Download or read book Development of Novel Analytical Methods with the Aim of Forensic Analyte Detection Using Ultra thin Layer Chromatography Surface Enhanced Raman Spectroscopy and Magneto elastic Wire Sensing written by Nichole Ann Crane and published by . This book was released on 2016 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this dissertation is to develop analytical methods that aid in the detection of forensic analytes. Forensic analytes require methods with increased sensitivity and low limit of detection capabilities. Improvements in separation techniques, surface enhanced Raman spectroscopic techniques, and wire-less gas sensing can each assist in the detection of trace evidence. When surface enhanced Raman is coupled with thin-layer chromatography a mixture of compounds can be separated and transferred to a metal substrate to be detected using Raman spectroscopy. Surface enhanced Raman scattering enhances the Raman signal intensity by placing a metal substrate in close proximity to an analyte. The new method gives a chemically specific intensified signal along with a chromatographic separation. A traditional separation is performed on a TLC plate, allowed to dry, wetted with a solvent, placed in contact with a metal substrate, and detected using Raman. More efficient chromatographic platforms can be implemented with this method. New efficient chromatographic platforms are also beneficial to the detection of forensic analytes. Recently, photolithographically nanofabricated open system pillar arrays have proved to be more efficient separation platforms when compared to traditional TLC. These platforms are a form of ultra-thin layer chromatography. This dissertation describes the effects of manipulation on the inter-pillar gap distances with respect to band dispersion. The studies herein manipulate the pillar arrays in order to optimize the separation platform. The third method developed involved gas sensing of volatile organic compounds. An amorphous ferromagnetic micro-wire was coated with a polymer, where the polymer swelled in response to the gas introduced. When the gas caused the polymer to swell a differential stress response was applied on the micro-wire. The fabricated sensor was tested on simple organic gases but has capabilities to detect low concentrations of low vapor pressure forensic analytes. All three projects were significant advancements in analytical method development. The analytes used were either fluorescent dyes or volatile organic compounds to test feasibility of each method. More efficient chromatographic platforms were fabricated, surface enhanced Raman was coupled to TLC, and a micro-wire gas sensor was calibrated for the studies performed in this dissertation.
Download or read book Analytical Techniques in Forensic Science written by Rosalind Wolstenholme and published by John Wiley & Sons. This book was released on 2021-01-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth text that explores the interface between analytical chemistry and trace evidence Analytical Techniques in Forensic Science is a comprehensive guide written in accessible terms that examines the interface between analytical chemistry and trace evidence in forensic science. With contributions from noted experts on the topic, the text features a detailed introduction analysis in forensic science and then subsequent chapters explore the laboratory techniques grouped by shared operating principles. For each technique, the authors incorporate specific theory, application to forensic analytics, interpretation, forensic specific developments, and illustrative case studies. Forensic techniques covered include UV-Vis and vibrational spectroscopy, mass spectrometry and gas and liquid chromatography. The applications reviewed include evidence types such as fibers, paint, drugs and explosives. The authors highlight data collection, subsequent analysis, what information has been obtained and what this means in the context of a case. The text shows how analytical chemistry and trace evidence can problem solve the nature of much of forensic analysis. This important text: Puts the focus on trace evidence and analytical science Contains case studies that illustrate theory in practice Includes contributions from experts on the topics of instrumentation, theory, and case examples Explores novel and future applications for analytical techniques Written for undergraduate and graduate students in forensic chemistry and forensic practitioners and researchers, Analytical Techniques in Forensic Science offers a text that bridges the gap between introductory textbooks and professional level literature.
Download or read book Forensic Analytical Methods written by Thiago R L C Paixão and published by Royal Society of Chemistry. This book was released on 2019-08-13 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic analysis relates to the development of analytical methods from laboratory applications to in-field and in situ applications to resolve criminal cases. There has been a rapid expansion in the past few years in this area, which has led to an increase in the output of literature. This is the first book that brings together the understanding of the analytical techniques and how these influence the outcome of a forensic investigation. Starting with a brief introduction of the chemical analysis for forensic application, some forensic sampling and sample preparation, the book then describes techniques used in forensic chemical sensing in order to solve crimes. The techniques describe current forensic science practices in analytical chemistry and specifically the development of portable detectors to guide the authorities in the field. The book provides an excellent combination of current issues in forensic analytical methods for the graduates and professionals. It will cover the essential principles for students and directly relate the techniques to applications in real situations.
Download or read book Advances in Analytical Techniques for Forensic Investigation written by Priyanka Chhabra and published by John Wiley & Sons. This book was released on 2024-09-11 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is essential for anyone seeking to understand and apply the latest analytical techniques in forensic investigation, saving time, materials, energy, and manpower by providing guidance on the most appropriate techniques for different types of investigations. Advances in Analytical Techniques for Forensic Investigation is aimed to describe the applicability of different types of analytical techniques used for the forensic investigation, including FT-IR, chromatography, mass spectroscopy, NMR spectroscopy, atomic absorption spectroscopy, UV- vis spectroscopy, etc. This book will focus on current and emerging developments in the latest analytical techniques and methods used in the forensic investigation and sample analysis of various physical, chemical, and biological samples in order to facilitate the smooth conduction of justice.
Download or read book Chromatographic Techniques in the Forensic Analysis of Designer Drugs written by Teresa Kowalska and published by CRC Press. This book was released on 2018-01-31 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
Download or read book Forensic Applications of High Performance Liquid Chromatography written by Shirley Bayne and published by CRC Press. This book was released on 2017-07-27 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography has many roles in forensic science, ranging from toxicology to environmental analysis. In particular, high-performance liquid chromatography (HPLC) is a primary method of analysis in many types of laboratories. Maintaining a balance between practical solutions and the theoretical considerations involved in HPLC analysis, Forensic App
Download or read book Ink Analysis Using a Combination of Thin Layer Chromatography TLC and Surface enhanced Raman spectroscopy SERS Techniques written by Mashael Khaled Algareeb and published by . This book was released on 2015 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Forensic Analytical Techniques written by Barbara H. Stuart and published by John Wiley & Sons. This book was released on 2012-12-14 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will be an open learning / distance learning text in the Analytical Techniques for the Sciences (AnTS) covering analytical techniques used in forensic science. No prior knowledge of the analytical techniques will be required by the reader. An introductory chapter will provide an overview of the science of the materials used as forensic evidence. Each of the following chapters will describe the techniques used in forensic analysis. The theory, instrumentation and sampling techniques will be explained and examples of the application of each technique to particular forensic samples will be provided. The reader will be able to assess their understanding with the use of regular self assessment questions and discussion questions throughout the book. The user of the book will be able to apply their understanding to the application of specific techniques to particular analyses encountered in their professional life.
Download or read book Analytical Methods in Forensic Chemistry written by Mat H. Ho and published by Ellis Horwood. This book was released on 1990 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microextraction Techniques in Analytical Toxicology written by Rajeev Jain and published by CRC Press. This book was released on 2021-12-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings. This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered. Features: Provides a systematic review of microextraction techniques applied in analytical toxicology A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.
Download or read book Challenges in Detection Approaches for Forensic Science written by Lynn Dennany and published by Royal Society of Chemistry. This book was released on 2021-04-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic science combines analytical science with the requirements of law enforcement agencies and legislation. This can often pose challenges within the development of novel analytical methods, particularly with the drive to have more in-field and in-situ applications to facilitate the investigation of criminal cases. This book will explore the specific challenges encountered by forensic scientists and the developments that are being made to address these within the framework of the legislative requirements. It will provide a critical appraisal of the current challenges facing analytical approaches for the detection of forensic evidence and the state of the art technologies used to address these challenges. Providing an excellent combination of current research and how this pertains to forensic investigations, the book will also highlight key obstacles within this ever-changing environment. Aimed at graduates and forensic professionals, this is a unique oversight of the current work being undertaken within the development of analytical methods and also in the interpretation of complex crime scene samples.
Download or read book Analytical Method Development and Validation written by Michael E. Swartz and published by CRC Press. This book was released on 2018-10-03 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes analytical methods development, optimization and validation, and provides examples of successful methods development and validation in high-performance liquid chromatography (HPLC) areas. The text presents an overview of Food and Drug Administration (FDA)/International Conference on Harmonization (ICH) regulatory guidelines, compliance with validation requirements for regulatory agencies, and methods validation criteria stipulated by the US Pharmacopia, FDA and ICH.
Download or read book Review of written by DS. Isenschmid and published by . This book was released on 2002 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume of Handbook of Analytical Separations and is entitled Forensic Science. While several topics in forensic science are included, the first part of the book, Forensic toxicology, make up the bulk of this volume (597 pp.) This part of the book is divided into three sections: illicit drugs, therapeutic drugs, and other topics of toxicological relevance. A review of the analytical toxicology of many major drug classes are considered in the individual chapters that make up the first two sections of this part of the book. Chapter topics include opiate agonists, cocaine and metabolites, amphetamines, hallucinogens, cannabinoids, sedatives and hypnotics, antidepressants and antipsychotics, nonopioid analgesics, and a catch-all chapter that includes cardiac glycosides, oral antidiabetics, and muscle relaxants. Each chapter first reviews methods used to isolate drugs from biological matrices (and plant material where applicable) Included are traditional liquid-liquid and solid-phase extraction procedures as well as newer isolation techniques such as supercritical fluid extraction. Separation methods discussed in most chapters include thin layer chromatography, liquid and gas chromatography and in some cases, capillary electrophoresis. Derivatization methods, if applicable, are either presented in a distinct section of a chapter or incorporated into the discussion of detection techniques. Methods of detection are usually integrated into the discussion of each separation technique. In addition to mass spectrometric detection, I was glad to see that most authors also reviewed other detection techniques including nitrogen-phosphorus, diode-array, electron-capture, and fluorescence. Notably absent from most chapters, except the chapter on cannabinoids, was any discussion of immunoassays. This is unfortunate as important issues such as cross-reactivity to various compounds, interferences, and comparisons between different types of commercially available immunoassays are not presented to the user of this volume. Most authors considered the analysis of drugs in various matrices, although the manner in which this data were presented varied considerably. Some authors chose to include this in their discussion of isolation techniques while others chose to dedicate sections of their chapter to each type of matrix. A separate chapter on alternative matrices also occurs later in the book. The authors of the chapter on the analysis of cocaine analytes included a table that lists the analytes detected, specimen type, internal standards, column type, instrumentation details, performance characteristics, and reference. I found this to be extremely useful for method comparison and wish that each chapter would have included a table similar to this. In addition to analytical methods, many chapters also contain additional topics of forensic significance for the analytes discussed, e.g., morphine (poppy seeds), cocaine (stability), amphetamines (source differentiation), etc. In general, the chapters on illicit drugs were more thorough than the chapters on therapeutic drugs. However, many more analytes had to be considered in the latter section. The chapter on antidepressants and antipsychotics, in particular, was too brief. In addition, this chapter discussed tricyclic antidepressants, serotonin reuptake inhibitors, neuroleptics, and antipsychotics as a group. It would have been much more useful to have this information subdivided by drug class with greater emphasis on a review of the published methods, rather than methods used in the authors' laboratory. The chapter on sedatives and hypnotics did break down the drugs by class, but was also too brief in its review of this important group of drugs, especially the benzodiazepines. Unlike the chapters in the section on illicit drugs, the chapters on therapeutic drugs did not include other relevant issues to the analytes discussed (e.g., postmortem redistribution).
Download or read book The Analysis Of Drugs Of Abuse An Instruction Manual written by M D Cole and published by CRC Press. This book was released on 1994-11-30 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a self-teaching reference text for forensic chemistry laboratories and law enforcement agencies world-wide. The text includes sections on the importance of physical examinations of drugs and their wrappings; and the use of gas and high-performance chromatography.
Download or read book Developments in Analytical Methods in Pharmaceutical Biomedical and Forensic Sciences written by Giuseppe Piemonte and published by . This book was released on 1987 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Vibrational Spectroscopy written by Ricardo Aroca and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS. Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the art Offers interpretations of SEVS spectra for practicing analysts Discusses interpretation of SEVS spectra, which can often be very different to the non-enhanced spectrum - aids the practicing analyst
