Download or read book Circular Therapeutics written by Hillary Keeney and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Circular RNAs written by Christoph Dieterich and published by Humana Press. This book was released on 2018-01-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides established approaches for identifying, characterizing, and manipulating circRNAs in vitro, in vivo, and in silico. Chapters highlight the breakthroughs and the challenges in this new field of research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circular RNAs: Methods and Protocols aims to useful and informative for further study into this vital field.
Download or read book Rolling Circle Amplification RCA written by Vadim V. Demidov and published by Springer. This book was released on 2016-11-09 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest developments in rolling circle amplification (RCA) technology with applications in clinical diagnostic tests and molecular medicine. Topics covered include new enzymes useful in RCA, techniques involving RCA for enhanced signal amplification, novel RCA diagnostics, sensors for expediting RCA detection, and prospective RCA-based therapeutics. This is a valuable book for university professors and students in the field of biomedical engineering and biomolecular pharmacology as well as R&D managers of biotechnology and biopharmaceutical companies. Specifically, this book: Reviews prospective RCA-based therapeutics, including RCA-derived DNA nanoparticles that strongly bind to cancer cells Expands readers’ understanding of sensor systems for expediting detection of RCA products by using probe-tagged magnetic nanobeads Maximizes reader insights into novel RCA diagnostics, such as PNA openers-assisted RCA for detection of single target cells and in situ RCA diagnosis of cancer cells and malignant tissues Presents innovative methods for quasi-exponential enhancement of RCA-generated signals, such as nicking enzyme-assisted cascade RCA and RCA coupled with loop-mediated amplification Advance Praise for Rolling Circle Amplification (RCA): “This book provides a badly needed compendium of innovative RCA methods and applications. It should help further increase the community of scientists that have employed RCA in research and diagnostic programs.”— Charles Cantor, Professor Emeritus of Biomedical Engineering, Boston University Executive Director, Retrotope Inc. (USA) “In this new book Vadim Demidov has assembled an enticing menu of articles that illustrate the evolution of the RCA field, including improved protein parts for building superior DNA nanomachines, enhanced modalities of amplification and detection, diagnostic applications, and even a sampling of potential therapeutic applications. The reader will appreciate that while RCA has come of age, there is no lack of exciting surprises, turns, and twists in the continuing evolution of the technology.”— Paul Lizardi, Professor of Pathology, Yale University School of Medicine (retired) Investigator, University of Granada, Spain, President, PetaOmics, Inc., San Marcos, Texas.
Download or read book Civil War Pharmacy written by Michael Flannery and published by CRC Press. This book was released on 2004-05-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examine a previously unexplored aspect of Civil War military medicine! Here is the first comprehensive examination of pharmaceutical practice and drug provision during the Civil War. While numerous books have recounted the history of medicine in the Civil War, little has been said about the drugs that were used, the people who provided and prepared them, and how they were supplied. This is the first book to provide detailed discussion of the role of pharmacy. Among the topics covered in this essential volume are the duties of medical purveyors, the role of the hospital steward, and the nature and state of medical substances commonly used in the 1860s. This last subject would become a matter of considerable controversy and ultimately cost William Hammond, the brilliant and innovative Surgeon General, his career in the Union Army. This richly detailed book shows why the South found drug provision especially difficult and describes the valiant efforts of Confederate sympathizers to run the Union blockade in order to smuggle in their precious cargoes. You’ll also learn about the scurrilous privateers who were out to make a personal fortune at the expense of both the Union and the Confederacy. In addition, Civil War Pharmacy illuminates the systematic effort of pharmacists, physicians, and botanists to derive from Southern plants adequate substitutes for foreign substances that were difficult, if not impossible, to obtain in the Confederacy. In this painstakingly researched yet highly readable book, Michael A. Flannery, co-author of the critically acclaimed America’s Botanico-Medical Movements: Vox Populi, examines all these topics and more. In addition, he assesses the relative successes and failures of the pharmaceutical aspect of health care at the time—successes and failures that affected every man in army camps and in the field. Civil War Pharmacy: A History of Drugs, Drug Supply and Provision, and Therapeutics for the Union and Confederacy includes photographs, helpful tables and figures, and six appendices that make hard-to-find information easy to access and understand. You’ll find: the Standard Supply Table of Indigenous Remedies (1863) Circular No. 6 from the Surgeon General’s Office (May 4, 1863), calling for the removal of calomel and tartar emetic from the Supply Table instructions on reading and filling a 19th century prescription—with a glossary of Latin phrases and approximate measures, an excerpt from The Hospital Steward’s Manual, and more! a circular from the Confederate Medical Purveyor’s Office a Materia Medica for the South: A list of medicinal substances from Porcher’s Resources of the Southern Fields and Forests common prescriptions of the Civil War period as well as basic syrups of the era with monographs on their principal substances: alcohol, cinchona, hydrargyrum (mercury), opium, and quinine Packed with more information than can be listed here and, just as importantly, presented in a reader-friendly manner, this is a book that no one interested in Civil War history—or pharmacy history—should be without!
Download or read book RNA Based Regulation in Human Health and Disease written by and published by Academic Press. This book was released on 2020-08-19 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. - Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease - Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies - Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic - Features contributions from leading experts in the field
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System written by Anna Zampetaki and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Circular Cities written by Jo Williams and published by Routledge. This book was released on 2021-04-21 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: With cities striving to meet sustainable development goals, circular urban systems are gaining momentum, especially in Europe. This research-based book defines the circular city and circular development. It explains the shift in focus from a purely economic concept, which promotes circular business models in cities, to one that explores a new approach to urban development. This approach offers huge opportunities and addresses important sustainability issues: resource consumption and waste; climate change; the health of urban populations; social inequalities and the creation of sustainable urban economies. It examines the different approaches to circular development, drawing on research conducted in four European cities: Amsterdam, London, Paris and Stockholm. It explores different development pathways and levers for a circular urban transformation. It highlights the benefits of adopting a circular approach to development in cities, but acknowledges that these benefits are not shared equally across society. Finally, it focuses on the challenges to implementing circular development faced by urban actors. This ground-breaking book will be essential reading to scholars, students, practitioners and policymakers interested in the circular economy, urban sustainability, urban ecology, urban planning, urban regeneration, urban resilience, adaptive cities and regenerative cities.
Download or read book Gene Therapy for Viral Infections written by Patrick Arbuthnot and published by Academic Press. This book was released on 2015-06-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. - Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections - Bridges the gap between the basic science and the important medical applications of this technology - Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering - Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs - Arms the reader with the cutting-edge information needed to stay abreast of this developing field
Download or read book Soul and Spirit in Dance Movement Psychotherapy written by Jill Hayes and published by Jessica Kingsley Publishers. This book was released on 2013-06-28 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a contemporary synthesis of Jungian and Post-Jungian imaginal perspectives, animate ecological phenomenology, somatics and recent scholarship in dance movement and progressive spiritualities, this unique book discusses how the promotion of a fluid relationship between imagination and movement can bring the mover back into relationship with soul and spirit. This connection with soul and spirit is considered as an essential and powerful resource in mental health. The book provides a rich digest of theory and produces a clear framework for the application of transpersonal theories to Dance Movement Psychotherapy (DMP) practice, writing and research, illustrating the use and value of transpersonal perspectives through detailed case studies. Providing spiritual, soulful and mythological perspectives on DMP rooted in theory and practice, this book will be essential reading for dance movement psychotherapists, drama psychotherapists, expressive arts therapists, and dance movement psychotherapy students, drama psychotherapy students and arts therapy students.
Download or read book Peptide based Drug Discovery written by Ved Srivastava and published by Royal Society of Chemistry. This book was released on 2017-06-26 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.
Download or read book Delivery Strategies for Antisense Oligonucleotide Therapeutics written by Saghir Akhtar and published by CRC Press. This book was released on 2017-07-28 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
Download or read book Drive written by Daniel H. Pink and published by Penguin. This book was released on 2011-04-05 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestseller that gives readers a paradigm-shattering new way to think about motivation from the author of When: The Scientific Secrets of Perfect Timing Most people believe that the best way to motivate is with rewards like money—the carrot-and-stick approach. That's a mistake, says Daniel H. Pink (author of To Sell Is Human: The Surprising Truth About Motivating Others). In this provocative and persuasive new book, he asserts that the secret to high performance and satisfaction-at work, at school, and at home—is the deeply human need to direct our own lives, to learn and create new things, and to do better by ourselves and our world. Drawing on four decades of scientific research on human motivation, Pink exposes the mismatch between what science knows and what business does—and how that affects every aspect of life. He examines the three elements of true motivation—autonomy, mastery, and purpose-and offers smart and surprising techniques for putting these into action in a unique book that will change how we think and transform how we live.
Download or read book Beyond Technique in Solution Focused Therapy written by Eve Lipchik and published by Guilford Press. This book was released on 2011-09-12 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solution-focused therapy is often misunderstood to be no more than the techniques it is famous for—pragmatic, future-oriented questions that encourage clients to reconceptualize their problems and build on their strengths. Yet when applied in a "one-size-fits-all" manner, these techniques may produce disappointing results and leave clinicians wondering where they have gone wrong. This volume adds a vital dimension to the SFT literature, providing a rich theoretical framework to facilitate nonformulaic clinical decision making. The focus is on how attention to emotional issues, traditionally not emphasized in brief, strengths-based interventions, can help "unstick" difficult situations and pave the way to successful solutions.
Download or read book Suggestive Therapeutics written by Hippolyte Bernheim and published by . This book was released on 1880 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of RNA Biochemistry written by Roland K. Hartmann and published by John Wiley & Sons. This book was released on 2015-06-22 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.
Download or read book Gene Expression and Phenotypic Traits written by Yuan-Chuan Chen and published by BoD – Books on Demand. This book was released on 2020-04-01 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.
