Download or read book Context Dependency of Renin Angiotensin Aldosterone System Genes in Relation to Left Ventricular Structure written by Tatiana Kuznetsova and published by Leuven University Press. This book was released on 2004-09 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Variation in Sodium Regulating Genes in Relation to Blood Pressure and Associated Phenotypes in Caucasians and Chinese written by Jiguang Wang and published by Leuven University Press. This book was released on 2004-09 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Modulators of Pulmonary Function in Cystic Fibrosis and Genetic Susceptibility Factors of Emphysema written by Jennifer S. Yarden and published by Leuven University Press. This book was released on 2005 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardioselective Nitric Oxide Synthase Gene Transfer to Target Myocardial Ischemia written by Zsolt Szelid and published by Leuven University Press. This book was released on 2005 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.
Download or read book Genetic Variation and Environmental Factors in Biological and Arterial Ageing written by Tim Nawrot and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.
Download or read book Genetic Analysis of Herpesvirus Entry Receptors and Host Susceptibility to Herpes Simplex Virus Infection written by Frank Struyf and published by Leuven University Press. This book was released on 2004-09 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural and Functional Repercussions of Loss of Function and Clinical Mutants of Presenilin written by Omar Nyabi and published by Leuven University Press. This book was released on 2005 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
Download or read book Cell Repopulation of Bioprosthetic Heart Valves written by Jessa Yperman and published by Leuven University Press. This book was released on 2006 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemical Characterization and Validation of the Yeast Saccharomyces Cerevisiae as Model System for the Function of Human Protein Tau written by Tom Vandebroek and published by Leuven University Press. This book was released on 2006-09 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanism and Role of Cyclooxygenase 2 Up Regulation by Photodynamic Therapy written by Nico Hendrickx and published by Leuven University Press. This book was released on 2006 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Between Facts and Norms written by Pascal Borry and published by Leuven University Press. This book was released on 2005 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mouse Model for Chemical Induced Asthma written by Jeroen Vanoirbeek and published by Leuven University Press. This book was released on 2004-09 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neonatal Analgesia written by Karel Allegaert and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Measurement of CYP 3A4 and P GP Activity in Vivo Using Dynamic Breath and Urine Analysis written by Wim Lemahieu and published by Leuven University Press. This book was released on 2005 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. Contents include: General introduction, Measurement of intestinal CYP3A4 and P-Glycoprotein activity by a combined oral and intravenous 14C-Erythromycin breath and urine test, Alterations of CYP3A4 and P-Glycoprotein activity in vivo with time in renal graft recipients, CYP3A4 and P-Glycoprotein activity in healthy controls and transplant patients on cyclosporine vs. Tacrolimus vs. Sirolimus, Impact of gastric acid suppressants on cytochrome P450 3A4 and P-Glycoprotein: consequences for FK506 assimilation, Diarrhoea after transplantation: impact on cytochrome P4503A4/P-Glycoprotein and assimilation of calcineurin inhibitors, Discussion.
Download or read book Fatty Acid Synthase written by Ellen De Schrijver and published by Leuven University Press. This book was released on 2005 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fatty acid synthase (FAS) is a key lipogenic enzyme catalyzing the terminal steps in the synthesis of fatty acids. In the majority of normal tissues, FAS expression is low. In many human cancers, however, including cancer of the prostate, FAS expression and FAS activity are very high. As shown in the laboratory, overexpression of FAS in tumor cells is part of a more general and coordinate upregulation of multiple lipogenic genes caused, at least in part, by activation of sterol regulatory element binding proteins (SREBPs), transcription factors that play a key role in cellular lipid homeostasis. The mechanisms underlying the activation of the SREBP pathway and the increase in lipogenesis in tumor cells as well as the ultimate biological significance of this phenomenon remain poorly understood. Nonetheless there is evidence that overexpression of lipogenic genes occurs early in tumor development and that the degree of overexpression correlates with increasing tumor grade. Moreover, a number of studies suggest that inhibition of FAS selectively reduces proliferation of tumor cells and causes apoptosis, implying that FAS and other lipogenic enzymes may constitute interesting targets for antineoplastic therapy.
Download or read book Salivary and Mammary Gland Tumorigenesis in PLAG1 Transgenic Mice written by Isabella C. C. van Valckenborgh and published by Leuven University Press. This book was released on 2005 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. Contents include: Introduction: The normal salivary gland, Salivary gland tumors, Pleomorphic adenoma of the salivary glands, PLAG1, Unraveling human cancer using the mouse as a model system, Salivary gland transgenesis; Aims and Rationale; Material and Methods: Immunohistochemistry, Cytogenetic analysis, FISH analysis, Immunoflourescence, Cloning strategies, DNA sequencing, Transfections and luciferase assay, Western blot analysis, Generation of transgenic mouse strain by zygote micro-injection, PCR analysis, Isolation of RNA, Northern blot analysis, Isolation of DNA, Southern blot analysis, Labeling of DNA probes, Histology, Gene expression profiling; Results: Immunohistological localization studies of PLAG1 in human pleomorphic adenoma of the salivary gland, Human PLAG1 transgenic mouse strain, Study of PLAG1 and PLAGL2 target genes by microarray analysis; Discussion and Perspectives: Immunohistological localization studies of PLAG1 in the human pleomorphic adenoma of the salivary gland, Human PLAG1 transgenic mouse strain, Study of PLAG1 and PLAGL2 target genes by microarray analysis; General conclusions; Summary; References.
Download or read book A Prospective Study of Risk Factors for Low Back Disorders in Occupational Settings written by An van Nieuwenhuyse and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
