Download or read book Lysosomal Storage Disorders written by John A. Barranger and published by Springer Science & Business Media. This book was released on 2007-10-16 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: The knowledge of lysosomal biology and the consequences of its dysfunction have increased dramatically in the past 60 years. This book describes the nature of the lysosomal dysfunction and diseases as well as potential future treatments and therapies. Disease specific chapters provide thorough reviews of the clinical features of lysosomal storage disorders, their molecular basis and the commercial or experimental therapeutic approaches sought in this area. This is an invaluable resource for researchers in biochemical and molecular genetics, enzyme therapy, and gene transfer.

Download or read book Iminosugars written by Philippe Compain and published by John Wiley & Sons. This book was released on 2007-10-22 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Download or read book World Cars written by and published by . This book was released on 1976 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ford Cortina TD Four and Six Cylinder written by Ford Motor Company of Australia and published by . This book was released on 1974 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book British Ford Cars of the 1960s and 1970s written by James Taylor and published by The Crowood Press. This book was released on 2022-08-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1960s and 1970s were a pivotal period for Ford in Europe and, seen from a British perspective, were a time of experimentation and exploration. At the start of the 1960s Ford had models aimed at just two market sectors – small family saloons and large family saloons – but by the end of the 1970s they were represented in no fewer than five areas of the market with small hatchbacks, small saloons, medium saloons, sporty coupés and large saloons. And they had overtaken all rivals in Britain to be the best-selling manufacturer with (since 1967) the Cortina as the best-selling car. With over 270 photographs, this book details: the Ford company structure, businesses and key locations throughout the two decades; the factors influencing model design, engineering, styling and interior; specification and performance tables; market reception and sales; special editions, models produced overseas and conversions and finally, helpful buying advice for each model.

Download or read book Holden V Ford written by Steve Bedwell and published by ReadHowYouWant.com. This book was released on 2012 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holden versus Ford, Ford versus Holden, Red versus Blue, Blue versus Red, even the order in which you say these two precious words marks you for life as to which side of the white line you drive on. Going straight to the heart of what it means to be Australian, this book is a must-have addition to any Ford or Holden lovers bookshelf. Loyalty, faith, competition, love is expressed through two brands of motor car. Never before has this nation-dividing topic been faced head on, and written about in such a detailed and humorous way. Some highlights: Comprehensive history of Ford and Holden research and development in Australia. Extensive lists of all the Ford and Holden models released since the beginning of the twentieth century. The panel van craze that rocked the nation during the 1970s. The Great Race at Philip Island, Mt Panorama and the glory days of Ford versus Holden racing victories. A compendium of facts and trivia of all things Holden and Ford. Falling in love with a car of your dreams. With over 200 photos and great design! Holden v Ford is a full-throttle car book and the perfect Father's Day gift book.

Download or read book Ford Cortina written by and published by . This book was released on 1974 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Freedom by the Sword written by William A. Dobak and published by Simon and Schuster. This book was released on 2013-02-01 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Civil War changed the United States in many ways—economic, political, and social. Of these changes, none was more important than Emancipation. Besides freeing nearly four million slaves, it brought agricultural wage labor to a reluctant South and gave a vote to black adult males in the former slave states. It also offered former slaves new opportunities in education, property ownership—and military service. From late 1862 to the spring of 1865, as the Civil War raged on, the federal government accepted more than 180,000 black men as soldiers, something it had never done before on such a scale. Known collectively as the United States Colored Troops and organized in segregated regiments led by white officers, some of these soldiers guarded army posts along major rivers; others fought Confederate raiders to protect Union supply trains, and still others took part in major operations like the Siege of Petersburg and the Battle of Nashville. After the war, many of the black regiments took up posts in the former Confederacy to enforce federal Reconstruction policy. Freedom by the Sword tells the story of these soldiers' recruitment, organization, and service. Thanks to its broad focus on every theater of the war and its concentration on what black soldiers actually contributed to Union victory, this volume stands alone among histories of the U.S. Colored Troops.

Download or read book Cortina TD Four and Six Cylinder 1974 1977 written by Universal Publishers and published by . This book was released on 1982 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Emery and Rimoin s Principles and Practice of Medical Genetics and Genomics written by Reed E. Pyeritz and published by Academic Press. This book was released on 2018-11-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With detailed coverage in contributions from over 250 of the world’s most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. Clinical Principles and Applications thoroughly addresses general methods and approaches to genetic counseling, genetic diagnostics, treatment pathways, and drug discovery. Additionally, new and updated chapters explore the clinical implementation of genomic technologies, analytics, and therapeutics, with special attention paid to developing technologies, common challenges, patient care, and ethical and legal aspects. With regular advances in genomic technologies propelling precision medicine into the clinic, the seventh edition of Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. Fully revised and up-to-date, this new edition introduces genetic researchers, students, and health professionals to general principles of genetic counseling, genetic and genomic diagnostics, treatment pathways, drug discovery, and the application of genomic technologies, analytics, and therapeutics in clinical practice Examines key topics and developing areas within clinical genomics, including genetic evaluation of patients, clinical trials and drug discovery, genetic health records, cytogenetic analysis, diagnostic molecular genetics, small molecule genetic therapeutics, gene product replacement, clinical teratology, transplantation genetics, and ethical and legal aspects of genomic medicine Includes color images supporting identification, concept illustration, and method processing Features contributions by leading international researchers and practitioners of medical genetics

Download or read book Inborn Errors of Metabolism written by Brendan Lee and published by Oxford Monographs on Medical G. This book was released on 2014-10-13 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is an expansion on the known treatment model of IEMs, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this book includes coverage of newborn screening and an overarching treatment of IEMs as complex diseases.

Download or read book Tay Sachs Disease written by and published by Elsevier. This book was released on 2001-10-10 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tay-Sachs disease is a rare hereditary disease caused by a genetic mutation that leaves the body unable to produce an enzyme necessary for fat metabolism in nerve cells, producing central nervous system degeneration. In infants, it is characterized by progressive mental deterioration, blindness, paralysis, epileptic seizures, and death by age four. Adult-onset Tay-Sachs occurs in persons who have a genetic mutation that is similar but allows some production of the missing enzyme. There is no treatment for Tay-Sachs. A test to determine whether an infant is carrying the Tay-Sachs disease was introduced in 1969. However, work continues to be done to help find a cure. Because there is no cure for this deadly disease, genetic research is essential. Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.

Download or read book Lysosomes written by Paul Saftig and published by Springer Science & Business Media. This book was released on 2005-08-03 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

Download or read book Australian National Bibliography written by and published by . This book was released on 1983 with total page 1676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Film Directors written by Michael Singer and published by Lone Eagle Publishing Company, LLC. This book was released on 1993 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Macrophage as Therapeutic Target written by J. M. Aerts and published by Springer Science & Business Media. This book was released on 2003-07-10 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts

Download or read book CBT Case Formulation as Therapeutic Process written by Giovanni Maria Ruggiero and published by Springer Nature. This book was released on 2021-04-09 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reasserts the importance of case formulation as the first step in implementing effective cognitive behavioral therapies (CBT), centering it as the main operative tool of CBT approaches by which the therapist handles the whole psychotherapeutic process. Chapters discuss specific CBT interventions and components of the treatment, aspecific factors including therapeutic alliance and relationship, and theoretical and historical background of CBT practices. In addition, the book assumes that in CBTs the case formulation is a procedure which is continuously shared and reevaluated between patient and therapist throughout the course of treatment. This aspect is increasingly becoming the distinguishing feature of CBT approaches as it embodies CBT's basic tenets and implies full confidence in patients’ conscious agreement, transparent cooperation and explicit commitment with CBT’s model of clinical change.