Download or read book A Practical Guide to Compressor Technology written by Heinz P. Bloch and published by John Wiley & Sons. This book was released on 2006-09-18 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Complete overview of theory, selection, design, operation, and maintenance This text offers a thorough overview of the operating characteristics, efficiencies, design features, troubleshooting, and maintenance of dynamic and positive displacement process gas compressors. The author examines a wide spectrum of compressors used in heavy process industries, with an emphasis on improving reliability and avoiding failure. Readers learn both the theory underlying compressors as well as the myriad day-to-day practical issues and challenges that chemical engineers and plant operation personnel must address. The text features: Latest design and manufacturing details of dynamic and positive displacement process gas compressors Examination of the full range of machines available for the heavy process industries Thorough presentation of the arrangements, material composition, and basic laws governing the design of all important process gas compressors Guidance on selecting optimum compressor configurations, controls, components, and auxiliaries to maximize reliability Monitoring and performance analysis for optimal machinery condition Systematic methods to avoid failure through the application of field-tested reliability enhancement concepts Fluid instability and externally pressurized bearings Reliability-driven asset management strategies for compressors Upstream separator and filter issues The text's structure is carefully designed to build knowledge and skills by starting with key principles and then moving to more advanced material. Hundreds of photos depicting various types of compressors, components, and processes are provided throughout. Compressors often represent a multi-million dollar investment for such applications as petrochemical processing and refining, refrigeration, pipeline transport, and turbochargers and superchargers for internal combustion engines. This text enables the broad range of engineers and plant managers who work with these compressors to make the most of the investment by leading them to the best decisions for selecting, operating, upgrading, maintaining, and troubleshooting.

Download or read book Tier II and III Cities in India written by and published by Chillibreeze. This book was released on with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Repurposing and Repositioning written by Institute of Medicine and published by National Academies Press. This book was released on 2014-08-08 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.

Download or read book Drug Repositioning written by Michael J. Barratt and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Download or read book SARS CoV 2 and Coronacrisis written by Fr archpriest Evgeny I. Legach and published by Springer. This book was released on 2022-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is useful for administrators of different levels involved in counteracting COVID-19, surveillance professionals, clinicians, researchers specializing in epidemiology, microbiology, and infectious diseases, and politicians / legislators engaged in public health sector. We use an innovative approach of combining both epidemiological and sociological analyses, as the very problem is mainly an issue of correct governance. A team of authors from Europe, Russia and China summarizes their experience and knowledge useful for containing SARS-CoV-2 and overcoming social and managerial consequences of the pandemic. The editors are sure that sharing our different experience would help to elaborate necessary strategies, protocols, and principles that may be effectively applied in the future to avoid dramatic consequences of not only COVID-19 but also any possible epidemiological hazards for people and medicine.

Download or read book Plant Genomics and Biotechnology written by Isabelle Nickel and published by . This book was released on 2016-05-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a revolution in the field of agriculture in the last few decades which has evolved the field of plant genomics and related techniques and processes of biotechnology as well. This book comprises advanced research in this field. Most of the topics introduced in this book cover new concepts, techniques and the applications of plant genomics such as DNA recombination, genetically modified crops, genetic sequencing and mapping, genomic structures, etc. The various sub-fields of plant genomics along with technological progress that have future implications are glanced at in this book. The book is appropriate for students seeking detailed information in this area as well as for experts.

Download or read book Nonclinical Safety Assessment written by William J. Brock and published by John Wiley & Sons. This book was released on 2013-04-29 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.

Download or read book Linear Scaling Techniques in Computational Chemistry and Physics written by Robert Zaleśny and published by Springer Science & Business Media. This book was released on 2011-03-21 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Linear-Scaling Techniques in Computational Chemistry and Physics" summarizes recent progresses in linear-scaling techniques and their applications in chemistry and physics. In order to meet the needs of a broad community of chemists and physicists, the book focuses on recent advances that extended the scope of possible exploitations of the theory. The first chapter provides an overview of the present state of the linear-scaling methodologies and their applications, outlining hot topics in this field, and pointing to expected developments in the near future. This general introduction is then followed by several review chapters written by experts who substantially contributed to recent developments in this field. The purpose of this book is to review, in a systematic manner, recent developments in linear-scaling methods and their applications in computational chemistry and physics. Great emphasis is put on the theoretical aspects of linear-scaling methods. This book serves as a handbook for theoreticians, who are involved in the development of new efficient computational methods as well as for scientists, who are using the tools of computational chemistry and physics in their research.

Download or read book Reverse Hypothesis Machine Learning written by Parag Kulkarni and published by Springer. This book was released on 2017-03-30 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces a paradigm of reverse hypothesis machines (RHM), focusing on knowledge innovation and machine learning. Knowledge- acquisition -based learning is constrained by large volumes of data and is time consuming. Hence Knowledge innovation based learning is the need of time. Since under-learning results in cognitive inabilities and over-learning compromises freedom, there is need for optimal machine learning. All existing learning techniques rely on mapping input and output and establishing mathematical relationships between them. Though methods change the paradigm remains the same—the forward hypothesis machine paradigm, which tries to minimize uncertainty. The RHM, on the other hand, makes use of uncertainty for creative learning. The approach uses limited data to help identify new and surprising solutions. It focuses on improving learnability, unlike traditional approaches, which focus on accuracy. The book is useful as a reference book for machine learning researchers and professionals as well as machine intelligence enthusiasts. It can also used by practitioners to develop new machine learning applications to solve problems that require creativity.

Download or read book Anaerobic Digestion written by A. Wheatley and published by Springer. This book was released on 1990-11-30 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Built from Scratch written by Bernie Marcus and published by Crown Currency. This book was released on 2019-08-20 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the greatest entrepreneurial success stories of the past twenty years When a friend told Bernie Marcus and Arthur Blank that “you’ve just been hit in the ass by a golden horseshoe,” they thought he was crazy. After all, both had just been fired. What the friend, Ken Langone, meant was that they now had the opportunity to create the kind of wide-open warehouse store that would help spark a consumer revolution through low prices, excellent customer service, and wide availability of products. Built from Scratch is the story of how two incredibly determined and creative people—and their associates—built a business from nothing to 761 stores and $30 billion in sales in a mere twenty years. Built from Scratch tells many colorful stories associated with The Home Depot’s founding and meteoric rise; shows that a company can be a tough, growth-oriented competitor and still maintain a high sense of responsibility to the community; and provides great lessons useful to people in any business, from start-ups to the Fortune 500.

Download or read book Do Cool Sh t written by Miki Agrawal and published by Harper Collins. This book was released on 2013-08-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: An inspiring, irreverent manifesto for those seeking to blaze their own path to entrepreneurship and find fulfillment and happiness through bold action and big ideas. With zero experience and no capital, Miki Agrawal opened WILD, a farm-to-table pizzeria in New York City and Las Vegas, partnered up in a children's multimedia company called Super Sprowtz, and launched a patented high-tech underwear business called THINX. Miki, a successful serial social entrepreneur and angel investor, pulls back the curtain to reveal how you can live out loud, honor your hunches, and leave nothing on the table. Start your business on a shoestring budget, nail your brainstorming sessions and product testing, and get free press coverage—all while living your best life. Whether you’re a recent college graduate trying to find your way in the world, or a professional with a dead-end job and big dreams, Do Cool Sh*t will make you open your eyes, laugh out loud, and shout, "I can do that!" Do Cool Sh*t features a foreword by Tony Hsieh, the founder and CEO of Zappos.

Download or read book The Startup Playbook written by David Kidder and published by Chronicle Books. This book was released on 2012 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: " ... [The author] shares the inspiring experiences, lessons, and words to the wise from more than forty founders, along with his own playbook for startup success"--Page 4 of cover.

Download or read book Growing a Business written by Paul Hawken and published by Simon and Schuster. This book was released on 1988-10-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The companion volume to the public television series explains what it takes to be a successful entrepreneur.

Download or read book The Startup Owner s Manual written by Steve Blank and published by John Wiley & Sons. This book was released on 2020-03-17 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 100,000 entrepreneurs rely on this book. The National Science Foundation pays hundreds of startup teams each year to follow the process outlined in the book, and it's taught at Stanford, Berkeley, Columbia and more than 100 other leading universities worldwide. Why? The Startup Owner's Manual guides you, step-by-step, as you put the Customer Development process to work. This method was created by renowned Silicon Valley startup expert Steve Blank, co-creator with Eric Ries of the "Lean Startup" movement and tested and refined by him for more than a decade. This 608-page how-to guide includes over 100 charts, graphs, and diagrams, plus 77 valuable checklists that guide you as you drive your company toward profitability. It will help you: Avoid the 9 deadly sins that destroy startups' chances for success Use the Customer Development method to bring your business idea to life Incorporate the Business Model Canvas as the organizing principle for startup hypotheses Identify your customers and determine how to "get, keep and grow" customers profitably Compute how you'll drive your startup to repeatable, scalable profits. The Startup Owners Manual was originally published by K&S Ranch Publishing Inc. and is now available from Wiley. The cover, design, and content are the same as the prior release and should not be considered a new or updated product.

Download or read book Improving Machinery Reliability written by Heinz P. Bloch and published by Elsevier. This book was released on 1998-09-18 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: This totally revised, updated and expanded edition provides proven techniques and procedures that extend machinery life, reduce maintenance costs, and achieve optimum machinery reliability. This essential text clearly describes the reliability improvement and failure avoidance steps practiced by best-of-class process plants in the U.S. and Europe.

Download or read book EuroQSAR 2002 Designing Drugs and Crop Protectants written by M. G. Ford and published by Wiley-Blackwell. This book was released on 2003-12-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: