Download or read book The Republic of Yemen written by Marta Colburn and published by CIIR. This book was released on 2002 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Deep Learning Techniques and Optimization Strategies in Big Data Analytics written by Thomas, J. Joshua and published by IGI Global. This book was released on 2019-11-29 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many approaches have sprouted from artificial intelligence (AI) and produced major breakthroughs in the computer science and engineering industries. Deep learning is a method that is transforming the world of data and analytics. Optimization of this new approach is still unclear, however, and there’s a need for research on the various applications and techniques of deep learning in the field of computing. Deep Learning Techniques and Optimization Strategies in Big Data Analytics is a collection of innovative research on the methods and applications of deep learning strategies in the fields of computer science and information systems. While highlighting topics including data integration, computational modeling, and scheduling systems, this book is ideally designed for engineers, IT specialists, data analysts, data scientists, engineers, researchers, academicians, and students seeking current research on deep learning methods and its application in the digital industry.

Download or read book Optimization of Complex Systems Theory Models Algorithms and Applications written by Hoai An Le Thi and published by Springer. This book was released on 2019-06-15 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 112 papers selected from about 250 submissions to the 6th World Congress on Global Optimization (WCGO 2019) which takes place on July 8–10, 2019 at University of Lorraine, Metz, France. The book covers both theoretical and algorithmic aspects of Nonconvex Optimization, as well as its applications to modeling and solving decision problems in various domains. It is composed of 10 parts, each of them deals with either the theory and/or methods in a branch of optimization such as Continuous optimization, DC Programming and DCA, Discrete optimization & Network optimization, Multiobjective programming, Optimization under uncertainty, or models and optimization methods in a specific application area including Data science, Economics & Finance, Energy & Water management, Engineering systems, Transportation, Logistics, Resource allocation & Production management. The researchers and practitioners working in Nonconvex Optimization and several application areas can find here many inspiring ideas and useful tools & techniques for their works.

Download or read book Perioperative Fluid Therapy written by Robert G. Hahn and published by CRC Press. This book was released on 2016-04-19 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perioperative fluid therapy requires the correct selection, amount, and composition of fluids based on the patient's underlying pathology, state of hydration, and type and duration of surgical stress. Filling a gap in the literature, this source provides a solid foundation to practical perioperative fluid management, fluid solutions, and the utiliz

Download or read book Advances in Computational Toxicology written by Huixiao Hong and published by Springer. This book was released on 2019-05-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.

Download or read book Public Procurement and Human Rights written by Olga Martin-Ortega and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely work reflects on the role and obligations of the state as a buyer of goods and services, from the dual disciplinary perspectives of public procurement and human rights. Through theoretical and doctrinal analyses, and practice-focused case studies, it interrogates the evolving character of public procurement as an interface for multiple normative regimes and competing policies. Challenging the prevailing paradigm which subordinates human rights to narrowly-defined economic goals, insightful contributions advance a compelling case for greater inter-disciplinarity and policy coherence as crucial to realising international policies such as those embodied in the UN Guiding Principles on Business and Human Rights and 2030 Sustainable Development Goals.

Download or read book Blood Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2015-02-02 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Download or read book Handbook of Molecular Descriptors written by Roberto Todeschini and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative studies on structure-activity and structure-property relationships are powerful tools in directed drug research. In recent years, various strategies have been developed to characterize and classify structural patterns by means of molecular descriptors. It has become possible not only to assess diversities or similarities of structure databases, but molecular descriptors also facilitate the identification of potential bioactive molecules from the rapidly increasing number of compound libraries. They even allow for a controlled de-novo design of new lead structures. This is the most comprehensive collection of molecular descriptors and presents a detailed review from the origins of this research field up to present day. This practically oriented reference book gives a thorough overview of the different molecular descriptors representations and their corresponding molecular descriptors. All descriptors are listed with their definition, symbols and labels, formulas, some numerical examples, data and molecular graphs, while numerous figures and tables aid comprehension of the definitions. Cross-references throughout, a list of acronyms and notations allow easy access to the information needed to solve a specific research problem. Examples of descriptor calculations along with tables of descriptor values for a set of selected reference compounds and an up-to-date reference list add to the practical value of the book, making it an invaluable guide for all those dealing with bioactive molecules as well as for researchers.

Download or read book A Primer on QSAR QSPR Modeling written by Kunal Roy and published by Springer. This book was released on 2015-04-11 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/or properties. It explains how the sub-discipline of Cheminformatics is used for many applications such as risk assessment, toxicity prediction, property prediction and regulatory decisions apart from drug discovery and lead optimization. The authors also present, in basic terms, how QSARs and related chemometric tools are extensively involved in medicinal chemistry, environmental chemistry and agricultural chemistry for ranking of potential compounds and prioritizing experiments. At present, there is no standard or introductory publication available that introduces this important topic to students of chemistry and pharmacy. With this in mind, the authors have carefully compiled this brief in order to provide a thorough and painless introduction to the fundamental concepts of QSAR/QSPR modelling. The brief is aimed at novice readers.

Download or read book Essential Notes in General Surgery written by Mohammed Othman Almaimani and published by Trafford Publishing. This book was released on 2021-03-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Notes in General Surgery is a summary of years of work, after reading several text books, articles, attending the conferences, hospital daily rounds, and many review courses. It is précis, digested, updated and provides essential knowledge that will help you pass the board exams, especially the American, Canadian, and Saudi board exams. This book was designed to be sufficiently used by medical students, general surgery residents and senior general surgeon. The book contains basic knowledge of the anatomy, physiology, pathology as well as history, physical examination, investigation, detailed management, operative intervention, and follow-up of each disease. The material is divided into three main sections: • Basic surgical principles Fluids, hemostasis, shock, surgical infection, trauma, wound healing, and critical care • General surgery Upper GIT, Colorectal, Hepatobiliary, and Endocrine surgery • Subspecialty Pediatric, Vascular, bariatric and Thoracic surgery. For enquiries [email protected]

Download or read book De novo Molecular Design written by Gisbert Schneider and published by John Wiley & Sons. This book was released on 2013-10-10 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

Download or read book Zygomycosis Caused by Apophysomyces Elegans written by and published by . This book was released on 1985 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transvestites and Transsexuals written by Richard F. Docter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to propose a theory of transvestism and secondary transsexualism, and to provide information concerning these behaviors. My view of these topics is much like that of Benjamin (1966) and nearly all other gender researchers. It holds that a syndrome of similar behaviors can be identified, ranging from fetishism through transvestism, transgenderism, and secondary transsexualism. But de scription is one thing and explanation of causes is another. I agree with other gender researchers (e. g. , Green & Money, 1969; Stoller, 1985c) who have concluded that the causes of transvestism and transsexualism re main largely unknown. But the fact that we cannot fully explain the origins of transvestism or secondary transsexualism does not mean that a comprehensive theory is impossible. Indeed, excellent theoretical statements have been proposed concerning each of these topics (Ban croft, 1972; Buckner, 1970; Buhrich & McConaghy, 1977a; Money & Ehrhardt, 1972; Ovesey & Person, 1973, 1976; Person & Ovesey, 1974a,b; Stoller, 1968a, 1974, 1985c). It is with considerable respect, therefore, that we acknowledge both the strong shoulders on which we stand, and also the more practical fact that we have drawn heavily upon the many contributions of these researchers. The approach I have adopted has the same scientific difficulties that confronted all of these previous workers.

Download or read book NHS Plc written by Allyson M. Pollock and published by Verso. This book was released on 2006-03-17 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: An analysis of the transition from universal, publicly funded health care to New Labour's application of market principles, 'NHS plc' portrays a national institution reaching crisis point and serves as a key lesson for those concerned with health care.

Download or read book Metal Specification Theory Analysis Application written by James R. Kramer and published by CRC Press. This book was released on 1988-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an up-to-date presentation of metal speciation in soils, sediments, and water by specialists in analytical chemistry, environmental engineering, oceanography, nutrition, and soil chemistry. fate and effects-measurements-and modeling-are the major themes in this book, with overviews and examples of the significance of metal speciation to solving environmental problems, and recommendations for additional research areas. This new reference discusses separation methods, extraction techniques; bioavailability as related to humans, plants, and aquatic organisms; applications showing importance of speciation in groundwater; industrial waste treatment systems, marines and lakes, solid-solution interface; fate of organic pollutants; nature of surfaces; binding of metals to oxides and sediments (dissolved and particulate matter); interpretations of reactions in multi-ligand systems.

Download or read book Cucumber Mosaic Virus written by Peter Palukaitis and published by . This book was released on 2019 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Structure Description written by Lemont Burwell Kier and published by . This book was released on 1999 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The electrotopological state is a new approach to defining key structural features of a molecule in drug design. Combining both electronic and topological attributes, the E-State index facilitates the development of a structure - activity model, the definition of a pharmacophore, and the search through a database for similar or dissimilar compounds. The background for the method, the concept of the intrinsic state, and the E-State index as a function of the atom or group within the field of all atoms in a molecule are all described in this primer for a new structure paradigm. Software on the bundled CD-ROM allows the reader to compute and display the E-State indices for molecules, while examples in the book illustrate strategies that can be used in drug research.