Download or read book Computational Model of Local Intravascular Drug Delivery written by Brinda Balakrishnan and published by . This book was released on 2007 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: (cont.) Drug release over several minutes maximized peak arterial drug concentrations, though arterial drug levels were not sustained. Mural thrombus did not alter the rate of drug release from a stent; however, clots increased local drug availability and reduced the extent of drug washout. Subsequently, variability in mural thrombi formation caused fluctuations in arterial drug levels. Computational modeling revealed that free diffusion of hydrophobic drugs was slower than experimental arterial drug absorption. Subsequently, a novel mechanism for arterial drug transport has been proposed in which drug diffuses faster through the arterial wall due to its association with carrier proteins. Within this thesis, we have elucidated that device, patient, and physician-dependent device implantation are among the factors governing arterial drug deposition; these subsequently dictate local efficacy and toxicity. Thus, rational design of improved local therapeutics requires consideration of how multiple interrelated factors intrinsic and extrinsic to the device determine local efficacy and toxicity.

Download or read book Sirolimus Eluting Stents written by Patrick W. Serruys and published by CRC Press. This book was released on 2004-11-29 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, sirolimus-eluting stents implantation has been shown to decrease restenosis markedly in selected patients. Nonetheless, the effects of SES implantation in complex, unselected patients, such as those commonly treated in daily practice ('the real world'), remains largely unknown. This book comprehensively evaluates the impact of SES implantation on the outcomes of patients treated in the real world of interventional cardiology. The authors have evaluated in detail the short- and long-term outcomes of several high-risk subsets not currently included in randomized trials. While it is specific to sirolimus, the book covers the major competing drug eluting stents, including paclitaxel.

Download or read book Coronary and Endovascular Stents An Issue of Interventional Cardiology Clinics E Book written by Sahil A. Parikh and published by Elsevier Health Sciences. This book was released on 2016-07-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Interventional Cardiology Clinics, edited by Dr. Sahil Parikh, is entitled "Coronary and Endovascular Stents" and covers a wide array of topics. Subjects covered include, but are not limited to, a historical review of stent development; the rationale for stenting; principles of stent design; the role of stent composition and surface modification; endovascular drug delivery and drug elution systems; design and clinical considerations for BRS and endovascular stent grafts; the pathology of endovascular stents, and stent failures.

Download or read book Microfluidics written by Yujun Song and published by John Wiley & Sons. This book was released on 2018-01-04 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.

Download or read book 13th International Conference on Biomedical Engineering written by Chwee Teck Lim and published by Springer Science & Business Media. This book was released on 2009-03-15 with total page 2355 pages. Available in PDF, EPUB and Kindle. Book excerpt: th On behalf of the organizing committee of the 13 International Conference on Biomedical Engineering, I extend our w- mest welcome to you. This series of conference began in 1983 and is jointly organized by the YLL School of Medicine and Faculty of Engineering of the National University of Singapore and the Biomedical Engineering Society (Singapore). First of all, I want to thank Mr Lim Chuan Poh, Chairman A*STAR who kindly agreed to be our Guest of Honour to give th the Opening Address amidst his busy schedule. I am delighted to report that the 13 ICBME has more than 600 participants from 40 countries. We have received very high quality papers and inevitably we had to turndown some papers. We have invited very prominent speakers and each one is an authority in their field of expertise. I am grateful to each one of them for setting aside their valuable time to participate in this conference. For the first time, the Biomedical Engineering Society (USA) will be sponsoring two symposia, ie “Drug Delivery S- tems” and “Systems Biology and Computational Bioengineering”. I am thankful to Prof Tom Skalak for his leadership in this initiative. I would also like to acknowledge the contribution of Prof Takami Yamaguchi for organizing the NUS-Tohoku’s Global COE workshop within this conference. Thanks also to Prof Fritz Bodem for organizing the symposium, “Space Flight Bioengineering”. This year’s conference proceedings will be published by Springer as an IFMBE Proceedings Series.

Download or read book Advanced Computational Methods in Life System Modeling and Simulation written by Minrui Fei and published by Springer. This book was released on 2017-09-01 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-volume set CCIS 761, CCIS 762, and CCIS 763 constitutes the thoroughly refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2017, and of the International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, held in Nanjing, China, in September 2017. The 208 revised full papers presented were carefully reviewed and selected from over 625 submissions. The papers of this volume are organized in topical sections on: Biomedical Signal Processing; Computational Methods in Organism Modeling; Medical Apparatus and Clinical Applications; Bionics Control Methods, Algorithms and Apparatus; Modeling and Simulation of Life Systems; Data Driven Analysis; Image and Video Processing; Advanced Fuzzy and Neural Network Theory and Algorithms; Advanced Evolutionary Methods and Applications; Advanced Machine Learning Methods and Applications; Intelligent Modeling, Monitoring, and Control of Complex Nonlinear Systems; Advanced Methods for Networked Systems; Control and Analysis of Transportation Systems; Advanced Sliding Mode Control and Applications; Advanced Analysis of New Materials and Devices; Computational Intelligence in Utilization of Clean and Renewable Energy Resources; Intelligent Methods for Energy Saving and Pollution Reduction; Intelligent Methods in Developing Electric Vehicles, Engines and Equipment; Intelligent Computing and Control in Power Systems; Modeling, Simulation and Control in Smart Grid and Microgrid; Optimization Methods; Computational Methods for Sustainable Environment.

Download or read book Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems written by Kamal Dua and published by Academic Press. This book was released on 2020-08-04 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. - Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases - Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases - Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Download or read book Endovascular Treatment of Peripheral Artery Disease and Critical Limb Ischemia An Issue of Interventional Cardiology Clinics E Book written by Ehrin J. Armstrong and published by Elsevier Health Sciences. This book was released on 2017-03-07 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Interventional Cardiology Clinics, guest edited by Dr. Ehrin Armstrong, will cover a wide variety of aspects of Endovascular Treatment of PAD and Critical Limb Ischemia. Topics covered in the issue include, but are not limited to: Current Status and Outcomes of Iliac Artery Endovascular Intervention; Current Endovascular Management of Acute Limb Ischemia; Mechanisms Underlying Drug Delivery to Peripheral Arteries; Biological Mechanisms of Restenosis After Endovascular Intervention; Drug Coated Balloons; Current Role of Atherectomy for Treatment of Femoropopliteal and Infrapopliteal Disease; Inframalleolar Intervention and Extreme Access for Limb Preservation; and Emerging and Future Therapeutic Options for Femoropopliteal and Infrapopliteal Endovascular Intervention, among others.

Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Download or read book Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers written by Emmanuel Garcion and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanomedicine written by Mingjun Zhang and published by CRC Press. This book was released on 2019-05-08 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a fundamental and comprehensive overview of nanomedicine from a systems engineering perspective, making it the first book in the field of quantitative nanomedicine based on systems theory. The book starts by introducing the concept of nanomedicine and provides basic mathematical modeling techniques that can be used to model nanoscale biomedical and biological systems. It then demonstrates how this idea can be used to model and analyze the central dogma of molecular biology, tumor growth and the immune system. Broad applications of the idea are further illustrated by Bayesian networks, multiscale and multiparadigm modeling and AFM engineering.

Download or read book Computational Modeling for Assessing Coronary Artery Pathophysiology written by Christos Bourantas and published by Frontiers Media SA. This book was released on 2022-09-27 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanotechnology Methods for Neurological Diseases and Brain Tumors written by Yasemin Gürsoy Özdemir and published by Academic Press. This book was released on 2017-07-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer's, Parkinson's and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Gerard Marshall Raj and published by Springer Nature. This book was released on 2019-11-16 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Download or read book Advances in Heat Transfer written by and published by Academic Press. This book was released on 2015-10-27 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heat Transfer fills the information gap between regularly scheduled journals and university-level textbooks by providing in-depth review articles over a broader scope than in traditional journals or texts. The articles, which serve as a broad review for experts in the field are also of great interest to non-specialists who need to keep up-to-date with the results of the latest research. This serial is essential reading for all mechanical, chemical, and industrial engineers working in the field of heat transfer, or in graduate schools or industry. Compiles the expert opinions of leaders in the industry Fills the information gap between regularly scheduled journals and university-level textbooks by providing in-depth review articles over a broader scope than in traditional journals or texts Essential reading for all mechanical, chemical, and industrial engineers working in the field of heat transfer, or in graduate schools or industry