Download or read book Complement mediated Hemolytic Anemias An Issue of Hematology Oncology Clinics of North America written by Robert A. Brodsky and published by Elsevier Health Sciences. This book was released on 2015-10-20 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Robert Brodsky, is devoted to Complement-mediated Hemolytic Anemias. Articles in this outstanding issue include: Complement: An overview for the clinician; Warm autoimmune hemolytic anemia; Cold Agglutinin Disease; ABO incompatible blood transfusions; Paroxysmal cold hemoglobinuria; Paroxysmal nocturnal hemoglobinuria; Congenital CD59 deficiency; Atypical Hemolytic Uremic Syndrome (HUS); Typical Hemolytic Uremic Syndrome (HUS); Thrombotic thrombocytopenic purpura; and Pharmacologic complement inhibitors.
Download or read book Complement mediated Hemolytic Anemias written by Robert A. Brodsky and published by Elsevier. This book was released on 2015-06-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Robert Brodsky, is devoted to Complement-mediated Hemolytic Anemias. Articles in this outstanding issue include: Complement: An overview for the clinician; Warm autoimmune hemolytic anemia; Cold Agglutinin Disease; ABO incompatible blood transfusions; Paroxysmal cold hemoglobinuria; Paroxysmal nocturnal hemoglobinuria; Congenital CD59 deficiency; Atypical Hemolytic Uremic Syndrome (HUS); Typical Hemolytic Uremic Syndrome (HUS); Thrombotic thrombocytopenic purpura; and Pharmacologic complement inhibitors.
Download or read book Role of Complement Regulatory Protein Properdin in Hemolytic Anemias Caused by Complement Dysregulation written by Jin Chen and published by . This book was released on 2019 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The alternative pathway (AP) of the complement system can be activated excessively in several inflammatory diseases, particularly when there is a defect in regulatory components of the complement system. For instance, deficiency in glycosylphosphatidylinositol-anchored proteins, including complement regulators CD55 and CD59, leads to paroxysmal nocturnal hemoglobinuria (PNH), whereas defects of complement regulatory protein Factor H are associated with atypical hemolytic uremic syndrome (aHUS), both of which cause severe hemolysis and thrombotic pathologies. Despite Soliris being a breakthrough treatment for these two diseases, benefits from Soliris vary considerably among patients. Understanding the molecular mechanisms involved in complement regulation in these diseases is essential for developing new treatments. Properdin, the positive regulator of complement, is essential for complement amplification by stabilizing enzymatic convertases. In this study, the role of properdin in red blood cell (RBC) lysis and endothelial cell opsonization in these human AP-mediated diseases was addressed by developing in vitro assays using PNH patient RBCs and human primary endothelial cells, where the effects of inhibition of properdin were compared to other complement inhibitors. In in vitro PNH model using patient samples, inhibition of properdin completely prevented hemolysis on patient PNH type II and III RBCs, impairing the lysis significantly more than inhibition of Factor B, C3, and C5 (>17-fold, >68-fold, or >6-fold lower molar IC50 values, respectively, P0.0001-0.05). C5 inhibition (i.e., Soliris and OmCI) was inefficient as the IC50 could not be determined for the protection of most PNH patient RBCs from hemolysis (667nM, >25-fold than the anti-properdin MoAbs IC50). Inhibiting properdin was at least as or more efficient than the other complement inhibitors when comparing target/inhibitor ratios. In addition, using in vitro endothelial cell assays, the data indicate, for the first time, a critical role for properdin in promoting complement activation on human endothelial cells exposed to heme (a hemolysis by-product), and rH19-20 (to inhibit Factor H cell-surface protection), as occurs in aHUS. Inhibiting properdin attenuated complement activation by ~40% on endothelial cells that were exposed to heme and serum, while abolished complement activation on cells that were exposed to serum and rH19-20. Moreover, inhibition of properdin reduced complement activity by 75% on cells that were exposed to both heme and rH19-20 in the presence of serum. Altogether, the data indicate that properdin plays a key role in promoting RBC lysis and complement activation on human endothelial cells, contributing to the understanding of the pathogenesis of PNH and aHUS. Further studies aimed at determining the therapeutic value of inhibiting properdin in complement-mediated diseases, in particular those that are characterized by AP dysregulation, are warranted.
Download or read book Fast Facts Cold Agglutinin Disease written by Wilma Barcellini and published by Karger Medical and Scientific Publishers. This book was released on 2023-08-31 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold agglutinin disease (CAD) is a rare, autoimmune hemolytic anemia in which cold-reacting autoantibodies (cold agglutinins) bind to normal antigens on the surface of red blood cells during passage through the cooler peripheral circulation. These antibodies cause agglutination of red blood cells, leading to an immune response and premature destruction of the healthy red blood cells. The authors have written this resource to give clinicians the information they need to successfully diagnose and manage CAD in adult patients.
Download or read book Fast Facts Cold Agglutinin Disease written by Wilma Barcellini and published by Karger Medical and Scientific Publishers. This book was released on 2023 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold agglutinin disease (CAD) is a rare, autoimmune hemolytic anemia in which cold-reacting autoantibodies (cold agglutinins) bind to normal antigens on the surface of red blood cells during passage through the cooler peripheral circulation. These antibodies cause agglutination of red blood cells, leading to an immune response and premature destruction of the healthy red blood cells. The authors have written this resource to give clinicians the information they need to successfully diagnose and manage CAD in adult patients.
Download or read book Interpretation of Equine Laboratory Diagnostics written by Nicola Pusterla and published by John Wiley & Sons. This book was released on 2017-12-18 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures
Download or read book Acquired Immune Hemolytic Anemias written by Lawrence D. Petz and published by Churchill Livingstone. This book was released on 1980 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immune Cytopenias written by Robert McMillan and published by Churchill Livingstone. This book was released on 1983 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Silva s Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Download or read book The Veterinary ICU Book written by Wayne E. Wingfield and published by CRC Press. This book was released on 2020-06-03 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to the fundamental clinical signs of astute observation, careful differential diagnosis and analytical therapeutic decision-making in emergency veterinary settings. It clearly defines the physiological and clinical principles fundamental to the management of the critically ill small animal patient. With clear guidelines for organizing an emergency/critical care unit, the book also discusses ethical and legal concerns. The 80 expert authors have created a clinically specific resource for the specialist, residents in training, veterinary practitioners, technicians and students.Published by Teton New Media in the USA and distributed by CRC Press outside of North America.
Download or read book Chalk Talks in Internal Medicine written by Somnath Mookherjee and published by Springer Nature. This book was released on 2020-09-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.
Download or read book Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura written by Bernard S. Kaplan and published by CRC Press. This book was released on 1992-07-14 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents detailed discussions of the history, pathology, pathophysiology, and approaches to treatment of the complicated, constantly evolving syndromes known as thrombotic thromocytopenic purpura (TTP), from many different points of view. Hemolytic Uremic syndrome and Thrombotic Thrombocytopenic Purpura offers: extensive analyses of the relationship between HUS and TTP; epidemiological studies of HUS from the UK, Canada, Asia, South Africa and Argentina; investigations of non-renal complications of HUS; perspectives on atypical HUS and post-transplantation HUS; delineations of the association between verotoxin and HUS, HUS and pregnancy, and HUS and cancer and cancer tharapy; information on HUS/TTP in HIV-infected patients; explications of the pathology and pathogenesis of HUS; and approaches to treatment of HUS, prognosis, and long-term follow-up.;In addition, it covers the history and pathogenesis of TTP, von Willebrand factor abnormalities in TTP and HUS, platelet agglutinating proteins in TTP, and the treatment of TTP.;With over 2000 literature citations and figures, this book is for nephrologists, hematologists, oncologists, paediatricians, pathologists, gastroenterologists, internists, endocrinologists, infectious disease specialists, neurologists, gynaecologists, microbiologists, surgeons, geneticsts, epidemiologists, radiologists, and medical school students in these disciplines.
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Download or read book Pediatric Hematology written by Robert Wynn and published by Cambridge University Press. This book was released on 2017-02-16 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training.
Download or read book Anemia in the Young and Old written by Robert T. Means Jr. and published by Springer. This book was released on 2018-11-13 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a concise yet comprehensive overview of anemia in the young and old. The first section of the volume features age-specific diagnostic approaches to anemia, from the perinatal period to the elderly, with a particular emphasis on age-specific epidemiology, differential diagnosis, and testing. The second section focuses on specific anemia disorders, including inherited bone marrow failure syndromes, iron deficiency anemia, renal anemia, pure red cell anemia, and anemia of inflammation and chronic disease. Each chapter in this section revolves around a specific syndrome or group of syndromes, and addresses pathophysiology, diagnostic issues, natural history/prognosis, and treatment. Written by experts in the field, Anemia in the Young and Old: Diagnosis and Management is a valuable resource for clinicians and practitioners who treat the pediatric and elderly patient population afflicted with anemia.
Download or read book Hematology written by Ronald Hoffman and published by . This book was released on 2005 with total page 2821 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Haemolytic Anaemias written by Sir John Vivian Dacie and published by . This book was released on 1985 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
