Download or read book Cilia Ciliated Epithelium and Ciliary Activity written by José A. Rivera and published by Elsevier. This book was released on 2013-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia, Ciliated Epithelium, and Ciliary Activity reviews the state of knowledge of the activity of cilia and of the role these structures play in maintaining the normal physiology of the body, especially in the respiratory and genital systems. It relates the diversity of manifestations shown by cilia and ciliated epithelium in health and disease, and the effect of the physicochemical agents studied which influence the life and death of these structures. The volume is organized into five sections. Section A provides a general discussion on the history of studies on the ciliated epithelium; the distribution and morphology of cilia; development, regeneration and transformation of ciliated cells; and culture of cilia and ciliated epithelium. Section B deals with ciliary activity while Section C examines the effects of physical and chemical agents on cilia. Section D takes up the function of cilia. Section E contains a list of references of the literature on these topics from the historical beginning of studies in the field to the time of writing. This volume is intended to be a ready-made reference source for workers in the fields of biological sciences and medicine.

Download or read book Cilia Ciliated Epithelium and Ciliary Activity written by and published by . This book was released on 1962 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cilia Ciliated Epithelium and Ciliary Activity With Plates and with a Bibliography written by José Albert RIVERA and published by . This book was released on 1962 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cilia Mucus and Mucociliary Interactions written by Nadav Liron and published by CRC Press. This book was released on 1998-02-26 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions discusses the genetic determinants of mucociliary system structure and function explains ciliary wave activity in cell-cell communication elucidates many of the key physiological processes in ciliary regulation reveals possible means of treating irregularities in mucus secretion and clearance improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields

Download or read book Developmental Mechanisms Underlying the Formation of Ciliated Epithelia written by Jennifer Louise Stubbs and published by . This book was released on 2008 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many vertebrate organ systems contain a specialized ciliated epithelium decorated with motile cilia, which produce a ciliary flow in order to move mucus or fluid across the tissue surface. Examples include the proximal airways of the respiratory tract, oviduct, ependyma of the brain ventricles and the embryonic node. The importance motile cilia function in these specialized tissues to organ function is evident from human diseases such as primary ciliary dyskinesia (PCD) or immotile cilia syndrome. Patients with PCD are prone to chronic respiratory infections, sinus infections, in 50% of cases have situs inversus and in rare cases exhibit hydrocephalus. This broad array of phenotypes due to ciliary dysfunction clearly shows the importance of ciliated epithelia to organismal survival. A great deal is known about ciliary flow and how it relates to tissue function in relation to disease states. However, much less is known about how such tissues are formed during development, and what factors control the formation of cilia in these tissues. In this work I first describe the morphogenesis of the ciliated external epithelium of Xenopus laevis embryos, a tissue that closely resembles the respiratory epithelium in form and function. Cells with motile cilia cover the Xenopus embryo in a characteristic spacing pattern. This pattern arises early in development when cells in the inner layer of the ectoderm are selected by Notch signaling to form ciliated cell precursors (CCPs) that then undergo radial intercalation into the outer epithelial layer to form ciliated cells. Inhibition of Notch signaling results in an overproduction of CCPs; while radial intercalation becomes limiting ciliated cells maintain their spacing in the epithelium. Transgenic and transplantation assays to mark ciliated cells and intercalating populations, respectively, indicate that intercalating cells are free to wedge basolaterally, but can only insert apically at vertices where multiple outer cells make contact, likely making apical insertion the rate-limiting step during radial intercalation. Ciliated cell spacing also appears to be influenced by several other factors including competition with intercalating non-ciliated cell populations for vertices, cell morphology, and limitations on apical insertion likely imposed by the outer layer. Suggesting that cells other than the ciliated cells themselves can affect the ciliated cell spacing pattern, and thus final tissue architecture observed in such an epithelium. In the second part of this dissertation I describe a role for FoxJ1, a forkhead transcription factor, in the specification of node-like cilia in Xenopus and zebrafish embryos. Monociliate cells at the embryonic node generate a leftward fluid flow responsible for left-right asymmetry breaking in mouse, fish and Xenopus embryos. These cilia share features of both primary sensory cilia and motile cilia found on multiciliate cells, but how these cilia are specified in relation to other cilia is unknown. Using knockdown by morpholino injection, I show that FoxJ1 plays a conserved role in basal body docking in multiciliate cells found on the external epithelium of Xenopus embryos. However, in contrast to results in the mouse, I also show that FoxJ1 is required for formation of the node-like cilia in Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle. Additionally, I show that misexpression of FoxJ1 is sufficient to induce ectopic GRP-like cilia on the surface epithelial cells of Xenopus embryos. Microarray analysis further indicates that FoxJ1 can induce ectopic cilia formation by upregulating the expression of genes required for cilia structure as well as genes required for cilia motility. Together these results indicate that node-like cilia in Xenopus and zebrafish are likely generated using a genetic pathway similar to that used to specify cilia in multiciliate cells. The studies presented in this dissertation shed light on the both the morphogenetic events that underlies the formation of the ciliated external epithelium in Xenopus embryos, but also on the specification of two different cilia subtypes that form on the epithelia of developing Xenopus embryo.

Download or read book A Study of the Fine Structure of ciliated Epithelia written by and published by Ardent Media. This book was released on with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cilia and Mucus written by Matthias Salathe and published by CRC Press. This book was released on 2001-07-27 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities. Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos! Examines the rol

Download or read book An Experimental Study of the Ciliated Epithelium of the Fresh water Mussel written by Orin Merwin Lofthus and published by . This book was released on 1941 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Download or read book Kendig and Chernick s Disorders of the Respiratory Tract in Children E Book written by Robert W. Wilmott and published by Elsevier Health Sciences. This book was released on 2012-02-25 with total page 1163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.

Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Download or read book Atlas of Histology of the Juvenile Rat written by George A Parker and published by Academic Press. This book was released on 2016-05-04 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. Written and edited by highly experienced, board-certified toxicologic pathologists Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies Detailed figure legends and chapter narratives present the salient features of each organ at each time interval Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification

Download or read book Nasal Physiology and Pathophysiology of Nasal Disorders written by Özlem Önerci Celebi and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal physiology and pathophysiology. With the help of numerous tables, schematic drawings, and color photographs, it helps readers gain a better understanding of the impact of structural changes and the process of disease development, and to make treatment decisions. Each chapter has been written by a leading expert in the field and addresses one important aspect in an accessible way. Covering all four functions of the nose: respiration, defense, olfaction and cosmesis, the book discusses the various techniques for the clinical evaluation of nasal function as well as current trends and future directions in nasal physiologic research. This second edition also includes additional chapters on rhinomanometry, local nasal inflammation, T cells and B cells, and artificial intelligence for the nose. Given its scope, the book is a valuable resource for both experienced otorhinolaryngologists and novices in the field.

Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Download or read book Dyneins written by Stephen M. King and published by Academic Press. This book was released on 2011-08-11 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features