Download or read book Design Synthesis Biological Evaluation and Molecular Modeling of Novel Taxane based Anticancer Agents and Paclitaxel Mimics written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Novel Tumor targeting Taxane based Anticancer Agents written by Jin Chen and published by . This book was released on 2006 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Download or read book Design Synthesis and Biological Evaluations of Novel Taxane based and Taxane free Anticancer Agents written by Xudong Geng and published by . This book was released on 2002 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anticancer Agents written by Qiao-Hong Chen and published by MDPI. This book was released on 2021-03-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Download or read book Design Synthesis and Biological Evaluation of Novel Taxane based Anticancer Agents and Their Applications to Tumor targeting Drug Delivery Systems written by Xianrui Zhao and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Novel Taxane based Anticancer Agents and Their Tumor Targeting Delivery written by Larisa Kuznetsova and published by . This book was released on 2005 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Tumor targeting Taxane based Anticancer Agents and MDR Modulators written by Xinyuan Wu and published by . This book was released on 2003 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Medicinal Chemistry of Novel Taxane based Anticancer Agents written by Songnian Lin and published by . This book was released on 1999 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Paclitaxel Analogs and Tyloindicine H as Antitumor Agents written by Yanbin Liu and published by . This book was released on 2000 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anticancer Agents written by Qiao-Hong Chen and published by . This book was released on 2021 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Download or read book Design Synthesis and Biological Evaluation of Taxane based Anticancer Agents written by Qing Huang and published by . This book was released on 2006 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design Synthesis and Biological Evaluation of Compounds with Medicinal Value written by Maria Sinicropi and published by . This book was released on 2021 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
Download or read book Design Synthesis and Structure activity Relationship SAR of Novel Taxane Anti cancer Agents written by Christopher P. Borella and published by . This book was released on 2001 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Modeling Study Synthesis and Biological Evaluation of Combretastatin A 4 Analogues as Anticancer Agents and Tubulin Inhibitors1 written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Some Novel Nucleotide Prodrugs as Potential Anticancer Agents written by Costantino Congiatu and published by . This book was released on 2006 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Modeling Design Synthesis and Evaluation of Targeted Polymeric Prodrugs for Cancer Treatment written by Sreeja Jayant and published by . This book was released on 2007 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Novel Cyclin dependent Kinase 9 Inhibitors as Anticancer Agents written by Hamad Musfer Alkhtani and published by . This book was released on 2015 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
