Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Download or read book Autism Spectrum Disorders written by Stephen Deutsch and published by BoD – Books on Demand. This book was released on 2011-08-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.
Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.
Download or read book Copy Number Variations in Autism Spectrum Disorders written by Marina Konyukh and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genome wide Copy Number Variation in Autism Spectrum Disorders written by Brooke Sheppard and published by . This book was released on 2012 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Early Intervention in Psychotic Disorders written by Tandy Miller and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Early Intervention in Psychiatric Disorders, Prague, Czech Republic, October 22-27, 1998
Download or read book Early Start Denver Model for Young Children with Autism written by Sally J. Rogers and published by Guilford Publications. This book was released on 2020-05-14 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: From leading authorities, this state-of-the-art manual presents the Early Start Denver Model (ESDM), the first comprehensive, empirically tested intervention specifically designed for toddlers and preschoolers with autism spectrum disorder. Supported by the principles of developmental psychology and applied behavior analysis, ESDM’s intensive teaching interventions are delivered within play-based, relationship-focused routines. The manual provides structured, hands-on strategies for working with very young children in individual and group settings to promote development in such key domains as imitation; communication; social, cognitive, and motor skills; adaptive behavior; and play. Implementing individualized treatment plans for each child requires the use of an assessment tool, the Early Start Denver Model Curriculum Checklist for Young Children with Autism. A nonreproducible checklist is included in the manual for reference, along with instructions for use; 8½" x 11" checklists are sold separately in sets of 15 ready-to-use booklets. See also the authors' related parent guide, An Early Start for Your Child with Autism.
Download or read book Population Neuroscience written by Tomas Paus and published by Springer Science & Business Media. This book was released on 2013-03-23 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is Newton’s brain different from Rembrandt’s? Does a mother’s diet during pregnancy impact brain growth? Do adolescent peers leave a signature in the social brain? Does the way we live in our middle years affect how our brains age? To answer these and many other questions, we can now turn to population neuroscience. Population neuroscience endeavors to identify environmental and genetic factors that shape the function and structure of the human brain; it uses the tools and knowledge of genetics (and the “omics” sciences), epidemiology and neuroscience. This text attempts to provide a bridge spanning these three disciplines so that their practitioners can communicate easily with each other when working together on large-scale imaging studies of the developing, mature and aging brain. By understanding the processes driving variations in brain function and structure across individuals, we will also be able to predict an individual’s risk of (or resilience against) developing a brain disorder. In the long term, the hope is that population neuroscience will lay the foundation for personalized preventive medicine and, in turn, reduce the burden associated with complex, chronic disorders of brain and body.
Download or read book DNA Copy Number Variation in Autism written by Ashwin Adur and published by . This book was released on 2009 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Autism is a childhood neurodevelopmental and psychiatric disorder that involves the impairment of social skills and communication. The genetics behind the inheritance and susceptibility of this disorder are not well known but have recently been studied. Lately, DNA Copy number variation (CNV) in autistic individuals has been a topic of high interest, and has been shown to have an association with this disorder. CNV generally refers to differences in the germ line DNA content between individuals. CNVs span from 1-kb to multi-megabases, and represent a significant portion of genetic variation in normal humans. Significant work has been done in the field of Autism Spectrum Disorder (ASD) genetics to find CNVs implicated in the development of autism and the variation of phenotype. In order to identify new disease alterations, we are conducting CNV discovery studies on 10 autistic children and their families. We expect our findings will lead to a better understanding of pathophysiology and to new avenues of therapeutic treatment. We conducted CNV discovery in 10 autistic children using array Comparative Genome Hybridization (aCGH) on a tiling-resolution whole genome BAC microarray. This platform can detect CNVs>50-kb. From the high confidence CNV calls (based on standard deviation and signal-to-noise Ratios), we filtered out all variants that are found in 4% or more of normal individuals. We have identified over 100 high confidence candidate CNVs that have rarely or never been reported previously. In addition, we have begun to determine if any variants were created de novo in the affected child (i.e., were not inherited from parents). Some candidate de novo variants span many genes and could have functional effects. We conclude that it is worth conducting more genome-wide CNV discovery in autism, and testing suggestive CNVs for association in large numbers of autism patients.
Download or read book ADHD written by Hojka Gregoric Kumperscak and published by BoD – Books on Demand. This book was released on 2021-11-24 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent neurodevelopmental disorder. Previously, it was considered a disorder that affected children only. Recently, however, there is no doubt that ADHD can affect adults as well, but with different clinical presentation. Thus, it is critical to understand how the clinical picture of the disorder changes with development. Traditional ADHD diagnostic procedures are broadening and incorporating new entities like endophenotypes. Comorbidity is a rule, especially if ADHD is not recognized and treated early. New genetic studies bring deeper and more concise knowledge about the disorder’s etiology. This book addresses these aspects of ADHD to bring about more clarity and understanding of the disorder.
Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2017-03-30 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients
Download or read book The Autisms written by Mary Coleman and published by OUP USA. This book was released on 2012-01-05 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rev. ed. of: Biology of the autistic syndromes / Christopher Gillberg, Mary Coleman. 3rd ed. 2000.
Download or read book Copy Number Variation in Chinese Patients with Autism Spectrum Disorder written by Shui-Lam Mak and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Copy Number Variation in Chinese Patients With Autism Spectrum Disorder" by Shui-lam, Mak, 麥瑞琳, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Introduction Although autism spectrum disorder (ASD) may have a multifactorial etiology, there is a strong genetic basis of the condition. With use of chromosomal microarray according to recommendation of international standards, copy number variations of uncertain significance (CNV VUS) are frequently found. The difficulty encountered in interpretation of CNV VUS may lead to challenges in genetic counselling and clinical management. In this study, we aim to study the CNV findings in Chinese children with ASD in Hong Kong, and to gather information with an aim to reclassify CNV VUS found in these children. Methods Patients with ASD of the department of Paediatrics QMH/HKU were recruited if their Array Comparative Genomic Hybridization (aCGH) were performed within the period from Jan 2011 to August 2014. Diagnosis of ASD was performed by developmental paediatricians and clinical psychologists using the Diagnostic and Statistical Manual of Mental Disorders, Fourth or Fifth Edition (DSM IV/V) criteria. The array was performed in Tsan Yuk Hospital Prenatal Diagnostic Laboratory (TYHPDL) using NimbleGen CGX-135k oligonucleotide array and Agilent CGX 60k oligonucleotide array. Array results were analyzed, information was gathered from the literature and existing databases with an aim to re-classify CNV VUS occurring in our ASD cohort. Results Among 288 patients with ASD in our cohort, 10 patients carried pathogenic or likely pathogenic CNVs (3.47%). Among the CNV VUS, we found that one CNV overlapping DPP10 (hg[19]chr2:116,534,689-116,672,358) was commonly occurring in TYHPDL database. The frequency of the CNV overlapping DPP10 in our ASD cohort was 0.35%; and 0.96% (9 from 935 individuals) in controls. The CNV was not statistically associated with ASD probands (P=0.467). The total frequency of the CNV overlapping DPP10 among all samples in TYHPDL was 1.01%. Similar CNVs were thought to be likely pathogenic in previous genetic study recruiting mainly Caucasians. However, there were individuals with typical development or not having ASD possessing similar CNVs in TYHPDL database as well as control databases focusing on Chinese population (9 in TYHPDL database, 1 in Singapore Genome Variation Project SGVP, 24 in The Singapore Prospective Study Program SP2). Conclusion Our study supported that the CNV overlapping DPP10 observed in our cohort may be more prevalent among Chinese and the study seemed to suggest that it was a CNV polymorphism among Hong Kong Chinese. This result would reclassify the CNV VUS to be likely benign in our locality. It also re-emphasized the need to account for ancestry and ethnicity for the precise interpretation of clinical microarray data. Subjects: Autism spectrum disorders in children - Genetic aspects
Download or read book Stem Cell Epigenetics written by and published by Academic Press. This book was released on 2020-08-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. Analyzes the role of epigenetics in embryonic stem cell regulation Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting Features chapter contributions by leading international experts
Download or read book The Neuroscience of Autism Spectrum Disorders written by Joseph D. Buxbaum and published by Academic Press. This book was released on 2012-10-25 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available
Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Download or read book A Genomic Copy Number Variation Study in Autism Spectrum Disorder written by Rachel Greenblatt and published by . This book was released on 2007 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt:
