Download or read book Chronic Myelocytic Leukemia and Interferon written by Dieter Huhn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on the effect of recombinant human interferon (rIFN) on the growth of colonies of multi potential hematopoietic progenitors have demonstrated that IFN inhibits the growth of these cells in culture. The inhibitory effect of IFN was more pronounced in multilineage colony forming cells (CFU-GEMMT) of marrow cells of patients with chronic myelogenous leukemia (CML) compared with stern cells of normal marrow. T cell colony formation (CFU-TL) of phi_positive T cells obtained from primary multilineage hematopoietic colonies was inhibited by rIFN. Inhibition of T cell colony formation of Phi T cells was more profound by IFN compared with secondary T cells of healthy individuals. Southern blot analysis of secondary T cells from normal individuals revealed a germ line pattern when examined for T cell receptor (TcR) gene re arrangements using the cDNA of the beta chain. Subcloned Phi T cells of one patient with CML demonstrated gene rearrangements of the TcR. We also demonstrated the disappearance of phi_positive multilineage hematopoietic colonies when marrow cells were preincubated with IFN and subsequently cultured in the presence of IFN. The cytoconversion of the Phi chromosome in metaphases obtained from individually analyzed multilineage hematopoietic colonies suggests that IFN might allow the restoration of nonclonal hematopoiesis in patients with CML. Acknowledgement. Supported in part by Deutsche Forschungsgemeinschaft and the Medical Research Council of Canada. References 1. Koeffler HP, Golde DW (1981) Chronic myelogenous 1eukelnia - new concepts.
Download or read book Chronic Myelocytic Leukemia and Interferon written by Dieter Huhn and published by Springer. This book was released on 1988-06-08 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on the effect of recombinant human interferon (rIFN) on the growth of colonies of multi potential hematopoietic progenitors have demonstrated that IFN inhibits the growth of these cells in culture. The inhibitory effect of IFN was more pronounced in multilineage colony forming cells (CFU-GEMMT) of marrow cells of patients with chronic myelogenous leukemia (CML) compared with stern cells of normal marrow. T cell colony formation (CFU-TL) of phi_positive T cells obtained from primary multilineage hematopoietic colonies was inhibited by rIFN. Inhibition of T cell colony formation of Phi T cells was more profound by IFN compared with secondary T cells of healthy individuals. Southern blot analysis of secondary T cells from normal individuals revealed a germ line pattern when examined for T cell receptor (TcR) gene re arrangements using the cDNA of the beta chain. Subcloned Phi T cells of one patient with CML demonstrated gene rearrangements of the TcR. We also demonstrated the disappearance of phi_positive multilineage hematopoietic colonies when marrow cells were preincubated with IFN and subsequently cultured in the presence of IFN. The cytoconversion of the Phi chromosome in metaphases obtained from individually analyzed multilineage hematopoietic colonies suggests that IFN might allow the restoration of nonclonal hematopoiesis in patients with CML. Acknowledgement. Supported in part by Deutsche Forschungsgemeinschaft and the Medical Research Council of Canada. References 1. Koeffler HP, Golde DW (1981) Chronic myelogenous 1eukelnia - new concepts.
Download or read book Chronic Myelocytic Leukemia and Interferon written by Dieter Huhn and published by Springer. This book was released on 1988-01-01 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Myelocytic Leukemia and Interferon written by Dieter Huhn and published by . This book was released on 1988-06-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Myeloid Leukemia written by Rüdiger Hehlmann and published by Springer. This book was released on 2016-08-17 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.
Download or read book Interferon Treatment of Chronic Myelogenous Leukemia written by Bergsagel, Daniel E and published by Mississauga, Ont. : Medicine Group. This book was released on 1993 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Myeloid Leukemia written by Rüdiger Hehlmann and published by Springer Nature. This book was released on 2021-06-02 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib.
Download or read book Medical Management of Chronic Myelogenous Leukemia written by Moshe Talpaz and published by CRC Press. This book was released on 1998-10-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable reference provides a timely summary of current therapies for chronic myelogenous leukemia (CML), discussing both basic pathophysiology and new experimental strategies. Combining the insights of over 30 prominent researchers in the field, Medical Management of Chronic Myelogenous Leukemia compares interferon therapy with conventional chemotherapy covers chronic, accelerated, and Philadelphia-negative phases details standard therapy with IFN- regimens and allogenic stem cell transplantation describes the utility and limitations of CML animal models profiles clinical trials testing IFN in combination with other agents assesses improvements in survival times among CML patients reviews the effectiveness of Southern blot monitoring traces the development of oligonucleotides as potential therapeutic agents outlines therapy with monoclonal antibodies, targeted NK cells, and immune T cells and more! Containing over 1500 references, tables, drawings, and photographs, Medical Management of Chronic Myelogenous Leukemia is suitable for clinical oncologists, hematologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, and residents, fellows, and medical school students in these disciplines.
Download or read book The Use of Alpha Interferon in the Management of Chronic Myeloid Leukaemia written by R. G. Richards and published by . This book was released on 1997 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medifocus Guidebook On Chronic Myelogenous Leukemia written by Medifocus.com, Inc. Staff and published by Medifocus_com Inc. This book was released on 2012-02-02 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MediFocus Guidebook on Chronic Myelogenous Leukemia is the most comprehensive, up-to-date source of information available. You will get answers to your questions, including risk factors of Chronic Myelogenous Leukemia, standard and alternative treatment options, leading doctors, hospitals and medical centers that specialize in Chronic Myelogenous Leukemia, results of the latest clinical trials, support groups and additional resources, and promising new treatments on the horizon. This one of a kind Guidebook offers answers to your critical health questions including the latest treatments, clinical trials, and expert research; high quality, professional level information you can trust and understand culled from the latest peer-reviewed journals; and a unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks. This Guidebook was updated on February 2, 2012.
Download or read book Leukemias written by J. Fleischer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current problems in research and treatment of leukemias as discussed at the symposium of the International Society of Haematology on leukemias in Dresden (Germany) are dealt with in detail in this volume. The characterization of leukemic cells and the evaluation of their function are themes, with the first hints emerging of the possibility of relating them to the intensity of treatment required. The cytokines, responsible for cooperation between cells, are also of great importance, and the beginnings of therapeutic applications can be discerned here. Not only are the cytokines themselves very interesting, but also the application of cells producing cytokines according to the range of macrophages found. The emphasis on cell-to-cell relationship is thus a main topic of the book. Of course, other treatment such as bone marrow transplantation and interferon therapy play an important part, too, and the latest results of chemotherapy are reported. A further essential area covered is the diagnosis and therapy of chronic leukemic diseases, the inclusion of which suitably rounds off the book. I am very grateful to the out standing specialists from both the West and the East who contributed to the symposium and this book: an important sign of collaboration and integration for the future.
Download or read book Handbook of Chronic Myeloid Leukemia written by Timothy P Hughes and published by Springer. This book was released on 2014-11-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.
Download or read book Interferons written by Carlo Aul and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.
Download or read book Interferons in Oncology written by John F. Smyth and published by Springer. This book was released on 1987 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Myeloid Leukemia written by Angelo M Carella and published by CRC Press. This book was released on 2001-07-05 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, an international team of experts in chronic myeloid leukemia share their expertise. In particular, they contribute their insights on the latest advances in understanding this disease, and the implications those developments have for its management. They explore many topics, including a review of molecular and cellular biology, discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. Chronic Myeloid Leukemia is ideal for oncologists and other specialists in the field.
Download or read book Chronic Myeloid Leukemia written by Angelo M. Carella and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This text, containing contributions from an international team of experts in chronic myeloid leukaemia, examines the advances being made in our understanding of this disease, and the implications these have for its management. Topics covered include a review of molecular and cellular biology, discussion of conventional chemotherapy and interferon therapy, and developments in allografting and autografting.
Download or read book Leukemias written by Stefan Faderl and published by John Wiley & Sons. This book was released on 2011-09-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area
