Download or read book CMOS based Microelectrode Array for Communication with Electrogenic Cells written by Flavio Heer and published by . This book was released on 2005 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Growing Cells Atop Microelectronic Chips written by Andreas Hierlemann and published by . This book was released on 2011 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vitro Neuronal Networks written by Michela Chiappalone and published by Springer. This book was released on 2019-05-09 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
Download or read book Quantitative Biology Dynamics of Living Systems written by Noriko Hiroi and published by Frontiers Media SA. This book was released on 2017-07-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required. Quantities are not only the bridge between mathematical description and biological observations; they often stand as essential elements similar to genome information in genetics. This important realization has greatly rejuvenated research in the area of Quantitative Biology. Because of the increased need for precise quantification, a new era of technological development has opened. For example, spatio-temporal high-resolution imaging enables us to track single molecule behavior in vivo. Clever artificial control of experimental conditions and molecular structures has expanded the variety of quantities that can be directly measured. In addition, improved computational power and novel algorithms for analyzing theoretical models have made it possible to investigate complex biological phenomena. This research topic is organized on two aspects of technological advances which are the backbone of Quantitative Biology: (i) visualization of biomolecules, their dynamics and function, and (ii) generic technologies of model optimization and numeric integration. We have also included articles highlighting the need for new quantitative approaches to solve some of the long-standing cell biology questions. In the first section on visualizing biomolecules, four cutting-edge techniques are presented. Ichimura et al. provide a review of quantum dots including their basic characteristics and their applications (for example, single particle tracking). Horisawa discusses a quick and stable labeling technique using click chemistry with distinct advantages compared to fluorescent protein tags. The relatively small physical size, stability of covalent bond and simple metabolic labeling procedures in living cells provides this type of technology a potential to allow long-term imaging with least interference to protein function. Obien et al. review strategies to control microelectrodes for detecting neuronal activity and discuss techniques for higher resolution and quality of recordings using monolithic integration with on-chip circuitry. Finally, the original research article by Amariei et al. describes the oscillatory behavior of metabolites in bacteria. They describe a new method to visualize the periodic dynamics of metabolites in large scale cultures populations. These four articles contribute to the development of quantitative methods visualizing diverse targets: proteins, electrical signals and metabolites. In the second section of the topic, we have included articles on the development of computational tools to fully harness the potential of quantitative measurements through either calculation based on specific model or validation of the model itself. Kimura et al. introduce optimization procedures to search for parameters in a quantitative model that can reproduce experimental data. They present four examples: transcriptional regulation, bacterial chemotaxis, morphogenesis of tissues and organs, and cell cycle regulation. The original research article by Sumiyoshi et al. presents a general methodology to accelerate stochastic simulation efforts. They introduce a method to achieve 130 times faster computation of stochastic models by applying GPGPU. The strength of such accelerated numerical calculation are sometimes underestimated in biology; faster simulation enables multiple runs and in turn improved accuracy of numerical calculation which may change the final conclusion of modeling study. This also highlights the need to carefully assess simulation results and estimations using computational tools.
Download or read book A CMOS Self Powered Front End Architecture for Subcutaneous Event Detector Devices written by Jordi Colomer-Farrarons and published by Springer Science & Business Media. This book was released on 2011-02-17 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: A CMOS Self-Powered Front-End Architecture for Subcutaneous Event-Detector Devices presents the conception and prototype realization of a Self-Powered architecture for subcutaneous detector devices. The architecture is designed to work as a true/false (event detector) or threshold level alarm of some substances, ions, etc... that are detected through a three-electrodes amperometric BioSensor approach. The device is envisaged as a Low-Power subcutaneous implantable application powered by an inductive link, one emitter antenna at the external side of the skin and the receiver antenna under the skin. The sensor is controlled with a Potentiostat circuit and then, a post-processing unit detects the desired levels and activates the transmission via a backscattering method by the inductive link. All the instrumentation, except the power module, is implemented in the so called BioChip. Following the idea of the powering link to harvest energy of the magnetic induced link at the implanted device, a Multi-Harvesting Power Chip (MHPC) has been also designed.
Download or read book Axon Neurobiology Fine Scale Dynamics of Microstructure and Function written by Haruyuki Kamiya and published by Frontiers Media SA. This book was released on 2020-12-09 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Wireless Power Transfer and Data Communication for Intracranial Neural Recording Applications written by Kerim Türe and published by Springer Nature. This book was released on 2020-03-04 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes new circuits and systems for implantable wireless neural monitoring systems and explains the design of a batteryless, remotely-powered implantable micro-system, designed for continuous neural monitoring. Following new trends in implantable biomedical applications, the authors demonstrate a system which is capable of efficient remote powering and reliable data communication. Novel architecture and design methodologies are used for low power and small area wireless communication link. Additionally, hermetically sealed packaging and in-vivo validation of the implantable device is presented.
Download or read book Development of a Dual mode CMOS Microelectrode Array for the Simultaneous Study of Electrochemical and Electrophysiological Activities in the Brain written by Geoffrey Mulberry and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical diagnostic devices are in high demand due to increasing cases of neurodegenerative diseases in the aging population and pandemic outbreaks in our increasingly connected global community. Devices capable of detecting the presence of a disease in its early stages can have dramatic impacts on how it can be treated or eliminated. High cost and limited accessibility to diagnostic tools are the main barriers preventing potential patients from receiving a timely disease diagnosis. This dissertation presents several devices that are aimed at providing higher quality medical diagnostics at a low cost. Brain function is commonly studied with systems detecting the action potentials that are formed when neurons fire. CMOS technology enables extremely high-density electrode arrays to be produced with integrated amplifiers for high-throughput action potential measurement systems while greatly reducing the cost per measurement compared to traditional tools. Recently, CMOS technology has also been used to develop high-throughput electrochemical measurement systems. While action potentials are important, communication between neurons occurs by the flow of neurotransmitters at the synapses, so measurement of action potentials alone is incapable of fully studying neurotransmission. In many neurodegenerative diseases the breakdown in neurotransmission begins well before the disease manifests itself. The development of a dual-mode CMOS device that is capable of simultaneous high-throughput measurement of both action potentials and neurotransmitter flow via an on-chip electrode array is presented in this dissertation. This dual-mode technology is useful to those studying the dynamic decay of the neurotransmission process seen in many neurodegenerative diseases using a low-cost CMOS chip. This dissertation also discusses the development of more traditional diagnostic devices relying on PCR, a method commonly used only in centralized laboratories and not readily available at the point-of-care. These technologies will enable faster, cheaper, more accurate, and more accessible diagnostics to be performed closer to the patient.
Download or read book Stretchable Bioelectronics for Medical Devices and Systems written by John A. Rogers and published by Springer. This book was released on 2016-03-31 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent advances in soft and stretchable biointegrated electronics. A renowned group of authors address key ideas in the materials, processes, mechanics, and devices of soft and stretchable electronics; the wearable electronics systems; and bioinspired and implantable biomedical electronics. Among the topics discussed are liquid metals, stretchable and flexible energy sources, skin-like devices, in vitro neural recording, and more. Special focus is given to recent advances in extremely soft and stretchable bio-inspired electronics with real-world clinical studies that validate the technology. Foundational theoretical and experimental aspects are also covered in relation to the design and application of these biointegrated electronics systems. This is an ideal book for researchers, engineers, and industry professionals involved in developing healthcare devices, medical tools and related instruments relevant to various clinical practices.
Download or read book Emerging Trends in Neuro Engineering and Neural Computation written by Asim Bhatti and published by Springer. This book was released on 2017-03-23 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on neuro-engineering and neural computing, a multi-disciplinary field of research attracting considerable attention from engineers, neuroscientists, microbiologists and material scientists. It explores a range of topics concerning the design and development of innovative neural and brain interfacing technologies, as well as novel information acquisition and processing algorithms to make sense of the acquired data. The book also highlights emerging trends and advances regarding the applications of neuro-engineering in real-world scenarios, such as neural prostheses, diagnosis of neural degenerative diseases, deep brain stimulation, biosensors, real neural network-inspired artificial neural networks (ANNs) and the predictive modeling of information flows in neuronal networks. The book is broadly divided into three main sections including: current trends in technological developments, neural computation techniques to make sense of the neural behavioral data, and application of these technologies/techniques in the medical domain in the treatment of neural disorders.
Download or read book 3D Microelectrode Arrays MEAS for the Study and Interrogation of Electrogenic Cells in Fabricated Microenvironments written by Charles M. Didier and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the complexity of in vitro biological systems have enabled new possibilities for "Organ-on-a-Chip" systems with greater physiological relevancy. Microphysiological Systems (MPS) represent one such advance which incorporates a sophisticated biological construct with a custom designed biological sensor. As the world grapples with grand challenges such as the Opioid Crisis, novel neural MPS offer a means to address both the safety and efficacy of alternative therapeutics, while potentially accelerating the bench-to-market timeframe for lifesaving addiction treatments. Investigations into custom microfabrication processes for such in vitro combinatorial biosensors are thus warranted. This Dissertation addresses the development of a 3D microelectrode array (MEA) biosensor, designed for integration with a custom peripheral-central nervous system, nociceptive circuit. For such Biological MicroElectroMechanical Systems (BioMEMS) sensors, the dielectric layer is crucial as an insulator and part of the cellular microenvironment. Nanoporous silicon dioxide (SiO2) represents an excellent material for this application, however, can be difficult to incorporate on polymer-based BioMEMS platforms. After development of the baseline 3D MEA platform that can integrate several sensing modalities on a single chip, the work presented in this Dissertation further establishes a novel polydopamine (PDA) mediated chemistry for nanoporous SiO2 / Polyethylene Glycol / Matrigel microenvironment definition. Dorsal Root Ganglion (DRG)/nociceptor and Dorsal Horn (DH) neural spheroids were then matured atop this 3D MEA platform, and spontaneous / evoked compound action potentials (CAPs) were successfully recorded during and at the 6-month timepoints. Lastly, inhibitory drug trials enabled confirmation of multi-part biological activity, indicative of the neural coculture that enables a novel 3D MEA-integrated neural 3D MPS, demonstrated for the first time to our knowledge, for long-term electrophysiological applications.
Download or read book Handbook of Flexible and Stretchable Electronics written by Muhammad M. Hussain and published by CRC Press. This book was released on 2019-11-11 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flexibility and stretchability of electronics are crucial for next generation electronic devices that involve skin contact sensing and therapeutic actuation. This handbook provides a complete entrée to the field, from solid-state physics to materials chemistry, processing, devices, performance, and reliability testing, and integrated systems development. This work shows how microelectronics, signal processing, and wireless communications in the same circuitry are impacting electronics, healthcare, and energy applications. Key Features: • Covers the fundamentals to device applications, including solid-state and mechanics, chemistry, materials science, characterization techniques, and fabrication; • Offers a comprehensive base of knowledge for moving forward in this field, from foundational research to technology development; • Focuses on processing, characterization, and circuits and systems integration for device applications; • Addresses the basic physical properties and mechanics, as well as the nuts and bolts of reliability and performance analysis; • Discusses various technology applications, from printed electronics to logic and memory devices, sensors, actuators, displays, and energy storage and harvesting. This handbook will serve as the one-stop knowledge base for readership who are interested in flexible and stretchable electronics.
Download or read book Advances in Network Electrophysiology written by Makoto Taketani and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Network Electrophysiology: Using Multi Electrode Arrays explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. It reviews the recent progress in both electronics and computational tools developed to analyze the functional operations of large ensembles of neurons using multi-electrode arrays and in vitro preparations. In addition, it gives readers a sense of the applications made possible by these technological tools. This volume is the reference for researchers, industry, graduate students, and postdoctoral fellows in all areas of neuroscience, cognitive neuroscience, pharmaceutical science, and bioengineering.
Download or read book Fully Integrated CMOS Microelectrode Array for Electrochemical Measurements written by Jörg Rothe and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CMOS Biotechnology written by Hakho Lee and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lately, there has been a growing interest in exploiting the benefits of the ICs for areas outside of the traditional application spaces. One noteable area is found in biology Bioanalytical instruments have been miniaturized on ICs to study various biophenomena or to actuate biosystems. These biolab-on-IC systems utilize the IC to facilitate faster, repeatable, and standardized biological experiments at low cost with a small volume of biological sample. The research activities in this field are expected to enjoy substantial growth in the foreseeable future. BioCMOS Technologies reviews these exciting recent efforts in joining CMOS technology with biology.
Download or read book High Density Microelectrode Array Platform in CMOS Technology written by Jan Müller and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
