Download or read book Complement Inhibitory Proteins and Their Role in Tumorigenesis written by and published by . This book was released on 2001 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complement is a major effector mechanism of the immune system. Membrane complement inhibitors on the surface of breast tumor cells, may play a crucial role in determining tumorigenesis and the outcome of antibody-mediated immunotherapy. The objective of this proposal is to determine the role of complement and complement inhibitors in tumorigenesis and to determine whether reversing the effects of tumor-expressed complement inhibitors will allow effective immune-mediated clearance of tumor cells. We have established rodent models of human cancer that are suitable for evaluating the role of complement and complement inhibitors in the growth and control of breast cancer (and is likely applicable to many types of cancer). We have shown for the first time in vivo that a complement inhibitor expressed on a tumor cell surface can promote tumor growth, and have shown that different complement associated effector mechanisms can operate to control tumor growth.
Download or read book Complement Inhibitory Membrane Proteins and Their Role in Tumorigenesis written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this is to determine the role of complement and complement inhibitors in tumorigenesis and to determine whether reversing the effects of tumor-expressed complement inhibitors will allow effective immune-mediated clearance of tumor cells. The work proposed is based on developing rodent models of human breast cancer in which human tumor cells express rodent complement inhibitors. Toward the project aims, we have: 1. Transfected various human breast cancer cell lines with rodent complement inhibitors and isolated stably expressing cell lines; 2. Shown that the expression of rat complement inhibitors on human breast cancer cells (and a neuroblastoma cell line) protects transfected cells from lysis by rat complement; 3. Established rat models of human cancer and demonstrated for the first time in vivo that a complement inhibitor expressed on a tumor cell surface can promote tumor growth. Our data strengthen the hypothesis that the modulation of complement inhibitors on a tumor cell surface will provide an effective therapy when combined with complement-activating anti-tumor antibodies. Neutralization of complement regulatory proteins may also enhance a normally ineffective cytolytic humoral immune response.
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book The Role of Complement in Tumors written by Barbara Rolfe and published by Frontiers Media SA. This book was released on 2020-03-23 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanoscience in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-08-13 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. - Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology - Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology - Coherently structured book written by experts working in the fields covered
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Download or read book Stress Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.
Download or read book Oncogene Proteins written by Peter B. Murphy and published by Nova Publishers. This book was released on 2008 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogene proteins are proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene. This new book presents the latest research in the field from around the world.
Download or read book New Advancement in Tumor Microenvironment Remodeling and Cancer Therapy written by Xiangsheng Zuo and published by Frontiers Media SA. This book was released on 2024-03-18 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor microenvironment (TME) refers to the area with non-malignant cells, signaling molecules and blood vessels that surrounds and feeds tumor cells. A tumor can change its microenvironment, and TME is also known to profoundly impact the occurrence, growth, metastasis and therapeutic response and resistance of tumors. The special paracrine characteristics, microvascular system, extracellular matrix components and stromal cells in TME promote local tumor immune suppression and could alter the penetration and distribution of drugs into tumor tissues. Accumulating evidence demonstrates that currently available tumor therapies (i.e., chemotherapy, radiotherapy, anti-vascular therapy, small molecule targeted therapy, immune checkpoint inhibitors) also in turn greatly affect the structure, function, and physical and chemical properties of TME, leading to TME remodeling. However, whether and how interaction of tumor cells and TME modeling can be dissected and targeted to further understand the underlying molecular mechanisms and establish effective new tumor therapies remains elusive.
Download or read book Negative Regulators of Innate Immunity and their Role in Host Responses to Injury and Infection 2nd edition written by Maciej Lech and published by Frontiers Media SA. This book was released on 2024-07-22 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every organism must recognize damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs) to react rapidly. The immune system requires potent negative regulators to control unnecessary or overshooting responses and balance the homeostasis in all tissues. A significant number of negative regulators of pattern recognition receptors (PRR) consist of modified innate sensors and downstream molecules that regulate inflammatory signals initiated by sterile, damage-associated inflammation as well as responses to pathogens. These conserved mechanisms contribute to immune homeostasis, maintain a constant number of immune cells, and limit the activation of the cells during frequent stimulations by antigens. The same mechanisms enable maintaining the symbiotic relationship between host and tissue microbiota. Moreover, negative regulators of PRRs play a fundamental role in the training of the host immune system and the development of immune tolerance. They ensure that the response of immune cells is precise and potent enough to eliminate the source of inflammation but do not develop into fatal inflammatory disease. The complex cellular environment in which cells are organized allows interactions between different cell types. Various environmental signals determine their phenotype, the degree of maturation, and responses. Regulatory mechanisms and molecules determine the necessity and efficiency of host defense, disease progression, and restoring of the homeostasis. Various studies have revealed the crucial role of homeostasis and mechanisms of immune-control under physiological and pathological conditions, as well as their substantial potential as a target in clinical applications. However, the molecular instruments that reshape the tissue responses remain poorly understood. In this Research Topic, we welcome contributions as Original Research, Reports, Case Reports, Reviews, Mini Reviews, and Perspective articles focusing on immunomodulatory molecules in the context of the host response to pathogen and tissue injury. Manuscripts on the following subtopics are welcome: 1. Regulation of inflammatory responses by negative regulators of diverse PRRs (TLRs, NLRs, RLRs, CLRs, etc.) 2. Maintaining of tissue homeostasis and disorders caused by an imbalance between triggers and negative regulators 3. Strategies used by pathogens targeting modifications of negative regulators
Download or read book The Neutrophil written by Jon S. Abramson and published by Oxford University Press, USA. This book was released on 1993 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third book in the group devoted to the "natural" immune system, this volume provides the ideal detailed, up-to-date overview of neutrophil function. Distilling new information alongside observations of the past, the book focuses on some of the most critical developments in currentneutrophil research. Specific examples of diseases resulting from neutrophil dysfunction and deficiency are brought to life by clinical case studies. An essential source of current research into this exciting field, this volume will be invaluable for advanced students and researchers in immunology,cell biology, and medicine.
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book AACR 2018 Proceedings Abstracts 3028 5930 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2018-04-10 with total page 2995 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interleukins in Cancer Biology written by Arseniy Yuzhalin and published by Academic Press. This book was released on 2014-06-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . - Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer - Categorizes and clarifies all interleukins based on their role in cancer - Contains comprehensive and exhaustive information on each molecule
