Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Download or read book Double Side Blade Niche in Stem Cell Potency and Potential Application written by Rita Yen-Hua Huang and published by Frontiers Media SA. This book was released on 2022-09-30 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Complexes that Modify Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2003-01-08 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

Download or read book Crosstalk between cancer associated fibroblasts and tumor cells in the tumor microenvironment An emerging target of anti cancer immunotherapy written by Bo Kong and published by Frontiers Media SA. This book was released on 2023-08-31 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genomics and Epigenomics of Cancer Immunotherapy Challenges and Clinical Implications written by Xiao-Jie Lu and published by Frontiers Media SA. This book was released on 2021-08-10 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cardiovascular Development and Congenital Malformations written by Michael Artman and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Congenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance. This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding and unique treatise on this pressing topic. Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development. Sections are accompanied by editorial overviews which integrate new findings and place the information into a broader context.

Download or read book New immunotherapy strategies and related therapeutic targets for gastrointestinal malignancies written by Chi Chun Wong and published by Frontiers Media SA. This book was released on 2024-03-13 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the treatment options for gastrointestinal malignancies mainly include surgery, chemotherapy, radiotherapy, and molecular targeted therapy, etc. Drug therapy is one of the main treatments for patients with advanced stages, but the efficacy of chemotherapy seems to have reached a plateau, and the progress of traditional molecular targeted therapy is relatively slow. In addition, the benefits of the current chemotherapy combined with targeted therapy for patients with advanced stages of gastrointestinal malignancies are still not satisfactory. Tumor immunotherapy is an emerging therapeutic approach and is a current research hotspot, and there are hopes that immunotherapy can help further improve the prognosis and quality of life for patients with gastrointestinal malignancies. At the same time, potential targets of immunotherapeutic drugs and prognostic biomarkers for gastrointestinal malignancies have been less studied than other common cancers, such as lung cancer. Prognostic biomarker studies are the beginning of exploring new drug targets and revealing potential mechanisms of tumor progression. Immunotherapies, particularly PD1 or PD-L1 antagonists, have demonstrated effective therapeutic efficacy against various types of cancer. To date, many PD1 drugs are available for cancer treatment, and more than 100 PD1 drugs are in clinical trials. However, the question of how to screen sensitive patients and predict the efficacy of immunotherapy remains unresolved. In addition, predictive biomarkers and treatment guidelines for immunotherapy of gastrointestinal malignancies have hardly been studied.

Download or read book First Supplemental National Defense Appropriation Bill for 1944 written by United States. Congress. House. Committee on Appropriations and published by . This book was released on 1943 with total page 1646 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lewin s Essential GENES written by Benjamin Lewin and published by Jones & Bartlett Publishers. This book was released on 2009-03-02 with total page 831 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Lewin's Essential GENES is the most accessible, student-friendly text of its kind! Completely revised and rewritten, the Second Edition continues to provide students with the latest findings in the field of molecular biology and molecular genetics. An exceptional new pedagogy enhances student learning and helps readers understand and retain key material like never before. New Concept and Reasoning Checks at the end of each chapter section, End of Chapter Questions and Further Readings for each chapter, and several categories of special topics boxes within each chapter expand and reinforce important concepts. The reorganization of topics in this edition allows students to focus more sharply on the key material at hand and improves the natural flow of course material. New end-of-chapter questions reviews major points in the chapter and allow students to test themselves on important course material.

Download or read book Enhanced biological mechanism study drug discovery and individualized medicine with single cell multiomics data and integrative analysis written by Panwen Wang and published by Frontiers Media SA. This book was released on 2023-07-20 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Complexity of tumor microenvironment a major culprit in cancer development written by Ihtisham Bukhari and published by Frontiers Media SA. This book was released on 2023-01-04 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lewin s Essential GENES written by Jocelyn E. Krebs and published by Jones & Bartlett Learning. This book was released on 2020-02-10 with total page 1066 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively reorganized and revised with the latest data from this rapidly changing field, Lewin's Essential GENES, Third Edition, provides students with a comprehensive overview of molecular biology and molecular genetics.

Download or read book Novel Biomarkers for Predicting Response to Cancer Immunotherapy written by Jinghua Pan and published by Frontiers Media SA. This book was released on 2023-07-11 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.

Download or read book Solutions Manual for An Introduction to Genetic Analysis written by David Scott and published by Macmillan. This book was released on 2010-12-24 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception, Introduction to Genetic Analysis (IGA) has been known for its prominent authorship including leading scientists in their field who are great educators. This market best-seller exposes students to the landmark experiments in genetics, teaching students how to analyze experimental data and how to draw their own conclusions based on scientific thinking while teaching students how to think like geneticists. Visit the preview site at www.whfreeman.com/IGA10epreview

Download or read book Advances in the Treatment of Hormonal Receptor positive HR Breast Cancer written by Deniz Can Guven and published by Frontiers Media SA. This book was released on 2024-10-09 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most common cancer in women. Breast cancer subtypes are classified according to histologic features, including morphology and receptor status. Information on the expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2), as well as the proliferation index Ki67 (in early-stage disease), are relevant for clinical decisions. Molecular tests are now available to further classify the disease into subgroups, stratify risk or estimate the benefit of interventions. Some examples of such tests include the Recurrence Score (OncotypeDX), PAM50 (Prosigna), Mammaprint, Blueprint, and Breast Cancer Index (BCI), among others.

Download or read book The Role of Immediate Early Genes in Neuropsychiatric Illness written by Amelia L. Gallitano and published by Frontiers Media SA. This book was released on 2020-03-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Introduction to Genetic Analysis written by Anthony J.F. Griffiths and published by Macmillan. This book was released on 2008 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an introduction to genetic analysis. This book covers contemporary genetics, and helps students understand the essentials of genetics, featuring various experiments, teaching them how to analyze data, and how to draw their own conclusions