Download or read book Doppel written by Lindsay Smith and published by Macmillan. This book was released on 2014-03-18 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Told in a series of espionage transmissions, DOPPEL is the story of a British agent in occupied France. When he meets a charismatic SS officer who seems to be guarding a great and powerful secret, he must decide whether to abandon his mission and discover what the Nazi is planning. But the truth might be darker and more dangerous than anything the British—or the Germans—can imagine. 'Doppel' is a companion story to Lindsay Smith's novel, Sekret. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Download or read book Doppel Debussy written by Nekobungi Sumire and published by Amaitorte. This book was released on 2024-05-27 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delphine, the translator, neglecting her looming deadlines, was spending her days drowning in alcohol at nightclubs. However, one evening, she was persuaded to drink a mysterious beverage called Doppel Debussy. It was a drink that could create a copy of oneself by expelling one's personality as a jelly. Realising that her copy possessed the same abilities as herself, Delphine seized the opportunity to push her work onto it... An original short gag manga by Nekobungi Sumire, a personality-expelling jelly world expressed through a combination of black and white and colour.
Download or read book Doppel Banger written by Sarah Robinson and published by Books by Sarah Robinson. This book was released on 2024-10-15 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: Firefighter by day, drag queen by night. This one of a kind standalone romantic comedy in the Queerly Devoted series by Sarah Robinson is a boundary pushing bisexual romance as firefighter Mike Dougherty—stage name Madame Michelle in drag—meets Isa Reyes, a Filipina crisis management professional who has no interest in adding any more drama to her life. Isa Reyes is five foot two and exists solely on her father’s lumpia and her mother’s cynicism to fuel her sixty hour work weeks in crisis management. When she’s not working behind the scenes on the latest political scandal, hostile corporate takeover, or bailing a client out of jail, Isa finds herself sitting on the sidelines of her best friends’ lives. Always the bridesmaid, never the bride, Isa is tired of watching life pass her by and is determined to find the perfect alpha male to ride off into the sunset with. In walks the alpha male of all alpha males—Michael Dougherty, lieutenant firefighter at DC Fire & EMS and Mr. July in the charity firefighter calendar, and her new point of contact for her contract. It’s her job to fix the department’s reputation and he’s there to give her everything she needs…in more ways than just professional. But there’s a lot more to Mike than meets the eye and when she runs into him on stage in a very different context, she realizes that everything she thought she wanted in a man might be in question. Battling the expectations of her family, the professionalism of her job, her lifetime living on the sidelines, and the pull of her heart, Isa navigates her own stereotypes as she takes a leap onto center stage.
Download or read book Farm Chemicals written by and published by . This book was released on 1910 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Fertilizer written by and published by . This book was released on 1911 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumors of the Central Nervous System Volume 5 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-09-28 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme. The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
Download or read book AACR 2016 Abstracts 2697 5293 written by American Association for Cancer Research (AACR) and published by CTI Meeting Technology. This book was released on 2016-03-28 with total page 1518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
Download or read book Prion Diseases and Copper Metabolism written by D. Brown and published by Elsevier. This book was released on 2002-10-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the effects of copper on biochemical properties and prion proteins of brain cells, and newer techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases. - Focuses on metabolism of copper and manganese, which are found in Scrapie of sheep; BSE, the "Mad Cow" disease; and CJD, one of the human prion diseases - Discusses the effects of copper on biochemical properties, prion proteins of brain cells and new techniques for their study - Stems from the proceedings of the international workshop at Christ's College, Cambridge University in 2001
Download or read book Androgens II and Antiandrogens Androgene II und Antiandrogene written by A. Hughes and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Teutsch englisches Lexicon 2 U Verb Aufl written by Christian Ludwig and published by . This book was released on 1745 with total page 1354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2004-11-29 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the success of the Handbook of Laboratory Animal Science and completing Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume III provides the final component to present a comprehensive overview of animal models in biomedical research.As with Volume II, this new volume add
Download or read book Sessional Papers written by Great Britain. Parliament. House of Commons and published by . This book was released on 1907 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parliamentary Papers written by Great Britain. Parliament. House of Commons and published by . This book was released on 1907 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diplomatic and Consular Reports Miscellaneous Series written by Great Britain. Foreign Office and published by . This book was released on 1906 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prions written by Bridgette V. Doupher and published by Nova Publishers. This book was released on 2006 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are disease-causing agents that are neither bacterial nor fungal nor viral and contain no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. Prions have been held responsible for a number of degenerative brain diseases, including scrapie (a fatal disease of sheep and goats), mad cow disease, Creutzfeldt-Jacob disease, fatal familial insomnia, kuru, an unusual form of hereditary dementia known as Gertsmann-Straeussler-Scheinker disease, and possibly some cases of Alzheimer's disease. This book presents the latest research in this dynamic field.
Download or read book Physiological function of the cellular prion protein PrPc 1hnc written by Sanja Ramljak and published by Logos Verlag Berlin GmbH. This book was released on 2008-11-15 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The physiological role of the cellular prion protein (PrPc) is still not fully understood. This study gives a further insight into the possible physiological function(s) of PrPc via recognizing proteome changes influenced by different levels of PrPc expression in human embryonic kidney (HEK) 293 and PrPc-deficient (Prnp0/0 ) ell line. The two cell lines gave largely non-intersecting results. A high proportion of proteins deregulated following PrPc overexpression in HEK 293 cells is involved in energy metabolism and cellular homeostasis. Hence, the previously reported increased sensitivity of PrPc overexpressing cells to apoptotic stimuli might be caused by perturbed expression of proteins essential for energy production and maintenance of cellular homeostasis. A particularly significant point of the present study is PrPc overexpression-induced regulation of several proteins which are known to contribute to Alzheimer and Parkinson disease pathogenesis. This finding may be helpful in understanding the common molecular mechanisms underlying the pathogenesis of prion diseases and other neurodegenerative disorders. Conversely, the introduction of the human prion protein gene (PRNP) into Prnp0/0 cells correlated positively with regulation of proteins mainly implied in protection against oxidative stress and apoptosis. This finding is in line with earlier reports demonstrating rescue of Prnp0/0 neurons from apoptosis following an introduction of prion protein gene. Altogether, the presence/absence and the level of PrPc expression seem to be crucial for the fluctuation between PrPc's pro- and anti- apoptotic properties. In addition, this study provides first time evidence for PrPc-induced up-regulation of the glycolytic enzyme, lactate dehydrogenase (LDH) after transient focal cerebral ischemia in wild-type mice as compared to Prnp00 mice. The possibility that LDH and its product lactate, known to protect neural tissue against hypoxia/ischemia, might be involved in previously described PrPc-mediated neuroprotection against ischemic injury is considered.
Download or read book AACR 2022 Proceedings Part A Online Only and April 10 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2022-05-09 with total page 2287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
