Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1976 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Deuterium and Shift Calculation written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1931 Vrey, Brickwedde, and Murphy discovered the hydrogen isotope deuterium. The isotopic enrichment was found to arise from the fact that the electrolysis oflight water is faster than of heavy water [1,2]. This success showed that although different isotopes of an element behave identically from a chemical standpoint the different isotopic masses nevertheless lead to both isotope effects on equilibrium as well as on rate constants of chemical reactions. Soon, ratios of equilibrium constants of isotopic reactions were called "equilibrium isotope effects" (EIE), ratios of isotopic rate constants "kinetic isotope effects" (KIE). Isotope effects have been found to be especially large for those elements which are directly involved in bond breaking and bond formation during the reaction studied [3]. Such effects are, therefore, referred to as "primary". Isotopic substitution in atomic sites which maintain all chemical bonds with their neighbors during the reaction of interest leads then only to smaller "secondary" isotope effects. Because of the unique mass relation between the different hydrogen isotopes hydrogen/deuterium isotope effects are particularly large and have attracted most attention. The largest contributions to these effects arise from changes in the vibrational frequencies of the reactants. The theory of equilibrium isotope effects has been founded by Vrey [4] and Bigeleisen [5,6] and has widely been accepted [3].

Download or read book Journal of the American Chemical Society written by American Chemical Society and published by . This book was released on 1975 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Society are included in v. 1-59, 1879-1937.

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1972-04 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Natural Products Chemistry Enzymes enzyme mechanisms proteins and aspects of NO chemistry written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen

Download or read book Technique of Organic Chemistry Investigation of rates and mechanisms of reactions 2 pts written by Arnold Weissberger and published by . This book was released on 1961 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bibliography of Mass Spectroscopy Literature for 1971 written by and published by . This book was released on 1973 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Catalysis in Chemistry and Enzymology written by William P. Jencks and published by Courier Corporation. This book was released on 1987-01-01 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exceptionally clear coverage of mechanisms for catalysis, forces in aqueous solution, carbonyl- and acyl-group reactions, practical kinetics, more.

Download or read book Organic and Bio organic Mechanisms written by Michael I. Page and published by Prentice Hall. This book was released on 1997 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive and detailed discussion of the investigation of organic and bioorganic reaction mechanisms. It addresses questions such as: 'How are bonds between atoms rearranged?', 'What sort of structural changes take place to cause bond fission and formation?' and 'How do catalysts lower the activation energies of reactions?'.

Download or read book Annual Review of Biochemistry written by James Murray Luck and published by . This book was released on 1963 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigation of Rates and Mechanisms of Reactions written by S. L. Friess and published by . This book was released on 1961 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Program and Abstracts written by Jürgen Sauer and published by . This book was released on 1988 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bibliography of Mass Spectroscopy Literature for 1970 written by and published by . This book was released on 1972 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Download or read book Comprehensive Dissertation Index 1861 1972 Chemistry written by Xerox University Microfilms and published by . This book was released on 1973 with total page 958 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases written by Rona R. Ramsay and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

Download or read book Organic Reaction Mechanisms 1983 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 1983 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 1983. The 19th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.