Download or read book Combined Digital Breast Tomosynthesis and Near infrared Spectral Tomography for Breast Lesion Characterization written by Kelly E. Michaelsen and published by . This book was released on 2014 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false positive results that can lead to invasive and possibly unnecessary biopsies. Digital breast tomosynthesis (DBT) is a recently approved screening method that takes multiple X-ray images at different positions relative to the breast, rendering excellent three-dimensional anatomic detail of the breast. Near-infrared spectral tomography (NIRST) was added into a DBT system, to provide co-localized information about the metabolic status of the tissue, specifically quantification of blood content, oxygen saturation, water and lipid levels. When used alone, NIRST is hampered by low spatial resolution. The hypothesis in this work was that noninvasive differentiation between malignant and benign lesions can be more accurately obtained by combining spatial information from DBT and functional information from NIRST in a single exam. To this end, the NIRST hardware has been integrated into an existing DBT unit, allowing completely co-registered X-ray and optical data. Early simulation work demonstrated the potential of this synergistic combination, optimized for short scanning time, low cost and complexity. The system was built and tested to obtain both clinical quality DBT scans and high fidelity NIRST data. Breast-mimicking phantoms assessed size, contrast and depth resolution as well as chromophore recovery. A total of 32 normal subjects were examined and the recovered tissue metabolic markers were analyzed with respect to patient demographics. Finally, 13 women with abnormal mammographic findings were imaged prior to biopsy and the results demonstrate correlation between hemoglobin content and histo-pathological diagnosis. The addition of NIRST imaging to DBT could aid in clinical decision making and decrease the number of biopsies which are performed with negative results, improving patient experience.
Download or read book Breast Tomosynthesis E Book written by Liane E Philpotts and published by Elsevier Health Sciences. This book was released on 2016-11-02 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of tomosynthesis in breast imaging is growing rapidly due to its superior ability to identify and characterize normal findings, benign lesions, and breast cancer, as well as its optimal performance with dense breast tissue. Providing unparalleled coverage of this breakthrough breast imaging modality, Breast Tomosynthesis explains how this new modality can lead to enhanced interpretation and better patient outcomes. This new reference is an indispensable guide for today's practitioner looking to keep abreast of the latest developments with correlative findings, practical interpretation tips, physics, and information on how tomosynthesis differs from conventional 2D FFDM mammography. Over 900 high-quality images offer visual guidance to effectively reading and interpreting this key imaging modality. - Includes over 900 high-quality tomosynthesis and mammography images representing the spectrum of breast imaging. - Features the latest Breast Imaging Reporting and Data System (or BI-RADS) standards updated in February 2014. - Highlights practical tips to interpreting this new modality and how it differs from 2D mammography. - Details how integration of tomosynthesis drastically changes lesion work-up and overall workflow in the department. - "Tomo Tips" boxes offer tips and pitfalls for expert clinical guidance.
Download or read book Atlas of Breast Tomosynthesis written by Martin Sonnenschein and published by Springer. This book was released on 2017-06-08 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This superbly illustrated atlas of breast tomosynthesis covers all aspects and applications of the technology, which reduces tissue overlap and facilitates the recognition of small cancers. After clear explanation of basic principles of the technique, individual chapters address diagnostic criteria, indications, and use of breast tomosynthesis as a screening tool. The findings obtained in the full range of benign and malignant conditions, including postoperative changes, are then presented with the aid of a wealth of high-quality illustrations from case examples. Detailed attention is paid to the BI-RADS classification, bearing in mind the ability of tomosynthesis to reduce categorizations as BI-RADS 3 and 0, thereby decreasing the recall rate. The book concludes by examining tomosynthesis-guided interventions such as vacuum-assisted breast biopsy and galactography.
Download or read book Combined MRI and Near infrared Spectroscopy for Increased Specificity of Breast Cancer Imaging written by Michael A. Mastanduno and published by . This book was released on 2013 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy procedures. Therefore, there is a growing need for superior biomarkers derived from the lesion during the scan so that MRI's high sensitivity can be matched by a high specificity. Near-Infrared Spectroscopy (NIRS) has been examined here to augment MR by providing information about blood content, blood oxygen saturation, water, lipid, and scatter components. This functional information is correlated with tumor malignancy; however, the low spatial resolution of NIRS imaging has limited its usefulness as a single system. An instrument that synergistically combines the strengths of MRI and NIRS into one patient exam has been developed to non-invasively image high-contrast intrinsic properties of malignant breast lesions. This work concentrates on the development of instrumentation and methods to optimize a multimodal imaging technology and describes the results of a prospective clinical trial (n=50 subjects). The hypothesis was that NIRS could increase the specificity above MRI alone, to distinguish malignant lesions from benign prior to biopsy. This increased sensitivity was achieved through a customized 9 wavelength NIRS system, developed with an optical fiber interface compatible with most clinical MR breast coils. The study was carried out at Xijing Hospital in Xi'an China. Through this partnership, we showed that MRI/NIRS characterization of MR-identified regions was correlated to the histopathological diagnosis of that same region, as assessed by pathology on the surgically removed tissues. This hybrid imaging technology could aid healthcare decisions, by adding information to clinical MRI exams, lowering the number of necessary breast biopsies preformed, and thereby improving patients' quality of life.
Download or read book Optimizing Near infrared Spectral Tomography for Diagnostic Imaging and Monitoring of Breast Cancer Treatment written by Yan Zhao and published by . This book was released on 2017 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Near-infrared spectral tomography (NIRST) has been intensively investigated for clinical application in breast imaging, by providing functional information about physiologically related biomarkers such as oxy- and deoxy-hemoglobin, water, lipid and scatter component. In this thesis, a series of studies on system development and reconstruction algorithm were completed to improve the imaging quality of MR-guide NIRST and to predicate breast cancer response to neo-adjuvant chemotherapy. To optimize image recovery which maximizes difference between malignant and benign lesions, non-linear iterative reconstructions of MR-Guided NISRT images were recovered using an L-curve based algorithm, and applied to clinical trial data. The statistical analyses have shown that the new approach dramatically improved the statistical significance for differentiating malignant from benign lesions. While MRI guide NIRST has been utilized to detect breast cancer, NIRST is also used to predicate and monitor breast tumor responses in patients with locally advanced breast cancer undergoing neoadjuvant treatment. Based on an existing hybrid NIRST system developed at Dartmouth, a compact and portable NIRST system has been developed for imaging patients in the infusion unit while patients are awaiting or undergoing infusion. This system can acquire frequency-domain and continuous-wave data simultaneously at 12 wavelengths in the wavelength range of 660nm to 1064nm. Novel soft gel based homogenous and heterogamous tissue-mimicking phantoms with sphere-shape inclusions have been developed, to mimic human breasts. The phantom experiments indicate that the reconstructed optical images highly depend on the position of imaging plane, especially in the case of small inclusions. Tomographic images of breast collagen content have been recovered for the first time, and image reconstruction approaches with and without collagen content included have been validated in simulation studies, which indicate that including collagen content into the reconstruction procedure can significantly reduce the overestimation in total hemoglobin, water and lipid, and underestimates in oxygen saturation. A group of 10 normal subjects were imaged, and significantly higher (p
Download or read book Breast Imaging An Issue of Radiologic Clinics of North America E Book written by Sarah M. Friedewald and published by Elsevier Health Sciences. This book was released on 2017-04-19 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Radiologic Clinics of North America focuses on Breast Imaging, and is edited by Dr. Sarah M. Friedewald. Articles will include: Evidence to Support Screening Women in Their 40s; Evidence to Support Screening Women Annually; High Risk Screening and Use of Risk Assessment Models; Breast Tomosynthesis: Clinical Evidence; Breast Tomosynthesis: Practical Considerations; Synthesized Digital Mammography Imaging; Breast Density Legislation and Clinical Evidence; Whole Breast Screening Ultrasound Implemenation; Breast MRI in the Newly Diagnosed Breast Cancer Patient; MRI: Future Imaging Techniques; Breast PET-MR; Update on Pre-Operative Needle Localization Techniques, and more!
Download or read book Digital Breast Tomosynthesis written by Alberto Tagliafico and published by Springer. This book was released on 2016-05-03 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive description of the screening and clinical applications of digital breast tomosynthesis (DBT) and offers straightforward, clear guidance on use of the technique. Informative clinical cases are presented to illustrate how to take advantage of DBT in clinical practice. The importance of DBT as a diagnostic tool for both screening and diagnosis is increasing rapidly. DBT improves upon mammography by depicting breast tissue on a video clip made of cross‐sectional images reconstructed in correspondence with their mammographic planes of acquisition. DBT results in markedly reduced summation of overlapping breast tissue and offers the potential to improve mammographic breast cancer surveillance and diagnosis. This book will be an excellent practical teaching guide for beginners and a useful reference for more experienced radiologists.
Download or read book Breast Imaging written by Andrew D.A. Maidment and published by Springer. This book was released on 2012-07-13 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 11th International Workshop on Digital Mammography, IWDM 2012, held in Philadelphia, PA, USA, in July 2012. The 42 revised full papers and 58 revised poster papers presented were carefully reviewed and selected from numerous initial submissions. The papers are organized in topical sections on contrast-enhancing imaging, digital mammography methods, tomosynthesis system design, tomosynthesis - image quality and dose, clinical tomosynthesis, functional breast imaging, breast computed tomography, computer-aided diagnosis and image processing, tomosynthesis reconstruction, and breast density.
Download or read book A Multimodal Breast Cancer Imaging System Using Coregistered Dynamic Diffuse Optical Tomography and Digital Breast Tomosynthesis written by Bernhard B. Zimmermann and published by . This book was released on 2017 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) is an emerging noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (1 Hz+) image acquisition rate to enable tracking of hemodynamic changes induced by the mammographic breast compression. The most significant advance enabling fast acquisition was the design and construction of a direct analog-to-digital conversion frequency-domain near-infrared spectroscopy (FD-NIRS) component. It achieves simultaneous dual wavelength operation at 685 nm and 830 nm by concurrent 67.5 MHz and 75 MHz frequency modulation of each laser source, respectively, followed by digitization using a high-speed analog to digital converter and real-time hybrid FPGA-assisted demodulation by discrete Fourier transform (DFT). The overall DOT system integrates 96 CW-NIRS and 24 FD-NIRS source locations, as well as 32 CW-NIRS and 20 FD-NIRS detection locations into low-profile plates that mate to the DBT compression paddle and x-ray detector cover, respectively. The plates and the embedded optical fibers are made of plastic to minimize x-ray absorption and thus allow true simultaneous acquisition of the DBT image. We first characterize each major system component individually, and then demonstrate overall performance using static and dynamic tissue-like phantoms, as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.
Download or read book Diagnostic Imaging Breast E Book written by Wendie A. Berg and published by Elsevier Health Sciences. This book was released on 2019-06-17 with total page 1350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Breast, third edition, is an invaluable resource not only for radiologists, but for all health care professionals involved in the management of breast disease. From screening and diagnostic mammography and tomosynthesis, ultrasound, and MR to contrast-enhanced mammography and molecular imaging, Drs. Wendie Berg and Jessica Leung, along with their expert author team, provide carefully updated information in a concise, bulleted format. Thousands of high-quality illustrations highlight not only image acquisition and interpretation, but also screening guidelines, breast anatomy, genetic testing, image-guided procedures, determining the extent of disease and much more. This book provides essential, clinically-focused details for everyday breast imaging. Features more than 4,000 annotated, updated images throughout, including imaging findings complemented by histopathologic and clinical correlates of the spectrum of breast disease Provides timely coverage of less common but important topics such as gender reassignment, disease-causing mutations and risk assessment, malignancy in pregnancy, nodal disease in breast cancer care, and male breast disease Discusses new technologies, including abbreviated MR, contrast-enhanced mammography, and automated breast ultrasound Includes updated information on evolving medical, oncologic, surgical, and radiation, and oncoplastic treatment of the breast cancer patient, along with discussion of ongoing trials and future directions Offers expanded and updated information on dense breast reporting, screening recommendations, patients at elevated risk, and imaging paradigms in patients with dense breasts, as well as analysis of various updated breast cancer screening guidelines Uses bulleted, succinct text for fast and easy comprehension of essential information
Download or read book Breast Imaging Companion written by Gilda Cardenosa and published by Lippincott Williams & Wilkins. This book was released on 2016-12-19 with total page 1730 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pragmatic, common sense approach to the detection, evaluation and management of breast diseases and related imaging findings! The fourth edition of this best selling “how-to” book includes major revisions, including the expansion of the screening mammography and breast MRI chapters, as well as the addition of digital breast tomosynthesis studies. Rather than having selected cropped images, the print and online versions of this book provide the reader with thousands of high quality images and complete imaging evaluations, from the screening images to the diagnostic mammogram, and—when appropriate—images from ultrasound, MRI, imaging guided biopsy, and preoperative wire localizations. Bulleted “key-facts” describe clinical, imaging and histological findings for a spectrum of breast diseases. With this book, breast-imaging radiologists are strongly encouraged to provide clinical, imaging and pathology concordance for optimal patient care, as well as direct and clinically relevant communication with providers and patients.
Download or read book Breast MRI written by Katja Pinker and published by Academic Press. This book was released on 2022-09-22 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians.Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound. - Spans the whole spectrum of breast MRI, including basic imaging techniques, indications, interpretation, and the latest cutting-edge techniques - Reviews multiparametric MRI and abbreviated protocols, providing an outlook on the future of this technique - Discusses the predictive and prognostic value of MRI as well as the evolving field of radiomics/genomics and AI
Download or read book Digital Breast Tomosynthesis written by Joerg Barkhausen and published by Thieme. This book was released on 2015-11-23 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Digital Breast Tomosynthesis: Technique and Cases is a comprehensive and timely introduction to a significant technological advance in breast cancer imaging. This state-of-the-art guide explains the technique of digital breast tomosynthesis (DBT), describes results from available clinical studies, offers recommendations for the use of DBT in routine practice, and discusses the latest developments and possible future trends in DBT. The main part of the book contains 45 highly illustrated case reports that allow readers to explore the practical aspects of DBT and deepen their knowledge of this important new modality in breast imaging. Key Features: Presents 45 superbly illustrated case reports showcasing the application of DBT to clinical practice Examines the results of all currently available clinical trials and studies Evaluates the use of DBT alongside mammography and versus mammography Includes high-quality images from the various modalities in breast imaging: 2D mammography, DBT, and ultrasound, to enable comparison of their strengths and limitations Combines expertise in the fields of radiology and gynecology with an interdisciplinary team of contributors Provides video clips of the DBT data set for most cases on the Thieme MediaCenter Authoritative and up to date, this volume is essential for radiology practitioners, residents, and fellows who wish to learn about the potential of DBT and stay at the forefront of technological developments in their field. The wealth of clinically relevant information is useful for any radiologist considering the establishment of DBT as a new imaging tool in their practice.
Download or read book Physics of Mammographic Imaging written by Mia K. Markey and published by CRC Press. This book was released on 2012-11-09 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the increasing number of digital mammograms and the advent of new kinds of three-dimensional x-ray and other forms of medical imaging, mammography is undergoing a dramatic change. To meet their responsibilities, medical physicists must constantly renew their knowledge of advances in medical imaging or radiation therapy, and must be prepared to function at the intersection of these two fields. Physics of Mammographic Imaging gives an overview on the current role and future potential of new alternatives to mammography in the context of clinical need, complementary approaches, and ongoing research. This book provides comprehensive coverage on the fundamentals of image formation, image interpretation, analysis, and modeling. It discusses the use of mammographic imaging in the detection, diagnosis, treatment planning, and monitoring of breast cancer. Expert authors give a balanced summary of core topics such as digital mammography, contrast-enhanced mammography, stereomammography, breast tomosynthesis, and breast CT. The book highlights the use of mammographic imaging with complementary breast imaging modalities such as ultrasound, MRI, and nuclear medicine techniques. It discusses critical issues such as computer-aided diagnosis, perception, and quality assurance. This is an exciting time in the development of medical imaging, with many new technologies poised to make a substantial impact on breast cancer care. This book will help researchers and students get up to speed on crucial developments and contribute to future advances in the field.
Download or read book Alternative Breast Imaging written by Keith D. Paulsen and published by Springer Science & Business Media. This book was released on 2006-01-11 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical imaging has been transformed over the past 30 years by the advent of computerized tomography (CT), magnetic resonance imaging (MRI), and various advances in x-ray and ultrasonic techniques. An enabling force behind this progress has been the (so far) exponentially increasing power of computers, which has made it practical to explore fundamentally new approaches. In particular, what our group terms "model-based" modalities-which produce tissue property images from data using nonlinear, iterative numerical modeling techniques-have become increasingly feasible. Alternative Breast Imaging: Four Model-Based Approaches explores our research on four such modalities, particularly with regard to imaging of the breast: (1) MR elastography (MRE), (2) electrical impedance spectroscopy (EIS), (3) microwave imaging spectroscopy (MIS), and (4) near infrared spectroscopic imaging (NIS). Chapter 1 introduces the present state of breast imaging and discusses how our alternative modalities can contribute to the field. Chapter 2 looks at the computational common ground shared by all four modalities. Chapters 2 through 10 are devoted to the four modalities, with each modality being discussed first in a theory chapter and then in an implementation-and-results chapter. The eleventh and final chapter discusses statistical methods for image analysis in the context of these four alternative imaging modalities. Imaging for the detection of breast cancer is a particularly interesting and relevant application of the four imaging modalities discussed in this book. Breast cancer is an extremely common health problem for women; the National Cancer Institute estimates that one in eight US women will develop breast cancer at least once in her lifetime. Yet the efficacy of the standard (and notoriously uncomfortable) early-detection test, the x-ray mammogram, has been disputed of late, especially for younger women. Conditions are thus ripe for the development of affordable techniques that replace or complement mammography. The breast is both anatomically accessible and small enough that the computing power required to model it, is affordable.
Download or read book Breast Imaging written by Hiroshi Fujita and published by Springer. This book was released on 2014-06-23 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 12th International Workshop on Breast Imaging, IWDM 2014, held in Gifu City, Japan, in June/July 2014. The 24 revised full papers and 73 revised poster papers presented together with 6 invited talks were carefully reviewed and selected from 122 submissions. The papers are organized in topical sections on screening outcomes, ultrasound, breast density, imaging physics, CAD, tomosynthesis and ICT and image processing.
Download or read book Characterization of Breast Cancer Using an Endogenous Tumor Spectral Marker written by Shanshan Xu and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging has enjoyed a large following in cancer in general and breast cancer in particular (i.e., diffuse optical imaging, DOI and diffuse optical tomography, DOT). Optical imaging biomarkers emerge from modeling specific near-infrared (NIR) absorption signatures that are sensitive indicators of important molecular concentration and disposition. We have developed Diffuse Optical Spectroscopic Imaging (DOSI) by increasing spectral information content for the purpose of increasing access to molecular targets and states. Malignancy-specific optical imaging biomarkers may be important because the above-mentioned changes in tumor hemoglobin, water and lipids are a necessary but not a sufficient condition to classify therapeutic response. We note that for all therapeutic imaging assessments (i.e., mammography, ultrasound, MRI, PET) that the same case is true for their respective contrast mechanisms. By a novel spectral analysis method, we have discovered the presence of absorption signatures that are unique to malignant lesions. A reproducible absorption spectrum (Specific Tumor Component, STC) with several distinct spectral features emerges when compared with the normal absorption spectra (the flat line near zero) measured from the normal tissue of these subjects plus an additional 21 patients without any evidence of malignancy. These data demonstrate the existence of a spectral signature that acts as an optical biomarker for malignancy. We are not aware of any other such biomarker that combines high specificity with ease of application in the imaging field. This DOSI-measured malignancy-specific biomarker STC provides an ideal non-invasive surrogate biomarker for breast lesion detection and differentiation. Although STC offers both spectroscopic and quantitative information for breast malignancy, this method relies on complicated data analysis and lacks of standardization. Thus, it is still far from a clinical reality. In order to carry out a quantitative assessment of its potential in becoming a standardized clinical detection modality for tumor detection/prediction/prognosis, the longitudinal temporal stability of signatures must be evaluated and the detection limit must be set. The overall clinical goal is to evaluate the possibilities for STC detection method to become a future clinical practice. Building the linkage between pre-existing detection modalities (pathological biomarkers, DCE-MRI) and novel spectral signature detection is essential. The medical interpretation of the findings from conventional tools will shed light on the understanding and further employment of STC biomarker. Similarly, STC detection with a high diagnosis sensitivity and specificity could be very well an adjunct method for traditional modalities.
