Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Download or read book The Education of an Idealist written by Samantha Power and published by HarperCollins. This book was released on 2019-09-10 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW YORK TIMES, WALL STREET JOURNAL, AND USA TODAY BESTSELLER An intimate, powerful, and galvanizing memoir by Pulitzer Prize winner, human rights advocate, and former US Ambassador to the UN Samantha Power. Named one of the best books of the year: The New York Times • National Public Radio • Time • The Economist • The Washington Post • Vanity Fair • Christian Science Monitor • Publishers Weekly • Audible “Her highly personal and reflective memoir . . . is a must-read for anyone who cares about our role in a changing world.”—President Barack Obama Includes an updated afterword Tracing her distinctly American journey from immigrant to war correspondent to presidential Cabinet official, Samantha Power’s acclaimed memoir is a unique blend of suspenseful storytelling, vivid character portraits, and shrewd political insight. After her critiques of US foreign policy caught the eye of Senator Barack Obama, he invited her to work with him on Capitol Hill and then on his presidential campaign. When Obama won the presidency, Power went from being an activist outsider to serving as his human rights adviser and, in 2013, becoming the youngest-ever US Ambassador to the United Nations. Power transports us from her childhood in Dublin to the streets of war-torn Bosnia to the White House Situation Room and the world of high-stakes diplomacy, offering a compelling and deeply honest look at navigating the halls of power while trying to put one’s ideals into practice. Along the way, she lays bare the searing battles and defining moments of her life, shows how she juggled the demands of a 24/7 national security job with raising two young children, and makes the case for how we each can advance the cause of human dignity. This is an unforgettable account of the power of idealism—and of one person’s fierce determination to make a difference. “This is a wonderful book. […] The interweaving of Power’s personal story, family story, diplomatic history and moral arguments is executed seamlessly and with unblinking honesty.”—THOMAS L. FRIEDMAN, The New York Times Book Review “Truly engrossing…A pleasure to read.”—RACHEL MADDOW “A beautiful memoir about the times we’re living in and the questions we must ask ourselves…I honestly couldn’t put it down.” —CHERYL STRAYED, author of Wild “Power’s compelling memoir provides critically important insights we should all understand as we face some of the most vexing issues of our time.” —BRYAN STEVENSON, author of Just Mercy

Download or read book Unveiling the Tumor Microenvironment by Machine Learning to Develop New Immunotherapeutic Strategies Volume I B written by Nan Zhang and published by Frontiers Media SA. This book was released on 2023-10-24 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment (TME) plays a critical role in tumor proliferation, progression, and therapeutic responses. TME is a complex network of cancer cells, stromal cells, and, most importantly, infiltrating immune cells. Cancer cells regulate numerous biological functions through direct or indirect interaction with TME components. Emerging evidence suggests that TME crucially influences the response to both chemotherapy and immunotherapy. As scientific research has entered the big data era with the fast development of high-throughput sequencing technologies, machine learning has been gradually widely applied to extract important knowledge from big data bioinformatics. Thus, characterizing the TME landscape in cancer and identifying different immune-related TME phenotypes using machine learning-based bioinformatics analyses, in vitro experiments, and in vivo experiments are of great interest and significance.

Download or read book New immunotherapy strategies and related therapeutic targets for gastrointestinal malignancies written by Chi Chun Wong and published by Frontiers Media SA. This book was released on 2024-03-13 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the treatment options for gastrointestinal malignancies mainly include surgery, chemotherapy, radiotherapy, and molecular targeted therapy, etc. Drug therapy is one of the main treatments for patients with advanced stages, but the efficacy of chemotherapy seems to have reached a plateau, and the progress of traditional molecular targeted therapy is relatively slow. In addition, the benefits of the current chemotherapy combined with targeted therapy for patients with advanced stages of gastrointestinal malignancies are still not satisfactory. Tumor immunotherapy is an emerging therapeutic approach and is a current research hotspot, and there are hopes that immunotherapy can help further improve the prognosis and quality of life for patients with gastrointestinal malignancies. At the same time, potential targets of immunotherapeutic drugs and prognostic biomarkers for gastrointestinal malignancies have been less studied than other common cancers, such as lung cancer. Prognostic biomarker studies are the beginning of exploring new drug targets and revealing potential mechanisms of tumor progression. Immunotherapies, particularly PD1 or PD-L1 antagonists, have demonstrated effective therapeutic efficacy against various types of cancer. To date, many PD1 drugs are available for cancer treatment, and more than 100 PD1 drugs are in clinical trials. However, the question of how to screen sensitive patients and predict the efficacy of immunotherapy remains unresolved. In addition, predictive biomarkers and treatment guidelines for immunotherapy of gastrointestinal malignancies have hardly been studied.

Download or read book Carcinomas New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1093 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Carcinomas. The editors have built Carcinomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Carcinomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Carcinomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book The Role of Immediate Early Genes in Neuropsychiatric Illness written by Amelia L. Gallitano and published by Frontiers Media SA. This book was released on 2020-03-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Novel Biomarkers for Predicting Response to Cancer Immunotherapy written by Jinghua Pan and published by Frontiers Media SA. This book was released on 2023-07-11 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.

Download or read book Solutions Manual for An Introduction to Genetic Analysis written by David Scott and published by Macmillan. This book was released on 2010-12-24 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception, Introduction to Genetic Analysis (IGA) has been known for its prominent authorship including leading scientists in their field who are great educators. This market best-seller exposes students to the landmark experiments in genetics, teaching students how to analyze experimental data and how to draw their own conclusions based on scientific thinking while teaching students how to think like geneticists. Visit the preview site at www.whfreeman.com/IGA10epreview

Download or read book Double Side Blade Niche in Stem Cell Potency and Potential Application written by Rita Yen-Hua Huang and published by Frontiers Media SA. This book was released on 2022-09-30 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Salmonellosis New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salmonellosis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Salmonellosis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Salmonellosis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Enhanced biological mechanism study drug discovery and individualized medicine with single cell multiomics data and integrative analysis written by Panwen Wang and published by Frontiers Media SA. This book was released on 2023-07-20 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lewin s Essential Genes written by Jocelyn E. Krebs and published by Jones & Bartlett Publishers. This book was released on 2013 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt: Condensed ed. of: Genes X / Benjamin Lewin. c2011.

Download or read book Crosstalk between cancer associated fibroblasts and tumor cells in the tumor microenvironment An emerging target of anti cancer immunotherapy written by Bo Kong and published by Frontiers Media SA. This book was released on 2023-08-31 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Introduction to Genetic Analysis written by Anthony J.F. Griffiths and published by Macmillan. This book was released on 2008 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an introduction to genetic analysis. This book covers contemporary genetics, and helps students understand the essentials of genetics, featuring various experiments, teaching them how to analyze data, and how to draw their own conclusions

Download or read book Emerging Roles and Mechanisms of Stromal Cells in Carcinomas at the Molecular Level written by Jaewoo Hong and published by Frontiers Media SA. This book was released on 2022-10-18 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fibrosis inflammation and cancers Dangerous liaisons to be depicted and targeted written by Denisa Baci and published by Frontiers Media SA. This book was released on 2023-08-22 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biochemistry of Collagens Laminins and Elastin written by Morten Karsdal and published by Academic Press. This book was released on 2019-05-28 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability