Download or read book What s Wrong With My Mouse written by Jacqueline N. Crawley and published by John Wiley & Sons. This book was released on 2007-03-23 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Download or read book Life s rewards written by Richard J. Beninger and published by Oxford University Press. This book was released on 2018-07-18 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its discovery in the 1960s, a vast and wide-ranging body of research has accumulated about the dopaminergic system. Life's Rewards: Linking Dopamine, Incentive Learning, Schizophrenia, and the Mind offers a broad synthesis of our current understanding of this chemical, addressing, amongst others, its intricate relationship with learning and memory, psychopathology, social co-operation, and drug abuse. Aimed at students and researchers in neuroscience and psychology, Life's Rewards: Linking Dopamine, Incentive Learning, Schizophrenia, and the Mind is essential reading for anyone interested in the relationship between dopamine and reward-related incentive learning.

Download or read book Head First written by David Tomen and published by Balboa Press. This book was released on 2022-11-25 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of NootropicsExpert.com and his YouTube channel, David Tomen offers a revolutionary reference and repair manual for your brain. Through studying the clinical research and experimenting with dozens of natural nootropic supplements, the author has successfully restored his own health. And now shares with you an all-natural method to take control of your own cognitive health. In Head First, 2nd Edition you’ll get: • Detailed reviews of 102 of the most popular natural nootropic supplements used today; supported by hundreds and hundreds of peer-reviewed clinical studies from leading research institutions and universities from around the world • Learn which supplements to buy and which to avoid • Get clear and easy to understand instructions on how to use each supplement including dosage recommendations (often different than what’s on the bottle) • Stay safe from possible side effects; avoid drug interactions • Know how each supplement works in your brain and why; neuroscience that anyone can understand and apply • A chapter on how your brain works and why these natural supplements work • 2 chapters on recommended nootropic stacks (supplement combinations) for treating; anxiety, ADHD, depression, anxiety, learning & memory, mental fatigue, OCD, PTSD, and more • Discover what functional and mainstream medicine has missed if you are dealing with memory problems, impaired thinking, mental fatigue, anxiety, or depression and how to deal with your issues naturally! Fans of David’s work and contribution to the neurohacking community are also encouraging their doctors and psychiatrists to make Head First, 2nd Editon part of their reference library. When you take care of your “Head First”, everything else naturally falls into place. You’re full potential is within reach at last. Today is the day to go “Head First”! And get your happy back. For the last decade, author and world-traveler David Tomen has worked to deal with Adult ADD. And the brain fog, mental fatigue and memory loss that comes with hypothyroidism. Through studying the clinical data and experimenting with dozens of natural nootropic supplements, the author has successfully restored his own health. With cognition, memory and mood better than before. Through his writing and videos, the author is now empowering people around the world to take control of their own cognitive health. Fans of David’s work and contribution to the neurohacking community are also encouraging their doctors and psychiatrists to make Head First part of their library. When you take care of your Head First, everything else falls into place. You’re full potential is within reach at last. Today is the day to go Head First!

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2013-01-28 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers G protein coupled receptors - Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation

Download or read book AACN AANN Protocols for Practice Monitoring Technologies in Critically Ill Neuroscience Patients written by American Association of Critical-Care Nurses (AACN), and published by Jones & Bartlett Publishers. This book was released on 2008-08-14 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: AACN Protocols for Practice: Monitoring Neuroscience Patients provides clinicians at the point of care with the latest research findings in patient care in a format which is easy to understand and integrate into clinical practice. Each protocol guides clinicians in the appropriate selection of patients, use and application of management principles, initial and ongoing monitoring, discontinuation of therapies or interventions, and selected aspects of quality control.

Download or read book Me Myself and Why written by Jennifer Ouellette and published by Penguin. This book was released on 2014-01-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: As diverse as people appear to be, all of our genes and brains are nearly identical. In Me, Myself, and Why, Jennifer Ouellette dives into the miniscule ranges of variation to understand just what sets us apart. She draws on cutting-edge research in genetics, neuroscience, and psychology-enlivened as always with her signature sense of humor-to explore the mysteries of human identity and behavior. Readers follow her own surprising journey of self-discovery as she has her genome sequenced, her brain mapped, her personality typed, and even samples a popular hallucinogen. Bringing together everything from Mendel's famous pea plant experiments and mutations in The X-Men to our taste for cilantro and our relationships with virtual avatars, Ouellette takes us on an endlessly thrilling and illuminating trip into the science of ourselves

Download or read book Guide to Research Techniques in Neuroscience written by Matt Carter and published by Academic Press. This book was released on 2022-03-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. - Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods - Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more - Clear, straightforward explanations of each technique for anyone new to the field - A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture - Detailed recommendations on where to find protocols and other resources for specific techniques - "Walk-through" boxes that guide readers through experiments step-by-step

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Download or read book From Neuron to Cognition via Computational Neuroscience written by Michael A. Arbib and published by MIT Press. This book was released on 2016-11-04 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition. This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using computational tools to trace a path from neurons and circuits to behavior and cognition. Moreover, the chapters show how computational neuroscience—methods for modeling the causal interactions underlying neural systems—complements empirical research in advancing the understanding of brain and behavior. The chapters—all by leaders in the field, and carefully integrated by the editors—cover such subjects as action and motor control; neuroplasticity, neuromodulation, and reinforcement learning; vision; and language—the core of human cognition. The book can be used for advanced undergraduate or graduate level courses. It presents all necessary background in neuroscience beyond basic facts about neurons and synapses and general ideas about the structure and function of the human brain. Students should be familiar with differential equations and probability theory, and be able to pick up the basics of programming in MATLAB and/or Python. Slides, exercises, and other ancillary materials are freely available online, and many of the models described in the chapters are documented in the brain operation database, BODB (which is also described in a book chapter). Contributors Michael A. Arbib, Joseph Ayers, James Bednar, Andrej Bicanski, James J. Bonaiuto, Nicolas Brunel, Jean-Marie Cabelguen, Carmen Canavier, Angelo Cangelosi, Richard P. Cooper, Carlos R. Cortes, Nathaniel Daw, Paul Dean, Peter Ford Dominey, Pierre Enel, Jean-Marc Fellous, Stefano Fusi, Wulfram Gerstner, Frank Grasso, Jacqueline A. Griego, Ziad M. Hafed, Michael E. Hasselmo, Auke Ijspeert, Stephanie Jones, Daniel Kersten, Jeremie Knuesel, Owen Lewis, William W. Lytton, Tomaso Poggio, John Porrill, Tony J. Prescott, John Rinzel, Edmund Rolls, Jonathan Rubin, Nicolas Schweighofer, Mohamed A. Sherif, Malle A. Tagamets, Paul F. M. J. Verschure, Nathan Vierling-Claasen, Xiao-Jing Wang, Christopher Williams, Ransom Winder, Alan L. Yuille

Download or read book Patch Clamping written by Areles Molleman and published by John Wiley & Sons. This book was released on 2003-06-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns

Download or read book Surgically Treated Intracerebral Haemorrhage written by Lovisa Tobieson and published by Linköping University Electronic Press. This book was released on 2019-04-17 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mortality and morbidity of intracerebral haemorrhage (ICH) is excessively high, and the case fatality rate has not improved in the last decades. Although surgery for ICH can be life-saving, no positive effect on functional outcome has been found in large cohorts of ICH patients. Increased understanding of the pathophysiology of ICH is needed to develop improved treatment strategies. In 17 ICH patients, paired cerebral microdialysis (CMD) catheters were inserted in the perihaemorrhagic zone (PHZ) and in normal uninjured cortex at time of surgery. Despite normalisation of cerebral blood flow, a persistent metabolic crisis indicative of mitochondrial dysfunction was detected in the PHZ. This metabolic pattern was not observed in the uninjured cortex. CMD was also used to sample proteins for proteomic analysis. A distinct proteome profile that changed over time was found in the PHZ when compared to the seemingly normal, uninjured cortex. However, protein adsorption to CMD membranes, which may interfere with concentration measurements, was substantial. Surgical treatment of 578 ICH patients was analysed in a nation-wide retrospective multi-centre study in Sweden over five years. Patients selected for surgery had similar age, pre-operative level of consciousness and co-morbidity profiles, but ICH volume and the proportion of deep-seated ICH differed among the six neurosurgical centres. Furthermore, there was variability in the post-operative care, including the use and duration of intracranial pressure monitoring, cerebrospinal fluid drainage and mechanical ventilation. In conclusion, the results of this thesis show that: (i) Despite surgical removal of an ICH a metabolic crisis caused by mitochondrial dysfunction, a potential future therapeutic target, persists in the perihaemorrhagic zone. (ii-iii) CMD is a valuable tool in ICH research for sampling novel biomarkers using proteomics, which may aid in the development of improved therapeutic interventions. However, caveats of the technique, such as protein adsorption to the CMD membrane, must be considered. (iv) The nation-wide study illustrates similar clinical features in patients selected for ICH surgery, but substantial variability in ICH volume and location as well as neurocritical care strategies among Swedish neurosurgical centres. Development of refined clinical guidelines may reduce such intercentre variability and lead to improved functional outcome for ICH patients.

Download or read book Current Protocols in Neuroscience written by Jacqueline N. Crawley and published by Current Protocols. This book was released on 1997-06-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Protocols in Neuroscience (CPN) draws from techniques in molecular neurobiology, neurophysiology, neuroanatomy, neuropharmacology, and behavioral neuroscience to meet the specific needs of researchers in the full range of disciplines that is involved in studying the brain, nervous system, and corresponding behaviors. The editorial board of CPN have assembled an outstanding range of methods to enable users to explore their fields in greater depth and branch into related areas. The one-volume, looseleaf manual features carefully edited techniques with authors' troubleshooting tips and helpful comments that come from extensive experience in using these procedures. Quarterly updates, filed into the looseleaf, keep you and your laboratory current with the latest developments in this rapidly changing field. The initial purchase includes one year of updates and then subscribers may renew their annual subscriptions. Current Protocols publishes a family of laboratory manuals for bioscientists, including Molecular Biology, Immunology, Human Genetics, Protein Science, Cytometry, Cell Biology, Pharmacology, and Toxicology.

Download or read book Understanding Light Microscopy written by Jeremy Sanderson and published by John Wiley & Sons. This book was released on 2019-03-04 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to the enlightening world of the modern light microscope There have been rapid advances in science and technology over the last decade, and the light microscope, together with the information that it gives about the image, has changed too. Yet the fundamental principles of setting up and using a microscope rests upon unchanging physical principles that have been understood for years. This informative, practical, full-colour guide fills the gap between specialised edited texts on detailed research topics, and introductory books, which concentrate on an optical approach to the light microscope. It also provides comprehensive coverage of confocal microscopy, which has revolutionised light microscopy over the last few decades. Written to help the reader understand, set up, and use the often very expensive and complex modern research light microscope properly, Understanding Light Microscopy keeps mathematical formulae to a minimum—containing and explaining them within boxes in the text. Chapters provide in-depth coverage of basic microscope optics and design; ergonomics; illumination; diffraction and image formation; reflected-light, polarised-light, and fluorescence microscopy; deconvolution; TIRF microscopy; FRAP & FRET; super-resolution techniques; biological and materials specimen preparation; and more. Gives a didactic introduction to the light microscope Encourages readers to use advanced fluorescence and confocal microscopes within a research institute or core microscopy facility Features full-colour illustrations and workable practical protocols Understanding Light Microscopy is intended for any scientist who wishes to understand and use a modern light microscope. It is also ideal as supporting material for a formal taught course, or for individual students to learn the key aspects of light microscopy through their own study.

Download or read book Gale Directory of Databases written by and published by . This book was released on 1993 with total page 1572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a guide to computer-readable databases available online, in CD-ROM format, or in other magnetic formats. Details include database descriptions, costs, and whom to contact for purchase. The material is indexed alphabetically, and by subject, vendor, and producer.

Download or read book Physiology of Myelin Forming Cells from Myelination to Neural Modulators written by Mauricio Antonio Retamal and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Methods in Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2001-06-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents

Download or read book Neurodevelopmental Processes in Health and Disease Bridging Basic and Clinical Research written by Edna Grünblatt and published by Frontiers Media SA. This book was released on 2021-12-03 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: