Download or read book Current Progress in Protein Kinase Research written by Bailey Graham and published by Murphy & Moore Publishing. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinase refers to an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specified molecules or substrates. Kinases may modify lipids, carbohydrates, proteins, or other molecules. Protein modifying kinases are called protein kinases. Kinase signaling is essential for regulating various metabolic events. AMP-activated protein kinase or AMPK is an enzyme, which is activated when the intracellular ATP levels are lower. It is one of the major regulators of cellular and organismal metabolism in eukaryotes, which is necessary for all cells to maintain a balance between ATP consumption and ATP generation. It is also known to play an essential role in regulating growth. AMPK can regulate lipid and glucose metabolism, therefore it is studied extensively as a suitable therapeutic target for treating obesity. This book unfolds the innovative aspects of protein kinase and kinase signaling. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.
Download or read book Protein Kinases written by James Robert Woodgett and published by Oxford University Press, USA. This book was released on 1994 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Molecular Biology is a series of books designed to report on rapidly evolving, key areas of molecular biology research. Individual chapters are written by leading researchers who are specialists in their fields. Each book is carefully organized to provide an integrated analysis of current progress in the area covered. Protein kinases share a unique catalytic function and are involved in virtually all regulated processes, from ion transport and metabolic pathways to DNA replication and differentiation. They act as powerful transducers of information, amplifying weak signals or integrating complex messages. Above all, they are the primary mechanism for acute coordination of the myriad of processes that continuously flux during the life cycle of the cell. The daunting progress made in the last decade in this area has been encapsulated in this book, written by established experts in the field. Protein Kinases presents detailed, up-to-date discussions of structural, functional, and genetic aspects of protein phosphorylation research. It is essential reading for all those interested in signal transduction and the control of cellular processes by protein phosphorylation.
Download or read book Protein Kinases Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Proline Directed Protein Kinases Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proline-Directed Protein Kinases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Proline-Directed Protein Kinases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proline-Directed Protein Kinases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Kinases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Advances in Protein Kinase C Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Kinase C Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protein Kinase C in a concise format. The editors have built Advances in Protein Kinase C Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinase C in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Protein Kinase C Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Kinases in Drug Discovery written by Rossen Donev and published by Academic Press. This book was released on 2021-02-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. - Contains timely chapters written by well-renown authorities in their field - Includes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students - Integrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients
Download or read book Kinase Drug Discovery written by Richard A. Ward and published by Royal Society of Chemistry. This book was released on 2012 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experience in the industry of well over 200 years, which has resulted in a book of great interest to the kinase field and across drug discovery more generally. Readers will gain a real insight into the huge challenges and opportunities which this target class has presented drug discovery scientists. The many chapters cover a wide breadth of topics, are well written and include high quality colour and black and white images. Topics covered include an outline of how medicinal chemistry has been able to specifically exploit this unique target class, along with reflections on the mechanisms of kinases inhibitors. Also covered is resistance to kinase inhibitors caused by amino acid mutations, case studies of kinase programs and reviews areas beyond protein kinases and beyond the human kinome. Also described are modern approaches to finding kinase leads and the book finishes with a reflection of how kinase drug discovery may progress over the coming years.
Download or read book Proline Directed Protein Kinases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proline-Directed Protein Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Proline-Directed Protein Kinases in a concise format. The editors have built Proline-Directed Protein Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proline-Directed Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proline-Directed Protein Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Kinases as Drug Targets written by Bert Klebl and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.
Download or read book Progress in Cell Cycle Research written by Laurent Meijer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest volume in this highly regarded series covers current advances in the fast-moving field of cell cycle research by gathering reviews otherwise scattered throughout the literature. Contributions encompass fields from cell and molecular biology to biochemistry.
Download or read book Protein Kinases Current Progress written by Michelle McGuire and published by . This book was released on 2015-03-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive book provides information regarding the current progress in protein kinases. Proteins are the hardest working part of a cell. As controllers of protein function, protein kinases are concerned with the regulation of cellular activities through complex signaling corridors, permitting fine tuning of physiological tasks. This book is a contributive effort, with inputs from experts in their respective spheres, showcasing the spirit of collaborative efforts across fields and boundaries which exist in contemporary science. In this book, light has been shed on existing works and on recent information on the purpose of protein kinases in different systems. Also discussed are the consequences of these discoveries pertaining to disease, treatment, and medicinal development.
Download or read book Protein Kinase mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Current Advances in Protein Biochemistry written by and published by . This book was released on 1997 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Next Generation Kinase Inhibitors written by Paul Shapiro and published by Springer Nature. This book was released on 2020-07-14 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signaling in Plants written by František Baluška and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive monograph on all emerging topics in plant signaling. The book addresses diverse aspects of signaling at all levels of plant organization. Emphasis is placed on the integrative aspects of signaling.
