Download or read book Combinatorial Strategies Applied to Catalyst Development written by and published by . This book was released on 1997 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: The performed research demonstrates that important ligand classes can be synthesized on solid supports and can be used directly without purification to prepare asymmetric catalysts. For the catalyst system that was evaluated, the ligands prepared in parallel on support provided comparable enantioselectivities to purified ligands prepared individually over several steps in solution. Enantioselectivities greater than 90% ee were observed. These results hold promise for parallel synthesis and evaluation approaches in asymmetric catalyst optimization. A sulfinamide chiral auxiliary has also been developed. Auxiliary loading, diastereoselective transformations, and auxiliary removal all proceed in high yields. Auxiliary removal is accomplished by first activating the auxiliary linkage followed by nucleophilic release. Modification of the sulfinamide auxiliary as a support-bound linkage will allow the stereodefined synthesis of libraries of chiral compounds.
Download or read book Symposium Combinatorial Methods for Catalyst Development written by Symposium: Combinatorial Methods for Catalyst Development and published by . This book was released on 2005 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinatorial Development of Solid Catalytic Materials written by Manfred Baerns and published by World Scientific. This book was released on 2009 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive treatment of combinatorial development of heterogeneous catalysts. In particular, two computer-aided approaches that have played a key role in combinatorial catalysis and high-throughput experimentation during the last decade OCo evolutionary optimization and artificial neural networks OCo are described. The book is unique in that it describes evolutionary optimization in a broader context of methods of searching for optimal catalytic materials, including statistical design of experiments, as well as presents neural networks in a broader context of data analysis. It is the first book that demystifies the attractiveness of artificial neural networks, explaining its rational fundamental OCo their universal approximation capability. At the same time, it shows the limitations of that capability and describes two methods for how it can be improved. The book is also the first that presents two other important topics pertaining to evolutionary optimization and artificial neural networks: automatic generating of problem-tailored genetic algorithms, and tuning evolutionary algorithms with neural networks. Both are not only theoretically explained, but also well illustrated through detailed case studies. Sample Chapter(s). Chapter 1: Background of Combinatorial Catalyst Development (63 KB). Contents: Background of Combinatorial Catalyst Development (M Baerns); Approaches in the Development of Heterogeneous Catalysts (M Baerns); Mathematical Methods of Searching for Optimal Catalytic Materials (M Holena); Generating Problem-Tailored Genetic Algorithms for Catalyst Search (M Holena); Analysis and Mining of Data Collected in Catalytic Experiments (M Holena); Artificial Neural Networks in the Development of Catalytic Materials (M Holena); Tunning Evolutionary Algorithms with Artificial Neural Networks (M Holena); Improving Neural Network Approximations (M Holena); Applications of Combinatorial Catalyst Development and An Outlook on Future Work (M Baerns). Readership: Chemists and chemical engineers from academia and industry working in catalysis; materials scientists; graduate students dealing with catalytic chemistry interested in computer-aided methods.
Download or read book Synthesis of Solid Catalysts written by Krijn P. de Jong and published by John Wiley & Sons. This book was released on 2009-06-22 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical book combines recent progress with a discussion of the general aspects of catalyst preparation. The first part deals with the basic principles of solid catalyst preparation, explaining the main aspects of sol-gel chemistry and interfacial chemistry, followed by such techniques as co-precipitation and immobilization. New tools for catalyst preparation research, including microspectroscopy and high-throughput experimentation, are also taken into account. The second part heightens the practical relevance by providing six case studies on such topics as the preparation of zeolites, hydrotreating catalysts, methanol catalysts and gold catalysts
Download or read book Combinatorial Methods for Catalyst Development written by A.M. Gaffney and published by . This book was released on 2005 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles and Methods for Accelerated Catalyst Design and Testing written by E.G. Derouane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: High throughput experimentation has met great success in drug design but it has, so far, been scarcely used in the field ofcatalysis. We present in this book the outcome of a NATO ASI meeting that was held in Vilamoura, Portugal, between July 15 and 28, 2001, with the objective of delineating and consolidating the principles and methods underpinning accelerated catalyst design, evaluation, and development. There is a need to make the underlying principles of this new methodology more widely understood and to make it available in a coherent and integrated format. The latter objective is particularly important to the young scientists who will constitute the new catalysis researchers generation. Indeed, this field which is at the frontier offundamental science and may be a renaissance for catalysis, is one which is much more complex than classical catalysis itself. It implies a close collaboration between scientists from many disciplines (chemistry, physics, chemical and mechanical engineering, automation, robotics, and scientific computing in general). In addition, this emerging area of science is also of paramount industrial importance, as progress in this area would collapse the time necessary to discover new catalysts or improve existing ones.
Download or read book Combinatorial Materials Science written by Marc D. Porter and published by John Wiley & Sons. This book was released on 2007-08-17 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial Materials Science describes new developments and research results in catalysts, biomaterials, and nanomaterials, together with informatics approaches to the analysis of Combinatorial Science (CombiSci) data. CombiSci has been used extensively in the pharmaceutical industry, but there is enormous potential in its application to materials design and characterization. Addressing advances and applications in both fields, Combinatorial Materials Science: Integrates the scientific fundamentals and interdisciplinary underpinnings required to develop and apply CombiSci concepts Discusses the development and use of CombiSci for the systematic and accelerated investigation of new phenomena and of the complex structure-function interplay in materials Covers the development of new library design strategies for materials processing and for high-throughput tools for rapid sampling Uses a unique, unified approach of applying combinatorial methods to unravel the non-linear structure-function relationships in diverse materials (both hard and soft), together with advances in informatics With chapters written by leading researchers in their specialty areas, this authoritative guide is a must-have resource for scientists and engineers in materials science research, biochemists, chemists, immunologists, cell biologists, polymer scientists, chemical and mechanical engineers, statisticians, and computer scientists. It is also a great text for graduate-level courses in materials science/engineering, polymer science, chemical engineering, and chemistry.
Download or read book Combinatorial and High Throughput Discovery and Optimization of Catalysts and Materials written by Radislav A. Potyrailo and published by CRC Press. This book was released on 2006-07-19 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combina
Download or read book Development of Methodologies for Asymmetric Synthesis and Drug Discovery written by Guangcheng Liu and published by . This book was released on 1998 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinatorial and Composition Spread Techniques in Materials and Device Development written by and published by . This book was released on 2001 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinatorial Catalysis and High Throughput Catalyst Design and Testing written by E.G. Derouane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalysts are central in modern industrial chemistry and there is an urgent need to develop new catalysts. Such a rapid pace of development brings with it a new set of challenges at all levels of research, from synthesis and characterization to testing and modelling. This book reviews the current status of combinatorial catalysis, scientific catalyst design techniques, methods for preparing inorganic combinatorial libraries, experimental design methods, data processing, system modelling an simulation, and catalyst testing. The individual contributions reveal the development of high throughput catalyst design and test methods and identify the main challenges in the field, including new catalyst preparation techniques, rapid performance evaluation, and new microreactor configurations. Readership: All those working in catalytic process analysis and development. The extensive review of catalysis principles is especially relevant for postgraduate students seeking to pursue studies in catalysis.
Download or read book Basic Principles in Applied Catalysis written by Manfred Baerns and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a team of internationally recognized experts, this book addresses the most important types of catalytic reactions and catalysts as used in industrial practice. Both applied aspects and the essential scientific principles are described. The main topics can be summarized as follows: heterogeneous, homogeneous and biocatalysis, catalyst preparation and characterization, catalytic reaction engineering and kinetics, catalyst deactivation and industrial perspective.
Download or read book Experimental Design for Combinatorial and High Throughput Materials Development written by James N. Cawse and published by Wiley-Interscience. This book was released on 2003 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable reference to increasingly popular experimental methods In the past decade, combinatorial and high throughput experimental methods have revolutionized the pharmaceutical industry, allowing researchers to conduct more experiments in a week than was previously possible in a year. Now high throughput experimentation is rapidly spreading from its origins in the pharmaceutical world to larger industrial research establishments such as GE and DuPont, and even to smaller companies and universities. Consequently, researchers need to know the kinds of problems, desired outcomes, and appropriate patterns for these new strategies. Editor James Cawse's far-reaching study identifies and applies, with specific examples, these important new principles and techniques. Experimental Design for Combinatorial and High Throughput Materials Development progresses from methods that are now standard, such as gradient arrays, to mathematical developments that are breaking new ground. The former will be particularly useful to researchers entering the field, while the latter should inspire and challenge advanced practitioners. The book's contents are contributed by leading researchers in their respective fields. Chapters include: * High Throughput Synthetic Approaches for the Investigation of Inorganic Phase Space * Combinatorial Mapping of Polymer Blends Phase Behavior * Split-Plot Designs * Artificial Neural Networks in Catalyst Development * The Monte Carlo Approach to Library Design and Redesign The text also contains over 200 useful charts and drawings. Industrial chemists, chemical engineers, materials scientists, and physicists working in combinatorial and high throughput chemistry will find James Cawse's study to be an invaluable resource.
Download or read book Combinatorial Synthesis and Screening of Fuel Cell Catalysts written by Shrisudersan Jayaraman and published by . This book was released on 2004 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer electrolyte membrane fuel cells (PEMFCs) are compact power sources that can operate with high efficiencies and low emission of environmentally harmful gases. One of the major barriers impeding the development of PEMFCs as a competitive energy source is the inability of existing anode catalysts to oxidize fuels other than hydrogen at sufficient levels due to catalyst deactivation by carbon monoxide (CO) and other partial oxidation products. The focus of this research is the development and application of combinatorial strategies to construct and interrogate electrooxidation (anode) catalysts pertaining to PEMFCs to discover catalysts with enhanced performance in catalyst deactivating environments. A novel method (known as the "gel-transfer" method) for synthesizing catalyst composition gradient libraries for combinatorial catalyst discovery was developed. This method involved transferring a spatial concentration gradient of precursor metal salts created within a polymer gel on to a solid conducting substrate by electrochemical reduction. Chemically sensitive surface-imaging techniques, namely scanning electrochemical microscopy (SECM) and optical screening with a pH-dependent fluorescence probe, were used to characterize the combinatorial catalyst samples. The utilitization of SECM as a screening tool to measure the activity of multicomponent catalyst libraries towards fuel cell electrooxidation reactions was established with simple catalyst libraries including a platinum coverage gradient and platinum-ruthenium and platinum-ruthenium-molybdenum arrays. A platinum-ruthenium surface composition gradient was constructed through the gel-transfer method and its reactivity towards hydrogen oxidation in the presence of a catalyst poison (CO) was mapped using the SECM. Ruthenium composition between 20 and 30% exhibited superior performance than the rest of the binary. The gel-transfer method was extended to construct a ternary platinum-ruthenium-rhodium catalyst library and its reactivity towards several electrooxidation reactions including oxidation of hydrogen, CO, methanol, and ethanol was mapped using a pH-sensitive fluorescent probe. Trends in reactivity for these reactions as a function of catalyst composition were determined. Future directions of this research are also presented.
Download or read book Combinatorial Materials Synthesis written by Xiao-Dong Xiang and published by CRC Press. This book was released on 2003-08-19 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pioneered by the pharmaceutical industry and adapted for the purposes of materials science and engineering, the combinatorial method is now widely considered a watershed in the accelerated discovery, development, and optimization of new materials. Combinatorial Materials Synthesis reveals the gears behind combinatorial materials chemistry and thin-film technology, and discusses the prime techniques involved in synthesis and property determination for experimentation with a variety of materials. Funneling historic innovations into one source, the book explores core approaches to synthesis and rapid characterization techniques for work with combinatorial materials libraries.
Download or read book Microreaction Technology Industrial Prospects written by W. Ehrfeld and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: Miniaturization has cost and time-saving advantages for numerous applications in chemistry, pharmacy, medicine and biotechnology. Additionally, microreaction technology offers new solutions for the automobile industry and environmental technology, e.g. fuel cells, or mobile sensor systems for on-the-spot analysis. Therefore, the 3rd International Conference on Microreaction Technology - IMRET 3 is an important forum for creating awareness of the wide variety of the new trends in this up-and-coming discipline.
Download or read book Comprehensive Coordination Chemistry II written by J. A. McCleverty and published by Newnes. This book was released on 2003-12-03 with total page 11845 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.
