Download or read book Cancer Associated Thrombosis written by Alok A. Khorana and published by CRC Press. This book was released on 2007-09-26 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides

Download or read book Thrombosis and Hemostasis in Cancer written by Gerald Soff and published by Springer. This book was released on 2020-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

Download or read book Coagulation in Cancer written by David Green and published by Springer Science & Business Media. This book was released on 2009-04-21 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coagulation in Cancer informs professionals working in the field of cancer about the pathophysiologic mechanisms of cancer-related thrombosis and bleeding. It provides assistance in recognizing the various bleeding and clotting disorders associated with cancer and includes current recommendations for the management of hemorrhage, and prevention and treatment of thrombosis in the patient with malignancy. This volume is a valuable addition to the literature on cancer and coagulation.

Download or read book Cancer Drug Delivery Systems Based on the Tumor Microenvironment written by Yasuhiro Matsumura and published by Springer Nature. This book was released on 2020-01-07 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

Download or read book Thrombosis and Hemostasis in Cancer written by Gerald Soff and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

Download or read book Thrombosis and Cancer written by Gilles Lugassy and published by CRC Press. This book was released on 2004-02-23 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery. It will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.

Download or read book Coagulation and Cancer written by Maria Benedetta Donati and published by . This book was released on 1988-01-01 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Coagulation in Cancer written by David Green and published by Springer. This book was released on 2010-11-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coagulation in Cancer informs professionals working in the field of cancer about the pathophysiologic mechanisms of cancer-related thrombosis and bleeding. It provides assistance in recognizing the various bleeding and clotting disorders associated with cancer and includes current recommendations for the management of hemorrhage, and prevention and treatment of thrombosis in the patient with malignancy. This volume is a valuable addition to the literature on cancer and coagulation.

Download or read book Coagulation Disorders in the Cancer Patient written by Eric J. Seifter and published by Blackwell/Futura. This book was released on 1984 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Experimental Metastasis Modeling and Analysis written by Anastasia Malek and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

Download or read book Hemostasis and Cancer written by Laszlo Muszbek and published by CRC Press. This book was released on 2019-06-04 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1987: The book is to give insight into the multisided relationship of hemostatic systems and malignancies and to help biomedical scientists and practicing clinicians obtain a better understanding of cancer research.

Download or read book Role of Coagulation Proteases Mediated Signaling in Cancer written by Abhishek Roy and published by Mohd Abdul Hafi. This book was released on 2024-02-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood coagulation is a highly conserved and spontaneous physiological response after vessel injury. It restricts the excessive blood loss from our body. It includes a plethora of plasma reactions resulting in the formation of thrombin and a series of tightly regulated intracellular reactions mediated by platelet activation. In the last century, our understanding of the mechanisms and effects of blood coagulation had made significant development. Beginning from the early clinical observations of rare patients with genetic clotting disorders, our vision has reached to the introduction of newer technologies: from blood coagulation experiments to protein chemistry, to gene targeting technologies and to cure hereditary disorders by external medicinal assistance. Recently in the last decade, several studies have suggested an important contribution of blood coagulation factors in tumor progression. Here in this thesis, I have tried to explore some unanswered questions regarding i) The activation of cancer signaling pathways by clotting factors in the tumor microenvironment and its impact on primary tumor growth. ii) Intravascular activation of blood coagulation and its impact on tumor metastasis. iii) Targeting the molecular mechanism of the inflammatory ability of cancer cells to improve the therapeutic approach against cancer progression.

Download or read book Coagulation and Cancer written by Maria Benedetta Donati and published by . This book was released on 1988 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Heparanase written by Israel Vlodavsky and published by Springer Nature. This book was released on 2020-04-09 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Download or read book Coagulation and Cancer written by and published by . This book was released on 1990 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Coagulation Profile In Cancer Patients written by Sandeepan Halder and published by LAP Lambert Academic Publishing. This book was released on 2014-04 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: By Dr. Sandeepan Halder: Have you ever wondered how a man machine works? As "the machine man," I would like to take this opportunity to explain how our body's haemostasis works by answering some of the most frequently asked questions. The main goal of my research is to understand better correlation between cancer patients and coagulation disturbances. This concise manual will give you, the exhaustive coverage of the current pathogenesis of coagulation disturbances in underlying cancer with the associated clinical correlation. The focus is on the most common and challenging aspects which a clinician and pathologist, both encounters while dealing with the malignant condition. This generously illustrated and user-friendly volume will provide the entire spectrum of coagulation cascade, mechanism of DIC, coagulation factor inhibitors and simple laboratory test to pick up the underlying disorder in cancer patients. "How all is happening in our system?" the answer to your curiosity is here.

Download or read book Pancreatic Cancer Cystic Neoplasms and Endocrine Tumors written by Hans G. Beger and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management is a modern, expertly crafted and clinically focused guide to the diagnosis, management and best-practice care of patients suffering from pancreatic cancer, cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to the leading society guidelines, its main focus is on the many endoscopic and radiologic diagnostic techniques, medical and surgical management of both full-blown cancer and other tumors, and the risks of each form of treatment. Also covered in detail are issues of tumor recurrence and long-term outcome of treatment. Brought to you by highly skilled national and international leaders in the specialty and an experienced editor team, this is an invaluable guide to practicing gastroenterologists and surgeons in the hospital and clinical environment, as well as oncologists and endocrinologists managing patients with pancreatic tumorous lesions.