Download or read book Comprehensive Natural Products Chemistry Enzymes enzyme mechanisms proteins and aspects of NO chemistry written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Download or read book Comprehensive Natural Products Chemistry written by Derek Barton and published by Newnes. This book was released on 1999-02-18 with total page 11380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products Chemistry

Download or read book Encyclopedia of Biological Chemistry written by and published by Academic Press. This book was released on 2013-01-08 with total page 3223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension

Download or read book Comprehensive Natural Products Chemistry DNA and aspects of molecular biology written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume is intended to cover the chemistry of one of the most widely studied and important natural products, DNA. Discussed in detail are physicochemical properties of the molecule itself as well as small-molecule natural products that are known to interact with it. Also included are methods to synthesize and manipulate DNA and modified analogues. Twenty chapters are devoted to this overall topic.The first five relate to the structure of DNA; the first focuses on thermodynamics and kinetics of double helix formation; the next two describe triple- and tetra- helical structures formed by DNA; and the last two focus on methods for probing DNA structure (specifically, NMR methods and chemical probing methods, respectively).Chapters 6-12 focus on the chemistry of natural DNA and modified analogues. The first of these addresses nonenzymatic methods for synthesizing DNA, and the next chapter, on methods for attachment of reporter groups t

Download or read book Comprehensive Natural Products II written by and published by Elsevier. This book was released on 2010-03-05 with total page 7944 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Download or read book Chemistry of Plant Phosphorus Compounds written by Arlen Frank and published by Elsevier. This book was released on 2013-06-03 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a high level reference source for scientists engaged in any aspect of plant research - chemistry, biochemistry or physiology - with primary focus on the chemistry of phosphorus-containing compounds that occur naturally in the plant kingdom, and specifically in the higher plants (Plantae). The book is comprehensive with respect to nomenclature, physical properties, and distribution worldwide. There are many tables of actual data on phosphorus compounds occurring in whole plants and parts of plants. The tables provide detailed data that is needed by the food industry, agriculture, etc as many of the phosphorus compounds are common to both plants and animals. Two appendices cover other aspects including changes in phosphorus-containing compounds during germination and their accumulation during growth and senescence. The final sections of the book comprise separate indexes of plants, compounds and authors. Comprehensive examination of phosphorus compounds found in plants Extensive tables listing types of compounds and their occurrence in plants including: Nomenclature; Occurrence; Physical Properties; Synthesis; Hydrolysis; Phosphorylation; Extraction; Separation and Analysis Easy to use indexes of plants, compounds and authors

Download or read book Comprehensive Natural Products Chemistry Prebiotic chemistry molecular fossils nucleosides and RNA written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This 19-chapter volume summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and several chapters reviewing the latest advances in our understanding of the vast array of biological processes in which RNA is involved.The first five chapters deal with different approaches available to study RNA structure, covering NMR solution studies of secondary structure, thermodynamics, X-ray crystallographic approaches, RNA dynamics and the role of RNA structures in RNA: protein interactions.Three chapters are focused on RNA chemistry covering chemical and enzymatic probes for RNA, chemical RNA synthesis and the chemist

Download or read book Comprehensive Natural Products Chemistry Isoprenoids including carotenoids and steroids written by Derek H. R. Barton and published by Pergamon. This book was released on 1999 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume covers the dramatic advances which have been made in the lasttwo decades in the understanding of isoprenoid biosynthesis at thechemical, biochemical, and molecular genetic level. Tens of thousands ofisoprenoid metabolites - from pinenes to cholesterol, from ubiquinone tocarotene, from phytols to prenylated proteins, from dolichols togibberellins - have been isolated from essentially all forms of life, including prokaryotes, eukaryotes, and archaebacteria: from Escherichiacoli to mammals, from extremophiles and fungi to marine and terrestrialplants. All of these isoprenoids can be derived from a single, five-carbonacyclic precursor, isopentenyl diphosphate. Early chapters in this Volumedetail the key findings that have led to an understanding of the metabolicpathways leading to isopentenyl diphosphate, including both the classicalroute involving mevalonic acid as well as the recently discoveredpyruvate-triose phosphat

Download or read book Organic Syntheses Based on Name Reactions and Unnamed Reactions written by Alfred Hassner and published by Elsevier. This book was released on 2013-10-22 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.

Download or read book Comprehensive Natural Products Chemistry Miscellaneous natural products including marine natural products pheromones plant hormones and aspects of ecology written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Volume 8 summarizes the chemistry of various biofunctional molecules and bioactive natural products of both terrestrial and marine origin. In accord with the recent trend of research in this area, ecological significance of bioactive natural products is emphasized throughout the volume. A short introductory chapter describes the progress in this field in general and stresses the importance of chirality in natural products chemistry. Chemistry of plant hormones is treated in depth in Chapter 2, covering the auxins, gibberellins, cytokinins, abscisic acid, ethylene, brassinosteroids and jasmonic acid. Chapter 3 on plant chemical ecology includes plant-animal interactions, plant-plant interactions and plant-microbe interactons. Chapter 4 on insect pheromones, kairomones and allomones is structured according to the carbon skeleton of each compound, considering its biogenetic pathways. Chapter 5 describes insect hormones (juvenile hormones, moultin

Download or read book Comprehensive Natural Products Chemistry Amino acids peptides porphyrins and alkaloids written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume covers the exciting advances made in the chemistry, biochemistry and molecular biology of amino acid, peptide and alkaloid biosynthesis. The fourteen chapters in this volume briefly introduce classical approaches to deciphering biosynthetic pathways, but largely focus on a synergistic approach, i.e. one applying both chemical and genetic methods to uncover the mysteries associated with the synthesis of some of the worlds most beautiful molecules. Two chapters review our current understanding of alkaloid biosynthesis, which provided much of the impetus for the growth of organic chemistry in the century. Two chapters are devoted to the biosynthesis of Heme prosthetic groups, which have attracted the attention of numerous chemists and biologists over the years. Five chapters focus on peptide and antibiotic biosynthesis, in keeping with the fantastic advances that have been made in understanding non-ribosomal peptide synthesis and the u

Download or read book Comprehensive Natural Products Chemistry Carbohydrates and their derivatives including tannins cellulose and related lignins written by Derek H. R. Barton and published by . This book was released on 1999 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume, containing 20 chapters, focuses on the biosynthesis of the different classes of carbohydrates and their derivatives. The first part of this volume concentrates on the three classes of glycan-bearing molecules that mediate bio-recognition events, namely, glycoproteins, glycolipids, and glycosaminoglycans. Thus, the first four chapters highlight the key role played by glycosidases and glycosyl transferases in the processing of glycan chains in glycoproteins and on inhibitors of the glycosidases. The next two chapters feature the biosynthesis of glycosphingolipids, sphingolipid transport and degradation, and the regulation of glycolipid biosynthesis in developing tissues and tumor cells. Chapter 7 is devoted to the biosynthesis of proteoglycans with particular emphasis on the glycosaminoglycans. In the second part, the volume treats the molecules of importance in protozoans and bacteria. Thus, chapter 8 describes the biosynthesis o

Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.

Download or read book Gene Therapy of Cancer written by Stanton L. Gerson and published by Elsevier. This book was released on 2002-04-04 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Provides in-depth description of targeted systems and treatment strategies Explains the underlying cancer biology necessary for understanding a given therapeutic approach Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses Presents translational focus with emphasis on requirements for clinical implementation Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Download or read book Comprehensive Natural Products Chemistry Cumulative indexes written by Derek H. R. Barton and published by . This book was released on 1999 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Elsevier. This book was released on 2024-09-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics, Second Edition, a volume within the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible view of the field, from basic principles to applications in disease therapeutics. Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.The new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges, are also discussed. Each chapter has been updated to include a chapter summary, keywords and definitions, and further color figure and charts for learning reinforcement, along with clinical research case studies illustrating key research in the field and making findings and research approaches more actionable for readers. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings, and the pharmaceutical industry Instructs researchers, students, and clinicians in better interpreting and employing pharmacoepigenetics in drug development, efficiency, and safety Incorporates recent advances, including epigenetic drugs and biomolecules with epigenetic effects in cancer, cardiovascular disorders, brain disorders, and COVID-19 Includes chapter definitions, key words, and summaries to reinforce understanding, as well clinical research case studies illustrating key research in the field