometries and a variety of process parameters, including mechanical vibration. Comparison of model predictions with experimental data attributes high accuracy of predicted particle and gas properties. Furthermore, sensitivity analyses are conducted to identify potential weaknesses in underlying model assumptions. Hereby, the validity of underlying assumptions is confirmed and potential optimization parameters for different applications are identified. The proposed model is unprecedented in terms of range of process parameters, variety of particle properties and dryer geometries, tested and found valid for.
Download or read book Process Simulation of Technical Precipitation Processes The Influence of Mixing written by Metzger, Lukas and published by KIT Scientific Publishing. This book was released on 2018-03-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Process Modelling and Simulation written by César de Prada and published by MDPI. This book was released on 2019-09-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.
Download or read book Discrete particle modeling of a fluidized bed granulator written by Lennart Fries and published by Cuvillier Verlag. This book was released on 2012-10-29 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Size-enlargement and structuration processes in fluidized beds such as granulation and agglomeration play an important role in the pharmaceutical and fine chemical industries as well as in food technology to improve the flowability and the instant properties of solid products. Dustfree and free-flowing particles can be produced in a process with favourable heat- and mass transfer conditions. Furthermore, this technology allows the formulation of particles with novel functionalities by applying coating layers or via the encapsulation of active ingredients. Several interdependent micro mechanisms including particle collisions, wetting, drying and phase transitions govern the process dynamics and complicate predictions on the effect of variable operating conditions on product properties such as structure, strength and re-dissolution behaviour. Profound knowledge on these mechanisms is needed to understand the influence of individual process parameters on the final product properties. A suitable approach to model the particle interactions in fluidized beds is the Discrete Element Method (DEM) coupled with Computational Fluid Dynamics (CFD). Information on gas and particle velocities, particle rotation and collision dynamics, which are very complicated to measure in fluidized beds, can be studied in detail with this technique. This thesis presents DEM-CFD simulation results for three different granulator configurations (top-spray, Wurster-coater, spouted bed) in comparison to experimental results, regarding the agglomeration of amorphous maltodextrin (DE 21). In simulation and experiment the identical geometry of the equipment was used. Mechanical material properties, such as the coefficient of restitution and the Young’s modulus, which are required for the DEM model and which are frequently used as fitting parameters, were measured via static and dynamic deformation tests using maltodextrin agglomerates, beads and bars. The strength of the experimentally produced agglomerates was characterized with a compression tester. Their flow behaviour was assessed with the help of a shear cell. Very promising results were obtained showing that the homogeneity of particle wetting can well be approximated with the residence time distribution of the particles inside the spray zone.Homogeneous wetting allows achieving a narrow product size distribution (Fries et al., 2011a).Furthermore, the growth rate of the agglomerates can well be correlated with the simulated wetting intensity, the collision frequency and the collision velocity distribution inside the spray zone. The agglomerate strength shows a strong correlation with the particle-wall collision frequency and velocity distribution found in the simulations. Good agreement was found between the simulation results for the maximum particle deformation and for the energy dissipation during collisions and the measured deformation at the breakage point and the breakage energy. Due to the high numerical effort, DEM is only suitable for small scale applications. However, the obtained information on the kinetics of particle-particle interactions can be applied as input for macroscopic process models in the framework of a multi scale modeling scheme (Fries et al., 2011b; Werther et al., 2011). It can be concluded that DEM is a powerful tool for the detailed characterization of fluidized bed granulators. Highly relevant practical answers can be obtained from the model such as the choice of the optimal equipment geometry depending on material properties and product requirements. The model can point out where to position the spray nozzles in order to achieve homogeneous particle wetting and if a draft tube is helpful to maintain stable particle circulation. Based on such findings the model shows potential to increase the throughput of a fluidized bed granulator, while avoiding a bed collapse.
Download or read book Fluidized Bed Reactors Processes and Operating Conditions written by John G. Yates and published by Springer. This book was released on 2016-09-27 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluidized-bed reactor is the centerpiece of industrial fluidization processes. This book focuses on the design and operation of fluidized beds in many different industrial processes, emphasizing the rationale for choosing fluidized beds for each particular process. The book starts with a brief history of fluidization from its inception in the 1940’s. The authors present both the fluid dynamics of gas-solid fluidized beds and the extensive experimental studies of operating systems and they set them in the context of operating processes that use fluid-bed reactors. Chemical engineering students and postdocs as well as practicing engineers will find great interest in this book.
Download or read book Chemical Engineering Progress written by and published by . This book was released on 2006 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fluid Bed Technology in Materials Processing written by C. K. Gupta and published by CRC Press. This book was released on 1998-12-28 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluid Bed Technology in Materials Processing comprehensively covers the various aspects of fluidization engineering and presents an elaborate examination of the applications in a multitude of materials processing techniques. This singular resource discusses: All the basic aspects of fluidization essential to understand and learn about various techniques The range of industrial applications Several examples in extraction and process metallurgy Fluidization in nuclear engineering and nuclear fuel cycle with numerous examples Innovative techniques and several advanced concepts of fluidization engineering, including use and applications in materials processing as well as environmental and bio-engineering Pros and cons of various fluidization equipment and specialty of their applications, including several examples Design aspects and modeling Topics related to distributors effects and flow regimes A separate chapter outlines the importance of fluidization engineering in high temperature processing, including an analysis of the fundamental concepts and applications of high temperature fluidized bed furnaces for several advanced materials processing techniques. Presenting information usually not available in a single source, Fluid Bed Technology in Materials Processing serves Fluidization engineers Practicing engineers in process metallurgy, mineral engineering, and chemical metallurgy Researchers in the field of chemical, metallurgical, nuclear, biological, environmental engineering Energy engineering professionals High temperature scientists and engineers Students and professionals who adopt modeling of fluidization in their venture for design and scale up
Download or read book Computer Aided Applications in Pharmaceutical Technology written by Jelena Duris and published by Elsevier. This book was released on 2023-09-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations, Second Edition covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with an emphasis on their applications in process control, neural computing, data science, computer-aided biopharmaceutical characterization, as well as the application of computational fluid dynamics in pharmaceutical technology. Completely updated, the book introduces the theory and practice of computational tools through new case studies. Chapters cover Quality by Design in pharmaceutical development, overview data mining methodologies, present computer-aided formulation development, cover experimental design applications, and much more. Presents a comprehensive review of the current state of the art on various computer-aided applications in pharmaceutical technology Includes case studies to facilitate understanding of various concepts in computer-aided applications Covers applications such as the development of dosage forms and/or delivery systems, pharmaceutical unit operations, and relevant physiologically based pharmacokinetic simulations
Download or read book Systematic Methods of Chemical Process Design written by Lorenz T. Biegler and published by Prentice Hall. This book was released on 1997 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last 20 years, fundamental design concepts and advanced computer modeling have revolutionized process design for chemical engineering. Team work and creative problem solving are still the building blocks of successful design, but new design concepts and novel mathematical programming models based on computer-based tools have taken out much of the guess-work. This book presents the new revolutionary knowledge, taking a systematic approach to design at all levels.
