Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Download or read book Drug Induced Liver Toxicity written by Minjun Chen and published by Humana Press. This book was released on 2018-03-21 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.
Download or read book Transporters and Drug Metabolizing Enzymes in Drug Toxicity written by Albert P. Li and published by John Wiley & Sons. This book was released on 2021-07-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.
Download or read book Drug Induced Liver Injury DILI written by Cioms DILI Working Group and published by . This book was released on 2020-08-06 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This consensus report of the CIOMS DILI Working Group aims to provide a critical framework and essential set of tools to detect, diagnose, and manage DILI during drug development and in the post-marketing setting. The report is intended for clinical and basic pharmaceutical industry investigators who capture, analyze, and communicate liver safety data in drug development. It is also intended for regulatory scientists and expert consultants who comprehensively evaluate new products and emerging biomarkers for their association with DILI risk and for health care professionals who monitor and manage patients treated with potentially hepatotoxic drugs in clinical practice.
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Download or read book Liver Diseases written by Florentina Radu-Ionita and published by Springer Nature. This book was released on 2020-01-10 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.
Download or read book Drug Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Download or read book Drug induced Diseases written by James E. Tisdale and published by ASHP. This book was released on 2010 with total page 1134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first edition of this book was published in 2005, drug therapy has seen both breakthrough advances and sobering setbacks. The changes will continue. That's why every health care professional, hospital and health system, pharmacy, and medical school needs this invaluable reference. It will help you detect, prevent and manage drug-related diseases. And also remind you to always ask yourself the increasingly critical question: "Could this disease be drug-related?"
Download or read book Liver Immunology written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
Download or read book Drug Induced Liver Disease written by Neil Kaplowitz and published by Academic Press. This book was released on 2013-04-18 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease. - A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease - Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks - Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition - Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject
Download or read book Pharmacokinetics and Adverse Effects of Drugs written by Ntambwe Malangu and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.
Download or read book Adverse Drug Reactions written by Jack Uetrecht and published by Springer Science & Business Media. This book was released on 2009-12-18 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.
Download or read book Diagnosis of Liver Disease written by Etsuko Hashimoto and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described. The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.
Download or read book Textbook of Pediatric Gastroenterology Hepatology and Nutrition written by Anupam Sibal and published by JP Medical Ltd. This book was released on 2015-04-30 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Pediatric Gastroenterology, Hepatology and Nutrition is a comprehensive and up-to-date resource covering disorders of the liver and digestive system. This book is divided into three sections on gastroenterology, nutrition and hepatology respectively, encompassing 37 chapters. The book describes the pathophysiology of a range of paediatric disorders from diseases of the oesophagus and malnutrition, to chronic liver disease, as well as new genetic, metabolic and biochemical tests. Novel therapies are discussed for treatment of diseases such as tyrosinemia and neonatal haemochromtosis, and the hepatology section describes improved treatment for Hepatitis B and C in relation to liver transplantation. New modalities in endoscopy such as endoscopic ultrasound and capsule endoscopy in gastrointestinal disorders are also covered in detail. Enhanced by over 100 images and illustrations, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition is an extensive guide to conditions of the digestive system and liver, which will assist postgraduates, paediatric gastroenterologists and other paediatricians in their practice. Key Points 37 chapters covering a range of disorders of the digestive system and liver Introduces new therapies and treatment modalities 100+ images and illustrations
Download or read book Reactive Drug Metabolites written by Amit S. Kalgutkar and published by John Wiley & Sons. This book was released on 2012-09-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
