Download or read book Compartmental Modeling and Tracer Kinetics written by David H. Anderson and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is concerned with mathematical aspects of compartmental an alysis. In particular, linear models are closely analyzed since they are fully justifiable as an investigative tool in tracer experiments. The objective of the monograph is to bring the reader up to date on some of the current mathematical prob lems of interest in compartmental analysis. This is accomplished by reviewing mathematical developments in the literature, especially over the last 10-15 years, and by presenting some new thoughts and directions for future mathematical research. These notes started as a series of lectures that I gave while visiting with the Division of Applied ~1athematics, Brown University, 1979, and have developed in to this collection of articles aimed at the reader with a beginning graduate level background in mathematics. The text can be used as a self-paced reading course. With this in mind, exercises have been appropriately placed throughout the notes. As an aid in reading the material, the e~d of a proof is indicated by ~. Sub section titles are utilized to make it easier for the reader to skim over detailed material on a first reading and make the entire manuscript somewhat more accessible, especially to nonmathematicians in the biosciences. The preparation of this monograph has been a long task that would not have been completed without the influence of a number of individuals. I am especially indebted to H. T. Banks, J. W. Drane, J. Eisenfe1d, J. A. Jacquez, D. J.
Download or read book Tracer Kinetics in Biomedical Research written by Claudio Cobelli and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versus Noncompartmental Kinetic Parameters. 8. Parameter Estimation: Some Fundamentals of Regression Analysis. 9. Parameter Estimation in Noncompartmental Models. 10. Parameter Estimation in Compartmental Models. 11. Precursor-Product Models. Appendices. Index.
Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.
Download or read book Basic Sciences of Nuclear Medicine written by Magdy M. Khalil and published by Springer Nature. This book was released on 2021-05-26 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.
Download or read book Tracer Kinetics and Physiologic Modeling written by R.M. Lambrecht and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Imaging written by Shankar Vallabhajosula and published by Springer Science & Business Media. This book was released on 2009-07-13 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.
Download or read book Splines And Compartment Models An Introduction written by Karl-ernst Erich Biebler and published by World Scientific. This book was released on 2013-07-23 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents methods of mathematical modeling from two points of view. Splines provide a general approach while compartment models serve as examples for context related to modeling. The preconditions and characteristics of the developed mathematical models as well as the conditions surrounding data collection and model fit are taken into account. The substantial statements of this book are mathematically proven. The results are ready for application with examples and related program codes given.In this book, splines are algebraically developed such that the reader or user can easily understand and vary the numerical construction of the different kinds of spline functions. The classical compartment models of the pharmacokinetics are systematically analyzed and connected with lifetime distributions. As such, parameter estimation and model fit can be treated statistically with a varied minimum chi-square method. This method is applicable for single kinetics and also allows the calculation of average kinetics.
Download or read book Compartmental Modeling with Networks written by Gilbert G Walter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new advanced text/reference book presents compartmental models or flow models from an applications perspective. Essential topics and methods are introduced in an accessible style with many examples, providing a thorough and comprehensive presentation of compartmental models, model construction and applications.
Download or read book Compartmental Distribution Of Radiotracers written by James S. Robertson and published by CRC Press. This book was released on 2017-10-19 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of isotopic varieties of the chemical elements has had a strong impact on many branches of science. For some procedures isotopic tracers make possible methods that are simply easier or more accurate or more convenient than other methods. More importantly, however, there are some processes, particularly those involving steady-state conditions, that before the advent of isotopic tracers were considered to be not accessible to investigation, but which can be studied with these tracers. In biological studies the radioactive tracers have been especially useful because external detection methods can be employed in noninvasive or minimally invasive studies.
Download or read book Encyclopedia of Nonlinear Science written by Alwyn Scott and published by Routledge. This book was released on 2006-05-17 with total page 1107 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 438 alphabetically-arranged essays, this work provides a useful overview of the core mathematical background for nonlinear science, as well as its applications to key problems in ecology and biological systems, chemical reaction-diffusion problems, geophysics, economics, electrical and mechanical oscillations in engineering systems, lasers and nonlinear optics, fluid mechanics and turbulence, and condensed matter physics, among others.
Download or read book Nuclear Cardiac Imaging written by Ami E. Iskandrian and published by Oxford University Press, USA. This book was released on 2015-10-22 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive resource for nuclear cardiologists and nuclear clinicians on the technical, physiological, diagnostic and prognostic considerations of cardiac diagnostic techniques performed with the aid of radiopharmaceuticals.
Download or read book Youmans and Winn Neurological Surgery E Book written by H. Richard Winn and published by Elsevier Health Sciences. This book was released on 2022-01-21 with total page 7439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. - Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. - 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. - Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. - An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. - Each clinical section contains chapters on technology specific to a clinical area. - Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Download or read book Trace Elements in Man and Animals 9 written by National Research Council Canada and published by NRC Research Press. This book was released on 1997 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents papers from an international meeting of specialists from a variety of disciplines sharing an interest in trace elements. The papers are organized into broad categories covering such topics as trace element interactions in the food supply and nutrition; trace elements and genetic regulation; trace elements in pregnancy and lactation; assessment of trace element status; kinetic modelling; trace elements in the environment and food supply; trace elements, brain function, and behaviour; membrane function and cell signalling; analytical, experimental, and isotopic techniques; ethics of trace element research; defining trace element requirements of infants; trace element intervention studies; trace elements and animal production, free-radical mediated disease, and food and nutrition policy; analytical quality control; infection and immune function; trace element binding proteins; trace elements in growth and metabolism; mechanisms of trace element toxicity; and metabolic and physiological consequences of trace element deficiencies.
Download or read book General Anatomy written by Leondes and published by CRC Press. This book was released on 1997-11-01 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of anatomy systems elements and diagnosis has been revolutionized by new techniques in powerful computations, image processing, and modalities such as computer-aided tomography (CAT) and magnetic resonance, among others. It is therefore an appropriate topic to be included in this series that studies the marriage of computer capabilities and medical imaging, which exemplifies a significant manifestation of relatively recent, valuable technologies known as the second industrial revolution. A few of the issues studied in this book are boundary detection and the applications of image segmentation; functional imaging; the registration of scans of patients undergoing cranio-maxillo-facial surgery; image processing techniques for the noninvasive alternative to needle biopsy for patients with liver disease; knowledge-based diagnosis support for mammogram image analysis; and input function monitors, necessary to quantify physiologic function. This book clearly reveals the effectivene
Download or read book PET written by Michael E. Phelps and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi cians, and scientists with backgrounds from various physical, biological, and medical specialty areas. Each chapter presents material in a straightforward man ner that is well illustrated and explained. Because of the diverse audience for the book, certain chapters or sections of chapters will be of more interest than oth ers to certain segments of the readership. Chapter 1 introduces the fundamental physics upon which PET imaging sys tems is based and discusses in detail the technologies and methods used to pro duce PET images. The chapter starts out by reviewing the physics of positron emission and annihilation and explains how positron range and photon non colinearity in coincidence detection place certain limits on spatial resolution.
Download or read book Biomedical Information Technology written by David Dagan Feng and published by Academic Press. This book was released on 2019-10-22 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Information Technology, Second Edition, contains practical, integrated clinical applications for disease detection, diagnosis, surgery, therapy and biomedical knowledge discovery, including the latest advances in the field, such as biomedical sensors, machine intelligence, artificial intelligence, deep learning in medical imaging, neural networks, natural language processing, large-scale histopathological image analysis, virtual, augmented and mixed reality, neural interfaces, and data analytics and behavioral informatics in modern medicine. The enormous growth in the field of biotechnology necessitates the utilization of information technology for the management, flow and organization of data. All biomedical professionals can benefit from a greater understanding of how data can be efficiently managed and utilized through data compression, modeling, processing, registration, visualization, communication and large-scale biological computing. - Presents the world's most recognized authorities who give their "best practices" - Provides professionals with the most up-to-date and mission critical tools to evaluate the latest advances in the field - Gives new staff the technological fundamentals and updates experienced professionals with the latest practical integrated clinical applications
Download or read book Positron Emission Tomography written by Timothy H. Witney and published by Springer Nature. This book was released on 2023-11-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores key concepts and experimental design related to Positron Emission Tomography (PET) imaging that have revolutionized our understanding of human biology. The first part focuses on recent advances in radiotracer probe development to enable the detection of materials, from large macromolecules to complicated drug-like structures. The next section describes how key physiological and pathophysiological processes can be interrogated and quantifiably measured with this imaging technique. Finally, chapters examine important technological developments in the field that are revolutionizing the way these innovative PET probes are utilized in the clinic. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Positron Emission Tomography: Methods and Protocols serves as an ideal guide for researchers looking to use imaging to revolutionize the way we diagnose and treat disease.
