Download or read book Design Synthesis and Characterization of Biodentritic Polymers written by Nathanael R. Luman and published by . This book was released on 2006 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Research concerning dendritic polymers continues to expand as further advances in synthetic methodology and characterization techniques translate to additional applications. Dendritic polymers composed of natural metabolites such as glycerol, succinic acid, myristic acid, glycine, and cholesterol are synthesized, functionalized, and evaluated as new medical materials. The design and synthesis of p[barbelow]oly(gl ycerol-s[barbelow]uccinic a[barbelow]cid) (PGLSA) dendrimers and dendrons are discussed, including comparing and contrasting the convergent versus the divergent methodologies for preparing such macromolecules. Specifically, the high yielding convergent synthesis of PGLSA dendrimers and dendrons is presented that facilitates the preparation of particularly interesting and complex polymers. For example, amphiphilic surface-block dendrimers which display aqueous self-assembly properties are described. Such amphiphilic dendrimers can preferentially solubilize hydrophibic molecules within spontaneously formed supramolecular aggregates in aqueous solution and may be useful for drug delivery applications. Photocrosslinkable dendritic macromolecules are prepared possessing methacrylate groups at the dendritic periphery. These polymers form three-dimensional hydrogels when irradiated with light and have desirable physical properties for wound sealing procedures. Additionally, quaternized amines are incorporated into amphiphilic surface-block dendrimers and these macromolecules display DNA binding capabilities. Such molecules are of interest for gene transfection applications. A cholesterol derivative is described which displays unique physical properties such as thermal transition temperature and critical aggregation concentration. Finally, layered dendrimers are designed and prepared that have distinct 1 H NMR chemical shifts in different generations. These dendrimers encapsulate Reichardt's dye and provide new insight into dendritic host/guest interactions. Overall, the family of dendritic PGLSA polymers presented provide methods of manipulating many key physical properties necessary for the development of new and improved patient treatments. Furthermore, the synthetic methods described herein can be utilized to prepare an entire host of functionalized macromolecules with degrees of precision highly unusual for macromolecular systems.
Download or read book Design Synthesis and Characterization of New Polymers for Bioanalytical Applications written by Laura Sola and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Characterization of Biomimieric Bioinspired and Bio related Functional Polymers for Atmospheric Water Recovery written by Abdullah Alqassar and published by . This book was released on 2019 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atmospheric water recovery in changing environments has received wide attention in environmental science and engineering communities due to rapid population growth and frequent droughts. This study is focused on the design, synthesis, and characterization of biomimetic, bioinspired, and bio-related functional polymers (b3p) to help resolve the water supply issue especially in arid or semi-arid regions. It is aimed to develop unique synthetic methods to access well-defined polymers with the aid of nanomaterials and metal to produce next generation polymer materials for better atmospheric water recovery. The design of such new b3p is bioinspired by some skin materials of biological species such as frogs, beetles, or spiders. Such synthetic efforts are also coupled with fundamental studies of the polymer functions and structures, providing renewed understanding of how molecular structure and processing parameters associated with different nanomaterials impact macroscopic properties.
Download or read book Polymers for Biomedicine written by Carmen Scholz and published by John Wiley & Sons. This book was released on 2017-06-28 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting dynamic developments in polymer synthesis, this book focuses on the chemical techniques to synthesize and characterize biomedically relevant polymers and macromolecules. • Aids researchers developing polymers and materials for biomedical applications • Describes biopolymers from a synthetic perspective, which other similar books do not do • Covers areas that include: cationically-charged macromolecules, pseudo-peptides, polydrugs and prodrugs, controlled radical polymerization, self-assembly, polycondensates, and polymers for surface modification
Download or read book Handbook of Biodegradable Polymers written by Andreas Lendlein and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.
Download or read book Handbook of Biodegradable Polymers written by Andreas Lendlein and published by Wiley-VCH. This book was released on 2011-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.
Download or read book Design Synthesis and Structure bioactivity Characterization of Novel Carbohydrate based Polymers as Nucleic Acid written by Chen-Chang Lee and published by . This book was released on 2008 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design Synthesis and Characterization of Poly carbonate ester s Based on Dihydroxyacetone for Use as Potential Biomaterials written by Jennifer Rose Weiser and published by . This book was released on 2013 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: The creation of new devices and materials with desirable biomedical characteristics, such as biocompatibility and easily tunable physico-chemical parameters, has played a key role in the advancement of the biomedical industry. In recent years, the combination of classical engineering principles with polymer chemistry has led to a wide range of materials that influence the manner in which drugs are delivered, tissues are engineered, and surgery is performed. The work presented in this thesis is focused on the design, synthesis, and characterization of a poly(carbonate-ester) biomaterial based on lactic acid (LA) and a carbonate form of dihydroxyacetone (DHAC) as vehicles for controlled release. The goal of this work was to synthesize a variety of pLAx-co-DHACy copolymers and characterize their behavior to better understand their structure/function relationships. The results show that random copolymers based on dihydroxyacetone and lactic acid are easily and reliably producible, with unique characteristics. In vitro degradation studies showed that the poly(carbonate-ester)s had an unexpected degradation pattern, in that the carbonate bond was more labile to hydrolysis than that of the ester bond. The resulting degradation pattern made from these biomaterials did not appear to have an acidic interior environment, due to a lack of visible viscous core commonly seen with bulk degrading lactic acid based polymers. Due to the insolubility of the poly(carbonate-ester)s, exploration of copolymer degradation was determined by the development of a newly discovered technique to quantify dihydroxyacetone release from the matrix using the bicinchoninic acid assay. Finally, the release kinetics and mechanism from these poly(carbonate-ester)s was studied following the incorporation of two different model proteins, bovine serum albumin and lysozyme. Their release behaviors and activities were analyzed to explore the controlled release capabilities of these materials and to identify their potential for the effective release of proteins.
Download or read book Processing Technology for Bio Based Polymers written by Khalid Mahmood Zia and published by Elsevier. This book was released on 2021-06-25 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Processing Technology for Bio-Based Polymers: Advanced Strategies and Practical Aspects brings together the latest advances and novel technologies surrounding the synthesis and manufacture of biopolymers, ranging from bio-based polymers to synthetic polymers from bio-derived monomers. Sections examine bio-based polymer chemistry, discuss polymerization process and emerging design technologies, cover manufacturing and processing approaches, explain cutting-edge approaches and innovative applications, and focus on biomedicals and other key application areas. Final chapters provide detailed discussion and an analysis of economic and environmental concerns, practical considerations, challenges, opportunities and future trends. This is a valuable resource for researchers, scientists and advanced students in polymer science, bio-based materials, nanomaterials, plastics engineering, biomaterials, chemistry, biotechnology, and materials science and engineering, as well as R&D professionals, engineers and industrialists interested in the development of biopolymers for advanced products and applications. Focuses on the processing of bio-based polymers, covering both traditional methods and innovative new approaches Offers novel opportunities and ideas for developing or improving technologies for biopolymer research, preparation and application Examines other key considerations, including reliability and end product, economic concerns, and environmental and lifecycle aspects
Download or read book Design Synthesis and Fabrication of Biodegradable Bioactive based Polymers for Controlled Release Applications written by Michelle Aimee Ouimet and published by . This book was released on 2013 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Formulation of Bioactive based Polymers written by Nicholas David Stebbins and published by . This book was released on 2015 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable, bioactive-based polymers have been successfully employed as sustained bioactive delivery systems. This dissertation describes bioactives that have been chemically incorporated into novel, biodegradable polymers via covalent bonds for controlled, sustained, and tunable release properties. Bioactives are released from polymers via hydrolytic degradation. The polymers described herein utilize alternative synthetic methods and a wide array of bioactives, including antibiotics, antioxidants, antimicrobials, and anti-inflammatory drugs. One goal is to focus on naturally-occurring bioactives that are generally regarded as safe (GRAS) by the FDA. First, poly(anhydride-amides) comprised of ampicillin were synthesized and formulated as coatings. Polymer adhesion onto medical-grade stainless steel surfaces was assessed and in vitro release characterized. Cytocompatibility and antibacterial activity elucidated polymer safety and efficacy for potential in vivo use. These localized delivery systems could mediate the issues caused by implant surgery. Second, poly(anhydride-esters) comprised solely of naturally-occurring phenols and EDTA were synthesized and physicochemical properties determined. Bioactive release was ascertained, in addition to antioxidant activity and activity against Gram-positive and Gram-negative bacteria. These polymers can act as potential preservatives, increasing cosmetic and food product shelf life through antioxidant and antimicrobial pathways. Third, through environmentally sustainable (i.e, green) methods, polyesters with pendant anti-inflammatory groups and a sugar-based backbone were prepared with minimal solvent use, enzymatic catalysis, and biorenewable reactants and reagents. Three comonomers of varying hydrophobicity were tested to elucidate changes in polymer thermal properties and bioactive release rate. Fourth, poly(anhydride-esters) with a mannitol backbone and multiple bioactive groups per repeat unit were developed as the first linear, biodegradable polymers with high bioactive loading (~70%) using a polyol. In vitro ibuprofen release was quantified and an anti-inflammatory assay determined that bioactive retained activity upon polymer degradation. Alteration of polyol, bioactive class, and other facets leads to highly tunable polymer properties. Last, to combat bacterial spoilage and oxidation, poly(anhydride-esters) containing natural antimicrobials were designed for food applications. Bioactive released from polymer exhibited radical scavenging ability and antibacterial activity. Furthermore, polymers were blended with current food packaging materials (e.g., polyethylene) and molded into films for active food packaging that contains a higher percentage of biodegradable content.
Download or read book Synthesis and Characterization of Biodegradable Polymers Based on Polydepsipeptides written by Yakai Feng and published by . This book was released on 2001 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dendrimers II written by Fritz Vögtle and published by Springer. This book was released on 2003-07-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume on dendrimers is again written by pioneers in the field. Their contributions illuminate the aspects of dendrimers mentioned in the subtitle, and also touch on areas beyond chemistry, namely material sciences as well as biological, medicinal, analytical, and nano aspects.
Download or read book The Cornea written by Gilbert Smolin and published by Little, Brown Medical Division. This book was released on 1994 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers both basic science and clincal aspects of the cornea and associated external diseases. In this edition the editors have incorporated relevant basic science information into the clinical science chapters. It also contains an expanded surgery section - especially refractive surgery. Emphasis on the third edition is on clinical information (the basic science has been incorporated into the clincial chapters). The clinical section has been expanded by ten per cent to reflect changes in the field.
Download or read book Supramolecular Design for Biological Applications written by Nobuhiko Yui and published by CRC Press. This book was released on 2002-03-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supramolecular chemistry is the outburst topic of the next generation of science. While the majority of biomedical research efforts to date have centered on utilizing well-known polymeric materials, the recent progress in supramolecular chemistry has introduced a fascinating new field of macromolecular architecture. Supramolecular Design fo
