Download or read book Comparison of the DNA Sequences of Simian Virus 40 Required for the Synthesis of Early RNA and Viral DNA written by Gerald Zachary Hertz and published by . This book was released on 1986 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Regulation of Simian Virus 40 Transcription written by Donald Charles Rio and published by . This book was released on 1983 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Simian Virus 40 Late Leader Region Mutants written by Alice Barkan and published by . This book was released on 1983 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Simian Virus 40 DNA Replication written by Stephen Todd Smale and published by . This book was released on 1986 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis and Function of Simian Virus 40 Late RNA Species written by Peter Joseph Good and published by . This book was released on 1987 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Factors Regulating Transcription of the Simian Virus 40 Major Late Promoter written by Steven Robert Wiley and published by . This book was released on 1993 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Viral DNA Sequences in Cells Transformed by Simian Virus 40 Adenovirus Type 2 and Adenovirus Type 5 written by and published by . This book was released on 1975 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carcinogenesis Abstracts written by and published by . This book was released on 1980 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Initiation of Simian Virus 40 SV40 DNA Replication written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that during initiation of SV40 DNA synthesis, a double hexamer of T antigen forms over the origin and acts as a bidirectional helicase. The subsequent events are much less clear. In fact, the structure on which DNA synthesis begins is not known, but has been hypothesized to be the double hexamer tightly associated with cellular initiation factors replication protein A (RPA), topoisomerase I (topo I) and more loosely with DNA polymerase & alpha;/primase (pol/prim). I now demonstrate that after a double hexamer forms over small origin fragments, a new structure consisting of a single hexamer associated with DNA is generated in an ATP dependent reaction from double hexamers. This structure, called the preinitiation complex (PIC), requires about 5 minutes to form whereas double hexamers are generated within 20 seconds. Importantly, PICs can associate with RPA and topo I whereas double hexamers, which have not been converted to PICs, can only bind to topo I. PICs are not simply T antigen hexamers associated with single-stranded DNA as the latter structures were shown not to bind RPA or topo I. Topo I can bind to an RPA-associated PIC, but RPA cannot bind to a topo I-associated PIC suggesting that the binding order is RPA then topo I. Importantly, DNA synthesis activity appears to be associated with the PICs but not with double hexamers. In this dissertation, a series of mutants with single-point substitutions in the helicase domain are generated to discover activities required for initiation of DNA replication. Four of these mutants (456 RA, 460ED, 462GA, and 499DA) are normal in their ability to hydrolyze ATP and are capable of associating into double hexamers in the presence of origin DNA. Furthermore, they possess normal ability to bind to single-stranded DNA. However, they fail to melt the early palindrome region of the origin. They also are severely impaired in unwinding origin-containing DNA fragments and in carrying out a helicase reaction with an M13 partial duplex DNA substrate. Interestingly, these mutants retain some ability to perform a helicase reaction with artificial replication forks, indicating that their intrinsic helicase activity is functional. Intriguingly, these mutants have almost completely lost their ability to bind to double-stranded DNA nonspecifically. Taken together, my data indicate that structural distortion and subsequent unwinding of the origin depend upon T antigen's ability to bind to DNA nonspecifically.
Download or read book The Pattern of Simian Virus 40 and Polyoma Virus Transcription in Productively Infected Cells written by Dona Mei Lindstrom and published by . This book was released on 1973 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Virology written by Jane Flint and published by John Wiley & Sons. This book was released on 2020-08-07 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to understand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses. This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest. Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources. Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Bibliography of Epidemiology written by and published by . This book was released on 1972 with total page 1438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Tumor Viruses written by Blossom Damania and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Download or read book THE ARRANGEMENT AND EXPRESSION OF INTEGRATED VIRAL DNA SEQUENCES IN MOUSE CELLS TRANSFORMED BY SIMIAN VIRUS 40 written by MARY ANN RICARD BENDER and published by . This book was released on 1981 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: simplified in the cloned cell lines derived from the primary transformant. Many of the cell lines studied share several SV40 integration arrangements. The cloned lines have lost some viral arrangements found in the parent cells, and have acquired new arrangements. These results suggest that the SV40 integration patterns in some transformed cells are not stable due to secondary alterations of the original viral arrangement.
Download or read book Current Research on Cancer Virology written by Current Cancer Research Project Analysis Center (U.S.) and published by . This book was released on 1975 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1275 references to research projects being conducted in the United States and elsewhere. Entries arranged under 9 topics, e.g., Antiviral procedures, Viral transmission, and Other viral carcinogenesis. Entries include title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
