Download or read book Drug Design and Discovery in Alzheimer s Disease written by Atta-ur Rahman and published by Elsevier. This book was released on 2015-06-27 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. - Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development - Describes existing drugs for AD and current molecular understanding of the condition - Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Download or read book Cholinesterase Inhibitors in Alzheimer s Disease written by Gordon Mallarkey and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alzheimer Disease written by Robert Becker and published by Springer Science & Business Media. This book was released on 1996-12-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the new potential treatments and research in the area of Alzheimer's disease. Special attention is given to international developments in all fields relevant to new drug development. Topics discussed include: progress in the international harmonization of drug development guidelines for dementia drugs; bioethics and law; development of rating instruments; behavioural treatments; and the activities of the Reagan Foundation. The text integrates basic and clinical research findings, and provides evaluation of new approaches to therapy by world leaders in the field. The potential benefit for Alzheimer patients and families resulting from these research programmes, from molecular biology to clinical pharmacology, is reviewed and evaluated.

Download or read book Neuro Geriatrics written by Babak Tousi and published by Springer. This book was released on 2017-12-06 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual takes a multidisciplinary approach to neurological disorders in the elderly. Comprehensive and practical, it includes the most recent diagnostic criteria and immediately accessible visual care paths including the latest pharmacologic and non-pharmacologic interventions. Covering a range of modalities, from the importance and impact of each disease to diagnostic criteria, genetics, laboratory and imaging findings, treatment and care paths, this book focuses on neurological conditions that occur commonly in older persons or which have a striking effect on their lives. The common types of dementias, Parkinson’s disease and related disorders, rapidly progressive diseases, seizure disorders and multiple sclerosis are covered. Issues commonly affecting this population, such as neurobehavioral symptoms and caregiver issues, are discussed. Neuro-Geriatrics: A Clinical Manual is aimed at any physician who treats the elderly with neurological disorders: neurologists, geriatricians and geriatric psychiatrists, both specialists and general practitioners.

Download or read book Subcortical Vascular Dementia written by Rita Moretti and published by Nova Publishers. This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular dementia is one of the most common forms of mental deterioration for the elderly, second only to Alzheimer's disease. It should not be defined as a single disease, but rather as a group of syndromes that relate to different vascular mechanisms. This is one of the first books to be solely dedicated to the specific class of vascular dementia known as subcortical vascular dementia. The strict focus of the chapters give an depth review that will clarify many different aspects and give an unprecedented amount of detail about this clinical problem. Considering that vascular dementia can be prevented with early diagnosis, the research presented in this book will be important for both students and specialists of this important field.

Download or read book Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders written by Adeboye Adejare and published by Academic Press. This book was released on 2016-09-20 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. - Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders - Examines different classes of compounds currently being used in discovery and development stages - Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions - Distills the most significant information across multiple areas of Alzheimer's disease research to provide a single, comprehensive, and balanced resource

Download or read book Pharmacotherapy of Alzheimer s Disease written by Serge Gauthier and published by CRC Press. This book was released on 1998-01-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough guide details clinical trials, the drugs currently available and the expectations of the doctor, family and carer

Download or read book Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2004-12-17 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Download or read book Cholinesterase Inhibitors for Alzheimer s Disease written by and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vijay Shukla was responsible for the coordination of the project, the protocol development and the selection of trials. [...] Becky Skidmore was responsible for the design and execution of the literature search strategies, for writing the methods section and associated appendix on literature searching; and for verifying and formatting bibliographic references. [...] The fact that many trials did not present measures of dispersion for continuous variables, the wide variety of trial designs and the poor quality of head-to-head trials further complicated the analyses. [...] It is associated with declines in higher cognitive abilities such as executive function, language, orientation and judgment.1 Changes in functional autonomy are recognized as a part of the disease process and are often the first clinical sign of AD.2 The treatment of dementias, such as AD, poses a challenge in health care, because of the aging population and the high costs of managing the disease. [...] The change in score from baseline to the final assessment was used in the analyses of all continuous variables (with the exception of CIBIC-plus and CGIC) to calculate the weighted mean difference (WMD) with 95% CI.

Download or read book Enzymes of the Cholinesterase Family written by A.S. Balasubramanian and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.

Download or read book Cholinesterase Inhibitors in Alzheimer s Disease written by Agneta Nordberg and published by . This book was released on 1993 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and published by BoD – Books on Demand. This book was released on 2021-01-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Download or read book Alzheimer s Disease written by Lit-Fui Lau and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will first review existing cholinesterase inhibitors prescribed for Alzheimer’s disease (AD) patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. This volume is part of a series that covers hot topics of frontier research summarized by reputed scientists in the field.

Download or read book Pathobiology of Alzheimer s Disease written by and published by Elsevier. This book was released on 1995-10-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.* * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text

Download or read book A History of Neuropsychology written by J. Bogousslavsky and published by Karger Medical and Scientific Publishers. This book was released on 2019-04-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychology has become a very important aspect for neurologists in clinical practice as well as in research. Being a specialized field in psychology, its long history is based on different historical developments in brain science and clinical neurology. In this volume, we want to show how present concepts of neuropsychology originated and were established by outlining the most important developments since the end of the 19th century. The articles of this book that cover topics such as aphasia, amnesia and dementia show a great multicultural influence due to an editorship and authorship that spans all developmental initiatives in Europe, Asia, and America. This book gives a better understanding of the development of higher brain function studies and is an interesting read for neurologists, psychiatrists, psychologists, neurosurgeons, historians, and anyone else interested in the history of neuropsychology.

Download or read book Severe Dementia written by Alistair Burns and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The later stages of dementia are as important, if not more so, as the earlier stages, since they harbour unique characteristics and events, which profoundly affect the lives of patients and their carers. Severe dementia has not had a high profile in the clinical literature as until recently prognosis was poor and there were few beneficial interventions. With the recent licensing of memantine, clinicians finally have a drug option that will delay disease progression. Severe Dementia is the first book to focus exclusively on severe dementia. It addresses both the clinical features of the disease and the social aspects of care. Introductory chapters on the differential diagnosis, neurochemistry and molecular pathology of severe dementia set the scene for the clinical discussion. Detailed clinical chapters on cognitive function, depression, physical effects, staging and function follow. All therapeutic interventions are then discussed, including memantine, anticholinesterases, neuroleptics and non-pharmacological treatment. The final chapters review the social and economic aspects of dementia care, including family involvement, person-centered care, palliative care, ethics and health economics. Written and edited by experts in geriatric psychiatry and geriatrics, Severe Dementia is of value to all clinicians involved in the management of this complex and vulnerable group of patients. It is also of interest to general practitioners and carers in nursing homes.