Download or read book Computational Optical Coherence Tomography for Polarization sensitive Imaging Aberration Correction and Wavefront Measurement written by Fredrick A. South and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Wavefront Sensorless Adaptive Optics Swept Source Optical Coherence Tomography at 1060nm written by Sujin Tom Lee and published by . This book was released on 2015 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) has revolutionized modern ophthalmology, providing depth resolved images of the retinal layers in a system that is suited to a clinical environment. A limitation on the performance and utilization of the OCT systems has been the lateral resolution; whereas the axial resolution is a function of the light source, the lateral resolution is dependent on the delivery optics. In this thesis, a compact lens based OCT system is presented that is capable of imaging the different retinal layers at a cellular lateral resolution with the combination of wavefront sensorless adaptive optics with dual variable optical elements. The central operating imaging wavelength of the wavelength swept OCT engine was 1060nm, close to the dispersion minimum of water (and the vitreous humor in the eye). A commercially available variable focal length lens is utilized to correct for a wide range of defocus commonly found in patient's eyes, and a multi-actuator deformable lens for aberration correction to obtain near diffraction limited imaging at the retina. A parallel processing computational platform permitted real-time image acquisition and display. Cross-sectional images of the retinal layers and en face images of the cone photoreceptor mosaic acquired in vivo from research subjects are presented.
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Download or read book Development and Application of Optical Coherence Tomography OCT written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. - Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. - Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.
Download or read book Optical Coherence Tomography Instrumentation and Application written by Yueli Chen and published by . This book was released on 2006 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.
Download or read book Application of Polarization Sensitive Optical Coherence Tomography PS OCT and Phase Sensitive Optical Coherence Tomography PhS OCT for Retinal Diagnostics written by Amit Shrikant Paranjape and published by . This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Enhanced Polarization-Sensitive Swept Source Optical Coherence Tomography (EPS-SS-OCT) instrument for high sensitivity cross-sectional imaging of Retinal Nerve Fiber Layer (RNFL) has been designed, constructed, and verified. The instrument is capable of measuring the thickness and birefringence of the RNFL. Birefringence change of the RNFL could serve as an early indicator of glaucoma. The associated image processing methods for completely automated, time efficient algorithm to segment the RNFL in images of the human retina recorded by the EPS-SS-OCT. Detected RNFL boundaries are used to compute peripapillary thickness maps. Numerical algorithms to compute the birefringence of the detected RNFL layer are presented along with the associated phase retardation and birefringence peripapillary maps. Glaucoma affects the vitality of retinal ganglion cell axons in the retinal nerve fiber layer (RNFL) and may be clinically detected through a change in RNFL birefringence. Comprehensive peripapillary maps of healthy and glaucoma suspect human RNFL birefringence were constructed using EPS-SS-OCT. Presence of macrophages is a hallmark of several retinal diseases such as drusen and age related macular degeneration. Application of photothermal Optical Coherence Tomography (OCT) to detect macrophages in ex vivo arteries which have engulfed nanoclusters of gold coated iron oxide (nanorose) is reported. Nanorose engulfed by macrophages in arteries absorb incident laser (800nm) energy and cause optical pathlength (OP) variation which is measured using photothermal OCT. OP variation in polydimethyl siloxane tissue phantoms containing varying concentrations of nanorose match values predicted from nanoparticle and material properties. Measurement of OP variation in arteries in response to laser excitation provides an estimate of nanorose concentration in arteries 2.5x109 particles/ml. OP variation in nanoparticle containing artery sections and tissue phantoms taking up nanorose has a different magnitude and profile from that observed in control aorta and phantoms without macrophages and is consistent with macrophage presence as identified with RAM-11 histology staining. Our results suggest that tissue regions with macrophages taking up nanorose can be detected using photothermal OCT.
Download or read book Development and Application of Polarization Sensitive Optical Coherence Tomography written by Peijun Tang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension of OCT, polarization sensitive optical coherence tomography (PSOCT) enables 3D imaging of the anisotropic biological samples, such as scar, tendon, muscle, collagen, and nerve fiber bundles. This thesis focuses on the development and application of PSOCT. This goal includes four specific aims. The first aim is to develop a single input PSOCT imaging system with an improved image contrast. To achieve this aim, the polarization state is utilized as the imaging parameter and visualized using the Stokes parameters-based color-encoded algorithm. The second aim is to develop an algorithm that can derive depth-resolved polarization parameters with the single input PSOCT system. Towards this aim, a PSOCT-based polarization state transmission model is proposed. Based on this model, a novel method that utilizes discrete differential geometry (DDG) combined with a series of 3D rotations is developed to derive the local axis orientation and phase retardation. The third aim is to use the developed DDG-based PST method to extract the collagen organization embedded within the soft biological tissues. To achieve this aim, the proposed method is utilized to image the local axis orientation of the collagen fibers of the rodent heart and human facial skin. The fourth aim is to use the multiparameter provided by the PSOCT to detect and characterize the white spot lesions in the enamel of the tooth. Towards this aim, multiple parameters in the PSOCT: scattering, attenuation, degree of polarization (DOP), local axis orientation, and local phase retardation of the sample are provided simultaneously for the comprehensive investigation of the location, depth, and severity of the white spot lesions.
Download or read book Adaptive Optics Optical Coherence Tomography for in Vivo Retinal Imaging written by Yifan Jian and published by . This book was released on 2014 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive micrometer-resolution volumetric imaging modality that has been employed in diverse applications. In this thesis, we first describe a GPU accelerated program to perform FDOCT data processing and real time 3D volumetric rendering. The real time visualization of volumetric images provided by the GPU acceleration was essential to the rest of the work described in this thesis. Small animal models of retinal diseases serve as a vital component in vision research, and non-invasive in vivo imaging is becoming an increasingly important tool in the field. We describe the first adaptive optics optical coherence tomography (AOOCT) imaging system for high resolution mouse retinal imaging. Images of mouse retina acquired with AOOCT showed significant improvement in the brightness and contrast of capillaries and nerve fiber bundles. However, the accuracy of wavefront sensing limited the performance of AOOCT. A novel wavefront sensorless adaptive optics (WSAO) OCT system was developed to overcome the issues associated with conventional wavefront sensing. Combination of WSAO with OCT allows coherence gated, depth resolved aberration correction. Images of both pigmented and albino mouse retinas acquired using WSAO OCT system demonstrated superior image quality. The real time high resolution WSAO OCT was leveraged for a time course study of laser exposure in the retina.
Download or read book Image Processing for Phase Sensitive Optical Coherence Tomography written by Bettina Heise and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2010-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase-sensitive imaging techniques, suitable for investigating structures in the micron range, are discussed in this book with a focus on optical coherence tomography (OCT). The probed samples are mostly of technical nature, but the methods in general are not restricted to technical applications. Moreover, several imaging aspects, originating from biological applications, recently have been transferred to technical material sciences. OCT imaging is presented here mainly by its phase-sensitive modifications: polarization-sensitive OCT (PS-OCT) and differential phase contrast OCT (DPC-OCT). The comparison to quantitative imaging in phase contrast microscopy techniques has been drawn to illustrate the similarities, differences, and limitations of both techniques. The potential for appropriate image processing is demonstrated in this context to obtain improved quantitative and localized information about specimens and material behavior. The book connects the field of optics, mathematics, and image processing from an interdisciplinary point of view.
Download or read book Optical Coherence Tomography for Retinal Diagnostics written by Biwei Yin and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OCT systems for application in ophthalmology, including polarization-sensitive optical coherence tomography (PS-OCT) for retinal nerve fiber layer (RNFL) birefringence measurement and dual-wavelength photothermal optical coherence tomography (DWP-OCT) for microvasculature blood oxygen saturation (SO2) measurement. In the study, a single-mode-fiber based polarization-sensitive swept-source OCT (PS-SS-OCT) with polarization modulator, polarization-sensitive bulk-optics balanced detection module is constructed and polarization processing methods based on Stokes vectors are applied to determine birefringence. PS-OCT is able to provide human subject's RNFL thickness, phase retardation, and birefringence information. Degradation in the degree of polarization (DOP) along depth is investigated and its difference between four quadrants of RNFL (superior, temporal, inferior and nasal) indicates the structural property difference. DWP-OCT is a novel functional OCT system consisting of a phase-sensitive optical coherence tomography system (PhS-OCT) and two photothermal excitation lasers. PhS-OCT is based on a swept-source laser operating in the 1060 nm wavelength range; the two photothermal excitation lasers with wavelength 770 nm and 800 nm are intensity modulated at different frequencies. PhS-OCT probe beam and two photothermal excitation beams are combined and incident on the sample, optical pathlength (op) change on the sample introduced by two photothermal excitation beams are measured and used for blood SO2 estimation. A polarization microscope is proposed for future study. The polarization microscope is an imaging technique providing molecular structure and orientation based on probe light's polarization state information. The polarization microscope uses a wavelength tunable light source, and can achieve any incident polarization state by a retarder-rotator combination. Specimen's birefringence can be determined based on the changing of detected light amplitude.
Download or read book Retinal Optical Coherence Tomography Image Analysis written by Xinjian Chen and published by Springer. This book was released on 2019-07-05 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.
Download or read book High speed Polarization sensitive Optical Coherence Tomography Toward Intraoperative Cancer Imaging written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Polarization in Biomedical Applications written by Valery V. Tuchin and published by Springer Science & Business Media. This book was released on 2006-10-12 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Download or read book Visible Light Wavefront Sensorless Adaptive Optics Optical Coherence Tomography written by Christine Huang and published by . This book was released on 2018 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) imaging has predominantly been performed using wavelengths in the near-infrared, however visible light (Vis) has been recently demonstrated, showing encouraging results for high quality retinal imaging. Using a broadband supercontinuum visible light source, a sensorless adaptive optics (SAO) multi-modal imaging system is presented driven by Vis-OCT for volumetric structural imaging, followed by acquisition of fluorescence emission from the sample. The coherence-gated, depth resolved Vis-OCT images can be used for image-guided SAO aberration correction when the fluorescent signal is too weak, providing structural and functional images with high resolution.
